BS8491

antibody from Bioworld Technology, Inc
Targeting: BIRC7 KIAP, ML-IAP, mliap, RNF50
Provider product page for BS8491
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8491 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ML IAP/BIRC7 polyclonal antibody
Antibody type
Polyclonal
Antigen
Baculoviral IAP repeat-containing protein 7; Kidney inhibitor of apoptosis protein; KIAP; Livin; Melanoma inhibitor of apoptosis protein; ML-IAP; RING finger protein 50; UNQ5800/PRO19607/PRO21344; KIAP; LIVIN; MLIAP; RNF50; BIRC7
Description
Inhibitor of apoptosis proteins (IAPs) contain conserved, unique aminoterminal baculovirus IAP repeats (BIRs) and usually a C-terminal RING finger domain. Immunoprecipitation and Western blot analysis indicate that ML-IAP, also known as melanoma inhibitor of apoptosis protein, kidney inhibitor of apoptosis protein (KIAP), livin or BIRC7, binds to caspase-3, -7, and -9, but only inhibits caspase-9. Additionally, ML-IAP physically interacts with SMAC through its BIR domain with a very high affinity and this interaction is very specific. The gene which encodes ML-IAP maps to human chromosome 20q13.3. There is controversy regarding the localization of this protein and its involvement in apoptosis, but it has been suggested that ML-IAP may play a complex role in the regulation of apoptosis.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BIRC7 protein structure - BS8491 shown in red.