Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 315601 - Provider product page
- Provider
- BioLegend
- Product name
- Purified anti-human CD98
- Antibody type
- Monoclonal
- Antigen
- Burkitt's lymphoma cell line Raji
- Description
- CD98 is a 125 kD disulfide-linked heterodimer protein also known as 4F2 and FRP-1. It is broadly expressed on activated and transformed cells (hematopoietic and non-hematopoietic), and at low levels on quiescent cells. CD98 has been characterized as a potential amino acid transporter (neutral and dibasic amino acids) that is involved in lymphocyte activation and integrin signaling. CD98 is composed of a light chain (45 kD) and a heavy chain (80 kD). Studies with knock-out mice indicate that the CD98 heavy chain is involved in integrin-dependent cell spreading and protection against anchorage deprivation-induced apoptosis. The MEM-108 antibody is useful for flow cytometry and immunoprecipitation.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.
Cantor J, Slepak M, Ege N, Chang JT, Ginsberg MH
Journal of immunology (Baltimore, Md. : 1950) 2011 Jul 15;187(2):851-60
Journal of immunology (Baltimore, Md. : 1950) 2011 Jul 15;187(2):851-60
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