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- Antibody Data
- Antigen structure
- References [23]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 20466-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20466-1-AP, RRID:AB_10694821
- Product name
- INF2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated INF2 antibody (Cat. #20466-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1.
Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.
APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells.
Multiple formin proteins participate in glioblastoma migration.
Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation.
FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.
Calcium Wave Promotes Cell Extrusion.
GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics.
Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
Hic-5 regulates Src-induced invadopodia rosette formation and organization.
INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway.
Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-mediated mitochondrial fission.
Inhibitory effect of Tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.
Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.
Nurr1 exacerbates cerebral ischemia-reperfusion injury via modulating YAP-INF2-mitochondrial fission pathways.
Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation.
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.
An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.
Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.
Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly.
González-Barriga A, Lallemant L, Dincã DM, Braz SO, Polvèche H, Magneron P, Pionneau C, Huguet-Lachon A, Claude JB, Chhuon C, Guerrera IC, Bourgeois CF, Auboeuf D, Gourdon G, Gomes-Pereira M
Frontiers in cellular neuroscience 2021;15:662035
Frontiers in cellular neuroscience 2021;15:662035
Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.
Wang B, Zhang C, Yu C, Zhu Y, Tang Q, Huang H, Zhao Z
Frontiers in microbiology 2021;12:684953
Frontiers in microbiology 2021;12:684953
APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homblé F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Pérez-Morga D, Pays E
Cell reports 2020 Mar 17;30(11):3821-3836.e13
Cell reports 2020 Mar 17;30(11):3821-3836.e13
Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells.
Teo JL, Gomez GA, Weeratunga S, Davies EM, Noordstra I, Budnar S, Katsuno-Kambe H, McGrath MJ, Verma S, Tomatis V, Acharya BR, Balasubramaniam L, Templin RM, McMahon KA, Lee YS, Ju RJ, Stebhens SJ, Ladoux B, Mitchell CA, Collins BM, Parton RG, Yap AS
Developmental cell 2020 Jul 6;54(1):75-91.e7
Developmental cell 2020 Jul 6;54(1):75-91.e7
Multiple formin proteins participate in glioblastoma migration.
Heuser VD, Kiviniemi A, Lehtinen L, Munthe S, Kristensen BW, Posti JP, Sipilä JOT, Vuorinen V, Carpén O, Gardberg M
BMC cancer 2020 Jul 29;20(1):710
BMC cancer 2020 Jul 29;20(1):710
Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation.
Santos JD, Pinto FR, Ferreira JF, Amaral MD, Zaccolo M, Farinha CM
The Biochemical journal 2020 Jul 17;477(13):2561-2580
The Biochemical journal 2020 Jul 17;477(13):2561-2580
FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.
Subramanian B, Chun J, Perez-Gill C, Yan P, Stillman IE, Higgs HN, Alper SL, Schlöndorff JS, Pollak MR
Journal of the American Society of Nephrology : JASN 2020 Feb;31(2):374-391
Journal of the American Society of Nephrology : JASN 2020 Feb;31(2):374-391
Calcium Wave Promotes Cell Extrusion.
Takeuchi Y, Narumi R, Akiyama R, Vitiello E, Shirai T, Tanimura N, Kuromiya K, Ishikawa S, Kajita M, Tada M, Haraoka Y, Akieda Y, Ishitani T, Fujioka Y, Ohba Y, Yamada S, Hosokawa Y, Toyama Y, Matsui T, Fujita Y
Current biology : CB 2020 Feb 24;30(4):670-681.e6
Current biology : CB 2020 Feb 24;30(4):670-681.e6
GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics.
Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R
Nature communications 2019 Nov 21;10(1):5271
Nature communications 2019 Nov 21;10(1):5271
Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
Tonsawan P, Dylewski J, Lewis L, Blaine J
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060
Hic-5 regulates Src-induced invadopodia rosette formation and organization.
Gulvady AC, Forsythe IJ, Turner CE
Molecular biology of the cell 2019 May 15;30(11):1298-1313
Molecular biology of the cell 2019 May 15;30(11):1298-1313
INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway.
Chen Z, Wang C, Yu N, Si L, Zhu L, Zeng A, Liu Z, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Mar;111:151-161
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Mar;111:151-161
Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-mediated mitochondrial fission.
Li X, Wu M, An D, Yuan H, Li Z, Song Y, Liu Z
Journal of cellular physiology 2019 Feb 11;
Journal of cellular physiology 2019 Feb 11;
Inhibitory effect of Tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.
Xie Z, Zhou Y, Duan X, Yang L
Journal of receptor and signal transduction research 2019 Apr;39(2):134-145
Journal of receptor and signal transduction research 2019 Apr;39(2):134-145
Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.
Heuser VD, Mansuri N, Mogg J, Kurki S, Repo H, Kronqvist P, Carpén O, Gardberg M
Breast cancer : basic and clinical research 2018;12:1178223418792247
Breast cancer : basic and clinical research 2018;12:1178223418792247
Nurr1 exacerbates cerebral ischemia-reperfusion injury via modulating YAP-INF2-mitochondrial fission pathways.
Zhang Z, Yu J
The international journal of biochemistry & cell biology 2018 Nov;104:149-160
The international journal of biochemistry & cell biology 2018 Nov;104:149-160
Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation.
Zhao H, Pan W, Chen L, Luo Y, Xu R
Journal of molecular histology 2018 Dec;49(6):599-613
Journal of molecular histology 2018 Dec;49(6):599-613
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.
Jin X, Wang J, Gao K, Zhang P, Yao L, Tang Y, Tang L, Ma J, Xiao J, Zhang E, Zhu J, Zhang B, Zhao SM, Li Y, Ren S, Huang H, Yu L, Wang C
PLoS genetics 2017 Apr;13(4):e1006748
PLoS genetics 2017 Apr;13(4):e1006748
Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.
Tamura H, Nakazato H, Kuraoka S, Yoneda K, Takahashi W, Endo F
Nephrology (Carlton, Vic.) 2016 Jun;21(6):467-75
Nephrology (Carlton, Vic.) 2016 Jun;21(6):467-75
An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.
Bartolini F, Andres-Delgado L, Qu X, Nik S, Ramalingam N, Kremer L, Alonso MA, Gundersen GG
Molecular biology of the cell 2016 Jun 1;27(11):1797-808
Molecular biology of the cell 2016 Jun 1;27(11):1797-808
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.
Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM
Cell 2016 Dec 1;167(6):1571-1585.e18
Cell 2016 Dec 1;167(6):1571-1585.e18
Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.
Shao X, Li Q, Mogilner A, Bershadsky AD, Shivashankar GV
Proceedings of the National Academy of Sciences of the United States of America 2015 May 19;112(20):E2595-601
Proceedings of the National Academy of Sciences of the United States of America 2015 May 19;112(20):E2595-601
Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly.
Skau CT, Plotnikov SV, Doyle AD, Waterman CM
Proceedings of the National Academy of Sciences of the United States of America 2015 May 12;112(19):E2447-56
Proceedings of the National Academy of Sciences of the United States of America 2015 May 12;112(19):E2447-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 20466-1-AP(INF2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 20466-1-AP(INF2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The INF2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human INF2. This antibody recognizes human, mouse, rat antigen. The INF2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
