Antibody data
- Antibody Data
- Antigen structure
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- Product number
- RB-02-0028-100 - Provider product page
- Provider
- RayBiotech, Inc.
- Product name
- Rabbit Anti-Human Livin
- Antibody type
- Polyclonal
- Antigen
- a synthetic peptide (Livin).
- Description
- Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Livin (BIRC7/ML-IAP) contains a single BIR domain and RING finger motif that is highly expressed in human melanomas and absent in normal tissues. It is localized in the nucleus and diffusely in the cytoplasm. The livin gene encodes two splicing variants, a 298 amino acid isoform (?) and a 280 amino acid form (?), with different biological activity to various apoptotic stimuli. In addition to directly inhibiting caspase activity, livin can promote the degradation of the proapoptotic protein Smac through the ubiquitin-proteasome pathway. This antibody was produced from a rabbit immunized with this peptide conjugated with KLH. The IgG fraction was purified from rabbit serum by Protein G affinity chromatography.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Biotin
- Antigen sequence
This antibody was produced from a r
abbit immunized with this peptide c
onjugated with KLH. The IgG fractio
n was purified from rabbit serum by
Protein G affinity chromatography.- Isotype
- IgG
- Vial size
- 100 µg
- Handling
- Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/ml.
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