60258-1-Ig

antibody from Proteintech Group

Targeting: ITGAX CD11C

Provider product page for 60258-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
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Validations
Immunohistochemistry [2]

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Product number: 60258-1-Ig - Provider product page
Provider: Proteintech Group
Product name: CD11c/Integrin Alpha X antibody
Antibody type: Monoclonal
Description: CD11c/Integrin Alpha X antibody (Cat. #60258-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2F1C10
Vial size: 20ul, 150ul

ITGAX protein structure - 60258-1-Ig shown in red.

Submitted references Allergen-induced dendritic cell autophagy drives immune imbalance in asthma.

Li Y, Zhou M, Ren Y, Li Y, Xiang J, Deng F, Yu J, Luo Z, Liu E, Fu Z, Liu B, Ding F
International immunopharmacology 2026 Jan 1;168(Pt 2):115897

Inhibition of HMGB1/NF-κB signaling restores Th17/Treg balance via dendritic cell modulation in liver transplant rejection.

Li L, Wang J, Huang L, Chen Y, Chen L
Frontiers in immunology 2025;16:1649366

Plasmacytoid and CD141+ Myeloid Dendritic Cells Cooperation with CD8+ T Cells in Lymph Nodes is Associated with HIV Control.

Vitallé J, Bachiller S, Dominguez-Molina B, Moysi E, Ferrando-Martínez S, Camacho-Sojo MI, Gallego I, Pérez-Gómez A, Jiménez-Leon MR, Gasca-Capote C, Ostos FJ, Rafii-El-Idrissi Benhnia M, Via LE, Mochón A, López-Cortes LF, Petrovas C, Koup RA, Ruiz-Mateos E
MedComm 2025 Sep;6(9):e70354

Co-loaded simvastatin-ginsenoside Rh2 liposomes enhance cellular immune responses as vaccine adjuvants.

Huang Y, Nie Q, Chen Z, Gong W, Cao W, Wang X, Liu Y, Meng Z
Biochemistry and biophysics reports 2025 Sep;43:102159

Tumor β-Catenin Expression Associated With Poor Prognosis to Anti-PD-1 Antibody Monotherapy in Non-small Cell Lung Cancer.

Muto S, Ozaki Y, Yamaguchi H, Watanabe M, Okabe N, Matsumura Y, Hamada K, Suzuki H
Cancer diagnosis & prognosis 2025 Jan-Feb;5(1):32-41

ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway.

Hu J, Cao J, Huang S, Chen Y
Frontiers in pharmacology 2024;15:1536478

Maturity and density of tertiary lymphoid structures associate with tumor metastasis and chemotherapy response.

Jiang S, Liao X, Ding X
Frontiers in medicine 2024;11:1435620

Pathogen-Mimicking Nanoparticles Based on Rigid Nanomaterials as an Efficient Subunit Vaccine Delivery System for Intranasal Immunization.

Wan H, Deng K, Huang Z, Yang Y, Jing B, Feng Y, Li Y, Liu Y, Lu M, Zhao X
Advanced healthcare materials 2024 Oct;13(26):e2401120

Successful treatment with guselkumab of anti-p200 pemphigoid associated with plaque psoriasis.

Kitayama S, Makino T, Kataoka K, Mori S, Takemoto K, Furukawa F, Torai R, Hayashi M, Mizawa M, Ishii N, Hashimoto T, Shimizu T
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2024 May;22(5):713-715

Characterising plasmacytoid and myeloid AXL+ SIGLEC-6+ dendritic cell functions and their interactions with HIV.

Warner van Dijk FA, Tong O, O'Neil TR, Bertram KM, Hu K, Baharlou H, Vine EE, Jenns K, Gosselink MP, Toh JW, Papadopoulos T, Barnouti L, Jenkins GJ, Sandercoe G, Haniffa M, Sandgren KJ, Harman AN, Cunningham AL, Nasr N
PLoS pathogens 2024 Jun;20(6):e1012351

Mucoadhesive chitosan-catechol as an efficient vaccine delivery system for intranasal immunization.

Deng K, Huang Z, Jing B, Zhu L, Feng Y, Jiang Q, Xu Z, Wan H, Zhao X
International journal of biological macromolecules 2024 Jul;273(Pt 1):133008

Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium.

Liang K, Barnett KC, Hsu M, Chou WC, Bais SS, Riebe K, Xie Y, Nguyen TT, Oguin TH 3rd, Vannella KM, Hewitt SM, Chertow DS, Blasi M, Sempowski GD, Karlsson A, Koller BH, Lenschow DJ, Randell SH, Ting JP
Science immunology 2024 Jul 12;9(97):eadn0178

Immunohistopathological analyses of a case of pemphigus vegetans with antibodies against desmoglein 1 and desmocollins 1-3.

Kimura A, Makino T, Kitayama S, Mizawa M, Ishii N, Hashimoto T, Shimizu T
The Journal of dermatology 2024 Dec;51(12):1711-1715

EZH2 elicits CD8(+) T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells.

Zhu CY, Zhai TT, Su M, Pan HC, Tang Q, Huang BH, Chi XR, Li N, Xie LH, Qiu SQ, Pan F, Huang GW
Communications biology 2024 Dec 19;7(1):1645

Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors.

Huang Z, Li B, Qin H, Mo X
Frontiers in oncology 2023;13:1006183

CCL19(+) dendritic cells potentiate clinical benefit of anti-PD-(L)1 immunotherapy in triple-negative breast cancer.

Wu SY, Zhang SW, Ma D, Xiao Y, Liu Y, Chen L, Song XQ, Ma XY, Xu Y, Chai WJ, Jin X, Shao ZM, Jiang YZ
Med (New York, N.Y.) 2023 Jun 9;4(6):373-393.e8

Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice.

Asano M, Kajita K, Fuwa M, Kajita T, Mori I, Akahoshi N, Ishii I, Morita H
Endocrinology 2023 Jan 9;164(3)

Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer.

Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, Tosello Boari J, Richer W, Menger L, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski LL, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Meseure D, Vincent-Salomon A, Reyal F, Dutertre CA, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J
Cell 2022 Mar 31;185(7):1189-1207.e25

Morphological analysis of cell distribution and network structure via gap junctions in swine corneal stroma.

Hoshino N, Takehana K, Hosotani M, Kametani K, Iwasaki T, Hasegawa Y, Ueda H, Watanabe T
The Journal of veterinary medical science 2022 Dec 14;84(12):1621-1632

Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling‒Mediated Sensory Neuron‒Dendritic Cell Communication.

Yin Q, Sun L, Cai X, Lou F, Sun Y, Wang B, Jiang B, Bao L, Li X, Song N, Tang S, Bai J, Wang Z, Wu Y, Zhou H, Wang H, Yu B, Li Q, Wang H
The Journal of investigative dermatology 2022 Aug;142(8):2173-2183.e6

In Situ Characterization of Human Lymphoid Tissue Immune Cells by Multispectral Confocal Imaging and Quantitative Image Analysis; Implications for HIV Reservoir Characterization.

Moysi E, Del Rio Estrada PM, Torres-Ruiz F, Reyes-Terán G, Koup RA, Petrovas C
Frontiers in immunology 2021;12:683396

Case Report: Dendritic Cells and Macrophages Capture Sperm in Chronically Inflamed Human Epididymis.

Zheng W, Zhang S, Chen X, Jiang S, Li Z, Li M
Frontiers in immunology 2021;12:629680

AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.

Fukuda K, Okamura K, Riding RL, Fan X, Afshari K, Haddadi NS, McCauley SM, Guney MH, Luban J, Funakoshi T, Yaguchi T, Kawakami Y, Khvorova A, Fitzgerald KA, Harris JE
The Journal of experimental medicine 2021 Sep 6;218(9)

Growth differentiation factor-15 promotes immune escape of ovarian cancer via targeting CD44 in dendritic cells.

Gao Y, Xu Y, Zhao S, Qian L, Song T, Zheng J, Zhang J, Chen B
Experimental cell research 2021 May 1;402(1):112522

Tumor β-catenin expression is associated with immune evasion in non-small cell lung cancer with high tumor mutation burden.

Muto S, Ozaki Y, Yamaguchi H, Mine H, Takagi H, Watanabe M, Inoue T, Yamaura T, Fukuhara M, Okabe N, Matsumura Y, Hasegawa T, Osugi J, Hoshino M, Higuchi M, Shio Y, Nanamiya H, Imai JI, Isogai T, Watanabe S, Suzuki H
Oncology letters 2021 Mar;21(3):203

Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex-mediated STAT1 downregulation.

Zhan X, Guo S, Li Y, Ran H, Huang H, Mi L, Wu J, Wang X, Xiao D, Chen L, Li D, Zhang S, Yan X, Yu Y, Li T, Han Q, He K, Cui J, Li T, Zhou T, Rich JN, Bao S, Zhang X, Li A, Man J
The Journal of experimental medicine 2020 May 4;217(5)

Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity.

Mustafa T, Li Q, Kelly LE, Gibbon A, Ryan I, Roffey K, Simonds S, Cowley MA, Sleeman MW
PloS one 2019;14(4):e0214621

The Extracellular Domain of the β(2) Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity.

Ristow LC, Tran V, Schwartz KJ, Pankratz L, Mehle A, Sauer JD, Welch RA
mBio 2019 Jul 9;10(4)

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

Anquetil F, Mondanelli G, Gonzalez N, Rodriguez Calvo T, Zapardiel Gonzalo J, Krogvold L, Dahl-Jørgensen K, Van den Eynde B, Orabona C, Grohmann U, von Herrath MG
Diabetes 2018 Sep;67(9):1858-1866

Lacrimal Gland Inflammation Deregulates Extracellular Matrix Remodeling and Alters Molecular Signature of Epithelial Stem/Progenitor Cells.

Umazume T, Thomas WM, Campbell S, Aluri H, Thotakura S, Zoukhri D, Makarenkova HP
Investigative ophthalmology & visual science 2015 Dec;56(13):8392-402

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human tonsillitis using 60258-1-Ig(ITGAX antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CD11c/Integrin alpha X antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human CD11c/Integrin alpha X. This antibody recognizes human,mouse antigen. The CD11c/Integrin alpha X antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 60258-1-Ig.pdf

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