14168-1-AP

antibody from Proteintech Group

Targeting: TLN1 ILWEQ, TLN

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

14168-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14168-1-AP, RRID:AB_2271861

Product name

Talin-1 antibody

Antibody type

Polyclonal

Description

KD/KO validated Talin-1 antibody (Cat. #14168-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Fucoidan SPW-05-S2 from Sargassum fusiforme inhibits African swine fever virus replication by blocking PAK2/Talin-1 mediated viral endocytosis and factory formation.

Wan S, Song B, Li S, Cao C, Lu M, Peng G, Ding K, Han K, Yu M
International journal of biological macromolecules 2026 May;360:151801

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Oncogenic role of talin-1 in glioma: Association with poor prognosis and regulation of the TGF-beta signaling pathway.

Li J, Zhang D, Zhou H, Hou L, Wang Y, Zhang Z, Wang Y, Li X, Yi L, Liu X, Wang Y, Xue X
Translational oncology 2026 Mar;65:102691

---

Enhancing Vascularized Bone Regeneration Through Oscillatory Fluid Flow-Regulated Gradient Lattice Porous Titanium Alloy.

Yang Y, Yuan T, Fan W, Gao P, Yang Y, Bai R, Yang W, Cai K
Advanced healthcare materials 2026 Feb;15(6):e02853

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Phospholipase C δ1 affects integrin-mediated cell adhesion and migration by altering available phosphatidylinositol 4,5-bisphosphate levels.

Yoneda A, Fujinaka R, Tsuchiya N, Yaita S, Suzuki S, Kishi Y, Nakamura Y, Satow R, Fukami K
Experimental cell research 2026 Feb 1;455(1):114857

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RAD23B Promotes Colorectal Cancer Metastasis via the Talin1/Integrin/PI3K/AKT/MMP9 Axis.

Li J, Chen Y, Hao Z, Zhang Z, Fan J, Liu X, Zhao X, Zhang H, Wu C
Oncology research 2025;33(11):3523-3541

---

Disulfidptosis-Related Genes as Novel Biomarkers and Therapeutic Targets in Dilated Cardiomyopathy.

Bo X, Fan J, Xu S, Zeng Y, Xu A, Wang X, Wang H, Kang P, Fu Y, Fan H, Tan X, Zhou Y
Journal of inflammation research 2025;18:9967-9988

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Podocyte Proteomics Revealed hUCMSC-Exosomes Ameliorate Diabetic Kidney Disease through Inhibiting Talin-1 Mediated EMT.

Zhang Z, Tang CM, Yu WZ, Yang XC, Yu N, Li XH, Ding WJ, Liu D, Ling MY, Song YP, Feng JC, Zou JR, Ma TM, Zhao CL, Xing YQ
Journal of proteome research 2025 Sep 5;24(9):4767-4779

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Dynamic rigidity changes enable rapid cell migration on soft substrates.

Yang J, Zhang Y, Wang S, Wang P, Dong L, Li L, Cheng Y, Huang X, Xue B, Wang W, Jiang C, Gu X, Cao Y, Wei Q
Nature communications 2025 Oct 2;16(1):8793

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Tenotomized Achilles tendons of MRL/MpJ mice show scar-mediated healing, but have superior recovery of biomechanical properties.

Tang N, Wilson K, Weldemariam MM, Tian H, Hart CD, Ramnath P, Sivalingam DS, Glazier J, Jiang J, Leong N, Lowe T, Kane MA, Iwamoto M, Kuo CK, Enomoto-Iwamoto M
bioRxiv : the preprint server for biology 2025 May 16;

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Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection.

Teng X, Wang Y, Huang H, Ding Y, Wang J, Liu M, Song K, Shao L, Yu Y, Yang Z, Shen Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501112

---

Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4.

Tan X, Cardin DL, Wang S, Xu Y, Russell WK
Proceedings of the National Academy of Sciences of the United States of America 2025 Jul 15;122(28):e2501347122

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Robust and Regular Micronano Binary Texture on the Complex Curved Surface for Enhanced Reendothelialization and Antithrombotic Performance.

Zhang J, Yu W, Li G, Li G, Chen B, Wang L, Yu Y, Liu Z, Li D
ACS nano 2025 Jan 28;19(3):3676-3693

---

IFIT3 promotes lymph node metastasis by interacting with LASP1 to activate FAK-ERK signaling in esophageal squamous cell carcinoma.

Cui Q, Zhou X, Chen X, Zhao X, Zhang R, Wang J, Li X, Wang G, Li B, Li M, Chen J, Gao X, Shi Y, Li W, Hong P, Li D
Cell death & disease 2025 Dec 18;17(1):110

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Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organization.

Cohen D, Lázaro-Diéguez F, Müsch A
Journal of cell science 2025 Dec 1;138(23)

---

Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films.

Wang X, Xu H, Ning F, Duan S, Hu Y, Ding X, Xu FJ
Macromolecular rapid communications 2025 Apr;46(7):e2400339

---

Granulosa Cell-Layer Stiffening Prevents Escape of Mural Granulosa Cells from the Post-Ovulatory Follicle.

Wang X, Liao J, Shi H, Zhao Y, Ke W, Wu H, Liu G, Li X, He C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2403640

---

Intermetallics triggering pyroptosis and disulfidptosis in cancer cells promote anti-tumor immunity.

Zhu Y, Wang X, Feng L, Zhao R, Yu C, Liu Y, Xie Y, Liu B, Zhou Y, Yang P
Nature communications 2024 Oct 8;15(1):8696

---

MβCD inhibits SFTSV entry by disrupting lipid raft structure of the host cells.

Cheng M, Zhang R, Li J, Ma W, Li L, Jiang N, Liu B, Wu J, Zheng N, Wu Z
Antiviral research 2024 Nov;231:106004

---

Harnessing Mechanical Stress with Viscoelastic Biomaterials for Periodontal Ligament Regeneration.

Zhang JJ, Li X, Tian Y, Zou JK, Gan D, Deng DK, Jiao C, Yin Y, Tian BM, Wu RX, Chen FM, He XT
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2309562

---

ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration.

Kosinski J, Sechi A, Hain J, Villwock S, Ha SA, Hauschulz M, Rose M, Steib F, Ortiz-Brüchle N, Heij L, Maas SL, van der Vorst EPC, Knoesel T, Altendorf-Hofmann A, Simon R, Sauter G, Bednarsch J, Jonigk D, Dahl E
Molecular oncology 2024 Jun;18(6):1486-1509

---

Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells.

Wang L, Sun S, Liu H, Zhang Q, Meng Y, Sun F, Zhang J, Liu H, Xu W, Ye Z, Zhang J, Sun B, Xu J
The FEBS journal 2024 Dec;291(23):5276-5289

---

Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.

Kersey AL, Cheng DY, Deo KA, Dubell CR, Wang TC, Jaiswal MK, Kim MH, Murali A, Hargett SE, Mallick S, Lele TP, Singh I, Gaharwar AK
Biomaterials 2024 Apr;306:122473

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Paxillin phase separation promotes focal adhesion assembly and integrin signaling.

Liang P, Wu Y, Zheng S, Zhang J, Yang S, Wang J, Ma S, Zhang M, Gu Z, Liu Q, Jiang W, Xing Q, Wang B
The Journal of cell biology 2024 Apr 1;223(4)

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Superhydrophilic and topography-regulatable surface grafting on PEEK to improve cellular affinity.

Zhang B, Leng J, Ouyang Z, Yang Z, Zhang Q, Li Q, Li D, Zhao H
Biomaterials advances 2023 Mar;146:213310

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Cas phosphorylation regulates focal adhesion assembly.

Kumar S, Stainer A, Dubrulle J, Simpkins C, Cooper JA
eLife 2023 Jul 25;12

---

Silica nanoparticles suppressed the spermatogenesis via downregulation of miR-450b-3p by targeting Layilin in spermatocyte of mouse.

Zhou G, Wang J, Ren L, Liu J, Li X, Zhang Y, Sang Y, Gao L, Li Y, Sun Z, Zhou X
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120864

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Talin1 regulates glucose metabolism and endometrial receptivity via GLUT-4 in patients with polycystic ovary syndrome and insulin resistance.

Li J, Chen S, Qin R, Liu X, Fan L, Wei M, Wei J, Lin J, Zheng F
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Dec;39(1):2231085

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Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2.

Hong WF, Zhu DX, Chen YJ, Shen XZ, Cui YH, Du SS, Liu TS, Liang L
Cancer letters 2023 Dec 1;578:216460

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Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia.

Cui D, Cui X, Xu X, Zhang W, Yu Y, Gao Y, Mei C, Zheng W
BMC cancer 2022 Sep 29;22(1):1027

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Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer.

Zhang Y, Sun L, Li H, Ai L, Ma Q, Qiao X, Yang J, Zhang H, Ou X, Wang Y, Chen G, Xue J, Zhu X, Zhao Y, Yang Y, Liu C
eLife 2022 Mar 14;11

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In Vivo and In Vitro Fibroblasts' Behavior and Capsular Formation in Correlation with Smooth and Textured Silicone Surfaces.

Huang SQ, Chen Y, Zhu Q, Zhang YM, Lei ZY, Zhou X, Fan DL
Aesthetic plastic surgery 2022 Jun;46(3):1164-1177

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Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling.

Yao Q, Wang H, Chen H, Li Z, Jiang Y, Li Z, Wang J, Xing Y, Liu F, Yu D, Yin S
Molecular neurobiology 2022 Jan;59(1):386-404

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Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.

Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521

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Mechanosensitive Piezo1 channels mediate renal fibrosis.

Zhao X, Kong Y, Liang B, Xu J, Lin Y, Zhou N, Li J, Jiang B, Cheng J, Li C, Wang W
JCI insight 2022 Apr 8;7(7)

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Altered Glycosylation in the Aging Heart.

Franzka P, Krüger L, Schurig MK, Olecka M, Hoffmann S, Blanchard V, Hübner CA
Frontiers in molecular biosciences 2021;8:673044

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Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca(2+) Signaling Pathway.

Liu L, Zhang Q, Xiao S, Sun Z, Ding S, Chen Y, Wang L, Yin X, Liao F, Jiang LH, Xue M, You Y
Frontiers in pharmacology 2021;12:606245

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Expression of Talin-1 in endometriosis and its possible role in pathogenesis.

Tang X, Li Q, Li L, Jiang J
Reproductive biology and endocrinology : RB&E 2021 Mar 9;19(1):42

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Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.

Wang Q, Tian X, Zhou W, Wang Y, Zhao H, Li J, Zhou X, Zhang H, Zhao T, Li P
Journal of diabetes research 2020;2020:3634974

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Nanotopography Enhances Dynamic Remodeling of Tight Junction Proteins through Cytosolic Liquid Complexes.

Huang X, Shi X, Hansen ME, Setiady I, Nemeth CL, Celli A, Huang B, Mauro T, Koval M, Desai TA
ACS nano 2020 Oct 27;14(10):13192-13202

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Comparison of Macrophage Activation Using γ-Globulin and Serum-derived Macrophage Activating Factor.

Akamatsu M, Mashiba R, Kawakatsu K, Ishikawa M, Nishikata T
Anticancer research 2020 Aug;40(8):4707-4710

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Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure.

Nakamura H, Shimizu T, Takatani A, Suematsu T, Nakamura T, Kawakami A
Virus research 2019 Aug;269:197643

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Surface changes of nanotopography by carbon ion implantation to enhance the biocompatibility of silicone rubber: an in vitro study of the optimum ion fluence and adsorbed protein.

Li X, Zhou X, Chen Y, Yu S, Chen X, Xia X, Shi X, Zhang Y, Fan D
Journal of materials science. Materials in medicine 2017 Sep 15;28(10):167

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Downregulation of Talin1 promotes hepatocellular carcinoma progression through activation of the ERK1/2 pathway.

Chen P, Lei L, Wang J, Zou X, Zhang D, Deng L, Wu D
Cancer science 2017 Jun;108(6):1157-1168

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 14168-1-AP(TLN1 antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using TLN1 antibody 14168-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human colon cancer using 14168-1-AP(TLN1 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human colon cancer using 14168-1-AP(TLN1 antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Talin-1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Talin-1. This antibody recognizes human,mouse,rat antigen. The Talin-1 antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.

Appendix

14168-1-AP.pdf

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