24324-1-AP

antibody from Proteintech Group

Targeting: SLC5A5 NIS

Provider product page for 24324-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [42]
Comments [0]
Validations
Western blot [2]
Flow cytometry [1]

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Product number: 24324-1-AP - Provider product page
Provider: Proteintech Group
Product name: Sodium iodide symporter antibody
Antibody type: Polyclonal
Description: Sodium iodide symporter antibody (Cat. #24324-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC5A5 protein structure - 24324-1-AP shown in red.

Submitted references Metabolomics reveals the implication of acetoacetate and ketogenic diet therapy in radioiodine-refractory differentiated thyroid carcinoma.

Wang J, Xu Q, Xuan Z, Mao Y, Tang X, Yang K, Song F, Zhu X
The oncologist 2024 Sep 6;29(9):e1120-e1131

Study of iodine transport and thyroid hormone levels in the human placenta under different iodine nutritional status.

Fu M, Ren Z, Gao Y, Zhang H, Guo W, Zhang W
The British journal of nutrition 2024 May 14;131(9):1488-1496

Mechanism of multi-organ compensation under different iodine intake in pregnant rats: results from a repeated-measures study of iodine metabolism.

Fu M, Zhang H, Gao Y, Yang R, Meng Q, Jin Q, Qi Y, Shi N, Zhang W
European journal of nutrition 2024 Mar;63(2):589-598

Effects of sub-chronic exposure to microcystin-LR on the endocrine system of male rats.

Wang YT, Wu QH, Chen L, Giesy JP, Xu LL, Xu WL, He J, Shi T, Liu YQ, Xiao SM, Wang YK, Chen F, Chen Y, Xu NH, Ge YL, Chu L, Yan YZ, Chen J, Xie P
The Science of the total environment 2024 Jan 1;906:166839

Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer.

Pan Z, Lu X, Xu T, Chen J, Bao L, Li Y, Gong Y, Che Y, Zou X, Tan Z, Huang P, Ge M
Cancer letters 2024 Jan 1;580:216496

Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice.

Tian XJ, Yin ZJ, Li ZJ, Wang ZZ, Xing Z, Liu CY, Wang LT, Wang CM, Zhang JF, Dong L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2305913

TESC promotes differentiated thyroid cancer development by activating ERK and weakening NIS and radioiodine uptake.

Guo Y, Cai Y, Song F, Zhu L, Hu Y, Liu Y, Ma W, Ge J, Zeng Q, Ding L, Li L, Zheng G, Ge M
Endocrine 2023 Sep;81(3):503-512

Lipid-Peptide-mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer.

Li Q, Zhang L, Lang J, Tan Z, Feng Q, Zhu F, Liu G, Ying Z, Yu X, Feng H, Yi H, Wen Q, Jin T, Cheng K, Zhao X, Ge M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(3):e2204334

Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1-Mediated Regulation.

Yu J, Shen S, Yan Y, Liu L, Luo R, Liu S, Wu Y, Li Y, Jiang J, Ying H
Nutrients 2023 Feb 9;15(4)

Association between radioactive iodine uptake and neutropenia in untreated Graves' disease.

Yang Q, Ke W, Pan F, Huang X, Liu J, Zha B
Endocrine connections 2023 Feb 1;12(2)

Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells.

Faria M, Vareda J, Miranda M, Bugalho MJ, Silva AL, Matos P
Cancers 2022 Oct 31;14(21)

High concentration of estradiol has a negative correlation with free thyroxine during the second trimester of pregnancy.

He L, Li X, Chen Z, Wang W, Wang K, Huang X, Yang Q, Ke W, Liu J, Zha B
Endocrine connections 2022 Oct 1;11(10)

Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation.

Xu Q, Zhou L, Ri H, Li X, Zhang X, Qi W, Ye L
Environmental toxicology and pharmacology 2022 Nov;96:104007

Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter.

Read ML, Brookes K, Thornton CEM, Fletcher A, Nieto HR, Alshahrani M, Khan R, Borges de Souza P, Zha L, Webster JRM, Alderwick LJ, Campbell MJ, Boelaert K, Smith VE, McCabe CJ
Cell chemical biology 2022 Mar 17;29(3):502-516.e7

Targeting IGF2BP2 Promotes Differentiation of Radioiodine Refractory Papillary Thyroid Cancer via Destabilizing RUNX2 mRNA.

Sa R, Liang R, Qiu X, He Z, Liu Z, Chen L
Cancers 2022 Mar 1;14(5)

IGF2BP2-dependent activation of ERBB2 signaling contributes to acquired resistance to tyrosine kinase inhibitor in differentiation therapy of radioiodine-refractory papillary thyroid cancer.

Sa R, Liang R, Qiu X, He Z, Liu Z, Chen L
Cancer letters 2022 Feb 28;527:10-23

Generation of a NIS-EGFP-Fluc triple-reporter human embryonic stem cell line by PiggyBac transposon system.

Huang P, Tian C, Chen Y, Zhou M, Ni J, Niu M, Liu X, Peng Z
Stem cell research 2022 Dec;65:102968

Di(2-ethylhexyl) phthalate induced thyroid toxicity via endoplasmic reticulum stress: In vivo and in vitro study.

Xu Q, Zhao T, Ri H, Ye J, Zhao W, Zhang Y, Ye L
Environmental toxicology 2022 Dec;37(12):2924-2936

Mechanisms of Sodium/Iodide Symporter-Mediated Mammary Gland Iodine Compensation during Lactation.

Fu M, Gao Y, Guo W, Meng Q, Jin Q, Yang R, Yang Y, Zhang Y, Zhang W
Nutrients 2022 Aug 31;14(17)

Downregulation of Rap1GAP Expression Activates the TGF-β/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells.

Yan Z, Yangyanqiu W, Shuwen H, Jing M, Haihong L, Gong C, Yin J, Qing Z, Weili G
BioMed research international 2021;2021:6840642

XBP1s Acts as a Tumor Suppressor to Inhibit the EMT Process and Metastasis of Papillary Thyroid Cancer.

Yang W, Xu X, Xu M, Zhou J, Xi Z, Guo H, Ming J, Huang T
OncoTargets and therapy 2021;14:2339-2348

Proteomics and Organoid Culture Reveal the Underlying Pathogenesis of Hashimoto's Thyroiditis.

Xiao H, Liang J, Liu S, Zhang Q, Xie F, Kong X, Guo S, Wang R, Fu R, Ye Z, Li Y, Zhang S, Zhang L, Kaudimba KK, Wang R, Kong X, Zhao B, Zheng X, Liu T
Frontiers in immunology 2021;12:784975

Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer.

Faria M, Domingues R, Bugalho MJ, Silva AL, Matos P
Cancers 2021 Oct 30;13(21)

MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells.

Faria M, Domingues R, Bugalho MJ, Matos P, Silva AL
Cancers 2021 Nov 22;13(22)

PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism.

Ha M, Huang X, Li L, Lu D, Liu C
The Science of the total environment 2021 Feb 25;757:143727

CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.

Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, Zuo Y, Sui S, Tian C, Hao J, Chen M, Hu S, Chen M, Long Q, Wang X, Zou L, Xie F, Guo W, Deng W
Cell death and differentiation 2021 Apr;28(4):1347-1363

TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells.

Faria M, Domingues R, Paixão F, Bugalho MJ, Matos P, Silva AL
PloS one 2020;15(2):e0228794

Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening.

Sondorp LHJ, Ogundipe VML, Groen AH, Kelder W, Kemper A, Links TP, Coppes RP, Kruijff S
Cancers 2020 Oct 31;12(11)

Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF(V600E) by synergistically decreasing global trimethylation of H3K27.

Fu H, Cheng L, Sa R, Jin Y, Chen L
Journal of cellular and molecular medicine 2020 Mar;24(6):3336-3345

REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.

Jiao C, Li L, Zhang P, Zhang L, Li K, Fang R, Yuan L, Shi K, Pan L, Guo Q, Gao X, Chen G, Xu S, Wang Q, Zuo D, Wu W, Qiao S, Wang X, Moses R, Xiao J, Li L, Dang Y, Li X
Cell death and differentiation 2020 Feb;27(2):497-508

Human Bone Marrow Mesenchymal Stem Cells Modified Hybrid Baculovirus-Adeno-Associated Viral Vectors Targeting (131)I Therapy of Hypopharyngeal Carcinoma.

Wang J, Kong D, Zhu L, Wang S, Sun X
Human gene therapy 2020 Dec;31(23-24):1300-1311

Dimerization of the Sodium/Iodide Symporter.

Thompson RJ, Fletcher A, Brookes K, Nieto H, Alshahrani MM, Mueller JW, Fine NHF, Hodson DJ, Boelaert K, Read ML, Smith VE, McCabe CJ
Thyroid : official journal of the American Thyroid Association 2019 Oct;29(10):1485-1498

Human Bone Marrow Mesenchymal Stem Cells Functionalized by Hybrid Baculovirus-Adeno-Associated Viral Vectors for Targeting Hypopharyngeal Carcinoma.

Wang J, Zhu L, Chen X, Huang R, Wang S, Dong P
Stem cells and development 2019 Apr 15;28(8):543-553

A somatic mutation of RasGRP3 decreases Na(+)/I(-) symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.

Song J, Qiu W, Deng X, Qiu Z, Fan Y, Yang Z
American journal of cancer research 2018;8(9):1847-1855

Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells.

Zhang H, Chen D
Thyroid research 2018;11:13

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.

Cheng L, Jin Y, Liu M, Ruan M, Chen L
Oncotarget 2017 Mar 21;8(12):19843-19854

Use of rhenium-188 for in vivo imaging and treatment of human cervical cancer cells transfected with lentivirus expressing sodium iodide symporter.

Zhang M, Shi S, Guo R, Miao Y, Li B
Oncology reports 2016 Oct;36(4):2289-97

2,3',4,4',5-Pentachlorobiphenyl Induces Inflammatory Responses in the Thyroid Through JNK and Aryl Hydrocarbon Receptor-Mediated Pathway.

Xu B, Yang H, Sun M, Chen H, Jiang L, Zheng X, Ding G, Liu Y, Sheng Y, Cui D, Duan Y
Toxicological sciences : an official journal of the Society of Toxicology 2016 Feb;149(2):300-11

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study.

Saunders NR, Dziegielewska KM, Møllgård K, Habgood MD, Wakefield MJ, Lindsay H, Stratzielle N, Ghersi-Egea JF, Liddelow SA
Frontiers in neuroscience 2015;9:123

In vivo molecular imaging and radionuclide (131I) therapy of human nasopharyngeal carcinoma cells transfected with a lentivirus expressing sodium iodide symporter.

Shi S, Zhang M, Guo R, Miao Y, Hu J, Xi Y, Li B
PloS one 2015;10(1):e0116531

Iodide- and glucose-handling gene expression regulated by sorafenib or cabozantinib in papillary thyroid cancer.

Ruan M, Liu M, Dong Q, Chen L
The Journal of clinical endocrinology and metabolism 2015 May;100(5):1771-9

Feasibility of lentiviral‑mediated sodium iodide symporter gene delivery for the efficient monitoring of bone marrow‑derived mesenchymal stem cell transplantation and survival.

Shi S, Zhang M, Guo R, Miao Y, Zhang M, Hu J, Xi Y, Li B
International journal of molecular medicine 2014 Dec;34(6):1547-54

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse stomach tissue were subjected to SDS PAGE followed by western blot with 24324-1-AP( SLC5A5 Antibody) at dilution of 1:600
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse testis tissue were subjected to SDS PAGE followed by western blot with 24324-1-AP( SLC5A5 Antibody) at dilution of 1:600
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Sodium iodide symporter antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Sodium iodide symporter. This antibody recognizes human, mouse, rat antigen. The Sodium iodide symporter antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
Appendix: 24324-1-AP.pdf

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