17-0128-42

antibody from Invitrogen Antibodies

Targeting: ITGAX CD11C

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

17-0128-42

Provider

Invitrogen Antibodies

Product name

CD11c Monoclonal Antibody (BU15), APC, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: The BU15 monoclonal antibody reacts with canine, human, and non-human primate CD11c, the 150 kDa integrin aX chain. CD11c non-covalently associates with β2 integrin to form the CD11c/CD18 heterodimer. This complex is expressed on monocytes, granulocytes, macrophages, NK, dendritic cells, and subset of T and B lymphocytes. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c also binds complement fragment iC3b to mediate phagocytosis of opsonized particles.

Antibody clone number

BU15

Concentration

5 µL/Test

References

Submitted references

Fat-1 Transgenic Mice With Augmented n3-Polyunsaturated Fatty Acids Are Protected From Liver Injury Caused by Acute-On-Chronic Ethanol Administration.

Warner J, Hardesty J, Song Y, Sun R, Deng Z, Xu R, Yin X, Zhang X, McClain C, Warner D, Kirpich I
Frontiers in pharmacology 2021;12:711590

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The Phenotypic Characterization of the Human Renal Mononuclear Phagocytes Reveal a Co-Ordinated Response to Injury.

Leone DA, Kozakowski N, Kornauth C, Waidacher T, Neudert B, Loeffler AG, Haitel A, Rees AJ, Kain R
PloS one 2016;11(3):e0151674

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Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs.

Zhou M, Wang L, Zhou S, Wang Z, Ruan J, Tang L, Jia Z, Cui M, Zhao L, Fu ZF
Oncotarget 2015 Nov 17;6(36):38504-16

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Enhancement of CTLs induced by DCs loaded with ubiquitinated hepatitis B virus core antigen.

Chen JH, Yu YS, Chen XH, Liu HH, Zang GQ, Tang ZH
World journal of gastroenterology 2012 Mar 28;18(12):1319-27

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Novel tools for functional analysis of CD11c: activation-specific, activation-independent, and activating antibodies.

Sadhu C, Hendrickson L, Dick KO, Potter TG, Staunton DE
Journal of immunoassay & immunochemistry 2008;29(1):42-57

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CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity.

Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE
Journal of leukocyte biology 2007 Jun;81(6):1395-403

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Canine neutrophil adhesion proteins and Fc-receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry.

Trowald-Wigh G, Johannisson A, Håkansson L
Veterinary immunology and immunopathology 1993 Oct;38(3-4):297-310

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Regulated expression and function of CD11c/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c/CD18.

Postigo AA, Corbí AL, Sánchez-Madrid F, de Landázuri MO
The Journal of experimental medicine 1991 Dec 1;174(6):1313-22

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-CD11c APC (purple histogram). Cells in the monocyte gate were used for analysis.