22008-1-AP

antibody from Proteintech Group

Targeting: EGR1 AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225

Provider product page for 22008-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Western blot [1]

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Product number: 22008-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22008-1-AP, RRID:AB_11182923
Product name: EGR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated EGR1 antibody (Cat. #22008-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

EGR1 protein structure - 22008-1-AP shown in red.

Submitted references Epigenetic regulation by KDM5A mediates the effects of prenatal PM(2.5) exposure on hippocampal development and synaptic integrity through the Shh signaling pathway.

Huang J, Song C, Liu Y, Zhang T, Wang T, Liu X, Yu L
Ecotoxicology and environmental safety 2024 May;276:116311

Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway.

Li Y, Lai J, Ran M, Yi T, Zhou L, Luo J, Liu X, Tang X, Huang M, Xie X, Li H, Yang Y, Zou W, Wu J
European journal of pharmacology 2024 May 15;971:176548

GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas.

He H, Liang L, Jiang S, Liu Y, Huang J, Sun X, Li Y, Jiang Y, Cong L
Cell death & disease 2024 Mar 11;15(3):205

Hippocampal estrogens rescued the decline of synaptic plasticity after surgery and anesthesia by inhibiting microglia overactivation.

Tan XX, Dai HY, Yao J, Wang JJ, Dai YC, Zhang TH, Qiu LL, Sun J
Behavioural brain research 2024 Feb 29;459:114794

EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells.

Tian Q, Chen JH, Ding Y, Wang XY, Qiu JY, Cao Q, Zhuang LL, Jin R, Zhou GP
Molecular biology reports 2024 Feb 26;51(1):365

EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer.

Yang Z, Chen F, Wei D, Chen F, Jiang H, Qin S
BMC cancer 2024 Feb 26;24(1):268

PD-L1 Expression Is Increased in LPS-Induced Acute Respiratory Distress Syndrome by PI3K-AKT-Egr-1/C/EBPδ Signaling Pathway.

Yan C, Chen J, Wang B, Wang J, Luo M, Tong J, Xu X, Zhang Q, Wang X
Inflammation 2024 Aug;47(4):1459-1478

Exploration and validation of therapeutic molecules for rheumatoid arthritis based on ferroptosis-related genes.

Aihaiti Y, Zheng H, Cai Y, Tuerhong X, Kaerman M, Wang F, Xu P
Life sciences 2024 Aug 15;351:122780

Iguratimod suppresses sclerostin and receptor activator of NF-κB ligand production via the extracellular signal-regulated kinase/early growth response protein 1/tumor necrosis factor alpha pathway in osteocytes and ameliorates disuse osteoporosis in mice.

Miura T, Etani Y, Noguchi T, Hirao M, Takami K, Goshima A, Kurihara T, Fukuda Y, Ochiai N, Kanamoto T, Nakata K, Okada S, Ebina K
Bone 2024 Apr;181:117026

HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction.

Zhu C, Piao Z, Jin L
Orphanet journal of rare diseases 2023 Sep 4;18(1):266

TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation.

Guo Q, Cheng ZM, Gonzalez-Cantú H, Rotondi M, Huelgas-Morales G, Ethiraj P, Qiu Z, Lefkowitz J, Song W, Landry BN, Lopez H, Estrada-Zuniga CM, Goyal S, Khan MA, Walker TJ, Wang E, Li F, Ding Y, Mulligan LM, Aguiar RCT, Dahia PLM
Cell reports 2023 Sep 26;42(9):113070

EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8.

Zhao Y, Sui L, Wu P, Li L, Liu L, Ma B, Wang W, Chi H, Wang Z-D, Wei Z, Hou Z, Zhang K, Niu J, Jin N, Li C, Zhao J, Wang G, Liu Q
Journal of virology 2023 Oct 31;97(10):e0102823

WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2.

Wang G, He X, Dai H, Lin L, Cao W, Fu Y, Diao W, Ding M, Zhang Q, Chen W, Guo H
Oncogenesis 2023 Oct 2;12(1):47

Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy.

Zhou X, Hong Y, Liu Y, Wang L, Liu X, Li Y, Yuan H, Hu F
Journal of nanobiotechnology 2023 Nov 14;21(1):422

Biomimetic Construction of Degradable DNAzyme-Loaded Nanocapsules for Self-Sufficient Gene Therapy of Pulmonary Metastatic Breast Cancer.

Jiang R, Li L, Li M
ACS nano 2023 Nov 14;17(21):22129-22144

Single-cell RNA sequencing reveals the transcriptomic landscape of kidneys in patients with ischemic acute kidney injury.

Tang R, Jin P, Shen C, Lin W, Yu L, Hu X, Meng T, Zhang L, Peng L, Xiao X, Eggenhuizen P, Ooi JD, Wu X, Ding X, Zhong Y
Chinese medical journal 2023 May 20;136(10):1177-1187

Ccdc25 regulates neurogenesis during the brain development.

Wang C, Qin J, Jiao J, Ji F
Developmental neurobiology 2023 Apr-May;83(3-4):91-103

Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk.

Qiu Y, Sha L, Zhang X, Li G, Zhu W, Xu Q
Frontiers in aging neuroscience 2022;14:896522

Calycosin attenuates renal ischemia/reperfusion injury by suppressing NF-κB mediated inflammation via PPARγ/EGR1 pathway.

Zhang N, Guan C, Liu Z, Li C, Yang C, Xu L, Niu M, Zhao L, Zhou B, Che L, Wang Y, Xu Y
Frontiers in pharmacology 2022;13:970616

TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.

Qin D, Liu P, Zhou H, Jin J, Gong W, Liu K, Chen S, Huang J, Fan W, Tao Z, Xu Y
Frontiers in immunology 2022;13:941608

Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice.

Liu Z, Guan C, Li C, Zhang N, Yang C, Xu L, Zhou B, Zhao L, Luan H, Man X, Xu Y
Frontiers in pharmacology 2022;13:862584

Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota.

Wu K, Liu X, Meng X, Cao L, Li H, Bi Y, Wang M, Wang M, Jiang Y
Frontiers in microbiology 2022;13:1084257

Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.

Wang L, Zhang T, Liu S, Mo Q, Jiang N, Chen Q, Yang J, Han YW, Chen JP, Huang FH, Li H, Zhou J, Luo JS, Wu JM
Pharmacological research 2022 Mar;177:106096

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I/R-induced renal fibrosis via downregulation of EGR1.

Ai K, Li X, Zhang P, Pan J, Li H, He Z, Zhang H, Yi L, Kang Y, Wang Y, Chen J, Li Y, Xiang X, Chai X, Zhang D
Molecular therapy. Nucleic acids 2022 Jun 14;28:77-86

Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.

Huang L, Shi Y, Hu J, Ding J, Guo Z, Yu B
Urolithiasis 2022 Dec 9;51(1):13

Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes Thrombocytopoiesis.

Yang S, Tang X, Wang L, Ni C, Wu Y, Zhou L, Zeng Y, Zhao C, Wu A, Wang Q, Xu X, Wang Y, Chen R, Zhang X, Zou L, Huang X, Wu J
International journal of molecular sciences 2022 Dec 17;23(24)

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex.

Brown JL, Hart DW, Boyle GE, Brown TG, LaCroix M, Baraibar AM, Pelzel R, Kim M, Sherman MA, Boes S, Sung M, Cole T, Lee MK, Araque A, Lesné SE
Acta neuropathologica communications 2022 Dec 14;10(1):180

CeO(2) nanoparticles induce pulmonary fibrosis via activating S1P pathway as revealed by metabolomics.

Cui L, Wang X, Zhao X, Sun B, Xia T, Hu S
Nano today 2022 Aug;45

miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages.

Qi F, Wang X, Zhao S, Wang C, Sun R, Wang H, Du P, Wang J, Wang X, Jiang G
Oncology letters 2022 Aug;24(2):273

EGR1 promoted anticancer effects of Scutellarin via regulating LINC00857/miR-150-5p/c-Myc in osteosarcoma.

Han J, Wang P, Xia X, Zhang L, Zhang H, Huang Y, Li X, Zhao W, Zhang L
Journal of cellular and molecular medicine 2021 Sep;25(17):8479-8489

The Egr-1/miR-15a-5p/GPX4 axis regulates ferroptosis in acute myocardial infarction.

Fan K, Huang W, Qi H, Song C, He C, Liu Y, Zhang Q, Wang L, Sun H
European journal of pharmacology 2021 Oct 15;909:174403

ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes.

Yu F, Gajendran B, Wang N, Sample KM, Liu W, Wang C, Hu A, Zacksenhaus E, Hao X, Ben-David Y
BMC cancer 2021 Jun 9;21(1):680

FSH directly regulates chondrocyte dedifferentiation and cartilage development.

Wang Y, Zhang M, Huan Z, Shao S, Zhang X, Kong D, Xu J
The Journal of endocrinology 2021 Feb;248(2):193-206

Stigmasterol upregulates immediate early genes and promotes neuronal cytoarchitecture in primary hippocampal neurons as revealed by transcriptome analysis.

Haque MN, Moon IS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Jul 15;46:164-175

HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.

Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H, Huang X
Oncotarget 2017 Aug 1;8(31):51123-51133

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The EGR1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EGR1. This antibody recognizes human, mouse antigen. The EGR1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 22008-1-AP.pdf

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