27189-1-AP

antibody from Proteintech Group

Targeting: ITGA6 CD49f

Provider product page for 27189-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
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Product number: 27189-1-AP - Provider product page
Provider: Proteintech Group
Product name: Integrin Alpha 6 antibody
Antibody type: Polyclonal
Description: Integrin Alpha 6 antibody (Cat. #27189-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ITGA6 protein structure - 27189-1-AP shown in red.

Submitted references INHBA Promotes the Progression of Gastric Cancer by Activating MAPK Signaling Pathway via Targeting ITGA6.

Zhou G, Zhang R, Nie L, Si Y, Liu T, Wang J, Han S, Xuan M, Wang J, Yu W
Oncology research 2026;34(3):25

Adhesion molecule with Ig-like domain 1 regulates stability of carotid plaque via TGFβ/Smad signaling pathway by interaction with TGFRII.

Hu X, Li X, Chen J, Li Y, Zhao Z, Yin X, Duan S, Wang B
Cellular signalling 2026 Jun;142:112412

Comprehensive exome profiling identifies ARHGEF12 mutation as a driver in gastric cancer with ovarian metastasis.

Zhang M, Chen G, Lin X, Zhang Y, Shi L, Li S, Li Y, Xiao X, Feng H
Theranostics 2025;15(16):8202-8221

Pan-cancer analysis of integrin alpha family and prognosis validation in head and neck squamous cell carcinoma.

Ji S, Hao F, Zhang C, Hu C, Ren H, Huang Q, Gu J
Frontiers in oncology 2025;15:1556226

Integrative multi-omics analysis decodes HOXC9-driven malignant transformation and metastasis in OSCC.

Xu M, Sun Z, Wang D, Li G, Feng W, Qiao C, Shi C, Liu Q, Chen P, An Z
iScience 2025 Sep 19;28(9):112919

A novel tumor microenvironment-related gene signature for prognostic prediction of intrahepatic cholangiocarcinoma.

Xu D, Lin H, Ma X, Sun Y, Wang W, Wang L
Scientific reports 2025 Nov 24;15(1):41570

KBU2046 exerts inhibition on chemokine gradient-mediated motility of esophageal squamous cell carcinoma through reducing integrin expression.

Li K, Chen J, Li W, Zhang Z, Xue Y, Zheng Y, Zhang Y, Zhang C, Bergan R, Zhao L
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167800

DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription.

Xia T, Yin H, Zhu Q, Zhang K, Xie H, Shan Y, Zhang S, Zhu R, Li K, Miao M, Lu Y, Wang Z, Zhao J, You Y, You B
Cell reports. Medicine 2025 Jun 17;6(6):102146

SNRPB-mediated regulation of DDX39A splicing promotes ovarian cancer progression by regulating α6 integrin subunit expression.

Li Y, Chen Z, Gao Y, Liu Y, Gao Q, Pu Y, Xiao H, Diao Y, Guo L, Yuan C, Yan S, Yang N, Kong B
Oncogene 2025 Jul;44(26):2170-2185

Unique gene patterns lead to distinct functional phenotypes and chemosensitivity profiles among subclones obtained from a single glioblastoma cell line.

Xu D, Jiang Y, Li J, Gong L, Yang Z, Zhang B, Li K, Zou J
Acta biochimica et biophysica Sinica 2025 Jul 16;57(11):1875-1887

Biomimetic Topological Micropattern Arrays Regulate the Heterogeneity of Cellular Fates in Lung Fibroblasts between Fibrosis and Invasion.

Zhu X, Mao S, Yang Y, Liu X, Liu Q, Zhang N, Yang Y, Li Y, Gao M, Bao J, Li W, Li Y
ACS nano 2025 Jan 14;19(1):580-599

Unveiling the therapeutic potential: KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro.

Chen J, Dai S, Zhang G, Wei S, Zhao X, Zheng Y, Wang Y, Wang X, Liu Y, Zhao L
Oncology research 2024;32(11):1791-1802

Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.

Deng Z, Yu L, Kuang Y, Zhou Z, Li X
International journal of nanomedicine 2024;19:2469-2485

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys.

Zhou M, Shi ZX, Liu Z, Ke SR, Wang CY, Liang XL, Hu QL, Zhang QK, Wang DL, Sun L, Lin YH, Dai Q, Zheng YF
Investigative ophthalmology & visual science 2024 Sep 3;65(11):43

Proteomics reveals the pharmacological mechanism of flavonoids from Astragali Complanati Semen in preventing chronic liver injury.

Chen L, Kong X, Zhou R, Hu J, Zhou R, Song Z, Tang Z, Wang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155910

FUT3 promotes gastric cancer cell migration by synthesizing Lea on ITGA6 and GLG1, affecting adhesion and vesicle distribution.

Wu F, Cao L, Zhang J, Cai S, Wu H, Miao J, Zhao L, Zhao C, Wang X, Ramzan MA, Ali S, Wu F, Ni L, Liu L, Qin Y, Huang C
Life sciences 2024 Dec 15;359:123193

A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.

Zhao X, Zhang S, Gao S, Chang HM, Leung PCK, Tan J
ACS applied materials & interfaces 2023 Mar 29;15(12):15084-15095

Expression of type VI collagen α3 chain in canine mammary carcinomas.

Araki M, Noguchi S, Kubo Y, Yasuda A, Koh M, Otsuka H, Yokosuka M, Soeta S
Research in veterinary science 2023 Jun;159:171-182

Expression of receptor-type tumour endothelial marker 8 in carcinoma cells showing luminal progenitor-like phenotypes in canine mammary gland carcinomas.

Araki M, Noguchi S, Kubo Y, Yasuda A, Koh M, Otsuka H, Yokosuka M, Soeta S
Journal of comparative pathology 2023 Jan;200:35-45

Interleukin-26-DNA complexes promote inflammation and dermal-epidermal separation in a modified human cryosection model of bullous pemphigoid.

Mizuno Y, Shibata S, Ito Y, Taira H, Sugimoto E, Awaji K, Sato S
Frontiers in immunology 2022;13:1013382

IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.

Li W, Wang Z, Wang H, Zhang J, Wang X, Xing S, Chen S
PeerJ 2022;10:e14201

Gelatin-grafted tubular asymmetric scaffolds promote ureteral regeneration via activation of the integrin/Erk signaling pathway.

Song B, Fang L, Mao X, Ye X, Yan Z, Ma Q, Shi Z, Hu Y, Zhu Y, Cheng Y
Frontiers in bioengineering and biotechnology 2022;10:1092543

Single-Cell RNA-Seq Reveals Heterogeneity of Cell Communications between Schwann Cells and Fibroblasts within Vestibular Schwannoma Microenvironment.

Xu M, Wang S, Jiang Y, Wang J, Xiong Y, Dong W, Yao Q, Xing Y, Liu F, Chen Z, Yu D
The American journal of pathology 2022 Sep;192(9):1230-1249

Glycoengineering human neural stem cells (hNSCs) for adhesion improvement using a novel thiol-modified N-acetylmannosamine (ManNAc) analog.

Du J, Liu X, Yarema KJ, Jia X
Biomaterials advances 2022 Mar;134:112675

TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin α6.

Hou S, Hao X, Li J, Weng S, Wang J, Zhao T, Li W, Hu X, Deng B, Gu J, Hang Q
Cell death & disease 2022 Jul 14;13(7):609

Midkine mediates dysfunction of liver sinusoidal endothelial cells through integrin α4 and α6.

Wu L, Chen H, Fu C, Xing M, Fang H, Yang F, Yang Q, Zhang Y, Li W, Chen Z
Vascular pharmacology 2022 Dec;147:107113

Comparative Analysis of mRNA and miRNA Expression between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak.

Zhang X, Bao P, Zheng Q, Chu M, Liang C, Guo X, Wu X, He M, Pei C, Yan P
Cells 2022 Dec 9;11(24)

EBV promotes vascular mimicry of dormant cancer cells by potentiating stemness and EMT.

Cheng T, Zhang S, Xia T, Zhang Y, Ji Y, Pan S, Xie H, Ren Q, You Y, You B
Experimental cell research 2022 Dec 15;421(2):113403

The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.

Wu S, Liu H, Zhou M, Shang Y, Luo L, Chen J, Yang J
Journal of reproductive immunology 2022 Aug;152:103647

Role of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infection.

Li Y, Li J, Wang X, Wu Q, Yang Q
Virulence 2021 Dec;12(1):2352-2365

Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.

Leng L, Ma J, Lv L, Wang W, Gao D, Zhu Y, Wu Z
Stem cell research & therapy 2020 Sep 23;11(1):415

MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6.

Tu Y, Ma T, Wen T, Yang T, Xue L, Cai M, Wang F, Guan M, Xue H
Biochemical and biophysical research communications 2020 Feb 26;523(1):46-53

MiR-302a-5p suppresses cell proliferation and invasion in non-small cell lung carcinoma by targeting ITGA6.

Chen W, Zhuang X, Qi R, Qiao T
American journal of translational research 2019;11(7):4348-4357

NFAT1 Hypermethylation Promotes Epithelial-Mesenchymal Transition and Metastasis in Nasopharyngeal Carcinoma by Activating ITGA6 Transcription.

Zhang J, Zheng ZQ, Yuan YW, Zhang PP, Li YQ, Wang YQ, Tang XR, Wen X, Hong XH, Lei Y, He QM, Yang XJ, Sun Y, Ma J, Liu N
Neoplasia (New York, N.Y.) 2019 Mar;21(3):311-321

Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus.

Xin X, Wang H, Han L, Wang M, Fang H, Hao Y, Li J, Zhang H, Zheng C, Shen C
Journal of virology 2018 May 1;92(9)

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