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- References [198]
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- Product number
- 11880-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11880-1-AP, RRID:AB_10640807
- Product name
- KLF4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KLF4 antibody (Cat. #11880-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references JianPi QingRe HuoXue Formula targets Cadherin-17 to induce apoptosis in chronic atrophic gastritis with intestinal metaplasia.
The Mechanism of KLF4-Mediated NF-κB/NLRP3 Pathway Regulating Arteriovenous Fistula Dysfunction.
Safeguarding VSMC Contractile Phenotype With In Situ circRNA-mediated Endothelial Olaratumab Engineering to Prevent Vascular Graft Stenosis.
Weiyan Tongluo Granules attenuate gastric intestinal metaplasia through PPARγ/NF-κB/CDX2 signaling pathway.
SETDB2-mediated transcriptional repression of IDE in sensory neurons promotes migraine-like pain behaviors in mice.
Dexmedetomidine Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting DNMT3B-Mediated Hypermethylation of the KLF4 Promoter.
Pseudoginsenoside F11 enhances YBX1-mediated transcriptional repression of PRPS2 to inhibit the stemness and pulmonary metastasis of triple- negative breast cancer.
Endothelial BMP6 Drives Hemodynamic-Dependent VSMCs Calcification in Carotid Atherosclerosis.
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.
BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1.
Oral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites.
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells.
Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.
H19 Promotes Odontogenic Differentiation of Human Dental Pulp Cells via miR-103a-3p-Mediated PIK3R1/AKT and KLF4 Pathways.
Engineered Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Liver Fibrosis by Delivering USP10 to Reprogram Macrophage Phenotype.
The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury.
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis.
Under Pressure: A unique mechanoresponsive mechanism of body site-specific keratin regulation in palmoplantar epidermis.
RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis.
Metformin limits cerebral cavernous malformation development by targeting KLF4-mediated mitochondrial damage.
Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma.
Age-Specific Biomarkers TREM1 and KLF4 in Ischemic Stroke: From Transcriptomic Discovery to Therapeutic Drug Screening.
Hypoxia promotes airway differentiation in the human lung epithelium.
Sleep deprivation-induced sympathetic activation promotes pro-tumoral macrophage phenotype via the ADRB2/KLF4 pathway to facilitate NSCLC metastasis.
Differential aortic aneurysm formation provoked by chemogenetic oxidative stress.
Transcriptional responses of three slc39a/zip members (zip4, zip5 and zip9) and their roles in Zn metabolism in grass carp (Ctenopharyngodon idella).
NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA.
Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis.
PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.
KLF4 mediates the contradictory effects of phenylethyl isothiocyanate in gastric cancer intervention.
TCF7 functions as a prognostic biomarker in bladder cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
PRMT6 Inhibits Malignant Progression of Melanoma by Antagonizing Trimethylation of Histone H3K4 to Downregulate ALDH1A1 Levels.
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming.
Identification of a new micropeptide altKLF4 derived from KLF4 that influences myeloma chemotherapeutic sensitivity.
Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells.
Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer.
Protective effect of ginseng extract and total ginsenosides on hematopoietic stem cell damage by inhibiting cell apoptosis and regulating the intestinal microflora.
RNF112, whose transcription is regulated by KLF4, inhibits colorectal cancer growth via promoting ubiquitin-dependent degradation of NAA40.
Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities.
Single-cell RNA sequencing of the carotid artery and femoral artery of rats exposed to hindlimb unloading.
Bisphenol S exposure promotes stemness of triple-negative breast cancer cells via regulating Gli1-mediated Sonic hedgehog pathway.
Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C.
Yiqi Huayu Jiedu formula inhibits JAK2/STAT3-mediated partial EMT in treating chronic atrophic gastritis.
Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer.
Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
Depletion of LINC01133 from cancer-associated fibroblasts exacerbates the progression of gastric adenocarcinoma.
Machine learning-based identification of kbhb-affected tumor cell subsets as prognostic and therapeutic targets in breast cancer.
TLR7-mediated immune response of renal myeloid-derived suppressor cells via RUNX1-KLF4 in systemic candidiasis.
Exosomal miR-146a-5p Derived from HSCs Accelerates Sepsis-induced Liver Injury by Suppressing KLF-4.
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear.
Role of Carvedilol in Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells by Upregulating microRNA-145 Expression.
Lactylation-boosted polycomb repression of KLF4 elicits glycolysis in retinoblastoma: A positive feedback circuit between histone modifications.
KLF4-induced upregulation of SOCS1 ameliorates myocardial ischemia/reperfusion injury by attenuating AC16 cardiomyocyte damage and enhancing M2 macrophage polarization.
Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco).
Mechanism of HDAC1 Regulating Iron Overload-Induced Neuronal Oxidative Damage After Cerebral Hemorrhage.
Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II.
Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming.
KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion.
Astrocyte-TREM2 alleviates brain injury by regulating reactive astrocyte states following ischemic stroke.
HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress.
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing.
Integrated mRNA-seq and miRNA-seq analysis reveals key transcription factors of HNF4α and KLF4 in ADPKD.
A novel combined therapeutic strategy of Nano-EN-IR@Lip mediated photothermal therapy and stem cell inhibition for gastric cancer.
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.
KLF4 promotes milk fat synthesis by regulating the PI3K-AKT-mTOR pathway and targeting FASN activation in bovine mammary epithelial cells.
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.
MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.
Oxidized ATM governs stemness of breast cancer stem cell through regulating ubiquitylation and acetylation switch.
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid- and IL4-Driven Macrophage Programming.
MiR-200b-3p elevates 5-FU sensitivity in cholangiocarcinoma cells via autophagy inhibition by targeting KLF4.
Preparation and antitumor activity of selenium nanocomposite stabilized by AAGL from Agerocybe aegerita.
Tet2 modulates M2 macrophage polarization via mRNA 5-methylcytosine in allergic rhinitis.
FOLR2(+) macrophage depletion from intestinal metaplasia to early gastric cancer: single-cell sequencing insight into gastric cancer progression.
MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4.
Loss of Smooth Muscle Tenascin-X Inhibits Vascular Remodeling Through Increased TGF-β Signaling.
YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells.
Bioinformatic analysis reveals the relationship between macrophage infiltration and Cybb downregulation in hyperoxia-induced bronchopulmonary dysplasia.
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Inhibition of the SLC35B2-TPST2 Axis of Tyrosine Sulfation Attenuates the Growth and Metastasis of Pancreatic Ductal Adenocarcinom.
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology.
Influences of lysine-specific demethylase 1 inhibitors on NO synthase-Kruppel-like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo.
Influences of repeated exposure to low levels of TiO(2) nanoparticles on Kruppel-like factors in 3D Caco-2 spheroids and mouse intestines.
Epithelial cells activate fibroblasts to promote esophageal cancer development.
Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.
Decreased Expression of KLF4 Leading to Functional Deficit in Pediatric Patients with Intestinal Failure and Potential Therapeutic Strategy Using Decanoic Acid.
TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750.
Paeoniflorin suppresses kidney inflammation by regulating macrophage polarization via KLF4-mediated mitophagy.
Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke.
LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
Inhibition of EphA2 protects against atherosclerosis by synergizing with statins to mitigate macrophage inflammation.
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.
miR-146a-5p Modulates Adult Hippocampal Neurogenesis Deficits Through Klf4/p-Stat3 Signaling in APP/PS1 Mice.
HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.
Commercial dishes with gelatin-free microstructured inserts for elongated stem cell self-renewal and pluripotency.
The KLF4-p62 axis prevents vascular endothelial cell injury via the mTOR/S6K pathway and autophagy in diabetic kidney disease.
KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription.
Iguratimod Attenuates Macrophage Polarization and Antibody-Mediated Rejection After Renal Transplant by Regulating KLF4.
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.
GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma.
Lef1 is transcriptionally activated by Klf4 and suppresses hyperoxia-induced alveolar epithelial cell injury.
SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway.
Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice.
Cilia proteins are biomarkers of altered flow in the vasculature.
Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells.
The role of KLF4 in melanogenesis and homeostasis in sheep melanocytes.
FAT1 downregulation enhances stemness and cisplatin resistance in esophageal squamous cell carcinoma.
Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation.
Curcumin attenuates vascular calcification via the exosomal miR-92b-3p/KLF4 axis.
Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.
DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma.
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
Toxicity evaluation of mesoporous silica particles Santa Barbara No. 15 amorphous in human umbilical vein endothelial cells: influence of particle morphology.
A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties.
Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the MERTK locus.
CDR1as regulated by hnRNPM maintains stemness of periodontal ligament stem cells via miR-7/KLF4.
Smooth muscle cell-specific knockout of interferon gamma (IFN-γ) receptor attenuates intimal hyperplasia via STAT1-KLF4 activation.
A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.
ET(A)R silencing ameliorated neurovascular injury after SAH in rats through ERK/KLF4-mediated phenotypic transformation of smooth muscle cells.
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.
Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles.
A Novel Long Non-Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis.
Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 Signaling in Cirrhotic Rats.
The preventive and therapeutic effects of AAV1-KLF4-shRNA in cigarette smoke-induced pulmonary hypertension.
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Cooperative activation of bovine herpesvirus 1 productive infection and viral regulatory promoters by androgen receptor and Krüppel-like transcription factors 4 and 15.
BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation.
ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.
A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes.
Modulating cancer stemness provides luminal a breast cancer cells with HER2 positive-like features.
miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo.
Pioneer transcription factors, progesterone receptor and Krüppel like transcription factor 4, cooperatively stimulate the bovine herpesvirus 1 ICP0 early promoter and productive late protein expression.
Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.
Using inducible lentiviral vectors to generate induced pluripotent stem cell line ZOCi001-A from peripheral blood cells of a patient with CRB1(-/-) retinitis pigmentosa.
The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs.
Long Noncoding RNA HOX Transcript Antisense RNA Gene rs17720428 Single Nucleotide Polymorphism Is Associated with Gastric Cancer Risk and Prognosis.
Deoxycholic Acid Upregulates the Reprogramming Factors KFL4 and OCT4 Through the IL-6/STAT3 Pathway in Esophageal Adenocarcinoma Cells.
LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4.
Oxidative stress-induced KLF4 activates inflammatory response through IL17RA and its downstream targets in retinal pigment epithelial cells.
Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the CRB1 locus.
Upregulation of the microRNA rno-miR-146b-5p may be involved in the development of intestinal injury through inhibition of Kruppel-like factor 4 in intestinal sepsis.
Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids.
miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis.
KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling.
KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling.
miR-92b-3p Functions As A Key Gene In Esophageal Squamous Cell Cancer As Determined By Co-Expression Analysis.
SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders.
SP1 regulates KLF4 via SP1 binding motif governed by DNA methylation during odontoblastic differentiation of human dental pulp cells.
MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway.
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF-β Signaling Pathway and Interaction With Histone Acetylation.
Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6.
SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression.
Role of Krüppel-like factor 4 in cigarette smoke-induced pulmonary vascular remodeling.
Quaking promotes the odontoblastic differentiation of human dental pulp stem cells.
Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency Acquisition.
Generation of an iPS cell line via a non-integrative method using urine-derived cells from a patient with USH2A-associated retinitis pigmentosa.
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells.
The histone methyltransferase SETD1A regulates thrombomodulin transcription in vascular endothelial cells.
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Soluble expression of recomb inant cMyc, Klf4, Oct4, and Sox2 proteins in bacteria and transduction into living cells.
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4.
CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma.
microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype.
miR-543 promotes colorectal cancer proliferation and metastasis by targeting KLF4.
Angiogenic Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury.
miR-103 Promotes Proliferation and Metastasis by Targeting KLF4 in Gastric Cancer.
Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression.
Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.
Vacuolar ATPase in phagosome-lysosome fusion.
Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/β-catenin signaling.
Krüppel-like factor 4 synergizes with CREB to increase the activity of apolipoprotein E gene promoter in macrophages.
The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells.
Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein.
LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16.
Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells.
Mai Z, Zheng Y, Xie J, Wen Y, Wang S, Huang Y, Tan H, Chen J, Wang C, Tao Y, Chen Q, Liu F, Liang Y, Chen X, Zhao Y, Li P, Yang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158037
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158037
The Mechanism of KLF4-Mediated NF-κB/NLRP3 Pathway Regulating Arteriovenous Fistula Dysfunction.
Wang Y, Deng J, Tan J, Meng Y
Acta Cardiologica Sinica 2026 Mar;42(2):186-197
Acta Cardiologica Sinica 2026 Mar;42(2):186-197
Safeguarding VSMC Contractile Phenotype With In Situ circRNA-mediated Endothelial Olaratumab Engineering to Prevent Vascular Graft Stenosis.
Hu S, Ling S, Liang F, Pan Y, Wang J, Bao W, Zhu J, Wang F, Du Y, Cui W, Yin M
Advanced materials (Deerfield Beach, Fla.) 2026 Mar;38(17):e22615
Advanced materials (Deerfield Beach, Fla.) 2026 Mar;38(17):e22615
Weiyan Tongluo Granules attenuate gastric intestinal metaplasia through PPARγ/NF-κB/CDX2 signaling pathway.
Liang Y, Su S, Jin T, Mou J, Wu H, Yan N, Li X, Yao S, Wen Y, Liu F, Li P
Chinese medicine 2026 Mar 4;21(1)
Chinese medicine 2026 Mar 4;21(1)
SETDB2-mediated transcriptional repression of IDE in sensory neurons promotes migraine-like pain behaviors in mice.
Zhang Y, Huang Z, Sun Y, Wang S, Tao Y, Lu W, Zhang Y, Jiang D, Ge J, Chen G, Jin X, Ji F, Wang Y, Yu Y, Zhang Y, Tao J
Cell reports 2026 Mar 24;45(4):117201
Cell reports 2026 Mar 24;45(4):117201
Dexmedetomidine Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting DNMT3B-Mediated Hypermethylation of the KLF4 Promoter.
Chen X, Hong J
Cardiovascular drugs and therapy 2026 Mar 10;
Cardiovascular drugs and therapy 2026 Mar 10;
Pseudoginsenoside F11 enhances YBX1-mediated transcriptional repression of PRPS2 to inhibit the stemness and pulmonary metastasis of triple- negative breast cancer.
Xu K, Bai Y, Chen H, Liu Y, Liu H, Liu Y, Wan X, Liu Y, Chen Y, Shi Y, Xiang R, Zeng B, Cui Y, Fan Y, Li J, Wang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158064
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158064
Endothelial BMP6 Drives Hemodynamic-Dependent VSMCs Calcification in Carotid Atherosclerosis.
Li S, Cao S, Li P, Zhang F, Ren G, Wang X, Zhao J, Liu C, Gao Y, Xu J, Wang Y, Xia Z, Xu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e02801
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e02801
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.
Chen Z, Zhao S, Chen D, Lou Y, Lu H, Yao Q, Lu J, Sun H
Cell & bioscience 2026 Jan 6;16(1):15
Cell & bioscience 2026 Jan 6;16(1):15
BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1.
Zhang J, Liu M, Ou H, Wang Z, He L, Xiao Y, Xie F, Yu D, Cao H, He W, Wang S, Zhang W, Zhang K, Zhang Y, Li M, Hao Q
Cell communication and signaling : CCS 2026 Jan 29;24(1)
Cell communication and signaling : CCS 2026 Jan 29;24(1)
Oral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites.
Zheng D, Chen S, Feng H, Zhang S, Zhang C, Wang Y, Tan W, Qing Q, Liu L, Liu X, Wang Z, Liang L, Sun J, Chen Y
British journal of pharmacology 2026 Feb;183(3):560-580
British journal of pharmacology 2026 Feb;183(3):560-580
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells.
Wang H, Luo K, Li S, Jin D, Ou L, Liu C, Wu Q
Journal of bioenergetics and biomembranes 2026 Feb 15;58(1)
Journal of bioenergetics and biomembranes 2026 Feb 15;58(1)
Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.
Zhou J, Huang Y, Li G, Zhao Z, Deng Y, Xian S, Hu Y, Yi M, Liu L
Scientific reports 2026 Feb 13;16(1)
Scientific reports 2026 Feb 13;16(1)
H19 Promotes Odontogenic Differentiation of Human Dental Pulp Cells via miR-103a-3p-Mediated PIK3R1/AKT and KLF4 Pathways.
Zhang J, Lin L, Dong H, Wang B, Chen X, Wang C, Lin L, Zhong J, Zheng G, Jiang Q
International dental journal 2026 Apr 30;76(4):109587
International dental journal 2026 Apr 30;76(4):109587
Engineered Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Liver Fibrosis by Delivering USP10 to Reprogram Macrophage Phenotype.
Tian S, Zhou X, Zheng L, Liu J, Zhang M, Ma S, Zheng X, Guo G, Ju R, Yang F, Liu Y, Li B, Hu Y, Xia E, Su R, Sun K, Cui L, Guo C, Zhou X, Wang J, Shang Y, Han Y
Biomaterials research 2025;29:0244
Biomaterials research 2025;29:0244
The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury.
Liu L, Chen F, Liu K, Xu F, Shen R, Jiang J, Lu F, Zhu J, Liu S, Wu L, Bian A, Privratsky JR, Crowley SD, Chen L, Xing C, Yuan Y, Huang Z, Mao H, Ren J
International journal of biological sciences 2025;21(13):5802-5820
International journal of biological sciences 2025;21(13):5802-5820
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
Huang QH, Tang XY, Huang QY, Zhi SB, Zheng XQ, Gan CY, Huang MF, Pan ZF, Zhong ZX
Biochemical pharmacology 2025 Sep;239:117014
Biochemical pharmacology 2025 Sep;239:117014
The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis.
Feng W, Wang H, Zhang G, Gao W, Li H, Liu H, Sun Y
Scientific reports 2025 Sep 29;15(1):33686
Scientific reports 2025 Sep 29;15(1):33686
Under Pressure: A unique mechanoresponsive mechanism of body site-specific keratin regulation in palmoplantar epidermis.
Steiner SN, Horst E, Athaiya M, Johnson CN, Shen JY, Kerns ML, Mehta G, Iglesias-Bartolome R, Coulombe PA
bioRxiv : the preprint server for biology 2025 Sep 17;
bioRxiv : the preprint server for biology 2025 Sep 17;
RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis.
Wang Y, Yang Q, Lin F, Song X, Yang G, Wen D, Yang Y, Wu B, Meng Y, Zhang N, Lu X, Xiong C, Zhao W, Liang J, Zhang T, Liu Y
Science advances 2025 Sep 12;11(37):eadw9519
Science advances 2025 Sep 12;11(37):eadw9519
Metformin limits cerebral cavernous malformation development by targeting KLF4-mediated mitochondrial damage.
Yan C, Ye Y, Liu N, Zhang D, Du W, Li Y, Li G, Li C, Li J, Ma S, Dai Z, Xiong Z, Wang Y, Men C, Bi R, Duan Q, Xu W, Husilengtu, Cao Y, Du J, Shi C
Biochemical and biophysical research communications 2025 Sep 1;777:152241
Biochemical and biophysical research communications 2025 Sep 1;777:152241
Targeting MCM10 disrupts cancer stemness and counteracts sorafenib resistance in hepatocellular carcinoma.
Zhang Z, Liang L, Li Y, Fan Y, Liu Y, He Z, Wu X, Cong L, Jiang Y, Wan T
Cancer gene therapy 2025 Oct;32(10):1076-1089
Cancer gene therapy 2025 Oct;32(10):1076-1089
Age-Specific Biomarkers TREM1 and KLF4 in Ischemic Stroke: From Transcriptomic Discovery to Therapeutic Drug Screening.
Zhou X, Bi J, Chen H, Wang Y, Li Y, Huang D, Ma X, Cai W, Jiang D, Guan T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71080
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71080
Hypoxia promotes airway differentiation in the human lung epithelium.
Dong Z, Wit N, Agarwal A, Reid AJ, Dubal D, Beier S, Mahbubani KT, Saeb-Parsy K, van den Ameele J, Nathan JA, Rawlins EL
Cell stem cell 2025 Nov 6;32(11):1705-1722.e9
Cell stem cell 2025 Nov 6;32(11):1705-1722.e9
Sleep deprivation-induced sympathetic activation promotes pro-tumoral macrophage phenotype via the ADRB2/KLF4 pathway to facilitate NSCLC metastasis.
Yin S, Wang J, Jia Y, Wang X, Zhao Y, Liu T, Lv W, Duan Y, Zhao S, Wang S, Liu L
iScience 2025 May 16;28(5):112321
iScience 2025 May 16;28(5):112321
Differential aortic aneurysm formation provoked by chemogenetic oxidative stress.
Das AA, Waldeck-Weiermair M, Yadav S, Spyropoulos F, Pandey A, Dutta T, Covington TA, Michel T
The Journal of clinical investigation 2025 May 1;135(9)
The Journal of clinical investigation 2025 May 1;135(9)
Transcriptional responses of three slc39a/zip members (zip4, zip5 and zip9) and their roles in Zn metabolism in grass carp (Ctenopharyngodon idella).
Guo JC, Xu PC, Xu YC, Zhang TH, Liu LL, Liu T, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2025 Mar;1868(1):195075
Biochimica et biophysica acta. Gene regulatory mechanisms 2025 Mar;1868(1):195075
NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA.
Li Z, Wu X
Thoracic cancer 2025 Mar;16(5):e70023
Thoracic cancer 2025 Mar;16(5):e70023
Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis.
Jiang Y, Zhang Y, Wang X, Xiang Y, Wang Z, Wang B, Ding Y, Gao Y, Rui B, Bai J, Ding Y, Chen C, Zhan Z, Liu X
Cell reports 2025 Mar 25;44(3):115399
Cell reports 2025 Mar 25;44(3):115399
PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC.
Zhang L, Cheng L, Ma Y, Li J, Zhong Y, Zhu X, Leng X, Xie F
Medical oncology (Northwood, London, England) 2025 Mar 12;42(4):102
Medical oncology (Northwood, London, England) 2025 Mar 12;42(4):102
KLF4 mediates the contradictory effects of phenylethyl isothiocyanate in gastric cancer intervention.
Zhang Q, Yang C, Zhou B, Gao X, Zhong C, Shi Y, Cao H, Zhu M
Medical oncology (Northwood, London, England) 2025 Jun 12;42(7):253
Medical oncology (Northwood, London, England) 2025 Jun 12;42(7):253
TCF7 functions as a prognostic biomarker in bladder cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
Zhang C, Cai H, Ye M, Wang L, Liu W, Huang Q, Peng X, Mao G, Zhang Q, Mei Y
Molecular and cellular biochemistry 2025 Jul;480(7):4135-4148
Molecular and cellular biochemistry 2025 Jul;480(7):4135-4148
PRMT6 Inhibits Malignant Progression of Melanoma by Antagonizing Trimethylation of Histone H3K4 to Downregulate ALDH1A1 Levels.
Cai M, Wang L, Sun M, Liu M, Liu Y
Pigment cell & melanoma research 2025 Jul;38(4):e70034
Pigment cell & melanoma research 2025 Jul;38(4):e70034
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming.
Liu J, Wu X, Yin Q, Zhang L, Liu K, Huang K, Xu J, Li X, Lin B, Zhu M, Li M
Journal of cellular and molecular medicine 2025 Jul;29(14):e70722
Journal of cellular and molecular medicine 2025 Jul;29(14):e70722
Identification of a new micropeptide altKLF4 derived from KLF4 that influences myeloma chemotherapeutic sensitivity.
Yao R, Zeng Y, Zhang Y, Cao X, Mao J, Li W, Xu K, Liu L
Cellular signalling 2025 Jul;131:111767
Cellular signalling 2025 Jul;131:111767
Effects of solamargine in hepatic metastasis of colorectal cancer: induction of ferroptosis and elimination of cancer stem cells.
Liu S, Wu J, Huang H, Hu B, Xie D, Cao F, Li J, Guo C, Peng W, Jin Y, Dai W
Chinese medicine 2025 Jul 11;20(1):110
Chinese medicine 2025 Jul 11;20(1):110
Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer.
Liu Y, Liu Z, Hu Y, Ling Y, Qing S, Liu Y, Zhan Y, Shen Z, Fang Y, Deng H
Nature communications 2025 Jul 1;16(1):5906
Nature communications 2025 Jul 1;16(1):5906
Protective effect of ginseng extract and total ginsenosides on hematopoietic stem cell damage by inhibiting cell apoptosis and regulating the intestinal microflora.
Liang Z, Gao X, Jing C, Yuan T, Zhang L, Yin Y, Ou J, Li X, Qi W, Zhao D, Su H, Zhang H
International journal of molecular medicine 2025 Jan;55(1)
International journal of molecular medicine 2025 Jan;55(1)
RNF112, whose transcription is regulated by KLF4, inhibits colorectal cancer growth via promoting ubiquitin-dependent degradation of NAA40.
Li C, Guan W, Geng D, Feng Y
Cell biology and toxicology 2025 Jan 6;41(1):22
Cell biology and toxicology 2025 Jan 6;41(1):22
Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities.
Zhao H, Park YM, Zheng Y, Mao Q, Collet C, Hu B, Zhou T, Lin L, Wong S, Pan Y, Monreal AV, Sinha UK, Sedghizadeh P, Soragni A, Lin DC
bioRxiv : the preprint server for biology 2025 Jan 22;
bioRxiv : the preprint server for biology 2025 Jan 22;
Single-cell RNA sequencing of the carotid artery and femoral artery of rats exposed to hindlimb unloading.
Li C, Pan Y, Wang Y, Li X, Tie Y, Li S, Wang R, Zhao X, Fan J, Yan X, Wang Y, Sun X
Cellular and molecular life sciences : CMLS 2025 Jan 21;82(1):50
Cellular and molecular life sciences : CMLS 2025 Jan 21;82(1):50
Bisphenol S exposure promotes stemness of triple-negative breast cancer cells via regulating Gli1-mediated Sonic hedgehog pathway.
Yi K, Chen W, Zhou X, Xie C, Zhong C, Zhu J
Environmental research 2025 Jan 1;264(Pt 1):120293
Environmental research 2025 Jan 1;264(Pt 1):120293
Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C.
Li Y, Li RY, Zhu JY, Chen M, Mu WJ, Luo HY, Li S, Yan LJ, Yin MT, Li X, Chen HM, Guo L
Nature metabolism 2025 Feb;7(2):401-420
Nature metabolism 2025 Feb;7(2):401-420
Yiqi Huayu Jiedu formula inhibits JAK2/STAT3-mediated partial EMT in treating chronic atrophic gastritis.
Yu W, Chen S, Guan X, He G, Zhang W, Zhang H, Huang S, Ye Z, Pan H, Zhong Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156356
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156356
Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer.
Deng M, Zhou Z, Chen J, Li X, Liu Z, Ye J, Wei W, Wang N, Peng Y, Luo X, Jiang L, Zhou F, Zheng X, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2408599
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2408599
Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
Xie B, Wu P, Liu H, Yang X, Huang L
Journal of translational medicine 2025 Feb 7;23(1):165
Journal of translational medicine 2025 Feb 7;23(1):165
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
Zhao Y, Yu H, Li J, Qian J, Li M, Zhang X, Wang M, Wang Y, Dong Y, You Y, Zhou Q, Gao D, Zhao Y, Liu B, Chen R, Ren Z, Wang Z, Zhang K, Cui J
Nature communications 2025 Feb 18;16(1):1736
Nature communications 2025 Feb 18;16(1):1736
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
Yang HX, Wang BX, Dong XL, Sun J, Miao ZL, Pan LL
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
Depletion of LINC01133 from cancer-associated fibroblasts exacerbates the progression of gastric adenocarcinoma.
Liang X, Jiang S, Zhang Q, Li J, Dong K, Zhang H, Wang L, Guan X, Wang Y, Fang T, Xue Y, Li Y, Qin W, Yu J, Wu J, Meng X, Sun W, Weng Y, Li M, Fu G, Pang S, Li L, Fu S, Cai M
iScience 2025 Dec 19;28(12):113886
iScience 2025 Dec 19;28(12):113886
Machine learning-based identification of kbhb-affected tumor cell subsets as prognostic and therapeutic targets in breast cancer.
Yuan Q, Sha Y, Ye R, Yu H, Ni L, Han J, Deng L
Journal of translational medicine 2025 Dec 11;24(1):71
Journal of translational medicine 2025 Dec 11;24(1):71
TLR7-mediated immune response of renal myeloid-derived suppressor cells via RUNX1-KLF4 in systemic candidiasis.
Chen D, Mo F, Pan L, Liu M, Liu L, Xing J, Xiao W, Liang G, Li L, Xie H, Wei H, Huang J, Shen J, Pan X
Journal of immunology (Baltimore, Md. : 1950) 2025 Dec 1;214(12):3497-3513
Journal of immunology (Baltimore, Md. : 1950) 2025 Dec 1;214(12):3497-3513
Exosomal miR-146a-5p Derived from HSCs Accelerates Sepsis-induced Liver Injury by Suppressing KLF-4.
Sheng Z, Song H, Gao X, Shu B, You Y, Liu Z
Inflammation 2025 Aug;48(4):2022-2035
Inflammation 2025 Aug;48(4):2022-2035
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489
Oncogene 2025 Aug;44(29):2474-2489
Unravelling the Role of PIEZO1 in Adipogenesis of Fibrogenic/Adipogenic Progenitors for Muscle Fat Infiltration After Rotator Cuff Tear.
Lin X, Song Q, Kuati A, Li Z, Zhou H, Feng S, Wang M, Zhu S, Cui G, Wang J, Shao X
Journal of cachexia, sarcopenia and muscle 2025 Aug;16(4):e70004
Journal of cachexia, sarcopenia and muscle 2025 Aug;16(4):e70004
Role of Carvedilol in Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells by Upregulating microRNA-145 Expression.
Yang G, Zhang Z, Ma X, Chen J, Shi H, Yang J, Han Q
Physiological research 2025 Aug 31;74(4):577-588
Physiological research 2025 Aug 31;74(4):577-588
Lactylation-boosted polycomb repression of KLF4 elicits glycolysis in retinoblastoma: A positive feedback circuit between histone modifications.
Yang L, Zuo S, Jia R, Gu X, Liao Q, Hua Y, Ge S, He M, Fan J, Tong X, Yuan T, Jia R, Fan X, Chai P, Wen X
Cancer letters 2025 Aug 10;625:217804
Cancer letters 2025 Aug 10;625:217804
KLF4-induced upregulation of SOCS1 ameliorates myocardial ischemia/reperfusion injury by attenuating AC16 cardiomyocyte damage and enhancing M2 macrophage polarization.
Zhou J, Luo W, Xie Z, Xia C, Zhao J
Journal of biochemical and molecular toxicology 2024 Sep;38(9):e23816
Journal of biochemical and molecular toxicology 2024 Sep;38(9):e23816
Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco).
Liu LL, Song CC, Abu-Elala N, Tan XY, Zhao T, Zheng H, Yang H, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2024 Sep;1867(3):195041
Biochimica et biophysica acta. Gene regulatory mechanisms 2024 Sep;1867(3):195041
Mechanism of HDAC1 Regulating Iron Overload-Induced Neuronal Oxidative Damage After Cerebral Hemorrhage.
Han J, Zhang J, Yao X, Meng M, Wan Y, Cheng Y
Molecular neurobiology 2024 Oct;61(10):7549-7566
Molecular neurobiology 2024 Oct;61(10):7549-7566
Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II.
Yao Q, Hu X, Bian T, Zhang Q, Xue Z, Lv Y, Ren S, Chen Y, Zhang D, Chen L
Journal of cellular and molecular medicine 2024 Oct;28(20):e70144
Journal of cellular and molecular medicine 2024 Oct;28(20):e70144
Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming.
Deochand DK, Dacic M, Bale MJ, Daman AW, Chaudhary V, Josefowicz SZ, Oliver D, Chinenov Y, Rogatsky I
Nature communications 2024 Oct 18;15(1):9000
Nature communications 2024 Oct 18;15(1):9000
KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion.
Tan Y, Wang J, Liu C, Wu S, Zhou M, Zhang Y, Yin T, Yang J
Journal of translational medicine 2024 Oct 10;22(1):922
Journal of translational medicine 2024 Oct 10;22(1):922
Astrocyte-TREM2 alleviates brain injury by regulating reactive astrocyte states following ischemic stroke.
Wang C, Dong J, Huang H, Zhou K, Liu Z, Milner R, Li L
Glia 2024 Nov;72(11):2061-2078
Glia 2024 Nov;72(11):2061-2078
HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress.
Wang L, Ren Z, Wu L, Zhang X, Wang M, Niu H, He X, Wang H, Chen Y, Shi G, Qian X
Molecular and cellular biochemistry 2024 Nov;479(11):3021-3036
Molecular and cellular biochemistry 2024 Nov;479(11):3021-3036
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Epithelial differentiation of gingival mesenchymal stem cells enhances re-epithelialization for full-thickness cutaneous wound healing.
Li Y, Dong L, Chen Y, Cai W, Yang G, Wang Y
Stem cell research & therapy 2024 Nov 28;15(1):455
Stem cell research & therapy 2024 Nov 28;15(1):455
Integrated mRNA-seq and miRNA-seq analysis reveals key transcription factors of HNF4α and KLF4 in ADPKD.
Huang L, Chen J, Fu L, Yang B, Zhou C, Mei S, Zhang L, Mao Z, Lu C, Xue C
Biochemical and biophysical research communications 2024 Nov 26;735:150848
Biochemical and biophysical research communications 2024 Nov 26;735:150848
A novel combined therapeutic strategy of Nano-EN-IR@Lip mediated photothermal therapy and stem cell inhibition for gastric cancer.
Yang L, Du YE, Liao F, Huang T, Liu Y, Liu J, Wang C, Zhan Z, Cao Y, Wang Z, Chen W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116486
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116486
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.
Lv L, Wei Q, Zhang J, Dong Y, Shan Z, Chang N, Zhao Y, Bian P, Yi Q
Cellular & molecular biology letters 2024 Mar 19;29(1):39
Cellular & molecular biology letters 2024 Mar 19;29(1):39
KLF4 promotes milk fat synthesis by regulating the PI3K-AKT-mTOR pathway and targeting FASN activation in bovine mammary epithelial cells.
Wu HY, Ji ZH, Xie WY, Guo HX, Zheng Y, Gao W, Yuan B
iScience 2024 Jun 21;27(6):109850
iScience 2024 Jun 21;27(6):109850
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.
Wang H, Guo S, Gao H, Ding J, Li H, Kong X, Zhang S, He M, Feng Y, Wu W, Xu K, Chen Y, Zhang H, Liu T, Kong X
The Journal of clinical investigation 2024 Jun 18;134(16)
The Journal of clinical investigation 2024 Jun 18;134(16)
MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.
Lu J, Zhao Q, Wang L, Li J, Wang H, Lv L, Yuan M, Chen Q, Zhang Z, Luo D, Sheng S, Yuan K, Liu G, Liu M, Shi Y, Guo Y, Dong Z
iScience 2024 Jul 19;27(7):110163
iScience 2024 Jul 19;27(7):110163
Oxidized ATM governs stemness of breast cancer stem cell through regulating ubiquitylation and acetylation switch.
Zhou X, Liu X, Wan X, Xu M, Wang R, Yang D, Peng M, Jin T, Tang R, Liu M, Hou Y
Biochemical and biophysical research communications 2024 Jan 8;691:149243
Biochemical and biophysical research communications 2024 Jan 8;691:149243
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.
Chen Y, Sun L, Liu H, Li J, Guo L, Wang Z
Immunity, inflammation and disease 2024 Feb;12(2):e1199
Immunity, inflammation and disease 2024 Feb;12(2):e1199
PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
Del Vecchio A, Mulé P, Fernández-Pérez D, Amato S, Lattanzi G, Zanotti M, Rustichelli S, Pivetti S, Oldani P, Mariani A, Iommazzo F, Koseki H, Facciotti F, Tamburri S, Ferrari KJ, Pasini D
Developmental cell 2024 Feb 5;59(3):368-383.e7
Developmental cell 2024 Feb 5;59(3):368-383.e7
Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid- and IL4-Driven Macrophage Programming.
Deochand DK, Dacic M, Bale MJ, Daman AW, Josefowicz SZ, Oliver D, Chinenov Y, Rogatsky I
bioRxiv : the preprint server for biology 2024 Feb 18;
bioRxiv : the preprint server for biology 2024 Feb 18;
MiR-200b-3p elevates 5-FU sensitivity in cholangiocarcinoma cells via autophagy inhibition by targeting KLF4.
Peng F, He R, Liu Y, Xie Y, Xiong G, Li X, Wang M, Zhao C, Zhang H, Xu S, Qin R
Non-coding RNA research 2024 Dec;9(4):1098-1110
Non-coding RNA research 2024 Dec;9(4):1098-1110
Preparation and antitumor activity of selenium nanocomposite stabilized by AAGL from Agerocybe aegerita.
Chen Y, Jin Y, Wang W, Zhang Y, Sun H, Wu A, Zhu H, Gong Y, Wang X, Tian L, Pan J
International journal of biological macromolecules 2024 Dec;282(Pt 3):137002
International journal of biological macromolecules 2024 Dec;282(Pt 3):137002
Tet2 modulates M2 macrophage polarization via mRNA 5-methylcytosine in allergic rhinitis.
Fan W, Liu P, Tan L, Lv H, Zhou H, Tao Z, Xu Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113495
International immunopharmacology 2024 Dec 25;143(Pt 3):113495
FOLR2(+) macrophage depletion from intestinal metaplasia to early gastric cancer: single-cell sequencing insight into gastric cancer progression.
He Y, Wang J, Deng Z, Feng H, Du M, Zhang D, Zhang G, Shi T, Chen W
Journal of experimental & clinical cancer research : CR 2024 Dec 19;43(1):326
Journal of experimental & clinical cancer research : CR 2024 Dec 19;43(1):326
MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4.
Li Z, Wang S, Guo T, Yan X, Chen C, Zhang W, Zhao J, Zhang J, Zhao S, Wang Y, Qi Y, Gu C
Cell death discovery 2024 Dec 18;10(1):494
Cell death discovery 2024 Dec 18;10(1):494
Loss of Smooth Muscle Tenascin-X Inhibits Vascular Remodeling Through Increased TGF-β Signaling.
Liang G, Lv XF, Huang W, Jin YJ, Roquid KA, Kawase H, Offermanns S
Arteriosclerosis, thrombosis, and vascular biology 2024 Aug;44(8):1748-1763
Arteriosclerosis, thrombosis, and vascular biology 2024 Aug;44(8):1748-1763
YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells.
Li S, Li X, Yang YB, Wu SF
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1198-1210
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1198-1210
Bioinformatic analysis reveals the relationship between macrophage infiltration and Cybb downregulation in hyperoxia-induced bronchopulmonary dysplasia.
He Y, Li D, Zhang M, Li F
Scientific reports 2024 Aug 29;14(1):20089
Scientific reports 2024 Aug 29;14(1):20089
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Li Q, Kang J, Liu N, Huang J, Zhang X, Pang K, Zhang S, Wang M, Zhao Y, Dong S, Li H, Zhao D, Lu F, Zhang W
Free radical biology & medicine 2024 Apr;216:118-138
Free radical biology & medicine 2024 Apr;216:118-138
Inhibition of the SLC35B2-TPST2 Axis of Tyrosine Sulfation Attenuates the Growth and Metastasis of Pancreatic Ductal Adenocarcinom.
Cai X, Li S, Zeng X, Xu M, Wang Z, Singhi AD, Tang D, Li S, Yates NA, Yang D, Xie W
Cellular and molecular gastroenterology and hepatology 2023;16(3):473-495
Cellular and molecular gastroenterology and hepatology 2023;16(3):473-495
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
Chen X, Shi W, Zhu L, Zhou X, Wang Y
Cellular signalling 2023 Sep;109:110752
Cellular signalling 2023 Sep;109:110752
FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.
Lei C, Kan H, Xian X, Chen W, Xiang W, Song X, Wu J, Yang D, Zheng Y
Nature communications 2023 Sep 2;14(1):5360
Nature communications 2023 Sep 2;14(1):5360
An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology.
Ni W, Zhang H, Mei Z, Hongyi Z, Wu Y, Xu W, Ma Y, Yang W, Liang Y, Gu T, Su Y, Fan S, Shen S, Hu Z
Redox biology 2023 Oct;66:102858
Redox biology 2023 Oct;66:102858
Influences of lysine-specific demethylase 1 inhibitors on NO synthase-Kruppel-like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo.
Yuan J, Que R, Zhao W, Song F, Cao Y, Yu B
Journal of applied toxicology : JAT 2023 Nov;43(11):1748-1760
Journal of applied toxicology : JAT 2023 Nov;43(11):1748-1760
Influences of repeated exposure to low levels of TiO(2) nanoparticles on Kruppel-like factors in 3D Caco-2 spheroids and mouse intestines.
Cao W, Liu M, Wang C, Jing G, Cao Y
Journal of applied toxicology : JAT 2023 May;43(5):706-718
Journal of applied toxicology : JAT 2023 May;43(5):706-718
Epithelial cells activate fibroblasts to promote esophageal cancer development.
Chen Y, Zhu S, Liu T, Zhang S, Lu J, Fan W, Lin L, Xiang T, Yang J, Zhao X, Xi Y, Ma Y, Cheng G, Lin D, Wu C
Cancer cell 2023 May 8;41(5):903-918.e8
Cancer cell 2023 May 8;41(5):903-918.e8
Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.
Yang Q, Chen S, Wang X, Yang X, Chen L, Huang T, Zheng Y, Zheng X, Wu X, Sun Y, Wu J
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926
Decreased Expression of KLF4 Leading to Functional Deficit in Pediatric Patients with Intestinal Failure and Potential Therapeutic Strategy Using Decanoic Acid.
Yan J, Zhao Y, Jiang L, Wang Y, Cai W
Nutrients 2023 Jun 7;15(12)
Nutrients 2023 Jun 7;15(12)
TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750.
Yi Q, Zhao Y, Xia R, Wei Q, Chao F, Zhang R, Bian P, Lv L
Cell death discovery 2023 Jun 26;9(1):191
Cell death discovery 2023 Jun 26;9(1):191
Paeoniflorin suppresses kidney inflammation by regulating macrophage polarization via KLF4-mediated mitophagy.
Cao Y, Xiong J, Guan X, Yin S, Chen J, Yuan S, Liu H, Lin S, Zhou Y, Qiu J, Wang D, Liu B, Zhou J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154901
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154901
Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.
Liu S, Wu J, Lu X, Guo C, Zheng Q, Wang Y, Hu Q, Bian S, Luo L, Cheng Q, Liu Z, Dai W
Experimental cell research 2023 Jul 1;428(1):113613
Experimental cell research 2023 Jul 1;428(1):113613
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.
Tabei A, Sakairi T, Hamatani H, Ohishi Y, Watanabe M, Nakasatomi M, Ikeuchi H, Kaneko Y, Kopp JB, Hiromura K
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133
The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke.
Wang C, Li L
Journal of neuroinflammation 2023 Feb 23;20(1):44
Journal of neuroinflammation 2023 Feb 23;20(1):44
LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
Xing Z, Du M, Zhen Y, Chen J, Li D, Liu R, Zheng J
Cellular signalling 2023 Dec;112:110907
Cellular signalling 2023 Dec;112:110907
Inhibition of EphA2 protects against atherosclerosis by synergizing with statins to mitigate macrophage inflammation.
Zeng J, Wu Q, Xiong S, Lu C, Zhang Z, Huang H, Xiong Y, Luo T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115885
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115885
Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.
Xiao Y, He Y, Xu C, Li M, Hu F, Wang W, Wang Z, Cao Y
Environmental toxicology 2023 Aug;38(8):1925-1938
Environmental toxicology 2023 Aug;38(8):1925-1938
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.
Lee C, Cho S, Jeong D
International journal of molecular sciences 2023 Aug 4;24(15)
International journal of molecular sciences 2023 Aug 4;24(15)
miR-146a-5p Modulates Adult Hippocampal Neurogenesis Deficits Through Klf4/p-Stat3 Signaling in APP/PS1 Mice.
Deng LJ, Wu D, Yang XF, Li T
Neuroscience 2023 Aug 21;526:314-325
Neuroscience 2023 Aug 21;526:314-325
HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.
Han Z, Hu H, Yin M, Lin Y, Yan Y, Han P, Liu B, Jing B
Molecular medicine (Cambridge, Mass.) 2023 Aug 1;29(1):104
Molecular medicine (Cambridge, Mass.) 2023 Aug 1;29(1):104
Commercial dishes with gelatin-free microstructured inserts for elongated stem cell self-renewal and pluripotency.
Ban Q, Hui W, Duan Q, Liu W, Zhang M, Li X, Kang H, Shi Z, Zhang Y, Hou J, Xu X, Ye S, Zhang B, Xu X
iScience 2023 Apr 21;26(4):106446
iScience 2023 Apr 21;26(4):106446
The KLF4-p62 axis prevents vascular endothelial cell injury via the mTOR/S6K pathway and autophagy in diabetic kidney disease.
Wang X, Su W, Ma M, Zhu L, Gao R, Qin C, Shao S, Gao D, Gao J, Zhang Z
Endokrynologia Polska 2022;73(5):837-845
Endokrynologia Polska 2022;73(5):837-845
KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription.
Wang J, Zhao M, Zhang H, Yang F, Luo L, Shen K, Wang X, Li Y, Zhang J, Zhang J, Wang K, Li J, Wang Y, Yang Y, Hu D
International journal of biological sciences 2022;18(8):3324-3336
International journal of biological sciences 2022;18(8):3324-3336
Iguratimod Attenuates Macrophage Polarization and Antibody-Mediated Rejection After Renal Transplant by Regulating KLF4.
Hang Z, Wei J, Zheng M, Gui Z, Chen H, Sun L, Fei S, Han Z, Tao J, Wang Z, Tan R, Gu M
Frontiers in pharmacology 2022;13:865363
Frontiers in pharmacology 2022;13:865363
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.
Zhang R, Xie L, Wu F, Xu J, Lu L, Cao L, Li L, Meng W, Zhang H, Shao C, Li X, Chen D
Frontiers in pharmacology 2022;13:828896
Frontiers in pharmacology 2022;13:828896
GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma.
Chen W, Wang H, Lu Y, Huang Y, Xuan Y, Li X, Guo T, Wang C, Lai D, Wu S, Zhao W, Mai H, Li H, Wang B, Ma X, Zhang X
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):1011-1022
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):1011-1022
Lef1 is transcriptionally activated by Klf4 and suppresses hyperoxia-induced alveolar epithelial cell injury.
Yang M, Huang X, Shen F, Yi J, Meng Y, Chen Y
Experimental lung research 2022 Sep-Oct;48(7-8):213-223
Experimental lung research 2022 Sep-Oct;48(7-8):213-223
SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway.
Chen Z, Jiang Z, Meng L, Wang Y, Lin M, Wei Z, Han W, Ying S, Xu A
Cell cycle (Georgetown, Tex.) 2022 Oct;21(19):2065-2078
Cell cycle (Georgetown, Tex.) 2022 Oct;21(19):2065-2078
Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice.
Yang D, Ran Y, Li X, Jiang X, Chen J, Sun J, Tian L, Teerds K, Bai W
Journal of hazardous materials 2022 Mar 5;425:127571
Journal of hazardous materials 2022 Mar 5;425:127571
Cilia proteins are biomarkers of altered flow in the vasculature.
Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R
JCI insight 2022 Mar 22;7(6)
JCI insight 2022 Mar 22;7(6)
Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells.
Mei J, Sheng X, Yan Y, Cai X, Zhang C, Tian J, Zhang M, Zhou J, Shan H, Huang C
BMC molecular and cell biology 2022 Jun 27;23(1):24
BMC molecular and cell biology 2022 Jun 27;23(1):24
The role of KLF4 in melanogenesis and homeostasis in sheep melanocytes.
Qin H, Chen Y, Wang S, Ge S, Pang Q
Acta histochemica 2022 Jan;124(1):151839
Acta histochemica 2022 Jan;124(1):151839
FAT1 downregulation enhances stemness and cisplatin resistance in esophageal squamous cell carcinoma.
Zhai Y, Shan C, Zhang H, Kong P, Zhang L, Wang Y, Hu X, Cheng X
Molecular and cellular biochemistry 2022 Dec;477(12):2689-2702
Molecular and cellular biochemistry 2022 Dec;477(12):2689-2702
Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation.
Li W, Long Q, Wu H, Zhou Y, Duan L, Yuan H, Ding Y, Huang Y, Wu Y, Huang J, Liu D, Chen B, Zhang J, Qi J, Du S, Li L, Liu Y, Ruan Z, Liu Z, Liu Z, Zhao Y, Lu J, Wang J, Chan WY, Liu X
Nature communications 2022 Dec 2;13(1):7414
Nature communications 2022 Dec 2;13(1):7414
Curcumin attenuates vascular calcification via the exosomal miR-92b-3p/KLF4 axis.
Chen C, Li Y, Lu H, Liu K, Jiang W, Zhang Z, Qin X
Experimental biology and medicine (Maywood, N.J.) 2022 Aug;247(16):1420-1432
Experimental biology and medicine (Maywood, N.J.) 2022 Aug;247(16):1420-1432
Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.
Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, He J, Li P, Chen X, Ding W, Zhong J, Zeng Z, Xie Z, Liu J, Zu X
Cell death & disease 2022 Aug 30;13(8):749
Cell death & disease 2022 Aug 30;13(8):749
DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma.
Jia X, Li L, Wang F, Xue Y, Wu T, Jia Q, Li Y, Wu C, Chen Y, Wu J, Su Y, Wang X, Zhuang T, Dong X, Ling J, Yuan J, Li Q
Cell death discovery 2022 Apr 5;8(1):166
Cell death discovery 2022 Apr 5;8(1):166
EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.
Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, Xue Z, Lu S, Dong Y, Song C, Zhang X, Zhou Y
Food & function 2022 Apr 20;13(8):4399-4420
Food & function 2022 Apr 20;13(8):4399-4420
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
Li K, Gao S, Ma L, Sun Y, Peng ZY, Wu J, Du N, Ren H, Tang SC, Sun X
Frontiers in oncology 2021;11:731561
Frontiers in oncology 2021;11:731561
Toxicity evaluation of mesoporous silica particles Santa Barbara No. 15 amorphous in human umbilical vein endothelial cells: influence of particle morphology.
Teng W, Yang Z, Wang S, Xiong D, Chen Y, Wu Z
Journal of applied toxicology : JAT 2021 Sep;41(9):1467-1478
Journal of applied toxicology : JAT 2021 Sep;41(9):1467-1478
A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties.
Liu S, Sun Y, Hou Y, Yang L, Wan X, Qin Y, Liu Y, Wang R, Zhu P, Teng Y, Liu M
Journal of hematology & oncology 2021 Oct 29;14(1):178
Journal of hematology & oncology 2021 Oct 29;14(1):178
Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the MERTK locus.
Tang X, Fu J, Chen Z, Luo L, Li DW, Liu Y
Stem cell research 2021 May;53:102310
Stem cell research 2021 May;53:102310
CDR1as regulated by hnRNPM maintains stemness of periodontal ligament stem cells via miR-7/KLF4.
Gu X, Li X, Jin Y, Zhang Z, Li M, Liu D, Wei F
Journal of cellular and molecular medicine 2021 May;25(9):4501-4515
Journal of cellular and molecular medicine 2021 May;25(9):4501-4515
Smooth muscle cell-specific knockout of interferon gamma (IFN-γ) receptor attenuates intimal hyperplasia via STAT1-KLF4 activation.
He L, Gao K, Liu H, Wang J, Li X, He C
Life sciences 2021 May 25;:119651
Life sciences 2021 May 25;:119651
A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.
Wen S, Qin Y, Wang R, Yang L, Zeng H, Zhu P, Li Q, Qiu Y, Chen S, Liu Y, Hou Y, Tang X, Liu M, Tu G
Cell death & disease 2021 May 1;12(5):437
Cell death & disease 2021 May 1;12(5):437
ET(A)R silencing ameliorated neurovascular injury after SAH in rats through ERK/KLF4-mediated phenotypic transformation of smooth muscle cells.
Zhang Z, Chen H, Liu L, Zhao G, He J, Liu H, Zhou C, Liu X, Sun X, Guo Z
Experimental neurology 2021 Mar;337:113596
Experimental neurology 2021 Mar;337:113596
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352
Clinical and translational medicine 2021 Mar;11(3):e352
Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.
Zhang L, Cao H, Tao H, Yang J, Gong W, Hu Q
Experimental and therapeutic medicine 2021 Jul;22(1):696
Experimental and therapeutic medicine 2021 Jul;22(1):696
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.
Zheng S, Ni J, Li Y, Lu M, Yao Y, Guo H, Jiao M, Jin T, Zhang H, Yuan A, Wang Z, Yang Y, Chen Z, Wu H, Hu W
Pharmacological research 2021 Jul;169:105685
Pharmacological research 2021 Jul;169:105685
Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles.
Lee MH, Lin CC, Thomas JL, Li JA, Lin HY
Materials today. Bio 2021 Jan;9:100091
Materials today. Bio 2021 Jan;9:100091
A Novel Long Non-Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis.
Qin Y, Hou Y, Liu S, Zhu P, Wan X, Zhao M, Peng M, Zeng H, Li Q, Jin T, Cui X, Liu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jan;8(2):2002232
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jan;8(2):2002232
Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 Signaling in Cirrhotic Rats.
Zhang L, Tai Y, Tang S, Zhao C, Tong H, Gao J, Tang C
Digestive diseases and sciences 2021 Jan;66(1):131-142
Digestive diseases and sciences 2021 Jan;66(1):131-142
The preventive and therapeutic effects of AAV1-KLF4-shRNA in cigarette smoke-induced pulmonary hypertension.
Sun D, Ding D, Li Q, Xie M, Xu Y, Liu X
Journal of cellular and molecular medicine 2021 Jan;25(2):1238-1251
Journal of cellular and molecular medicine 2021 Jan;25(2):1238-1251
Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.
Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry 2021 Jan-Jun;296:100547
The Journal of biological chemistry 2021 Jan-Jun;296:100547
Cooperative activation of bovine herpesvirus 1 productive infection and viral regulatory promoters by androgen receptor and Krüppel-like transcription factors 4 and 15.
Sawant L, Thunuguntla P, Jones C
Virology 2021 Jan 2;552:63-72
Virology 2021 Jan 2;552:63-72
BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation.
Yu S, Guo J, Sun Z, Lin C, Tao H, Zhang Q, Cui Y, Zuo H, Lin Y, Chen S, Liu H, Chen Z
Cell death & disease 2021 Feb 19;12(2):197
Cell death & disease 2021 Feb 19;12(2):197
ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.
Zhang M, Wang L, Yue Y, Zhang L, Liu T, Jing M, Liang X, Ma M, Xu S, Wang K, Wang X, Fan J
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65
A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes.
Degen M, Girousi E, Feldmann J, Parisi L, La Scala GC, Schnyder I, Schaller A, Katsaros C
Frontiers in cell and developmental biology 2020;8:583115
Frontiers in cell and developmental biology 2020;8:583115
Modulating cancer stemness provides luminal a breast cancer cells with HER2 positive-like features.
Mei Y, Cai D, Dai X
Journal of Cancer 2020;11(5):1162-1169
Journal of Cancer 2020;11(5):1162-1169
miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.
Sun L, Lin P, Chen Y, Yu H, Ren S, Wang J, Zhao L, Du G
Theranostics 2020;10(12):5581-5599
Theranostics 2020;10(12):5581-5599
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo.
Wu B, Jiang M, Liu X, Huang C, Gu Z, Cao Y
Nanotoxicology 2020 Oct;14(8):1017-1038
Nanotoxicology 2020 Oct;14(8):1017-1038
Pioneer transcription factors, progesterone receptor and Krüppel like transcription factor 4, cooperatively stimulate the bovine herpesvirus 1 ICP0 early promoter and productive late protein expression.
Sawant L, Wijesekera N, Jones C
Virus research 2020 Oct 15;288:198115
Virus research 2020 Oct 15;288:198115
Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.
Lv Y, Wang X, Li X, Xu G, Bai Y, Wu J, Piao Y, Shi Y, Xiang R, Wang L
PLoS biology 2020 Nov;18(11):e3000872
PLoS biology 2020 Nov;18(11):e3000872
Using inducible lentiviral vectors to generate induced pluripotent stem cell line ZOCi001-A from peripheral blood cells of a patient with CRB1(-/-) retinitis pigmentosa.
Tang X, Liu X, Chen Z, Luo L, Liu X, Deng J, Li DW, Liu Y
Stem cell research 2020 May;45:101817
Stem cell research 2020 May;45:101817
The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs.
Ignatova VV, Stolz P, Kaiser S, Gustafsson TH, Lastres PR, Sanz-Moreno A, Cho YL, Amarie OV, Aguilar-Pimentel A, Klein-Rodewald T, Calzada-Wack J, Becker L, Marschall S, Kraiger M, Garrett L, Seisenberger C, Hölter SM, Borland K, Van De Logt E, Jansen PWTC, Baltissen MP, Valenta M, Vermeulen M, Wurst W, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Rando OJ, Kellner SM, Bultmann S, Schneider R
Genes & development 2020 May 1;34(9-10):715-729
Genes & development 2020 May 1;34(9-10):715-729
Long Noncoding RNA HOX Transcript Antisense RNA Gene rs17720428 Single Nucleotide Polymorphism Is Associated with Gastric Cancer Risk and Prognosis.
Li Y, Zhang Z, Yang Y, Ma J
Genetic testing and molecular biomarkers 2020 Jan;24(1):38-46
Genetic testing and molecular biomarkers 2020 Jan;24(1):38-46
Deoxycholic Acid Upregulates the Reprogramming Factors KFL4 and OCT4 Through the IL-6/STAT3 Pathway in Esophageal Adenocarcinoma Cells.
Chen M, Ye A, Wei J, Wang R, Poon K
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820945302
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820945302
LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4.
Ning J, Zhang L, Guo H, Zhou S, Sun X, Bao W
Translational cancer research 2020 Feb;9(2):958-971
Translational cancer research 2020 Feb;9(2):958-971
Oxidative stress-induced KLF4 activates inflammatory response through IL17RA and its downstream targets in retinal pigment epithelial cells.
Sun Q, Gong L, Qi R, Qing W, Zou M, Ke Q, Zhang L, Tang X, Nie Q, Yang Y, Hu A, Ding X, Lu L, Liu Y, Li DW
Free radical biology & medicine 2020 Feb 1;147:271-281
Free radical biology & medicine 2020 Feb 1;147:271-281
Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the CRB1 locus.
Tang X, Chen Z, Tan X, Luo L, Liu X, Gong L, Li DW, Liu Y
Stem cell research 2020 Dec;49:102057
Stem cell research 2020 Dec;49:102057
Upregulation of the microRNA rno-miR-146b-5p may be involved in the development of intestinal injury through inhibition of Kruppel-like factor 4 in intestinal sepsis.
Tong L, Tang C, Cai C, Guan X
Bioengineered 2020 Dec;11(1):1334-1349
Bioengineered 2020 Dec;11(1):1334-1349
Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids.
Jiang Y, Gong H, Jiang S, She C, Cao Y
The Science of the total environment 2020 Dec 15;748:141384
The Science of the total environment 2020 Dec 15;748:141384
miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis.
Shi DM, Shi XL, Xing KL, Zhou HX, Lu LL, Wu WZ
Cellular signalling 2020 Aug;72:109650
Cellular signalling 2020 Aug;72:109650
KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling.
Li Y, Yu S, Li L, Chen J, Quan M, Li Q, Gao Y
Cell death & disease 2020 Apr 29;11(4):299
Cell death & disease 2020 Apr 29;11(4):299
KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling.
Li L, Yu S, Wu Q, Dou N, Li Y, Gao Y
International journal of biological sciences 2019;15(5):953-961
International journal of biological sciences 2019;15(5):953-961
miR-92b-3p Functions As A Key Gene In Esophageal Squamous Cell Cancer As Determined By Co-Expression Analysis.
Wang W, Fu S, Lin X, Zheng J, Pu J, Gu Y, Deng W, Liu Y, He Z, Liang W, Wang C
OncoTargets and therapy 2019;12:8339-8353
OncoTargets and therapy 2019;12:8339-8353
SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders.
Zhang Y, Cui G, Wang Y, Gong Y, Wang Y
International journal of molecular medicine 2019 Sep;44(3):995-1005
International journal of molecular medicine 2019 Sep;44(3):995-1005
SP1 regulates KLF4 via SP1 binding motif governed by DNA methylation during odontoblastic differentiation of human dental pulp cells.
Sun Z, Yu S, Chen S, Liu H, Chen Z
Journal of cellular biochemistry 2019 Sep;120(9):14688-14699
Journal of cellular biochemistry 2019 Sep;120(9):14688-14699
MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway.
Wang J, Zhang C, Li C, Zhao D, Li S, Ma L, Cui Y, Wei X, Zhao Y, Gao Y
Journal of cellular and molecular medicine 2019 May;23(5):3696-3710
Journal of cellular and molecular medicine 2019 May;23(5):3696-3710
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Yang H, Li J, Yang C, Liu H, Cao Y
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.
Zhu X, Du J, Yu J, Guo R, Feng Y, Qiao L, Xu Z, Yang F, Zhong G, Liu F, Cheng F, Chu M, Lin J
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Journal of molecular and cellular cardiology 2019 Jan;126:60-69
Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF-β Signaling Pathway and Interaction With Histone Acetylation.
Tao H, Lin H, Sun Z, Pei F, Zhang J, Chen S, Liu H, Chen Z
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Aug;34(8):1502-1516
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Aug;34(8):1502-1516
Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6.
Li Z, Jia Y, Han S, Wang X, Han F, Zhang J, Zhang W, Guan H, Hu D
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2278-2290
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2278-2290
SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression.
Chen W, Zhuo M, Lu X, Xia X, Zhao Y, Huang Z, Xu J, Li W, Yu C
International journal of biological sciences 2018;14(14):2051-2064
International journal of biological sciences 2018;14(14):2051-2064
Role of Krüppel-like factor 4 in cigarette smoke-induced pulmonary vascular remodeling.
Sun D, Li Q, Ding D, Li X, Xie M, Xu Y, Liu X
American journal of translational research 2018;10(2):581-591
American journal of translational research 2018;10(2):581-591
Quaking promotes the odontoblastic differentiation of human dental pulp stem cells.
Li S, Lin C, Zhang J, Tao H, Liu H, Yuan G, Chen Z
Journal of cellular physiology 2018 Sep;233(9):7292-7304
Journal of cellular physiology 2018 Sep;233(9):7292-7304
Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency Acquisition.
Li S, Xiao F, Zhang J, Sun X, Wang H, Zeng Y, Hu J, Tang F, Gu J, Zhao Y, Jin Y, Liao B
Stem cell reports 2018 Oct 9;11(4):973-987
Stem cell reports 2018 Oct 9;11(4):973-987
Generation of an iPS cell line via a non-integrative method using urine-derived cells from a patient with USH2A-associated retinitis pigmentosa.
Guo Y, Zeng Q, Liu S, Yu Q, Wang P, Ma H, Shi S, Yan X, Cui Z, Xie M, Xue Y, Zha Q, Li Z, Zhang J, Tang S, Chen J
Stem cell research 2018 May;29:139-142
Stem cell research 2018 May;29:139-142
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z
Nature communications 2018 Mar 28;9(1):1261
Nature communications 2018 Mar 28;9(1):1261
SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells.
Zhang X, Chen J, Sun L, Xu Y
Journal of cellular biochemistry 2018 Feb;119(2):2418-2426
Journal of cellular biochemistry 2018 Feb;119(2):2418-2426
The histone methyltransferase SETD1A regulates thrombomodulin transcription in vascular endothelial cells.
Li Z, Chen B, Weng X, Yu L, Song M, Fang M, Guo J, Xu Y
Biochimica et biophysica acta. Gene regulatory mechanisms 2018 Aug;1861(8):752-761
Biochimica et biophysica acta. Gene regulatory mechanisms 2018 Aug;1861(8):752-761
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Zhuang J, Shen L, Yang L, Huang X, Lu Q, Cui Y, Zheng X, Zhao X, Zhang D, Huang R, Guo H, Yan J
Theranostics 2017;7(12):3053-3067
Theranostics 2017;7(12):3053-3067
Soluble expression of recomb inant cMyc, Klf4, Oct4, and Sox2 proteins in bacteria and transduction into living cells.
Liu GD, Zhou SF, Ding XC, Fang CL, Mi SY, Gao XC, Han Q
International journal of ophthalmology 2017;10(4):560-566
International journal of ophthalmology 2017;10(4):560-566
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4.
Xu L, Sun H, Zhang M, Jiang Y, Zhang C, Zhou J, Ding L, Hu Y, Yan G
Molecular and cellular endocrinology 2017 Sep 5;452:138-147
Molecular and cellular endocrinology 2017 Sep 5;452:138-147
CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
Dou D, Zhao H, Li Z, Xu L, Xiong X, Wu X, Sun Y, Zeng S, Ouyang Q, Zhou D, Ma N, Lin G, Hu L
Stem cells and development 2017 Nov 15;26(22):1626-1636
Stem cells and development 2017 Nov 15;26(22):1626-1636
MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells.
Minami K, Taniguchi K, Sugito N, Kuranaga Y, Inamoto T, Takahara K, Takai T, Yoshikawa Y, Kiyama S, Akao Y, Azuma H
Oncotarget 2017 May 16;8(20):33064-33077
Oncotarget 2017 May 16;8(20):33064-33077
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma.
Xiao W, Gao Z, Duan Y, Yuan W, Ke Y
Journal of experimental & clinical cancer research : CR 2017 Mar 9;36(1):41
Journal of experimental & clinical cancer research : CR 2017 Mar 9;36(1):41
microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype.
Wang TM, Chen KC, Hsu PY, Lin HF, Wang YS, Chen CY, Liao YC, Juo SH
Journal of cellular and molecular medicine 2017 Dec;21(12):3592-3601
Journal of cellular and molecular medicine 2017 Dec;21(12):3592-3601
miR-543 promotes colorectal cancer proliferation and metastasis by targeting KLF4.
Zhai F, Cao C, Zhang L, Zhang J
Oncotarget 2017 Aug 29;8(35):59246-59256
Oncotarget 2017 Aug 29;8(35):59246-59256
Angiogenic Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury.
Zhou B, Zeng S, Li N, Yu L, Yang G, Yang Y, Zhang X, Fang M, Xia J, Xu Y
Arteriosclerosis, thrombosis, and vascular biology 2017 Apr;37(4):675-684
Arteriosclerosis, thrombosis, and vascular biology 2017 Apr;37(4):675-684
miR-103 Promotes Proliferation and Metastasis by Targeting KLF4 in Gastric Cancer.
Zheng J, Liu Y, Qiao Y, Zhang L, Lu S
International journal of molecular sciences 2017 Apr 26;18(5)
International journal of molecular sciences 2017 Apr 26;18(5)
Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression.
Zhang L, Zhang L, Xia X, He S, He H, Zhao W
Oncotarget 2016 May 24;7(21):30990-1000
Oncotarget 2016 May 24;7(21):30990-1000
Aldehyde dehydrogenase 1A1 up-regulates stem cell markers in benzo[a]pyrene-induced malignant transformation of BEAS-2B cells.
Liu Y, Lu R, Gu J, Chen Y, Zhang X, Zhang L, Wu H, Hua W, Zeng J
Environmental toxicology and pharmacology 2016 Jul;45:241-50
Environmental toxicology and pharmacology 2016 Jul;45:241-50
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.
Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z
Nature communications 2016 Dec 1;7:13608
Nature communications 2016 Dec 1;7:13608
Vacuolar ATPase in phagosome-lysosome fusion.
Kissing S, Hermsen C, Repnik U, Nesset CK, von Bargen K, Griffiths G, Ichihara A, Lee BS, Schwake M, De Brabander J, Haas A, Saftig P
The Journal of biological chemistry 2015 May 29;290(22):14166-80
The Journal of biological chemistry 2015 May 29;290(22):14166-80
Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/β-catenin signaling.
Shan T, Zhou C, Yang R, Yan F, Zhang P, Fu Y, Jiang H
Cell biology international 2015 Jan;39(1):35-43
Cell biology international 2015 Jan;39(1):35-43
Krüppel-like factor 4 synergizes with CREB to increase the activity of apolipoprotein E gene promoter in macrophages.
Stavri S, Simionescu M, Kardassis D, Gafencu AV
Biochemical and biophysical research communications 2015 Dec 4-11;468(1-2):66-72
Biochemical and biophysical research communications 2015 Dec 4-11;468(1-2):66-72
The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells.
Li W, Liu M, Su Y, Zhou X, Liu Y, Zhang X
Oncotarget 2015 Dec 29;6(42):44480-94
Oncotarget 2015 Dec 29;6(42):44480-94
Photodynamic therapy-mediated cancer vaccination enhances stem-like phenotype and immune escape, which can be blocked by thrombospondin-1 signaling through CD47 receptor protein.
Zheng Y, Zou F, Wang J, Yin G, Le V, Fei Z, Liu J
The Journal of biological chemistry 2015 Apr 3;290(14):8975-86
The Journal of biological chemistry 2015 Apr 3;290(14):8975-86
LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16.
Yin F, Lan R, Zhang X, Zhu L, Chen F, Xu Z, Liu Y, Ye T, Sun H, Lu F, Zhang H
Molecular and cellular biology 2014 Jan;34(2):158-79
Molecular and cellular biology 2014 Jan;34(2):158-79
Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells.
Zhang X, Lu F, Wang J, Yin F, Xu Z, Qi D, Wu X, Cao Y, Liang W, Liu Y, Sun H, Ye T, Zhang H
Cell reports 2013 Oct 31;5(2):445-57
Cell reports 2013 Oct 31;5(2):445-57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11880-1-AP(KLF4 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Confocal immunofluorescent analysis of human embronic stem cells with 11880-1-AP at dilution of 1:50. The PE shows staining with 11880-1-AP/PE. The DAPI shows nuclear staining by DAPI.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-KLF4 (IP:11880-1-AP, 3ug; Detection:11880-1-AP 1:500) with HeLa cells lysate 4650ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon using 11880-1-AP(KLF4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
