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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Immunohistochemistry [1]
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- Product number
- HPA021624 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA021624, RRID:AB_1844549
- Product name
- Anti-ACTL7A
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human ACTL7A, Gene description: actin-like 7A, Validated applications: IHC, Uniprot ID: Q9Y615, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella (MMAF) and ICSI outcomes
High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI.
Novel HYDIN variants associated with male infertility in two Chinese families
Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology.
Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest.
Shao Z, Zhu Y, Gu M, Guo S, Yu H, Li K, Tang D, Xu Y, Lv M
Asian Journal of Andrology 2024;26(1):91-98
Asian Journal of Andrology 2024;26(1):91-98
High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI.
Cardona Barberán A, Reddy Guggilla R, Colenbier C, Van der Velden E, Rybouchkin A, Stoop D, Leybaert L, Coucke P, Symoens S, Boel A, Vanden Meerschaut F, Heindryckx B
Human reproduction open 2024;2024(4):hoae057
Human reproduction open 2024;2024(4):hoae057
Novel HYDIN variants associated with male infertility in two Chinese families
Yu H, Shi X, Shao Z, Geng H, Guo S, Li K, Gu M, Xu C, Gao Y, Tan Q, Duan Z, Wu H, Hua R, Guo R, Wei Z, Zhou P, Cao Y, He X, Li L, Zhang X, Lv M
Frontiers in Endocrinology 2023;14
Frontiers in Endocrinology 2023;14
Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology.
Yang TY, Chen Y, Chen GW, Sun YS, Li ZC, Shen XR, Zhang YN, He W, Zhou D, Shi HJ, Xin AJ, Sun XX
Asian journal of andrology 2022 May-Jun;24(3):260-265
Asian journal of andrology 2022 May-Jun;24(3):260-265
Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest.
Xin A, Qu R, Chen G, Zhang L, Chen J, Tao C, Fu J, Tang J, Ru Y, Chen Y, Peng X, Shi H, Zhang F, Sun X
Science advances 2020 Aug;6(35):eaaz4796
Science advances 2020 Aug;6(35):eaaz4796
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human testis and skeletal muscle tissues using HPA021624 antibody. Corresponding ACTL7A RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
