Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11478-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11478-1-AP, RRID:AB_2098973
- Product name
- ERAL1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ERAL1 antibody (Cat. #11478-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.
The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome.
CLUH couples mitochondrial distribution to the energetic and metabolic status.
A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
MPV17L2 is required for ribosome assembly in mitochondria.
Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis.
Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit.
Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit.
Key J, Gispert S, Koornneef L, Sleddens-Linkels E, Kohli A, Torres-Odio S, Koepf G, Amr S, Reichlmeir M, Harter PN, West AP, Münch C, Baarends WM, Auburger G
Cells 2022 Dec 22;12(1)
Cells 2022 Dec 22;12(1)
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.
Reyes A, Favia P, Vidoni S, Petruzzella V, Zeviani M
PLoS genetics 2020 Jul;16(7):e1008923
PLoS genetics 2020 Jul;16(7):e1008923
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X
Acta neuropathologica 2019 Jun;137(6):939-960
Acta neuropathologica 2019 Jun;137(6):939-960
Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.
Luo T, Dunphy PS, McBride JW
Frontiers in cellular and infection microbiology 2017;7:178
Frontiers in cellular and infection microbiology 2017;7:178
The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome.
Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN
The Biochemical journal 2017 Jun 13;474(13):2145-2158
The Biochemical journal 2017 Jun 13;474(13):2145-2158
CLUH couples mitochondrial distribution to the energetic and metabolic status.
Wakim J, Goudenege D, Perrot R, Gueguen N, Desquiret-Dumas V, Chao de la Barca JM, Dalla Rosa I, Manero F, Le Mao M, Chupin S, Chevrollier A, Procaccio V, Bonneau D, Logan DC, Reynier P, Lenaers G, Khiati S
Journal of cell science 2017 Jun 1;130(11):1940-1951
Journal of cell science 2017 Jun 1;130(11):1940-1951
A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.
Chatzispyrou IA, Alders M, Guerrero-Castillo S, Zapata Perez R, Haagmans MA, Mouchiroud L, Koster J, Ofman R, Baas F, Waterham HR, Spelbrink JN, Auwerx J, Mannens MM, Houtkooper RH, Plomp AS
Human molecular genetics 2017 Jul 1;26(13):2541-2550
Human molecular genetics 2017 Jul 1;26(13):2541-2550
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A
The EMBO journal 2016 Dec 1;35(23):2566-2583
The EMBO journal 2016 Dec 1;35(23):2566-2583
MPV17L2 is required for ribosome assembly in mitochondria.
Dalla Rosa I, Durigon R, Pearce SF, Rorbach J, Hirst EM, Vidoni S, Reyes A, Brea-Calvo G, Minczuk M, Woellhaf MW, Herrmann JM, Huynen MA, Holt IJ, Spinazzola A
Nucleic acids research 2014 Jul;42(13):8500-15
Nucleic acids research 2014 Jul;42(13):8500-15
Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis.
He J, Cooper HM, Reyes A, Di Re M, Sembongi H, Litwin TR, Gao J, Neuman KC, Fearnley IM, Spinazzola A, Walker JE, Holt IJ
Nucleic acids research 2012 Jul;40(13):6109-21
Nucleic acids research 2012 Jul;40(13):6109-21
Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit.
He J, Cooper HM, Reyes A, Di Re M, Kazak L, Wood SR, Mao CC, Fearnley IM, Walker JE, Holt IJ
Nucleic acids research 2012 Jul;40(13):6097-108
Nucleic acids research 2012 Jul;40(13):6097-108
Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit.
Dennerlein S, Rozanska A, Wydro M, Chrzanowska-Lightowlers ZM, Lightowlers RN
The Biochemical journal 2010 Sep 15;430(3):551-8
The Biochemical journal 2010 Sep 15;430(3):551-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11478-1-AP(ERAL1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ERAL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ERAL1. This antibody recognizes human, mouse, rat antigen. The ERAL1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.