Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 60043 - Provider product page
- Provider
- STEMCELL Technologies Inc
- Product name
- Anti-Human CD51 Antibody, Clone NKI-M9
- Antibody type
- Monoclonal
- Description
- The NKI-M9 antibody reacts with CD51 (vitronectin receptor ? chain, or integrin ?V), a type I transmembrane glycoprotein containing two subunits (125 kDa and 24 kDa) which are generated by post-translational cleavage and are linked by a disulfide bond. CD51 associates non-covalently with integrin ?1 (CD29), ?3 (CD61), ?5, ?6, or ?8 to form heterodimeric cell adhesion receptors for extracellular matrix components such as fibrinogen, collagen, fibronectin, laminin, osteopontin, thrombospondin, vitronectin, and von Willebrand factor. For example, association of CD51 and CD61 forms the integrin ?v/?3 receptor primarily involved in binding vitronectin. In addition to mediating adhesion and cytoskeletal organization, CD51-containing integrins have roles in signal transduction and thereby modulate processes such as cell proliferation, differentiation, and migration. Both ligand binding and ligand-induced receptor clustering are necessary for initiating integrin-mediated responses. CD51 is expressed broadly on many types of cells, including endothelial cells, fibroblasts, monocytes, macrophages, platelets (at relatively low levels), and osteoclasts. It is also found on hepatoma, melanoma, and neuroblastoma cells.
- Reactivity
- Human
- Host
- Human
- Isotype
- IgG
- Vial size
- 100 µg
- Storage
- 2 - 8°C
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