15193-1-AP

antibody from Proteintech Group

Targeting: SLC3A2 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE

Provider product page for 15193-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [80]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 15193-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15193-1-AP, RRID:AB_2254909
Product name: CD98/SLC3A2 antibody
Antibody type: Polyclonal
Description: KD/KO validated CD98/SLC3A2 antibody (Cat. #15193-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC3A2 protein structure - 15193-1-AP shown in red.

Submitted references RBP-J-mediated suppression of LINC00324 promotes ferroptosis via SLC3A2 in silica-induced pulmonary fibrosis.

Wu W, Huang L, Fang W, Wang W, Zhou S, Wang R
Cellular signalling 2026 Mar;139:112329

Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.

Yu C, Zhang T, Yuan J, Su Y, Zhang H, Xu L, Li X, Cui J, Xu R, Zhou Y, Huang H, Zhou X, Zhou Y, Zhang E
Cancer cell international 2026 Jan 6;26(1):64

LRP8 Promotes colorectal cancer progression by suppressing ferroptosis through the SLC3A2/GPX4 signalling axis.

Zhu C, Qian Z, Yang S, Wang Y, Yang X, Du B, Cai H
European journal of medical research 2026 Feb 4;31(1)

SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo.

Wu L, Guo W, Wang H, Yang Y, Zhang H, He L, Chen J, He K, Wang X, Kang P, Chen J, Jiang L, Guo S, Chang Y, Jian Z, Li S, Sato Y, Yamagata K, Gao T, Yi X, Li C
Journal of advanced research 2026 Apr;82:901-916

Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication.

Shi X, Xia X, Xiao Y, Shu H, Xu Z, Liu M, Shi C, Zhang Y, Wei Y, Gong Y, Wang W, Chen Y, Liu J, Huang J, Shi M, Wang J, Wu W
International journal of biological sciences 2025;21(11):5097-5115

Epigenetically-Upregulated CD98 Shed Light on the Precancerous Diagnosis and Prognosis Prediction of Esophageal Cancer.

Zhang X, Sun M, Li N, Yu J, Wang W, Yang J, Wu H, Zhao L, Zhang H, Yang L, Li F, Sun Q, Chen Y, Cui X
Cancer science 2025 Sep;116(9):2592-2606

Mechanism of xihuang pill inhibition of SLC7A11 deubiquitination through downregulation of the OTUB1 to promote ferroptosis in triple-negative breast cancer.

Qiu Y, Zhang G, Su R, Chen Y, Yi C, Zhan S, Zhang H, Liu T, Li J, Wu Y, Yan X, Ma M
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120456

Inhibition of SLC3A2 Deletion-Mediated Ferroptosis by Bone Marrow Stromal Cells to Alleviate Inflammation and Fibrosis in Diabetic Kidney Disease.

Fan Y, Li YL, Huang LL, Yang J, Hou YY, Bai YH
Inflammation 2025 Oct;48(5):3219-3234

Analysis of the Correlation Between Depression-like Behaviors and Lipid Peroxidation in the Prefrontal Cortex of Mice: The Impact of Early Life Stress.

Mi X, Ye ZL, Zhang XJ, Dai XM, Luo ZS
Brain sciences 2025 Oct 15;15(10)

Targeting ZNRF2-mediated SLC3A2 plasma membrane translocation enhances ferroptosis in lung adenocarcinoma.

Zhang W, Li J, Zhao J, Lu D, Zhang M, Ma C, Yang Y, Gu L, Zhu J, Zeng Y, Huang JA, Liu Z
Oncogene 2025 Nov;44(45):4339-4351

Bovine viral diarrhea virus E2 targets SLC3A2 to modulate lipid peroxidation for replication advantage.

Wu D, Rehman FU, Zheng J, Yang K, Jiang C, Xu X, Yuan X, Guo A
International journal of biological macromolecules 2025 Nov;329(Pt 1):147663

CLDND1 as a prognostic ferroptosis-associated biomarker in oral squamous cell carcinoma.

Zang X, Yan D, Liu Y, Sun X, Zhang S, Li X, Wang X
Biochemical and biophysical research communications 2025 Nov 1;787:152788

TRPV4 as a Novel Regulator of Ferroptosis in Colon Adenocarcinoma: Implications for Prognosis and Therapeutic Targeting.

Ren X, Chen W, Liu Y, Chen Z, Wang X, Sun X
Digestive diseases and sciences 2025 Mar;70(3):1064-1077

Leucyl-tRNA synthetase regulates casein synthesis in dairy cows via the mTORC1-LAT1 pathway.

Ke Y, Du X, Chen B, Chen X, Song C, Fang X, Wang Y, Zhang C
Animal bioscience 2025 Jun;38(6):1259-1271

ESRP1 exerts anti-tumor role by promoting ferroptosis in diffuse-type gastric cancer.

Xu K, Chen H, Zhu X, Li H, Liu X, Sang Y, Wang X, Cui X, Cai B, Shang L, Chong W, Li L
Journal of experimental & clinical cancer research : CR 2025 Jun 18;44(1):176

ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA.

Wang S, Zhu L, Wang Y, Han Y, Wang Q, Yang W, Zhao L, Zhang Y, Pei D, Huang W, Jin A, Lin Z, Piao J
Cell death & disease 2025 Jul 23;16(1):549

DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism.

Wu X, Li Y, Wang W, Xu J, Zhao B, Sun W, Ge D, Xiong L, Dou X, Zou X, Wang L, Chen M
Scientific reports 2025 Jan 28;15(1):3542

Targeting estrogen-regulated system x(c)(-) promotes ferroptosis and endocrine sensitivity of ER+ breast cancer.

Cao J, Zhou T, Wu T, Lin R, Huang J, Shi D, Yu J, Ren Y, Qian C, He L, Wu G, Dong Z, Yuan S, Gu H
Cell death & disease 2025 Jan 20;16(1):30

IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A.

Wang X, Yang Y, Zhou X, Yu S, Luo X, Lu L, Gao Z, Yang J
Cell death discovery 2025 Jan 16;11(1):9

EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma.

Zhong X, Zhu Z, Du Y, Long L, Xie Z, Zhang Y, Yao H, Lin J, Chen F
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):349-363

CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes.

Gan X, Chi B, Zhang X, Ren M, Bie H, Jia Q, Fu Y, Li C, Zhou H, He S, Wang Y, Chen Y, Zhang S, Zhang Q, Zhao Z, Sun W, Yangzong Q, Zhongga C, Pan R, Chen X, Jia E
JACC. Basic to translational science 2025 Feb;10(2):131-147

HOXA13 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating SLC7A11 and SLC3A2.

Ma Y, Liu R, Qi P, Wei S, Ren Z, Zhang A, Fan B
Cellular signalling 2025 Dec;136:112168

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway.

Zhen Q, Xu Y, Xu Y, Liu X, Zhang Y, Ye D, Han S, Liu S, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e12599

GBP2 condensates promote ferroptosis to sensitize anti-PD-L1 immunotherapy in melanoma.

Liu X, Fang S, Ren X, Hong Y, Guo J, Liu X, Gao L, Nie H, Ning Y, Zhang M, Xu F, Liu L, Fang J, Pang Y, Zhao Q, Wang F, Wang H
Nature communications 2025 Dec 24;17(1):964

Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC.

Yang X, Wu Y, Zhang Q, Zhou Y, Chang S, Zhang C, Liu D
BMC cancer 2025 Dec 13;26(1):81

25HC Depleted PMs-Accessible Cholesterol to Restrict SFTSV Entry and Infectious-EVs Mediated Infection.

Zhang R, Li L, Li S, Yin S, Cheng M, Jing N, Li J, Wu Z, Wu C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70839

The EMC acts as a chaperone for membrane proteins.

Klose CJ, Meighen-Berger KM, Kulke M, Parr M, Steigenberger B, Zacharias M, Frishman D, Feige MJ
Nature communications 2025 Aug 2;16(1):7097

Oroxin A suppresses colorectal tumor growth by regulating the TRIM24-mediated ferroptosis and TSPO pathway.

He C, Weng C, Lai Z, Luo H, Chen K, Li T, Li W, Li G
iScience 2025 Aug 15;28(8):113196

Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.

Zhang H, Shi H, Li X, Zhou S, Song X, Ma N, Meng M, Chang G, Shen X
Redox biology 2025 Apr;81:103557

Short-term effects of subacute ruminal acidosis on ferroptosis and iron metabolism in the livers of lactating sheep fed a high-grain diet.

Zhang H, Shi H, Zhou S, Meng M, Ma N, Chang G, Shen X
Journal of dairy science 2025 Apr;108(4):4365-4380

Microvesicles carrying EV71 virions cross BBB through endocytic pathway to induce brain injury.

Tian X, Liu B, Li L, Yuan M, You Q, Zhang R, Chen D, Cheng M, Zheng N, He M, Wu Z
Cell communication and signaling : CCS 2025 Apr 14;23(1):183

ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis.

Wang H, Zhao W, Wang D, Chen J
Open medicine (Warsaw, Poland) 2024;19(1):20240941

Comprehensive analysis of disulfidptosis-related genes and the immune microenvironment in heart failure.

Zhao L, Zhang J, Song Q, Dai C, Qin Y, Li A
Frontiers in cell and developmental biology 2024;12:1516898

Correlation of disulfidptosis and periodontitis: New insights and clinical significance.

Fan Y, Liu W, Qi L, Zhao Q, Li S, Zou H, Kong C, Li Z, Ren J, Liu Z, Wang B
Archives of oral biology 2024 Oct;166:106046

A respiratory Streptococcus strain inhibits Acinetobacter baumannii from causing inflammatory damage through ferroptosis.

Sun Y, Li S, Che Y, Liang H, Guo Y, Xiao C
BMC microbiology 2024 Oct 28;24(1):437

Prolactin upregulates amino acid uptake in dairy cow mammary epithelial cells via LAT1.

Hou X, Song S, Xu Z, Shi Y, Yang Y, Zhang L, Cui Y, Wang C, Lin Y
Journal of dairy science 2024 Nov;107(11):9948-9959

Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis.

Pang C, Zhang H, Liu Y, Tang N, Tian K, Mu Y, Li X, Xiao L
Journal of cellular and molecular medicine 2024 May;28(9):e18377

Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ.

Xu F, Chen H, Zhou C, Zang T, Wang R, Shen S, Li C, Yu Y, Pei Z, Shen L, Qian J, Ge J
Frontiers of medicine 2024 Jun;18(3):465-483

Sleeve gastrectomy links the attenuation of diabetic kidney disease to the inhibition of renal tubular ferroptosis through down-regulating TGF-β1/Smad3 signaling pathway.

Liu C, Zhong M, Jin X, Zhu J, Cheng Y, Li L, Xu Q, Liu Q, Ding H, Zhang G
Journal of endocrinological investigation 2024 Jul;47(7):1763-1776

Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice.

Fan S, Lin L, Li P, Tian H, Shen J, Zhou L, Zhao Q, Zhang J, Qin Y, Tang C
Toxicology 2024 Jan;501:153689

In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.

Hou B, Ma P, Yang X, Zhao X, Zhang L, Zhao Y, He P, Zhang L, Du G, Qiang G
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117281

Identification and validation of a disulfidptosis-related genes prognostic signature in lung adenocarcinoma.

Zhang Y, Sun J, Li M, Hou L, Wang Z, Dong H, Xu W, Jiang R, Geng Y, Guan C, Zhu Z, Wang H, Gong Q, Zhang G
Heliyon 2024 Jan 15;10(1):e23502

β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway.

Zhao L, Miao H, Quan M, Wang S, Zhang Y, Zhou H, Zhang X, Lin Z, Piao J
Chemico-biological interactions 2024 Feb 1;389:110866

RNA-binding protein YBX3 promotes PPARγ-SLC3A2 mediated BCAA metabolism fueling brown adipogenesis and thermogenesis.

Chen LY, Wang LW, Wen J, Cao JD, Zhou R, Yang JL, Xiao Y, Su T, Huang Y, Guo Q, Zhou HY, Luo XH, Feng X
Molecular metabolism 2024 Dec;90:102053

METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4.

Shen C, Jiang Y, Lin J, Guo Q, Fang D
Journal of molecular histology 2024 Dec;55(6):1163-1175

LncRNA HOXA11-AS intercepts the POU2F2-mediated downregulation of SLC3A2 in osteoarthritis to suppress ferroptosis.

Yu B, Zeng A, Liu H, Yang Z, Gu C, Luo X, Fu M
Cellular signalling 2024 Dec;124:111399

Identification and validation of differentially expressed disulfidptosis-related genes in hypertrophic cardiomyopathy.

Fan H, Tan X, Xu S, Zeng Y, Zhang H, Shao T, Zhao R, Zhou P, Bo X, Fan J, Fu Y, Ding X, Zhou Y
Molecular medicine (Cambridge, Mass.) 2024 Dec 19;30(1):249

Harnessing host enhancers of SARS-CoV-2 entry as novel targets for antiviral therapy.

Williams N, Silva F, Schmolke M
Antiviral research 2024 Aug;228:105951

Integrated multi-omics profiling landscape of organising pneumonia.

Tang Y, Chu C, Bu S, Sun Q, Liu A, Xie J, Qiao S, Huang L, Wang H
Clinical and translational medicine 2024 Aug;14(8):e1782

CD98 heavy chain protein is overexpressed in non-small cell lung cancer and is a potential target for CAR T-cell therapy.

Yaga M, Hasegawa K, Ikeda S, Matsubara M, Hiroshima T, Kimura T, Shirai Y, Tansri W, Uehara H, Tachikawa M, Okairi Y, Sone M, Mori H, Kogue Y, Akamine H, Okuzaki D, Kawagishi K, Kawanaka S, Yamato H, Takeuchi Y, Okura E, Kanzaki R, Okami J, Nakamichi I, Nakane S, Kobayashi A, Iwazawa T, Tokunaga T, Yokouchi H, Yano Y, Uchida J, Mori M, Komuta K, Tachi T, Kuroda H, Kijima N, Kishima H, Ichii M, Futami S, Naito Y, Shiroyama T, Miyake K, Koyama S, Hirata H, Takeda Y, Funaki S, Shintani Y, Kumanogoh A, Hosen N
Scientific reports 2024 Aug 2;14(1):17917

Biomineralization-Tuned Nanounits Reprogram the Signal Transducer and Activator of Transcription 3 Signaling for Ferroptosis-Immunotherapy in Cancer Stem Cells.

Zhao Y, Fei Y, Zhao Y, Li M, Hu Y, Cai K, Yu SH, Luo Z
ACS nano 2024 Aug 13;18(32):21268-21287

Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.

Xiong L, Huang J, Wu C, Yuan Q, Wang S, Zhu L, Li Z, Sun Z, Fang Y, Li W, Hu G
Ecotoxicology and environmental safety 2023 Sep 15;263:115279

Synergistic ferroptosis-starvation therapy for bladder cancer based on hyaluronic acid modified metal-organic frameworks.

Wang Y, Xie K, Chen W, Fang Y, Mo Q, Zhang H, Zhao X, Li D, Tan W, Zhao P, Li F
Bioengineering & translational medicine 2023 May;8(3):e10515

Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy.

Fan R, Chen C, Mu M, Chuan D, Liu H, Hou H, Huang J, Tong A, Guo G, Xu J
ACS nano 2023 May 23;17(10):9126-9139

Anti-proliferation and anti-migration effects of Yishen Tongbi decoction in experimental rheumatoid arthritis by suppressing SLC3A2/integrin β3 signaling pathways.

Jiao W, Xu J, Wu D, Yu J, Zhang M, Liu L, Chen G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154741

Inhibition of endolysosome fusion increases exosome secretion.

Shelke GV, Williamson CD, Jarnik M, Bonifacino JS
The Journal of cell biology 2023 Jun 5;222(6)

USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.

Li J, Xiao X, Ou Y, Cao L, Guo M, Qi C, Wang Z, Liu Y, Shuai Q, Wang H, Sun P, Shi Y, Yang G, Yang S
Cancer communications (London, England) 2023 Jul;43(7):765-787

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.

Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74

Interferon-γ induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK/STAT1-mediated inhibition of system Xc().

Cao T, Zhou J, Liu Q, Mao T, Chen B, Wu Q, Wang L, Pathak JL, Watanabe N, Li J
Free radical biology & medicine 2023 Aug 20;205:116-128

Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements.

Shah NM, Jang HJ, Liang Y, Maeng JH, Tzeng SC, Wu A, Basri NL, Qu X, Fan C, Li A, Katz B, Li D, Xing X, Evans BS, Wang T
Nature genetics 2023 Apr;55(4):631-639

TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.

Gong H, Gao M, Lin Y, Liu J, Hu Z, Liu J
Oxidative medicine and cellular longevity 2022;2022:7843863

Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.

Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, Wang Q, Li Y, Zhong X, Li R, Zhu XH, Fang Z, Wei X, Jiang DS
International journal of biological sciences 2022;18(10):4118-4134

Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.

Liu H, Deng Z, Yu B, Liu H, Yang Z, Zeng A, Fu M
Cells 2022 Oct 30;11(21)

An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress.

Thompson L, Depledge DP, Burgess HM, Mohr I
Cell reports 2022 May 3;39(5):110767

BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection.

Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, Zhong X, Feng X, Fang ZM, Zhu XH, Wei X, Jiang DS
Pharmacological research 2022 Mar;177:106122

EHF is a novel regulator of cellular redox metabolism and predicts patient prognosis in HNSCC.

Oyelakin A, Nayak KB, Glathar AR, Gluck C, Wrynn T, Tugores A, Romano RA, Sinha S
NAR cancer 2022 Jun;4(2):zcac017

Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters.

Yu W, Wang Z, Yu X, Zhao Y, Xie Z, Zhang K, Chi Z, Chen S, Xu T, Jiang D, Guo X, Li M, Zhang J, Fang H, Yang D, Guo Y, Yang X, Zhang X, Wu Y, Yang W, Wang D
Nature communications 2022 Jun 21;13(1):3544

Mast cell surfaceome characterization reveals CD98 heavy chain is critical for optimal cell function.

Saha SS, Samanas NB, Miralda I, Shubin NJ, Niino K, Bhise G, Acharya M, Seo AJ, Camp N, Deutsch GH, James RG, Piliponsky AM
The Journal of allergy and clinical immunology 2022 Feb;149(2):685-697

Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.

Hasegawa K, Ikeda S, Yaga M, Watanabe K, Urakawa R, Iehara A, Iwai M, Hashiguchi S, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Yoshihara S, Manabe M, Ichihara H, Mugitani A, Aoyama Y, Nakao T, Hirose A, Hino M, Ueda S, Takenaka K, Masuko T, Akashi K, Maruno T, Uchiyama S, Takamatsu S, Wada N, Morii E, Nagamori S, Motooka D, Kanai Y, Oji Y, Nakagawa T, Kijima N, Kishima H, Ikeda A, Ogino T, Shintani Y, Kubo T, Mihara E, Yusa K, Sugiyama H, Takagi J, Miyoshi E, Kumanogoh A, Hosen N
Science translational medicine 2022 Feb 16;14(632):eaax7706

RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.

Chaoqun H, Rong Y, Yunpeng P, Xiaole Z, Wanli G, Chenyuan S, Dongya H, Yi M, Qiang L
Tissue & cell 2022 Dec;79:101940

L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.

Liu K, Peng Y, Lin L, Gong Z, Xiao W, Li Y
Nutrients 2022 Dec 28;15(1)

Regulation of Hook1-mediated endosomal sorting of clathrin-independent cargo by γ-taxilin.

Higashi S, Makiyama T, Sakane H, Nogami S, Shirataki H
Journal of cell science 2022 Dec 1;135(1)

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.

Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B
Cell reports 2021 Sep 21;36(12):109742

ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.

Lai X, Wang M, Zhu Y, Feng X, Liang H, Wu J, Nie L, Li L, Shao L
Journal of hazardous materials 2021 May 15;410:124566

Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer.

Sugiura M, Sato H, Okabe A, Fukuyo M, Mano Y, Shinohara KI, Rahmutulla B, Higuchi K, Maimaiti M, Kanesaka M, Imamura Y, Furihata T, Sakamoto S, Komiya A, Anzai N, Kanai Y, Luo J, Ichikawa T, Kaneda A
Translational oncology 2021 Jan;14(1):100915

Prolactin regulates LAT1 expression via STAT5 (signal transducer and activator of transcription 5) signaling in mammary epithelial cells of dairy cows.

Zhou J, Jiang M, Shi Y, Song S, Hou X, Lin Y
Journal of dairy science 2020 Jul;103(7):6627-6634

SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway.

Zhu B, Cheng D, Hou L, Zhou S, Ying T, Yang Q
Oncology reports 2017 May;37(5):2575-2582

Dominant Suppression of β1 Integrin by Ectopic CD98-ICD Inhibits Hepatocellular Carcinoma Progression.

Wu B, Zhou Y, Wang Y, Yang XM, Liu ZY, Li JH, Feng F, Chen ZN, Jiang JL
International journal of molecular sciences 2016 Nov 10;17(11)

Upregulation of CD147 protects hepatocellular carcinoma cell from apoptosis through glycolytic switch via HIF-1 and MCT-4 under hypoxia.

Ke X, Chen Y, Wang P, Xing J, Chen Z
Hepatology international 2014 Jul;8(3):405-14

CD147-CD98hc complex contributes to poor prognosis of non-small cell lung cancer patients through promoting cell proliferation via the PI3K/Akt signaling pathway.

Fei F, Li X, Xu L, Li D, Zhang Z, Guo X, Yang H, Chen Z, Xing J
Annals of surgical oncology 2014 Dec;21(13):4359-68

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 15193-1-AP(SLC3A2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using SLC3A2 antibody 15193-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human testis using 15193-1-AP(SLC3A2 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human testis using 15193-1-AP(SLC3A2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue