11880-1-AP

antibody from Proteintech Group

Targeting: KLF4 EZF, GKLF

Provider product page for 11880-1-AP

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ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [123]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: 11880-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11880-1-AP, RRID:AB_10640807
Product name: KLF4 antibody
Antibody type: Polyclonal
Description: KD/KO validated KLF4 antibody (Cat. #11880-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KLF4 protein structure - 11880-1-AP shown in red.

Submitted references Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco).

Liu LL, Song CC, Abu-Elala N, Tan XY, Zhao T, Zheng H, Yang H, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2024 Sep;1867(3):195041

Mechanism of HDAC1 Regulating Iron Overload-Induced Neuronal Oxidative Damage After Cerebral Hemorrhage.

Han J, Zhang J, Yao X, Meng M, Wan Y, Cheng Y
Molecular neurobiology 2024 Oct;61(10):7549-7566

HRD1 reduction promotes cholesterol-induced vascular smooth muscle cell phenotypic change via endoplasmic reticulum stress.

Wang L, Ren Z, Wu L, Zhang X, Wang M, Niu H, He X, Wang H, Chen Y, Shi G, Qian X
Molecular and cellular biochemistry 2024 Nov;479(11):3021-3036

A novel combined therapeutic strategy of Nano-EN-IR@Lip mediated photothermal therapy and stem cell inhibition for gastric cancer.

Yang L, Du YE, Liao F, Huang T, Liu Y, Liu J, Wang C, Zhan Z, Cao Y, Wang Z, Chen W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116486

IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.

Lv L, Wei Q, Zhang J, Dong Y, Shan Z, Chang N, Zhao Y, Bian P, Yi Q
Cellular & molecular biology letters 2024 Mar 19;29(1):39

KLF4 promotes milk fat synthesis by regulating the PI3K-AKT-mTOR pathway and targeting FASN activation in bovine mammary epithelial cells.

Wu HY, Ji ZH, Xie WY, Guo HX, Zheng Y, Gao W, Yuan B
iScience 2024 Jun 21;27(6):109850

Oxidized ATM governs stemness of breast cancer stem cell through regulating ubiquitylation and acetylation switch.

Zhou X, Liu X, Wan X, Xu M, Wang R, Yang D, Peng M, Jin T, Tang R, Liu M, Hou Y
Biochemical and biophysical research communications 2024 Jan 8;691:149243

KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling.

Chen Y, Sun L, Liu H, Li J, Guo L, Wang Z
Immunity, inflammation and disease 2024 Feb;12(2):e1199

PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.

Del Vecchio A, Mulé P, Fernández-Pérez D, Amato S, Lattanzi G, Zanotti M, Rustichelli S, Pivetti S, Oldani P, Mariani A, Iommazzo F, Koseki H, Facciotti F, Tamburri S, Ferrari KJ, Pasini D
Developmental cell 2024 Feb 5;59(3):368-383.e7

Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid- and IL4-Driven Macrophage Programming.

Deochand DK, Dacic M, Bale MJ, Daman AW, Josefowicz SZ, Oliver D, Chinenov Y, Rogatsky I
bioRxiv : the preprint server for biology 2024 Feb 18;

YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells.

Li S, Li X, Yang YB, Wu SF
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1198-1210

Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.

Li Q, Kang J, Liu N, Huang J, Zhang X, Pang K, Zhang S, Wang M, Zhao Y, Dong S, Li H, Zhao D, Lu F, Zhang W
Free radical biology & medicine 2024 Apr;216:118-138

Inhibition of the SLC35B2-TPST2 Axis of Tyrosine Sulfation Attenuates the Growth and Metastasis of Pancreatic Ductal Adenocarcinom.

Cai X, Li S, Zeng X, Xu M, Wang Z, Singhi AD, Tang D, Li S, Yates NA, Yang D, Xie W
Cellular and molecular gastroenterology and hepatology 2023;16(3):473-495

Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.

Chen X, Shi W, Zhu L, Zhou X, Wang Y
Cellular signalling 2023 Sep;109:110752

FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination.

Lei C, Kan H, Xian X, Chen W, Xiang W, Song X, Wu J, Yang D, Zheng Y
Nature communications 2023 Sep 2;14(1):5360

An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology.

Ni W, Zhang H, Mei Z, Hongyi Z, Wu Y, Xu W, Ma Y, Yang W, Liang Y, Gu T, Su Y, Fan S, Shen S, Hu Z
Redox biology 2023 Oct;66:102858

Influences of lysine-specific demethylase 1 inhibitors on NO synthase-Kruppel-like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo.

Yuan J, Que R, Zhao W, Song F, Cao Y, Yu B
Journal of applied toxicology : JAT 2023 Nov;43(11):1748-1760

Influences of repeated exposure to low levels of TiO(2) nanoparticles on Kruppel-like factors in 3D Caco-2 spheroids and mouse intestines.

Cao W, Liu M, Wang C, Jing G, Cao Y
Journal of applied toxicology : JAT 2023 May;43(5):706-718

Epithelial cells activate fibroblasts to promote esophageal cancer development.

Chen Y, Zhu S, Liu T, Zhang S, Lu J, Fan W, Lin L, Xiang T, Yang J, Zhao X, Xi Y, Ma Y, Cheng G, Lin D, Wu C
Cancer cell 2023 May 8;41(5):903-918.e8

Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.

Yang Q, Chen S, Wang X, Yang X, Chen L, Huang T, Zheng Y, Zheng X, Wu X, Sun Y, Wu J
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926

Decreased Expression of KLF4 Leading to Functional Deficit in Pediatric Patients with Intestinal Failure and Potential Therapeutic Strategy Using Decanoic Acid.

Yan J, Zhao Y, Jiang L, Wang Y, Cai W
Nutrients 2023 Jun 7;15(12)

TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750.

Yi Q, Zhao Y, Xia R, Wei Q, Chao F, Zhang R, Bian P, Lv L
Cell death discovery 2023 Jun 26;9(1):191

Paeoniflorin suppresses kidney inflammation by regulating macrophage polarization via KLF4-mediated mitophagy.

Cao Y, Xiong J, Guan X, Yin S, Chen J, Yuan S, Liu H, Lin S, Zhou Y, Qiu J, Wang D, Liu B, Zhou J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154901

Targeting CDK12 obviates the malignant phenotypes of colorectal cancer through the Wnt/β-catenin signaling pathway.

Liu S, Wu J, Lu X, Guo C, Zheng Q, Wang Y, Hu Q, Bian S, Luo L, Cheng Q, Liu Z, Dai W
Experimental cell research 2023 Jul 1;428(1):113613

The miR-143/145 cluster induced by TGF-β1 suppresses Wilms' tumor 1 expression in cultured human podocytes.

Tabei A, Sakairi T, Hamatani H, Ohishi Y, Watanabe M, Nakasatomi M, Ikeuchi H, Kaneko Y, Kopp JB, Hiromura K
American journal of physiology. Renal physiology 2023 Jul 1;325(1):F121-F133

The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke.

Wang C, Li L
Journal of neuroinflammation 2023 Feb 23;20(1):44

LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.

Xing Z, Du M, Zhen Y, Chen J, Li D, Liu R, Zheng J
Cellular signalling 2023 Dec;112:110907

Inhibition of EphA2 protects against atherosclerosis by synergizing with statins to mitigate macrophage inflammation.

Zeng J, Wu Q, Xiong S, Lu C, Zhang Z, Huang H, Xiong Y, Luo T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115885

Exposure to MoS2 nanosheets or bulk activated Kruppel-like factor 4 in 3D Caco-2 spheroids in vitro and mouse intestines in vivo.

Xiao Y, He Y, Xu C, Li M, Hu F, Wang W, Wang Z, Cao Y
Environmental toxicology 2023 Aug;38(8):1925-1938

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.

Lee C, Cho S, Jeong D
International journal of molecular sciences 2023 Aug 4;24(15)

miR-146a-5p Modulates Adult Hippocampal Neurogenesis Deficits Through Klf4/p-Stat3 Signaling in APP/PS1 Mice.

Deng LJ, Wu D, Yang XF, Li T
Neuroscience 2023 Aug 21;526:314-325

HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.

Han Z, Hu H, Yin M, Lin Y, Yan Y, Han P, Liu B, Jing B
Molecular medicine (Cambridge, Mass.) 2023 Aug 1;29(1):104

Commercial dishes with gelatin-free microstructured inserts for elongated stem cell self-renewal and pluripotency.

Ban Q, Hui W, Duan Q, Liu W, Zhang M, Li X, Kang H, Shi Z, Zhang Y, Hou J, Xu X, Ye S, Zhang B, Xu X
iScience 2023 Apr 21;26(4):106446

KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription.

Wang J, Zhao M, Zhang H, Yang F, Luo L, Shen K, Wang X, Li Y, Zhang J, Zhang J, Wang K, Li J, Wang Y, Yang Y, Hu D
International journal of biological sciences 2022;18(8):3324-3336

Iguratimod Attenuates Macrophage Polarization and Antibody-Mediated Rejection After Renal Transplant by Regulating KLF4.

Hang Z, Wei J, Zheng M, Gui Z, Chen H, Sun L, Fei S, Han Z, Tao J, Wang Z, Tan R, Gu M
Frontiers in pharmacology 2022;13:865363

ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.

Zhang R, Xie L, Wu F, Xu J, Lu L, Cao L, Li L, Meng W, Zhang H, Shao C, Li X, Chen D
Frontiers in pharmacology 2022;13:828896

GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma.

Chen W, Wang H, Lu Y, Huang Y, Xuan Y, Li X, Guo T, Wang C, Lai D, Wu S, Zhao W, Mai H, Li H, Wang B, Ma X, Zhang X
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):1011-1022

Lef1 is transcriptionally activated by Klf4 and suppresses hyperoxia-induced alveolar epithelial cell injury.

Yang M, Huang X, Shen F, Yi J, Meng Y, Chen Y
Experimental lung research 2022 Sep-Oct;48(7-8):213-223

SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway.

Chen Z, Jiang Z, Meng L, Wang Y, Lin M, Wei Z, Han W, Ying S, Xu A
Cell cycle (Georgetown, Tex.) 2022 Oct;21(19):2065-2078

Cyanidin-3-O-glucoside ameliorates cadmium induced uterine epithelium proliferation in mice.

Yang D, Ran Y, Li X, Jiang X, Chen J, Sun J, Tian L, Teerds K, Bai W
Journal of hazardous materials 2022 Mar 5;425:127571

Cilia proteins are biomarkers of altered flow in the vasculature.

Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R
JCI insight 2022 Mar 22;7(6)

Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells.

Mei J, Sheng X, Yan Y, Cai X, Zhang C, Tian J, Zhang M, Zhou J, Shan H, Huang C
BMC molecular and cell biology 2022 Jun 27;23(1):24

The role of KLF4 in melanogenesis and homeostasis in sheep melanocytes.

Qin H, Chen Y, Wang S, Ge S, Pang Q
Acta histochemica 2022 Jan;124(1):151839

FAT1 downregulation enhances stemness and cisplatin resistance in esophageal squamous cell carcinoma.

Zhai Y, Shan C, Zhang H, Kong P, Zhang L, Wang Y, Hu X, Cheng X
Molecular and cellular biochemistry 2022 Dec;477(12):2689-2702

Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation.

Li W, Long Q, Wu H, Zhou Y, Duan L, Yuan H, Ding Y, Huang Y, Wu Y, Huang J, Liu D, Chen B, Zhang J, Qi J, Du S, Li L, Liu Y, Ruan Z, Liu Z, Liu Z, Zhao Y, Lu J, Wang J, Chan WY, Liu X
Nature communications 2022 Dec 2;13(1):7414

Curcumin attenuates vascular calcification via the exosomal miR-92b-3p/KLF4 axis.

Chen C, Li Y, Lu H, Liu K, Jiang W, Zhang Z, Qin X
Experimental biology and medicine (Maywood, N.J.) 2022 Aug;247(16):1420-1432

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop.

Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, He J, Li P, Chen X, Ding W, Zhong J, Zeng Z, Xie Z, Liu J, Zu X
Cell death & disease 2022 Aug 30;13(8):749

DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma.

Jia X, Li L, Wang F, Xue Y, Wu T, Jia Q, Li Y, Wu C, Chen Y, Wu J, Su Y, Wang X, Zhuang T, Dong X, Ling J, Yuan J, Li Q
Cell death discovery 2022 Apr 5;8(1):166

EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.

Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, Xue Z, Lu S, Dong Y, Song C, Zhang X, Zhou Y
Food & function 2022 Apr 20;13(8):4399-4420

Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.

Li K, Gao S, Ma L, Sun Y, Peng ZY, Wu J, Du N, Ren H, Tang SC, Sun X
Frontiers in oncology 2021;11:731561

Toxicity evaluation of mesoporous silica particles Santa Barbara No. 15 amorphous in human umbilical vein endothelial cells: influence of particle morphology.

Teng W, Yang Z, Wang S, Xiong D, Chen Y, Wu Z
Journal of applied toxicology : JAT 2021 Sep;41(9):1467-1478

A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties.

Liu S, Sun Y, Hou Y, Yang L, Wan X, Qin Y, Liu Y, Wang R, Zhu P, Teng Y, Liu M
Journal of hematology & oncology 2021 Oct 29;14(1):178

Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the MERTK locus.

Tang X, Fu J, Chen Z, Luo L, Li DW, Liu Y
Stem cell research 2021 May;53:102310

CDR1as regulated by hnRNPM maintains stemness of periodontal ligament stem cells via miR-7/KLF4.

Gu X, Li X, Jin Y, Zhang Z, Li M, Liu D, Wei F
Journal of cellular and molecular medicine 2021 May;25(9):4501-4515

Smooth muscle cell-specific knockout of interferon gamma (IFN-γ) receptor attenuates intimal hyperplasia via STAT1-KLF4 activation.

He L, Gao K, Liu H, Wang J, Li X, He C
Life sciences 2021 May 25;:119651

A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.

Wen S, Qin Y, Wang R, Yang L, Zeng H, Zhu P, Li Q, Qiu Y, Chen S, Liu Y, Hou Y, Tang X, Liu M, Tu G
Cell death & disease 2021 May 1;12(5):437

ET(A)R silencing ameliorated neurovascular injury after SAH in rats through ERK/KLF4-mediated phenotypic transformation of smooth muscle cells.

Zhang Z, Chen H, Liu L, Zhao G, He J, Liu H, Zhou C, Liu X, Sun X, Guo Z
Experimental neurology 2021 Mar;337:113596

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352

Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.

Zhang L, Cao H, Tao H, Yang J, Gong W, Hu Q
Experimental and therapeutic medicine 2021 Jul;22(1):696

2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.

Zheng S, Ni J, Li Y, Lu M, Yao Y, Guo H, Jiao M, Jin T, Zhang H, Yuan A, Wang Z, Yang Y, Chen Z, Wu H, Hu W
Pharmacological research 2021 Jul;169:105685

Cellular reprogramming with multigene activation by the delivery of CRISPR/dCas9 ribonucleoproteins via magnetic peptide-imprinted chitosan nanoparticles.

Lee MH, Lin CC, Thomas JL, Li JA, Lin HY
Materials today. Bio 2021 Jan;9:100091

A Novel Long Non-Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis.

Qin Y, Hou Y, Liu S, Zhu P, Wan X, Zhao M, Peng M, Zeng H, Li Q, Jin T, Cui X, Liu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jan;8(2):2002232

Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 Signaling in Cirrhotic Rats.

Zhang L, Tai Y, Tang S, Zhao C, Tong H, Gao J, Tang C
Digestive diseases and sciences 2021 Jan;66(1):131-142

The preventive and therapeutic effects of AAV1-KLF4-shRNA in cigarette smoke-induced pulmonary hypertension.

Sun D, Ding D, Li Q, Xie M, Xu Y, Liu X
Journal of cellular and molecular medicine 2021 Jan;25(2):1238-1251

Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.

Dai DL, Li X, Wang L, Xie C, Jin Y, Zeng MS, Zuo Z, Xia TL
The Journal of biological chemistry 2021 Jan-Jun;296:100547

Cooperative activation of bovine herpesvirus 1 productive infection and viral regulatory promoters by androgen receptor and Krüppel-like transcription factors 4 and 15.

Sawant L, Thunuguntla P, Jones C
Virology 2021 Jan 2;552:63-72

BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation.

Yu S, Guo J, Sun Z, Lin C, Tao H, Zhang Q, Cui Y, Zuo H, Lin Y, Chen S, Liu H, Chen Z
Cell death & disease 2021 Feb 19;12(2):197

ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.

Zhang M, Wang L, Yue Y, Zhang L, Liu T, Jing M, Liang X, Ma M, Xu S, Wang K, Wang X, Fan J
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65

A Novel Van der Woude Syndrome-Causing IRF6 Variant Is Subject to Incomplete Non-sense-Mediated mRNA Decay Affecting the Phenotype of Keratinocytes.

Degen M, Girousi E, Feldmann J, Parisi L, La Scala GC, Schnyder I, Schaller A, Katsaros C
Frontiers in cell and developmental biology 2020;8:583115

Modulating cancer stemness provides luminal a breast cancer cells with HER2 positive-like features.

Mei Y, Cai D, Dai X
Journal of Cancer 2020;11(5):1162-1169

miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism.

Sun L, Lin P, Chen Y, Yu H, Ren S, Wang J, Zhao L, Du G
Theranostics 2020;10(12):5581-5599

The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.

Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438

Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo.

Wu B, Jiang M, Liu X, Huang C, Gu Z, Cao Y
Nanotoxicology 2020 Oct;14(8):1017-1038

Pioneer transcription factors, progesterone receptor and Krüppel like transcription factor 4, cooperatively stimulate the bovine herpesvirus 1 ICP0 early promoter and productive late protein expression.

Sawant L, Wijesekera N, Jones C
Virus research 2020 Oct 15;288:198115

Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.

Lv Y, Wang X, Li X, Xu G, Bai Y, Wu J, Piao Y, Shi Y, Xiang R, Wang L
PLoS biology 2020 Nov;18(11):e3000872

Using inducible lentiviral vectors to generate induced pluripotent stem cell line ZOCi001-A from peripheral blood cells of a patient with CRB1(-/-) retinitis pigmentosa.

Tang X, Liu X, Chen Z, Luo L, Liu X, Deng J, Li DW, Liu Y
Stem cell research 2020 May;45:101817

The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs.

Ignatova VV, Stolz P, Kaiser S, Gustafsson TH, Lastres PR, Sanz-Moreno A, Cho YL, Amarie OV, Aguilar-Pimentel A, Klein-Rodewald T, Calzada-Wack J, Becker L, Marschall S, Kraiger M, Garrett L, Seisenberger C, Hölter SM, Borland K, Van De Logt E, Jansen PWTC, Baltissen MP, Valenta M, Vermeulen M, Wurst W, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Rando OJ, Kellner SM, Bultmann S, Schneider R
Genes & development 2020 May 1;34(9-10):715-729

Long Noncoding RNA HOX Transcript Antisense RNA Gene rs17720428 Single Nucleotide Polymorphism Is Associated with Gastric Cancer Risk and Prognosis.

Li Y, Zhang Z, Yang Y, Ma J
Genetic testing and molecular biomarkers 2020 Jan;24(1):38-46

Deoxycholic Acid Upregulates the Reprogramming Factors KFL4 and OCT4 Through the IL-6/STAT3 Pathway in Esophageal Adenocarcinoma Cells.

Chen M, Ye A, Wei J, Wang R, Poon K
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820945302

LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4.

Ning J, Zhang L, Guo H, Zhou S, Sun X, Bao W
Translational cancer research 2020 Feb;9(2):958-971

Oxidative stress-induced KLF4 activates inflammatory response through IL17RA and its downstream targets in retinal pigment epithelial cells.

Sun Q, Gong L, Qi R, Qing W, Zou M, Ke Q, Zhang L, Tang X, Nie Q, Yang Y, Hu A, Ding X, Lu L, Liu Y, Li DW
Free radical biology & medicine 2020 Feb 1;147:271-281

Generation of a homozygous CRISPR/Cas9-mediated knockout H9 hESC subline for the CRB1 locus.

Tang X, Chen Z, Tan X, Luo L, Liu X, Gong L, Li DW, Liu Y
Stem cell research 2020 Dec;49:102057

Upregulation of the microRNA rno-miR-146b-5p may be involved in the development of intestinal injury through inhibition of Kruppel-like factor 4 in intestinal sepsis.

Tong L, Tang C, Cai C, Guan X
Bioengineered 2020 Dec;11(1):1334-1349

Multi-walled carbon nanotubes decrease neuronal NO synthase in 3D brain organoids.

Jiang Y, Gong H, Jiang S, She C, Cao Y
The Science of the total environment 2020 Dec 15;748:141384

miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis.

Shi DM, Shi XL, Xing KL, Zhou HX, Lu LL, Wu WZ
Cellular signalling 2020 Aug;72:109650

KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling.

Li Y, Yu S, Li L, Chen J, Quan M, Li Q, Gao Y
Cell death & disease 2020 Apr 29;11(4):299

KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling.

Li L, Yu S, Wu Q, Dou N, Li Y, Gao Y
International journal of biological sciences 2019;15(5):953-961

miR-92b-3p Functions As A Key Gene In Esophageal Squamous Cell Cancer As Determined By Co-Expression Analysis.

Wang W, Fu S, Lin X, Zheng J, Pu J, Gu Y, Deng W, Liu Y, He Z, Liang W, Wang C
OncoTargets and therapy 2019;12:8339-8353

SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders.

Zhang Y, Cui G, Wang Y, Gong Y, Wang Y
International journal of molecular medicine 2019 Sep;44(3):995-1005

SP1 regulates KLF4 via SP1 binding motif governed by DNA methylation during odontoblastic differentiation of human dental pulp cells.

Sun Z, Yu S, Chen S, Liu H, Chen Z
Journal of cellular biochemistry 2019 Sep;120(9):14688-14699

Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.

Yang H, Li J, Yang C, Liu H, Cao Y
Toxicology and applied pharmacology 2019 Jul 1;374:11-19

LncRNA NKILA regulates endothelium inflammation by controlling a NF-κB/KLF4 positive feedback loop.

Zhu X, Du J, Yu J, Guo R, Feng Y, Qiao L, Xu Z, Yang F, Zhong G, Liu F, Cheng F, Chu M, Lin J
Journal of molecular and cellular cardiology 2019 Jan;126:60-69

Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF-β Signaling Pathway and Interaction With Histone Acetylation.

Tao H, Lin H, Sun Z, Pei F, Zhang J, Chen S, Liu H, Chen Z
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Aug;34(8):1502-1516

Klf4 Alleviates Lipopolysaccharide-Induced Inflammation by Inducing Expression of MCP-1 Induced Protein 1 to Deubiquitinate TRAF6.

Li Z, Jia Y, Han S, Wang X, Han F, Zhang J, Zhang W, Guan H, Hu D
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2278-2290

SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression.

Chen W, Zhuo M, Lu X, Xia X, Zhao Y, Huang Z, Xu J, Li W, Yu C
International journal of biological sciences 2018;14(14):2051-2064

Role of Krüppel-like factor 4 in cigarette smoke-induced pulmonary vascular remodeling.

Sun D, Li Q, Ding D, Li X, Xie M, Xu Y, Liu X
American journal of translational research 2018;10(2):581-591

Quaking promotes the odontoblastic differentiation of human dental pulp stem cells.

Li S, Lin C, Zhang J, Tao H, Liu H, Yuan G, Chen Z
Journal of cellular physiology 2018 Sep;233(9):7292-7304

Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency Acquisition.

Li S, Xiao F, Zhang J, Sun X, Wang H, Zeng Y, Hu J, Tang F, Gu J, Zhao Y, Jin Y, Liao B
Stem cell reports 2018 Oct 9;11(4):973-987

Generation of an iPS cell line via a non-integrative method using urine-derived cells from a patient with USH2A-associated retinitis pigmentosa.

Guo Y, Zeng Q, Liu S, Yu Q, Wang P, Ma H, Shi S, Yan X, Cui Z, Xie M, Xue Y, Zha Q, Li Z, Zhang J, Tang S, Chen J
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Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z
Nature communications 2018 Mar 28;9(1):1261

SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells.

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The histone methyltransferase SETD1A regulates thrombomodulin transcription in vascular endothelial cells.

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TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11880-1-AP(KLF4 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Confocal immunofluorescent analysis of human embronic stem cells with 11880-1-AP at dilution of 1:50. The PE shows staining with 11880-1-AP/PE. The DAPI shows nuclear staining by DAPI.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-KLF4 (IP:11880-1-AP, 3ug; Detection:11880-1-AP 1:500) with HeLa cells lysate 4650ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon using 11880-1-AP(KLF4 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue