RA0703

antibody from Oursmab
Targeting: STAB1 CLEVER-1, FEEL-1, FELE-1, FEX1, KIAA0246, SCARH2, STAB-1
Provider product page for RA0703
Western blot
ELISA
Immunocytochemistry
Flow cytometry
Functional assay

Antibody data

Product number
RA0703 - Provider product page
Provider
Oursmab
Product name
Bexmarilimab (Biosimilar Reference Antibody) (STAB1)
Antibody type
Monoclonal
Description
Bexmarilimab is an investigational, first-in-class bispecific antibody designed as a macrophage-reprogramming immunotherapy. It simultaneously targets two receptors on tumor-associated macrophages (TAMs): Clever-1 (also known as Stabilin-1 or STAB1) and an undisclosed second immune cell receptor (widely reported to be CD40). Its dual mechanism aims to repolarize immunosuppressive ¡°M2-like¡± TAMs into pro-inflammatory, anti-tumor ¡°M1-like¡± macrophages and to enhance antigen presentation. It is currently in clinical development (Phase I/II) for the treatment of advanced solid tumors, particularly those with a ¡°cold¡± tumor microenvironment, such as certain liver and biliary tract cancers.
Reactivity
Human
Isotype
IgG
Vial size
100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg
Concentration
Bottled at the concentration indicated on the vial.
Storage
Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.
STAB1 protein structure - RA0703 shown in red.