Ab175559

antibody from Aladdin Scientific
Targeting: SLC3A2 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Provider product page for Ab175559
No application information provided.

Antibody data

Product number
Ab175559 - Provider product page
Provider
Aladdin Scientific
Product name
IGN523 (anti-CD98)
Antibody type
Recombinant
Description
IGN523 (anti-CD98) is a humanized monoclonal antibody targeting CD98. It can be used in patients with relapsed or refractory acute myeloid leukemia (AML).Purity³95% (SDS-PAGE&SEC)Endotoxin Level²1.0EU/mgProtein FunctionRequired for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
Reactivity
Human
Conjugate
Unconjugated
Vial size
100_g,10mg,1mg,5mg
Concentration
Lot by Lot
Storage
Store at -80_ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
SLC3A2 protein structure - Ab175559 shown in red.