55117-1-AP

antibody from Proteintech Group

Targeting: EGR1 AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225

Provider product page for 55117-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 55117-1-AP - Provider product page
Provider: Proteintech Group
Product name: EGR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated EGR1 antibody (Cat. #55117-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

EGR1 protein structure - 55117-1-AP shown in red.

Submitted references The D826V point mutation in IREB2 induces lipogenesis in adipose tissues.

Lv Y, Wu C, Xiao J, Yang W, Wang C, Wang J, Huang J, Guo Z, Liao S
Frontiers in cell and developmental biology 2026;14:1724485

EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.

Yang F, Liu D, Hu L, Tan H, Wei Y, Yang R, Huang B, Zou Q, Wu Q, He Y, Mai H, Lan X, Yan Y, Huang Z, Huang X, Fu Z, Deng Z, Huang Q, Yao S, Liang Y
Molecular and cellular endocrinology 2026 Mar;613:112721

Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics.

Guo F, Sun D, Ding H, Li Y, Yang B, Guo M, Ma Y, Qiao R, Li S, Zhang L, Zhang Q, Zhang M, Li W
BMC medicine 2026 Mar 3;24(1)

Radiation-induced glioblastoma stem cell-mediated T cell exhaustion via EGR1-Gal3-LAG3 axis in glioblastoma.

Huang H, Li C, You H, Zhang Z, Lin Q, Yang J, Yu H, Li Z, Cui G, Song K, Zhang Q, Chen Y, Wang X, Zhang J, Gu D, Cheng C, Shao J
Cancer letters 2026 Jan 1;636:218125

ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.

Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879

METTL16 promotes MASLD progression through the regulation of lipid synthesis and immune response.

Li G, Wang L, Zhang L, Guo J, Sun Q
Biology direct 2026 Apr 9;21(1)

Chronic Exposure to Cigarette Smoke Induces Pyroptosis in Pulmonary Epithelial Cells via EGR1/USP44/TRAF6 Axis in COPD.

Cao C, Zhong Z, Wu B, Zou B, Jia H, Xu J, Xiao G, Xia S
Journal of inflammation research 2025;18:16619-16635

sVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage.

Jiang N, Wu J, He Y, Zhang R, Ji M, Zhu L, Cui S, You Q, Cai Y, Liu B, Lyu R, Chen Y, Zhu J, Wu Z
EMBO reports 2025 Sep;26(18):4477-4502

Transcriptomic analysis identifies a potential target for bevacizumab resistant glioblastoma.

Lodha R, Muller-Greven G, Maqbool MA, Guo L, Buchan G, Singh K, Qadan MA, Chelakkot VS, Decker PA, Bakken K, Carlson BL, Burgenske D, Nowacki AS, Vasmatzis G, Kizilbash SH, Sarkaria JN, Gladson CL
Scientific reports 2025 Oct 22;15(1):36860

Human amniotic mesenchymal stem cell-derived exosome inhibits ferroptosis through the suppression of JNK/MAPK-mediated EGR1 expression in spontaneous intracerebral hemorrhage.

Wang Y, Zhou L, Xu K
Brain research bulletin 2025 Oct 15;231:111553

Lipoxin A4 suppresses neutrophil extracellular traps formation through the FPR2-dependent regulation of METTL3 in ischemic stroke.

Wei N, Lu T, Gu J, Cai H
Brain research bulletin 2025 Jan;220:111178

RNA splicing controls organ-wide maturation of postnatal heart in mice.

Li Z, Cao C, Zhao Q, Li D, Han Y, Zhang M, Mao L, Zhou B, Wang L
Developmental cell 2025 Jan 20;60(2):236-252.e8

Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity.

Li Y, You QL, Zhang SR, Huang WY, Zou WJ, Jie W, Li SJ, Liu JH, Lv CY, Cong J, Hu YY, Gao TM, Li JM
Molecular neurobiology 2025 Dec;62(12):15251-15266

Celecoxib and naproxen disrupt autophagy and activate EGR1 in kidney tubules.

Haghighi S, Haghighi A, Zádori ZS, Kovács K, Manzéger A, Kökény G
Experimental and molecular pathology 2025 Dec;144:105000

Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas.

Díaz NM, Sun X, Van Gelder RN, Lang RA, Buhr ED
Cell reports 2025 Aug 26;44(8):116045

Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams.

Lai S, Zhang L, Tu X, Ma X, Song Y, Cao K, Li M, Meng J, Shi Y, Wu Q, Yang C, Lan Z, Lau CG, Shi J, Ma W, Li S, Xue YX, Huang Z
Science advances 2024 Mar 22;10(12):eadk9484

N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21(cip1/waf1)/CDK2-Cyclin E1 axis-mediated cell cycle transition.

Liu R, Miao J, Jia Y, Kong G, Hong F, Li F, Zhai M, Zhang R, Liu J, Xu X, Wang T, Liu H, Hu J, Yang Y, He A
Oncogene 2023 May;42(20):1607-1619

Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease.

Guo Y, Miao X, Sun X, Li L, Zhou A, Zhu X, Xu Y, Wang Q, Li Z, Fan Z
JHEP reports : innovation in hepatology 2023 Jun;5(6):100724

Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy.

Fu W, Yang R, Li J
BMC biology 2023 Jun 6;21(1):132

Lentinan induces apoptosis of mouse hepatocellular carcinoma cells through the EGR1/PTEN/AKT signaling axis.

You J, Wu Q, Li Y, Li X, Lin Z, Huang J, Xue Y, Gulimiran A, Pan Y
Oncology reports 2023 Jul;50(1)

DDIT3 aggravates pulpitis by modulating M1 polarization through EGR1 in macrophages.

Wang Y, He Y, Dong W, Jia M, Yang C, Wang J
International immunopharmacology 2023 Jul;120:110328

Gene therapy targeting miR‑212‑3p exerts therapeutic effects on MAFLD similar to those of exercise.

Sun B, Zhang Y, Zhang M, Liu R, Yang W
International journal of molecular medicine 2023 Feb;51(2)

IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.

Ma ZG, Yuan YP, Fan D, Zhang X, Teng T, Song P, Kong CY, Hu C, Wei WY, Tang QZ
Nature communications 2023 Aug 16;14(1):4967

The Role of Early Growth Response Family Members 1-4 in Prognostic Value of Breast Cancer.

Hao L, Huang F, Yu X, Xu B, Liu Y, Zhang Y, Zhu Y
Frontiers in genetics 2021;12:680132

miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1.

Sheng S, Zou M, Yang Y, Guan M, Ren S, Wang X, Wang L, Xue Y
In vitro cellular & developmental biology. Animal 2021 Sep;57(8):763-774

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8

Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation.

Wang Y, Yao F, Wang L, Li Z, Ren Z, Li D, Zhang M, Han L, Wang SQ, Zhou B, Wang L
Nature communications 2020 May 22;11(1):2585

MicroRNA-217 ameliorates inflammatory damage of endothelial cells induced by oxidized LDL by targeting EGR1.

Yang X, Li D, Qi YZ, Chen W, Yang CH, Jiang YH
Molecular and cellular biochemistry 2020 Dec;475(1-2):41-51

MnO(2)-DNAzyme-photosensitizer nanocomposite with AIE characteristic for cell imaging and photodynamic-gene therapy.

Wang X, Dai J, Wang X, Hu Q, Huang K, Zhao Z, Lou X, Xia F
Talanta 2019 Sep 1;202:591-599

Abcam Monoclonal Egr-1 ab133695 is an effective primary antibody replacement for Santa Cruz sc-189 polyclonal Egr-1 in songbirds.

Scully EN, Sanchez JM, Sturdy CB
Heliyon 2019 Nov;5(11):e02938

Early growth response protein-1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney disease.

Yang YL, Hu F, Xue M, Jia YJ, Zheng ZJ, Li Y, Xue YM
American journal of physiology. Cell physiology 2019 Mar 1;316(3):C340-C352

Podocyte histone deacetylase activity regulates murine and human glomerular diseases.

Inoue K, Gan G, Ciarleglio M, Zhang Y, Tian X, Pedigo CE, Cavanaugh C, Tate J, Wang Y, Cross E, Groener M, Chai N, Wang Z, Justice A, Zhang Z, Parikh CR, Wilson FP, Ishibe S
The Journal of clinical investigation 2019 Mar 1;129(3):1295-1313

Hepatic miR-181b-5p Contributes to Glycogen Synthesis Through Targeting EGR1.

Wang S, Liang C, Ai H, Yang M, Yi J, Liu L, Song Z, Bao Y, Li Y, Sun L, Zhao H
Digestive diseases and sciences 2019 Jun;64(6):1548-1559

The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.

Wang Q, Wang HX, Shen JY, Zhang R, Hong JW, Li Z, Chen G, Li MX, Ding Z, Li J, Zhang JP, Zhang MR, Xu LC
Ecotoxicology and environmental safety 2019 Aug 15;177:58-65

Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.

Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, Shen L, Luo A, Wang S
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 55117-1-AP( EGR1 Antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The EGR1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human EGR1. This antibody recognizes human, mouse antigen. The EGR1 antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
Appendix: 55117-1-AP.pdf

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