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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Immunohistochemistry [1]
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- Product number
- 14-9761-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD11c Monoclonal Antibody (118/A5), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody 118/A5 recognizes human CD11c, a 150 kD type I transmembrane protein which is also known as integrin alpha X. Integrins are heterodimeric integral membrane proteins made up of an alpha and a beta chain and are involved in cell adhesion. The CD11/CD18 adhesion molecules consist of three heterodimers sharing a common beta subunit (CD18) with a distinct alpha subunit (CD11a, CD11b, CD11c). The CD11c/CD18 complex is expressed on dendritic cells (highly expressed on type 1 myeloid DCs), monocytes, macrophages, granulocytes, NK cells, and subsets of T and B cells. CD11c is also expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. CD11c plays a role in adhesion and CTL killing through its interactions with CD54, iC3b and fibrinogen.
- Antibody clone number
- 118/A5
- Concentration
- 0.5 mg/mL
Submitted references Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia.
Ammon C, Meyer SP, Schwarzfischer L, Krause SW, Andreesen R, Kreutz M
Immunology 2000 Jul;100(3):364-9
Immunology 2000 Jul;100(3):364-9
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
Bilsland CA, Diamond MS, Springer TA
Journal of immunology (Baltimore, Md. : 1950) 1994 May 1;152(9):4582-9
Journal of immunology (Baltimore, Md. : 1950) 1994 May 1;152(9):4582-9
The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia.
Schwarting R, Stein H, Wang CY
Blood 1985 Apr;65(4):974-83
Blood 1985 Apr;65(4):974-83
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- Invitrogen Antibodies (provider)
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- Experimental details
- Immunohistochemistry of formalin-fixed paraffin embedded human tonsil using 5 µg/mL Mouse IgG2b K Isotype Control Purified (left) or 5 µg/mL Anti-Human CD11c Purified (right) followed by Anti-Mouse IgG Biotin and Streptavidin HRP.Nuclei are counterstained with hematoxylin.
