20466-1-AP

antibody from Proteintech Group

Targeting: INF2 C14orf151, C14orf173, MGC13251

Provider product page for 20466-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 20466-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20466-1-AP, RRID:AB_10694821
Product name: INF2 antibody
Antibody type: Polyclonal
Description: KD/KO validated INF2 antibody (Cat. #20466-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

INF2 protein structure - 20466-1-AP shown in red.

Submitted references FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis.

Pan MH, Zhang KH, Wu SL, Pan ZN, Sun MH, Li XH, Ju JQ, Luo SM, Ou XH, Sun SC
eLife 2024 May 15;12

Missense Mutant Gain-of-Function Causes Inverted Formin 2 (INF2)-Related Focal Segmental Glomerulosclerosis (FSGS).

Subramanian B, Williams S, Karp S, Hennino MF, Jacas S, Lee M, Riella CV, Alper SL, Higgs HN, Pollak MR
bioRxiv : the preprint server for biology 2024 Jun 10;

Drebrin Protects Assembled Actin from INF2-FFC-mediated Severing and Stabilizes Cell Protrusions.

Rajan S, Aguirre R, Hong Zhou Z, Hauser P, Reisler E
Journal of molecular biology 2024 Feb 15;436(4):168421

Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer.

Peippo M, Gardberg M, Kronqvist P, Carpén O, Heuser VD
Journal of breast cancer 2023 Dec;26(6):525-543

Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1.

Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh SJ, Reiterer V, Parizadeh A, Felder E, Kahlhofer JC, Teis D, Kazanietz MG, Geley S, Eriksson L, Roca-Cusachs P, Farhan H
The EMBO journal 2022 Sep 15;41(18):e110596

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1.

González-Barriga A, Lallemant L, Dincã DM, Braz SO, Polvèche H, Magneron P, Pionneau C, Huguet-Lachon A, Claude JB, Chhuon C, Guerrera IC, Bourgeois CF, Auboeuf D, Gourdon G, Gomes-Pereira M
Frontiers in cellular neuroscience 2021;15:662035

Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.

Wang B, Zhang C, Yu C, Zhu Y, Tang Q, Huang H, Zhao Z
Frontiers in microbiology 2021;12:684953

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homblé F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Pérez-Morga D, Pays E
Cell reports 2020 Mar 17;30(11):3821-3836.e13

Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells.

Teo JL, Gomez GA, Weeratunga S, Davies EM, Noordstra I, Budnar S, Katsuno-Kambe H, McGrath MJ, Verma S, Tomatis V, Acharya BR, Balasubramaniam L, Templin RM, McMahon KA, Lee YS, Ju RJ, Stebhens SJ, Ladoux B, Mitchell CA, Collins BM, Parton RG, Yap AS
Developmental cell 2020 Jul 6;54(1):75-91.e7

Multiple formin proteins participate in glioblastoma migration.

Heuser VD, Kiviniemi A, Lehtinen L, Munthe S, Kristensen BW, Posti JP, Sipilä JOT, Vuorinen V, Carpén O, Gardberg M
BMC cancer 2020 Jul 29;20(1):710

Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation.

Santos JD, Pinto FR, Ferreira JF, Amaral MD, Zaccolo M, Farinha CM
The Biochemical journal 2020 Jul 17;477(13):2561-2580

FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.

Subramanian B, Chun J, Perez-Gill C, Yan P, Stillman IE, Higgs HN, Alper SL, Schlöndorff JS, Pollak MR
Journal of the American Society of Nephrology : JASN 2020 Feb;31(2):374-391

Calcium Wave Promotes Cell Extrusion.

Takeuchi Y, Narumi R, Akiyama R, Vitiello E, Shirai T, Tanimura N, Kuromiya K, Ishikawa S, Kajita M, Tada M, Haraoka Y, Akieda Y, Ishitani T, Fujioka Y, Ohba Y, Yamada S, Hosokawa Y, Toyama Y, Matsui T, Fujita Y
Current biology : CB 2020 Feb 24;30(4):670-681.e6

SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

Jin X, Wang J, Li Q, Zhuang H, Yang J, Lin Z, Lin T, Lv Z, Shen L, Yan C, Zheng J, Zhu J, Gong Z, Wang C, Gao K
American journal of cancer research 2019;9(12):2797-2812

Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-mediated mitochondrial fission.

Li X, Wu M, An D, Yuan H, Li Z, Song Y, Liu Z
Journal of cellular physiology 2019 Sep;234(9):16238-16251

GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics.

Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R
Nature communications 2019 Nov 21;10(1):5271

Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.

Tonsawan P, Dylewski J, Lewis L, Blaine J
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060

Hic-5 regulates Src-induced invadopodia rosette formation and organization.

Gulvady AC, Forsythe IJ, Turner CE
Molecular biology of the cell 2019 May 15;30(11):1298-1313

INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway.

Chen Z, Wang C, Yu N, Si L, Zhu L, Zeng A, Liu Z, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Mar;111:151-161

Inhibitory effect of Tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.

Xie Z, Zhou Y, Duan X, Yang L
Journal of receptor and signal transduction research 2019 Apr;39(2):134-145

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Heuser VD, Mansuri N, Mogg J, Kurki S, Repo H, Kronqvist P, Carpén O, Gardberg M
Breast cancer : basic and clinical research 2018;12:1178223418792247

Nurr1 exacerbates cerebral ischemia-reperfusion injury via modulating YAP-INF2-mitochondrial fission pathways.

Zhang Z, Yu J
The international journal of biochemistry & cell biology 2018 Nov;104:149-160

Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation.

Zhao H, Pan W, Chen L, Luo Y, Xu R
Journal of molecular histology 2018 Dec;49(6):599-613

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.

Jin X, Wang J, Gao K, Zhang P, Yao L, Tang Y, Tang L, Ma J, Xiao J, Zhang E, Zhu J, Zhang B, Zhao SM, Li Y, Ren S, Huang H, Yu L, Wang C
PLoS genetics 2017 Apr;13(4):e1006748

Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.

Tamura H, Nakazato H, Kuraoka S, Yoneda K, Takahashi W, Endo F
Nephrology (Carlton, Vic.) 2016 Jun;21(6):467-75

An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.

Bartolini F, Andres-Delgado L, Qu X, Nik S, Ramalingam N, Kremer L, Alonso MA, Gundersen GG
Molecular biology of the cell 2016 Jun 1;27(11):1797-808

Calcium-mediated actin reset (CaAR) mediates acute cell adaptations.

Wales P, Schuberth CE, Aufschnaiter R, Fels J, García-Aguilar I, Janning A, Dlugos CP, Schäfer-Herte M, Klingner C, Wälte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstädt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Söldner R
eLife 2016 Dec 6;5

FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM
Cell 2016 Dec 1;167(6):1571-1585.e18

Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.

Shao X, Li Q, Mogilner A, Bershadsky AD, Shivashankar GV
Proceedings of the National Academy of Sciences of the United States of America 2015 May 19;112(20):E2595-601

Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly.

Skau CT, Plotnikov SV, Doyle AD, Waterman CM
Proceedings of the National Academy of Sciences of the United States of America 2015 May 12;112(19):E2447-56

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A431 cells were subjected to SDS PAGE followed by western blot with 20466-1-AP(INF2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human kidney using 20466-1-AP(INF2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The INF2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human INF2. This antibody recognizes human, mouse, rat antigen. The INF2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20466-1-AP.pdf

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