Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 60037AD - Provider product page
- Provider
- STEMCELL Technologies Inc
- Product name
- Anti-Mouse CD49f Antibody, Clone GoH3, Alexa Fluor® 488
- Antibody type
- Monoclonal
- Description
- The GoH3 antibody reacts with CD49f (integrin ?6), an ~150 kDa transmembrane glycoprotein that associates non-covalently with CD29 (integrin ?1) or CD104 (integrin ?4) to form the heterodimeric receptors VLA-6 and ?6?4, which bind the extracellular matrix protein laminin. CD49f is a disulfide-linked dimer comprising an ~120 kDa heavy chain and an ~30 kDa membrane-bound light chain. Splice variants exist, which affect the cytoplasmic domain of the protein. CD49f is expressed on the surface of T cells, monocytes, platelets, placental trophoblasts, epithelial, and endothelial cells. It is involved in cell adhesion and regulating signaling pathways involved in a variety of processes, including the activation and proliferation of T cells, and the differentiation and maintenance of pluripotency of stem cells. CD49f is considered the most important marker for selecting mouse mammary stem and progenitor cells. The GoH3 antibody reacts with an extracellular epitope on CD49f and reportedly blocks integrin ?6 function in vivo and binding of integrin ?6 to laminin in vitro.
- Reactivity
- Human, Mouse, Bovine, Rabbit
- Isotype
- IgG
- Vial size
- 100 Tests
- Storage
- 2 - 8°C
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