orb153878

antibody from Biorbyt
Targeting: FLNB ABP-278, FH1, FLN1L, LRS1, TABP, TAP
Provider product page for orb153878
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
orb153878 - Provider product page
Provider
Biorbyt
Product name
FLNB antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal antibody to FLNB. Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (alphaactinin domain) located at the amino terminus is followed by as many as 24 tandem repeats of about 96 residues and the dimerization domain is located at the carboxy terminus. In addition to actin filaments, filamins associate with other structural and signaling molecules such as beta integrins, Rho/Rac/Cdc42, PKC, and the insulin receptor, primarily through the carboxyterminal dimerization domain (13). Filamin A, the most abundant, and filamin B are widely expressed isoforms, while filamin C is predominantly expressed in muscle (1). Filamin A is phosphorylated by PAK1 at Ser2152, which is required for PAK1mediated actin cytoskeleton reorganization
Reactivity
Human, Mouse, Rat
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 ul
Storage
Store at -20°C. Avoid freeze / thaw cycles.
FLNB protein structure - orb153878 shown in red.