15193-1-AP
antibody from Proteintech Group
Targeting: SLC3A2
4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Antibody data
- Antibody Data
- Antigen structure
- References [35]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
Comment
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- Product number
- 15193-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15193-1-AP, RRID:AB_2254909
- Product name
- CD98/SLC3A2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CD98/SLC3A2 antibody (Cat. #15193-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis.
Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis.
Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway.
Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice.
In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.
Identification and validation of a disulfidptosis-related genes prognostic signature in lung adenocarcinoma.
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway.
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
Synergistic ferroptosis-starvation therapy for bladder cancer based on hyaluronic acid modified metal-organic frameworks.
Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy.
Anti-proliferation and anti-migration effects of Yishen Tongbi decoction in experimental rheumatoid arthritis by suppressing SLC3A2/integrin β3 signaling pathways.
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc().
Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements.
TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.
An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress.
BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection.
EHF is a novel regulator of cellular redox metabolism and predicts patient prognosis in HNSCC.
Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters.
Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function.
Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.
RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
Regulation of Hook1-mediated endosomal sorting of clathrin-independent cargo by γ-taxilin.
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer.
Prolactin regulates LAT1 expression via STAT5 (signal transducer and activator of transcription 5) signaling in mammary epithelial cells of dairy cows.
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.
Dominant Suppression of β1 Integrin by Ectopic CD98-ICD Inhibits Hepatocellular Carcinoma Progression.
Upregulation of CD147 protects hepatocellular carcinoma cell from apoptosis through glycolytic switch via HIF-1 and MCT-4 under hypoxia.
CD147-CD98hc complex contributes to poor prognosis of non-small cell lung cancer patients through promoting cell proliferation via the PI3K/Akt signaling pathway.
Wang H, Zhao W, Wang D, Chen J
Open medicine (Warsaw, Poland) 2024;19(1):20240941
Open medicine (Warsaw, Poland) 2024;19(1):20240941
Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis.
Pang C, Zhang H, Liu Y, Tang N, Tian K, Mu Y, Li X, Xiao L
Journal of cellular and molecular medicine 2024 May;28(9):e18377
Journal of cellular and molecular medicine 2024 May;28(9):e18377
Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway.
Liu C, Zhong M, Jin X, Zhu J, Cheng Y, Li L, Xu Q, Liu Q, Ding H, Zhang G
Journal of endocrinological investigation 2024 Jul;47(7):1763-1776
Journal of endocrinological investigation 2024 Jul;47(7):1763-1776
Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice.
Fan S, Lin L, Li P, Tian H, Shen J, Zhou L, Zhao Q, Zhang J, Qin Y, Tang C
Toxicology 2024 Jan;501:153689
Toxicology 2024 Jan;501:153689
In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.
Hou B, Ma P, Yang X, Zhao X, Zhang L, Zhao Y, He P, Zhang L, Du G, Qiang G
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117281
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117281
Identification and validation of a disulfidptosis-related genes prognostic signature in lung adenocarcinoma.
Zhang Y, Sun J, Li M, Hou L, Wang Z, Dong H, Xu W, Jiang R, Geng Y, Guan C, Zhu Z, Wang H, Gong Q, Zhang G
Heliyon 2024 Jan 15;10(1):e23502
Heliyon 2024 Jan 15;10(1):e23502
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway.
Zhao L, Miao H, Quan M, Wang S, Zhang Y, Zhou H, Zhang X, Lin Z, Piao J
Chemico-biological interactions 2024 Feb 1;389:110866
Chemico-biological interactions 2024 Feb 1;389:110866
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
Xiong L, Huang J, Wu C, Yuan Q, Wang S, Zhu L, Li Z, Sun Z, Fang Y, Li W, Hu G
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
Synergistic ferroptosis-starvation therapy for bladder cancer based on hyaluronic acid modified metal-organic frameworks.
Wang Y, Xie K, Chen W, Fang Y, Mo Q, Zhang H, Zhao X, Li D, Tan W, Zhao P, Li F
Bioengineering & translational medicine 2023 May;8(3):e10515
Bioengineering & translational medicine 2023 May;8(3):e10515
Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy.
Fan R, Chen C, Mu M, Chuan D, Liu H, Hou H, Huang J, Tong A, Guo G, Xu J
ACS nano 2023 May 23;17(10):9126-9139
ACS nano 2023 May 23;17(10):9126-9139
Anti-proliferation and anti-migration effects of Yishen Tongbi decoction in experimental rheumatoid arthritis by suppressing SLC3A2/integrin β3 signaling pathways.
Jiao W, Xu J, Wu D, Yu J, Zhang M, Liu L, Chen G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154741
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154741
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Li J, Xiao X, Ou Y, Cao L, Guo M, Qi C, Wang Z, Liu Y, Shuai Q, Wang H, Sun P, Shi Y, Yang G, Yang S
Cancer communications (London, England) 2023 Jul;43(7):765-787
Cancer communications (London, England) 2023 Jul;43(7):765-787
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74
Cell death & disease 2023 Jan 31;14(1):74
Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc().
Cao T, Zhou J, Liu Q, Mao T, Chen B, Wu Q, Wang L, Pathak JL, Watanabe N, Li J
Free radical biology & medicine 2023 Aug 20;205:116-128
Free radical biology & medicine 2023 Aug 20;205:116-128
Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements.
Shah NM, Jang HJ, Liang Y, Maeng JH, Tzeng SC, Wu A, Basri NL, Qu X, Fan C, Li A, Katz B, Li D, Xing X, Evans BS, Wang T
Nature genetics 2023 Apr;55(4):631-639
Nature genetics 2023 Apr;55(4):631-639
TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.
Gong H, Gao M, Lin Y, Liu J, Hu Z, Liu J
Oxidative medicine and cellular longevity 2022;2022:7843863
Oxidative medicine and cellular longevity 2022;2022:7843863
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, Wang Q, Li Y, Zhong X, Li R, Zhu XH, Fang Z, Wei X, Jiang DS
International journal of biological sciences 2022;18(10):4118-4134
International journal of biological sciences 2022;18(10):4118-4134
Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.
Liu H, Deng Z, Yu B, Liu H, Yang Z, Zeng A, Fu M
Cells 2022 Oct 30;11(21)
Cells 2022 Oct 30;11(21)
An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress.
Thompson L, Depledge DP, Burgess HM, Mohr I
Cell reports 2022 May 3;39(5):110767
Cell reports 2022 May 3;39(5):110767
BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection.
Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, Zhong X, Feng X, Fang ZM, Zhu XH, Wei X, Jiang DS
Pharmacological research 2022 Mar;177:106122
Pharmacological research 2022 Mar;177:106122
EHF is a novel regulator of cellular redox metabolism and predicts patient prognosis in HNSCC.
Oyelakin A, Nayak KB, Glathar AR, Gluck C, Wrynn T, Tugores A, Romano RA, Sinha S
NAR cancer 2022 Jun;4(2):zcac017
NAR cancer 2022 Jun;4(2):zcac017
Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters.
Yu W, Wang Z, Yu X, Zhao Y, Xie Z, Zhang K, Chi Z, Chen S, Xu T, Jiang D, Guo X, Li M, Zhang J, Fang H, Yang D, Guo Y, Yang X, Zhang X, Wu Y, Yang W, Wang D
Nature communications 2022 Jun 21;13(1):3544
Nature communications 2022 Jun 21;13(1):3544
Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function.
Saha SS, Samanas NB, Miralda I, Shubin NJ, Niino K, Bhise G, Acharya M, Seo AJ, Camp N, Deutsch GH, James RG, Piliponsky AM
The Journal of allergy and clinical immunology 2022 Feb;149(2):685-697
The Journal of allergy and clinical immunology 2022 Feb;149(2):685-697
Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.
Hasegawa K, Ikeda S, Yaga M, Watanabe K, Urakawa R, Iehara A, Iwai M, Hashiguchi S, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Yoshihara S, Manabe M, Ichihara H, Mugitani A, Aoyama Y, Nakao T, Hirose A, Hino M, Ueda S, Takenaka K, Masuko T, Akashi K, Maruno T, Uchiyama S, Takamatsu S, Wada N, Morii E, Nagamori S, Motooka D, Kanai Y, Oji Y, Nakagawa T, Kijima N, Kishima H, Ikeda A, Ogino T, Shintani Y, Kubo T, Mihara E, Yusa K, Sugiyama H, Takagi J, Miyoshi E, Kumanogoh A, Hosen N
Science translational medicine 2022 Feb 16;14(632):eaax7706
Science translational medicine 2022 Feb 16;14(632):eaax7706
RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.
Chaoqun H, Rong Y, Yunpeng P, Xiaole Z, Wanli G, Chenyuan S, Dongya H, Yi M, Qiang L
Tissue & cell 2022 Dec;79:101940
Tissue & cell 2022 Dec;79:101940
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
Liu K, Peng Y, Lin L, Gong Z, Xiao W, Li Y
Nutrients 2022 Dec 28;15(1)
Nutrients 2022 Dec 28;15(1)
Regulation of Hook1-mediated endosomal sorting of clathrin-independent cargo by γ-taxilin.
Higashi S, Makiyama T, Sakane H, Nogami S, Shirataki H
Journal of cell science 2022 Dec 1;135(1)
Journal of cell science 2022 Dec 1;135(1)
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B
Cell reports 2021 Sep 21;36(12):109742
Cell reports 2021 Sep 21;36(12):109742
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Lai X, Wang M, Zhu Y, Feng X, Liang H, Wu J, Nie L, Li L, Shao L
Journal of hazardous materials 2021 May 15;410:124566
Journal of hazardous materials 2021 May 15;410:124566
Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer.
Sugiura M, Sato H, Okabe A, Fukuyo M, Mano Y, Shinohara KI, Rahmutulla B, Higuchi K, Maimaiti M, Kanesaka M, Imamura Y, Furihata T, Sakamoto S, Komiya A, Anzai N, Kanai Y, Luo J, Ichikawa T, Kaneda A
Translational oncology 2021 Jan;14(1):100915
Translational oncology 2021 Jan;14(1):100915
Prolactin regulates LAT1 expression via STAT5 (signal transducer and activator of transcription 5) signaling in mammary epithelial cells of dairy cows.
Zhou J, Jiang M, Shi Y, Song S, Hou X, Lin Y
Journal of dairy science 2020 Jul;103(7):6627-6634
Journal of dairy science 2020 Jul;103(7):6627-6634
SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.
Zhu B, Cheng D, Hou L, Zhou S, Ying T, Yang Q
Oncology reports 2017 May;37(5):2575-2582
Oncology reports 2017 May;37(5):2575-2582
Dominant Suppression of β1 Integrin by Ectopic CD98-ICD Inhibits Hepatocellular Carcinoma Progression.
Wu B, Zhou Y, Wang Y, Yang XM, Liu ZY, Li JH, Feng F, Chen ZN, Jiang JL
International journal of molecular sciences 2016 Nov 10;17(11)
International journal of molecular sciences 2016 Nov 10;17(11)
Upregulation of CD147 protects hepatocellular carcinoma cell from apoptosis through glycolytic switch via HIF-1 and MCT-4 under hypoxia.
Ke X, Chen Y, Wang P, Xing J, Chen Z
Hepatology international 2014 Jul;8(3):405-14
Hepatology international 2014 Jul;8(3):405-14
CD147-CD98hc complex contributes to poor prognosis of non-small cell lung cancer patients through promoting cell proliferation via the PI3K/Akt signaling pathway.
Fei F, Li X, Xu L, Li D, Zhang Z, Guo X, Yang H, Chen Z, Xing J
Annals of surgical oncology 2014 Dec;21(13):4359-68
Annals of surgical oncology 2014 Dec;21(13):4359-68
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15193-1-AP(SLC3A2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using SLC3A2 antibody 15193-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 15193-1-AP(SLC3A2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 15193-1-AP(SLC3A2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue