10593-1-AP

antibody from Proteintech Group

Targeting: SDC1 CD138, SDC, SYND1, syndecan

Provider product page for 10593-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [31]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 10593-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10593-1-AP, RRID:AB_2182736
Product name: CD138/Syndecan-1 antibody
Antibody type: Polyclonal
Description: CD138/Syndecan-1 antibody (Cat. #10593-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SDC1 protein structure - 10593-1-AP shown in red.

Submitted references MZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing SDC1 in glioblastoma.

Li G, Ma L, Feng C, Yin H, Bao J, Wu D, Zhang Z, Li X, Li Z, Yang C, Wang H, Fang F, Hu X, Li M, Xu L, Xu Y, Liang H, Yang T, Wang J, Pan J
BMC cancer 2024 Feb 16;24(1):220

SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes.

Zeng L, Zheng W, Liu X, Zhou Y, Jin X, Xiao Y, Bai Y, Pan Y, Zhang J, Shao C
Theranostics 2023;13(11):3725-3743

SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.

Zhang CL, Shen Q, Liu FD, Yang F, Gao MQ, Jiang XC, Li Y, Zhang XY, En GE, Pan X, Pang B
Scientific reports 2023 Oct 31;13(1):18727

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857

LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p.

Xia Z, Zhao S, Gao X, Sun H, Yang F, Zhu H, Gao H, Lu J, Zhou X
Technology in cancer research & treatment 2023 Jan-Dec;22:15330338231177807

Interleukin-32γ promotes macrophage-mediated chemoresistance by inducing CSF1-dependent M2 macrophage polarization in multiple myeloma.

Yan H, He D, Qu J, Liu Y, Xu R, Gu H, Chen J, Li Y, Zhang E, Zhao Y, He J, Cai Z
Cancer immunology, immunotherapy : CII 2023 Feb;72(2):327-338

Increased R-spondin 3 contributes to aerobic exercise-induced protection against renal vascular endothelial hyperpermeability and acute kidney injury.

Xu QF, Zhang H, Zhao Y, Liu D, Wei J, Jiang L, Liu YJ, Zhu XY
Acta physiologica (Oxford, England) 2023 Dec;239(4):e14036

Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer.

Wang N, Gu Y, Li L, Chi J, Liu X, Xiong Y, Zhong C
Journal of inflammation research 2022;15:3477-3499

SB431542 alleviates lupus nephritis by regulating B cells and inhibiting the TLR9/TGFβ1/PDGFB signaling.

Xia Y, Jiang C, Yang M, Liu T, Zou X, Li C, Wang X
Journal of autoimmunity 2022 Oct;132:102894

Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer.

Zhou Z, Ren Y, Yang J, Liu M, Shi X, Luo W, Fung KM, Xu C, Bronze MS, Zhang Y, Houchen CW, Li M
Gastroenterology 2022 Nov;163(5):1281-1293.e1

Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.

Feng X, Guo J, An G, Wu Y, Liu Z, Meng B, He N, Zhao X, Chen S, Zhu Y, Xia J, Li X, Yu Z, Li R, Ren G, Chen J, Wu M, He Y, Qiu L, Zhou J, Zhou W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(9):e2104491

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.

Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani O, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Cohen NM, Gershoni JM, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z
Cell 2022 Mar 31;185(7):1208-1222.e21

Glycocalyx is critical for blood-brain barrier integrity by suppressing caveolin1-dependent endothelial transcytosis following ischemic stroke.

Zhu J, Li Z, Ji Z, Wu Y, He Y, Liu K, Chang Y, Peng Y, Lin Z, Wang S, Wang D, Huang K, Pan S
Brain pathology (Zurich, Switzerland) 2022 Jan;32(1):e13006

The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium.

Wang LN, Wang L, Cheng G, Dai M, Yu Y, Teng G, Zhao J, Xu D
Cellular and molecular life sciences : CMLS 2022 Jan 31;79(2):110

Transcriptome analysis reveals transforming growth factor-β1 prevents extracellular matrix degradation and cell adhesion during the follicular-luteal transition in cows.

Guo B, Qu X, Chen Z, Yu J, Yan L, Zhu H
The Journal of reproduction and development 2022 Feb 18;68(1):12-20

Aurka loss in CD19(+) B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production.

Chen X, Wang C, Sun N, Pan S, Li R, Li X, Zhao J, Tong H, Tang Y, Han J, Qiao J, Qiu H, Wang H, Yang J, Ikezoe T
Theranostics 2021;11(10):4655-4671

Sclerosing mucoepidermoid carcinoma of the salivary glands: report of three cases with special concern to the counterpart accompanied by eosinophilia.

Harada H, Toyozumi Y, Sasaguri T, Kuyama K, Nakatsuka SI, Kurose A
Medical molecular morphology 2021 Sep;54(3):265-274

Clinical and Molecular Characterizations of Papillary Thyroid Cancer in Children and Young Adults: A Multicenter Retrospective Study.

Guo K, Qian K, Shi Y, Sun T, Chen L, Mei D, Dong K, Gu S, Liu J, Lv Z, Wang Z
Thyroid : official journal of the American Thyroid Association 2021 Nov;31(11):1693-1706

miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma.

Rossi M, Altomare E, Botta C, Gallo Cantafio ME, Sarvide S, Caracciolo D, Riillo C, Gaspari M, Taverna D, Conforti F, Critelli P, Bertucci B, Iannone M, Polerà N, Scumaci D, Arbitrio M, Amodio N, Di Martino MT, Paiva B, Tagliaferri P, Tassone P
Leukemia 2021 Mar;35(3):823-834

Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma.

Chen X, Cheng B, Dai D, Wu Y, Feng Z, Tong C, Wang X, Zhao J
Cell death discovery 2021 Feb 17;7(1):33

PLP2 Expression as a Prognostic and Therapeutic Indicator in High-Risk Multiple Myeloma.

Bai H, Zhu Y, Xu P, Chen B
BioMed research international 2020;2020:4286101

The cancer cell glycocalyx proteoglycan Glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis.

Moran H, Cancel LM, Mayer MA, Qazi H, Munn LL, Tarbell JM
Biorheology 2019;56(2-3):151-161

Predominant Role of Immunoglobulin G in the Pathogenesis of Splenomegaly in Murine Lupus.

Zhang Q, Xiang L, Zaman MH, Dong W, He G, Deng GM
Frontiers in immunology 2019;10:3020

CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma.

Xu R, Li Y, Yan H, Zhang E, Huang X, Chen Q, Chen J, Qu J, Liu Y, He J, Yi Q, Cai Z
Cell death & disease 2019 Oct 14;10(10):781

IL-33 induces production of autoantibody against autologous respiratory epithelial cells: a potential mechanism for the pathogenesis of COPD.

Li Q, Hu Y, Chen Y, Lv Z, Wang J, An G, Du X, Wang H, Corrigan CJ, Wang W, Ying S
Immunology 2019 Jun;157(2):137-150

Blockade of deubiquitinase USP7 overcomes bortezomib resistance by suppressing NF-κB signaling pathway in multiple myeloma.

Yao Y, Zhang Y, Shi M, Sun Y, Chen C, Niu M, Zhang Q, Zeng L, Yao R, Li H, Yang J, Li Z, Xu K
Journal of leukocyte biology 2018 Dec;104(6):1105-1115

Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer's disease model.

Liu YL, Chen WT, Lin YY, Lu PH, Hsieh SL, Cheng IH
Molecular neurodegeneration 2017 Apr 24;12(1):30

Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells.

Yao Y, Sun Y, Shi M, Xia D, Zhao K, Zeng L, Yao R, Zhang Y, Li Z, Niu M, Xu K
Oncotarget 2016 Nov 8;7(45):73497-73508

Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection.

Yang Z, Wang X, Chi X, Zhao F, Guo J, Ma P, Zhong J, Niu J, Pan X, Long G
Journal of virology 2016 Nov 1;90(21):9632-9643

Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer.

Wang X, Zuo D, Chen Y, Li W, Liu R, He Y, Ren L, Zhou L, Deng T, Wang X, Ying G, Ba Y
British journal of cancer 2014 Nov 11;111(10):1965-76

Reduced APRIL expression induces cellular senescence via a HSPG-dependent pathway.

Ding W, Ju S, Jiang S, Zhu L, Wang Y, Wang H
Pathology oncology research : POR 2009 Dec;15(4):693-701

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Raji cells were subjected to SDS PAGE followed by western blot with 10593-1-AP(SDC1,CD138 antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human ovary tumor using 10593-1-AP(SDC1,CD138 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CD138/Syndecan-1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CD138/Syndecan-1. This antibody recognizes human,mouse,rat antigen. The CD138/Syndecan-1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10593-1-AP.pdf

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