10-4168-F
antibody from ABEOMICS Inc.
Targeting: SLC3A2
4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10-4168-F - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-Human CD98 Antibody
- Antibody type
- Monoclonal
- Description
- CD98 was originally identified as a cell surface antigen associated with lymphocyte activation defined by 4F2 mAb; it is expressed in proliferating normal tissues and in almost all tumor cells. CD98 heterodimer consists of a type II single-pass transmembrane heavy chain (CD98hc, also known as 4F2 antigen heavy chain or FRP-1; encoded by the genes SLC3A2 and Slc3a2 for human and mouse, respectively) of ~80â85 kDa that is disulfide-linked with a multi-pass light chain of ~40 kDa. CD98 hc (heavy chain) is a type II transmembrane glycoprotein that is disulfide-linked to a non-glycosylated light chain of a member of the permease family. It has been reported that CD98 was functionally involved in lymphocyte activation, cell proliferation, and malignant transformation. CD98 forms the large neutral amino acid transporter that is a heterodimeric membrane transport protein to transport branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. Intestinal epithelial cells express CD98 under the physiological conditions. Recent reports indicate that CD98 is involved in the intestinal inflammation, which can be upregulated by interferon (IFN)-gamma in the intestine.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Antigen sequence
A partial length recombinant protei
n (a.a 162-371) of hCD98 was use
d as the immunogen for this antibod
y.- Isotype
- IgG
- Antibody clone number
- ABM5A27
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
No comments: Submit comment
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Cell surface flow analysis of FITC conjugated hCD98 on human PBMCs using 0.5 µg/ 10^6 cells of FITC conjugated hCD98 (Clone: ABM5A27). Green represents isotype control; red represents anti-hCD98 FITC conjugated antibody.
- Protocol
- Protocol