22008-1-AP

antibody from Proteintech Group

Targeting: EGR1 AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225

Provider product page for 22008-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [68]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 22008-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22008-1-AP, RRID:AB_11182923
Product name: EGR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated EGR1 antibody (Cat. #22008-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

EGR1 protein structure - 22008-1-AP shown in red.

Submitted references Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5-Dependent RNA Demethylation.

Qin T, Pan A, Miao Z, Zhao Y, Mo X, Sun H, Fan C, Guo J, Wu B, Shen W, Zheng Q, Lu J, Jiang X, Yin Z, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(17):e08376

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation.

Jia J, Gan Y, Li J, Li L, Meng H, Sun M, Ye L, Mao R, Cao X, Xia S, Bao X, Liu R, Zhang M, Xu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e17825

Paclitaxel drives TREM2(+) macrophage expansion underlying its inferior therapeutic efficacy compared to Nab-paclitaxel.

Xing Y, Zhong R, Li Q, Duan X, Xu M, Yu M, Liu C, He J, Sun Y, Wang Y, Guo X, Xu Y, Mo H, Ma F, Zhang H, Zhan J
Nature communications 2026 Feb 3;17(1)

Role of CTGF-LRP1 in impaired healing of cesarean section incisions.

He C, Ge S, Xia W, Wang Y, Yan L, Sun J, Yan L, Zhu Q, Zhao X, Zhang J
Nature communications 2026 Feb 28;17(1)

NOTCH3-R544C mutation drives endothelial dysfunction through inflammation, migration impairment, and lipid dysregulation.

Sun R, Li W, Liu N, Ji X, Zhao Z, Che N, Li A, Hu W, Zhang J
Journal of Alzheimer's disease : JAD 2026 Apr 21;:13872877261444309

Unveiling PANoptosis in Acute Kidney Injury: An Integrative Multi-Dimensional Approach to Identify Key Biomarkers.

Wang N, Zhang L, Xu Z, Xu Q, Lu Y, Niu P, Yan L, Wang L, Cao H, Shao F
Journal of inflammation research 2025;18:8735-8754

Single-Cell RNA Sequencing Reveals Microglial Heterogeneity and Functional States After Cerebral Ischemia-Reperfusion Injury.

Tang Y, Zhang Q, Qu Y, Yi L, Li F, Qu C, Shi S, Pan BF, Wen S, Sun R, Pan Y
Journal of inflammation research 2025;18:16931-16956

sVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage.

Jiang N, Wu J, He Y, Zhang R, Ji M, Zhu L, Cui S, You Q, Cai Y, Liu B, Lyu R, Chen Y, Zhu J, Wu Z
EMBO reports 2025 Sep;26(18):4477-4502

Egr1/Gc/vitamin transport axis mediates synergistic effect of macular thinning and underweight in age-related visual acuity decline.

Lin R, Hu C, Shen T, Wu Y, Cai W, Ren C, Li T, Jiang L, Wan Z, Xu Z, Ma J, Zhu M, Luo Y, Liang F, Yu D, Yu J
Experimental eye research 2025 Sep;258:110525

Ferulic acid promotes thrombopoiesis via TLR4/JAK2/STAT3 signaling: A novel therapeutic strategy for thrombocytopenia.

Liao R, Huang M, Liu Z, Wang X, Gan X, Hao L, Jiang P, Luo J, Huang Q, Mei Q, Wu A, Wang L, Wu J
Biochemical pharmacology 2025 Sep;239:117088

O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1.

Chen C, Gao Y, Xu G, Sun Y, Bao G, Liu W, Xu D, Yuan K, Cui Z
Cell death discovery 2025 Oct 16;11(1):462

MAP30 inhibits proliferation and metastasis of bladder cancer by increasing EGR1 expression and promoting the transcriptional activation of DUSP1.

Wang K, Gu Q, Xue C, Shi J, Wang K, He X
Molecular immunology 2025 Nov;187:48-60

KLK1 as an Epithelial-Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R-Mediated Fibroblast Phenotypic Transition.

Zhou L, Wang M, Liu S, Gu L, Liu S, Du Q, Zhang T, Ma Y, Zhao L, Wang J, Xu Q, Ling T, Cheng H, Chen H, Sun Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07063

Strychni Semen and its active compounds promote axon regeneration following peripheral nerve injury by suppressing myeloperoxidase in the dorsal root ganglia.

Zhang Y, Zhao XY, Liu MT, Zhou ZC, Cheng HB, Jiang XH, Zheng YR, Chen Z
Journal of integrative medicine 2025 Mar;23(2):169-181

CtBP2 Regulates Wnt Signal Through EGR1 to Influence the Proliferation and Apoptosis of DLBCL Cells.

Dong J, Li L, Zhang X, Yin X, Chen Z
Molecular carcinogenesis 2025 Jun;64(6):959-969

Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells.

Lai M, Zhou W, Zou W, Qiu L, Liang Z, Chen W, Wang Y, Guo B, Zhao C, Zhang S, Lai P, Hu L, Liu X, Jiang Y, Chen Y, Huang MJ, Bai X, Zou Z
Nature communications 2025 Jun 4;16(1):5206

Pancreatic alpha and beta cell fate choice is directed by apical-basal polarity dynamics.

Tiemann U, Tian C, Hermann F, Proks M, Skovgaard E, Kulik I, Di Y, Sedzinski J, Semb H
Developmental cell 2025 Jul 7;60(13):1871-1883.e5

Calycosin inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by downregulating early growth response 1.

Liu Y, Wang J, Cheng SW, Chen X, Bai Z, Zhou YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156884

Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway.

Ni C, Zhou L, Yang S, Ran M, Luo J, Cheng K, Huang F, Tang X, Xie X, Qin D, Mei Q, Wang L, Xiao J, Wu J
Journal of pharmaceutical analysis 2025 Jan;15(1):101054

Induction of Senescence in Lung Cancer Cells by Qidongning Formula via the Transcription Factor EGR1.

Zhou D, Yang WX, Wang CY, Qian CX, Xu L, Dong CS, Chen J, Gong YB
Integrative cancer therapies 2025 Jan-Dec;24:15347354241307007

SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.

Xin W, Zhou J, Peng Y, Gong S, Liao W, Wang Y, Huang X, Mao Y, Yao M, Qin S, Xiong J, Li Y, Lan Q, Huang Y, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells.

Li Y, Lu D, Xu F, Yang J, Li D, Yang C, Chen X, Wang X, Qing J, Zhang H, Zhang Y, Tang F, Qiao J, Klein OD, Zhang P, Zhou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e10243

CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Xu Q, Chen Y, Zhang H, Zhou K, Zhao Y, Deng W, Wang Z, Guo L, Liu H, Ren Z, Liu L, Tang Z, Jiang Z
Free radical biology & medicine 2025 Aug 16;236:188-203

GALNT18-Mediated O-Glycosylation Promotes Development of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma Through Activation of EGR1/TGF-β1/Smad Signaling.

Chen D, Nie Y, Shi L, Zhong D, Wu J, Jin B, Liu D
Molecular biotechnology 2025 Aug 15;

Genistin: A Novel Estrogen Analogue Targeting ERβ to Alleviate Thrombocytopenia.

Tang X, Liao R, Zhou L, Yi T, Ran M, Luo J, Huang F, Wu A, Mei Q, Wang L, Huang X, Wu J
International journal of biological sciences 2024;20(6):2236-2260

Mutant p53 achieves function by regulating EGR1 to induce epithelial mesenchymal transition.

Meng W, Yu S, Li Y, Wang H, Feng Y, Sun W, Liu Y, Sun S, Liu H
Tissue & cell 2024 Oct;90:102510

Cyclic negative pressure promotes chondrocyte growth: Association of IGF-2 with EGR-1.

Li X, Huang L, Liu B, Zhang Z, Zhou G, Guo Z, Song J, Wang X
Biomolecules & biomedicine 2024 Oct 17;24(6):1761-1775

Epigenetic regulation by KDM5A mediates the effects of prenatal PM(2.5) exposure on hippocampal development and synaptic integrity through the Shh signaling pathway.

Huang J, Song C, Liu Y, Zhang T, Wang T, Liu X, Yu L
Ecotoxicology and environmental safety 2024 May;276:116311

Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.

Li Y, Lai J, Ran M, Yi T, Zhou L, Luo J, Liu X, Tang X, Huang M, Xie X, Li H, Yang Y, Zou W, Wu J
European journal of pharmacology 2024 May 15;971:176548

GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas.

He H, Liang L, Jiang S, Liu Y, Huang J, Sun X, Li Y, Jiang Y, Cong L
Cell death & disease 2024 Mar 11;15(3):205

Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration.

Zheng SK, Zhao XK, Wu H, He DW, Xiong L, Cheng XG
Aging 2024 Jun 28;16(12):10216-10238

6-Thioguanine inhibits severe fever with thrombocytopenia syndrome virus through suppression of EGR1.

Jiang N, He Y, Wu J, You Q, Zhang R, Cheng M, Liu B, Cai Y, Lyu R, Wu Z
Antiviral research 2024 Jul;227:105916

Effect and mechanism of curcumin on colon cancer cell senescence through early growth response 1 (EGR1).

Xu D, Li L, Yu Z
Translational cancer research 2024 Jul 31;13(7):3251-3261

The EGR1/miR-139/NRF2 axis orchestrates radiosensitivity of non-small-cell lung cancer via ferroptosis.

Zhang L, Xu Y, Cheng Z, Zhao J, Wang M, Sun Y, Mi Z, Yuan Z, Wu Z
Cancer letters 2024 Jul 28;595:217000

Hippocampal estrogens rescued the decline of synaptic plasticity after surgery and anesthesia by inhibiting microglia overactivation.

Tan XX, Dai HY, Yao J, Wang JJ, Dai YC, Zhang TH, Qiu LL, Sun J
Behavioural brain research 2024 Feb 29;459:114794

EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells.

Tian Q, Chen JH, Ding Y, Wang XY, Qiu JY, Cao Q, Zhuang LL, Jin R, Zhou GP
Molecular biology reports 2024 Feb 26;51(1):365

EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer.

Yang Z, Chen F, Wei D, Chen F, Jiang H, Qin S
BMC cancer 2024 Feb 26;24(1):268

Aerobic exercise attenuates high-fat diet-induced glycometabolism impairments in skeletal muscle of rat: role of EGR-1/PTP1B signaling pathway.

Zhang L, Liu X, Hu J, Quan H, Lee SK, Korivi M, Wang L, Li T, Li W
Nutrition & metabolism 2024 Dec 31;21(1):113

PD-L1 Expression Is Increased in LPS-Induced Acute Respiratory Distress Syndrome by PI3K-AKT-Egr-1/C/EBPδ Signaling Pathway.

Yan C, Chen J, Wang B, Wang J, Luo M, Tong J, Xu X, Zhang Q, Wang X
Inflammation 2024 Aug;47(4):1459-1478

Exploration and validation of therapeutic molecules for rheumatoid arthritis based on ferroptosis-related genes.

Aihaiti Y, Zheng H, Cai Y, Tuerhong X, Kaerman M, Wang F, Xu P
Life sciences 2024 Aug 15;351:122780

Iguratimod suppresses sclerostin and receptor activator of NF-κB ligand production via the extracellular signal-regulated kinase/early growth response protein 1/tumor necrosis factor alpha pathway in osteocytes and ameliorates disuse osteoporosis in mice.

Miura T, Etani Y, Noguchi T, Hirao M, Takami K, Goshima A, Kurihara T, Fukuda Y, Ochiai N, Kanamoto T, Nakata K, Okada S, Ebina K
Bone 2024 Apr;181:117026

HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction.

Zhu C, Piao Z, Jin L
Orphanet journal of rare diseases 2023 Sep 4;18(1):266

TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation.

Guo Q, Cheng ZM, Gonzalez-Cantú H, Rotondi M, Huelgas-Morales G, Ethiraj P, Qiu Z, Lefkowitz J, Song W, Landry BN, Lopez H, Estrada-Zuniga CM, Goyal S, Khan MA, Walker TJ, Wang E, Li F, Ding Y, Mulligan LM, Aguiar RCT, Dahia PLM
Cell reports 2023 Sep 26;42(9):113070

EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8.

Zhao Y, Sui L, Wu P, Li L, Liu L, Ma B, Wang W, Chi H, Wang Z-D, Wei Z, Hou Z, Zhang K, Niu J, Jin N, Li C, Zhao J, Wang G, Liu Q
Journal of virology 2023 Oct 31;97(10):e0102823

WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2.

Wang G, He X, Dai H, Lin L, Cao W, Fu Y, Diao W, Ding M, Zhang Q, Chen W, Guo H
Oncogenesis 2023 Oct 2;12(1):47

Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy.

Zhou X, Hong Y, Liu Y, Wang L, Liu X, Li Y, Yuan H, Hu F
Journal of nanobiotechnology 2023 Nov 14;21(1):422

Biomimetic Construction of Degradable DNAzyme-Loaded Nanocapsules for Self-Sufficient Gene Therapy of Pulmonary Metastatic Breast Cancer.

Jiang R, Li L, Li M
ACS nano 2023 Nov 14;17(21):22129-22144

Single-cell RNA sequencing reveals the transcriptomic landscape of kidneys in patients with ischemic acute kidney injury.

Tang R, Jin P, Shen C, Lin W, Yu L, Hu X, Meng T, Zhang L, Peng L, Xiao X, Eggenhuizen P, Ooi JD, Wu X, Ding X, Zhong Y
Chinese medical journal 2023 May 20;136(10):1177-1187

Ccdc25 regulates neurogenesis during the brain development.

Wang C, Qin J, Jiao J, Ji F
Developmental neurobiology 2023 Apr-May;83(3-4):91-103

Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk.

Qiu Y, Sha L, Zhang X, Li G, Zhu W, Xu Q
Frontiers in aging neuroscience 2022;14:896522

Calycosin attenuates renal ischemia/reperfusion injury by suppressing NF-κB mediated inflammation via PPARγ/EGR1 pathway.

Zhang N, Guan C, Liu Z, Li C, Yang C, Xu L, Niu M, Zhao L, Zhou B, Che L, Wang Y, Xu Y
Frontiers in pharmacology 2022;13:970616

TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.

Qin D, Liu P, Zhou H, Jin J, Gong W, Liu K, Chen S, Huang J, Fan W, Tao Z, Xu Y
Frontiers in immunology 2022;13:941608

Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice.

Liu Z, Guan C, Li C, Zhang N, Yang C, Xu L, Zhou B, Zhao L, Luan H, Man X, Xu Y
Frontiers in pharmacology 2022;13:862584

Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota.

Wu K, Liu X, Meng X, Cao L, Li H, Bi Y, Wang M, Wang M, Jiang Y
Frontiers in microbiology 2022;13:1084257

Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.

Wang L, Zhang T, Liu S, Mo Q, Jiang N, Chen Q, Yang J, Han YW, Chen JP, Huang FH, Li H, Zhou J, Luo JS, Wu JM
Pharmacological research 2022 Mar;177:106096

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I/R-induced renal fibrosis via downregulation of EGR1.

Ai K, Li X, Zhang P, Pan J, Li H, He Z, Zhang H, Yi L, Kang Y, Wang Y, Chen J, Li Y, Xiang X, Chai X, Zhang D
Molecular therapy. Nucleic acids 2022 Jun 14;28:77-86

Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.

Huang L, Shi Y, Hu J, Ding J, Guo Z, Yu B
Urolithiasis 2022 Dec 9;51(1):13

Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes Thrombocytopoiesis.

Yang S, Tang X, Wang L, Ni C, Wu Y, Zhou L, Zeng Y, Zhao C, Wu A, Wang Q, Xu X, Wang Y, Chen R, Zhang X, Zou L, Huang X, Wu J
International journal of molecular sciences 2022 Dec 17;23(24)

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.

Brown JL, Hart DW, Boyle GE, Brown TG, LaCroix M, Baraibar AM, Pelzel R, Kim M, Sherman MA, Boes S, Sung M, Cole T, Lee MK, Araque A, Lesné SE
Acta neuropathologica communications 2022 Dec 14;10(1):180

CeO(2) nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics.

Cui L, Wang X, Zhao X, Sun B, Xia T, Hu S
Nano today 2022 Aug;45

miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages.

Qi F, Wang X, Zhao S, Wang C, Sun R, Wang H, Du P, Wang J, Wang X, Jiang G
Oncology letters 2022 Aug;24(2):273

EGR1 promoted anticancer effects of Scutellarin via regulating LINC00857/miR-150-5p/c-Myc in osteosarcoma.

Han J, Wang P, Xia X, Zhang L, Zhang H, Huang Y, Li X, Zhao W, Zhang L
Journal of cellular and molecular medicine 2021 Sep;25(17):8479-8489

The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction.

Fan K, Huang W, Qi H, Song C, He C, Liu Y, Zhang Q, Wang L, Sun H
European journal of pharmacology 2021 Oct 15;909:174403

ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes.

Yu F, Gajendran B, Wang N, Sample KM, Liu W, Wang C, Hu A, Zacksenhaus E, Hao X, Ben-David Y
BMC cancer 2021 Jun 9;21(1):680

FSH directly regulates chondrocyte dedifferentiation and cartilage development.

Wang Y, Zhang M, Huan Z, Shao S, Zhang X, Kong D, Xu J
The Journal of endocrinology 2021 Feb;248(2):193-206

Stigmasterol upregulates immediate early genes and promotes neuronal cytoarchitecture in primary hippocampal neurons as revealed by transcriptome analysis.

Haque MN, Moon IS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Jul 15;46:164-175

HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.

Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H, Huang X
Oncotarget 2017 Aug 1;8(31):51123-51133

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The EGR1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EGR1. This antibody recognizes human, mouse antigen. The EGR1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 22008-1-AP.pdf

: Show more