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Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
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Validation data
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- Product number
- AHO0102 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- MCL-1 Monoclonal Antibody (RC13)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- RC13
- Vial size
- 500 µL
- Concentration
- 0.4 mg/mL
- Storage
- 4° C
Submitted references Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
A phase I-II trial of fludarabine, bendamustine and rituximab (FBR) in previously treated patients with CLL.
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8.
Kump KJ, Miao L, Mady ASA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A, Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM, Khanna M, Stuckey JA, Nikolovska-Coleska Z
Journal of medicinal chemistry 2020 Mar 12;63(5):2489-2510
Journal of medicinal chemistry 2020 Mar 12;63(5):2489-2510
A phase I-II trial of fludarabine, bendamustine and rituximab (FBR) in previously treated patients with CLL.
Jain N, Balakrishnan K, Ferrajoli A, O'Brien SM, Burger JA, Kadia TM, Cortes JE, Ayres ML, Tambaro FP, Keating MJ, Gandhi V, Wierda WG
Oncotarget 2017 Mar 28;8(13):22104-22112
Oncotarget 2017 Mar 28;8(13):22104-22112
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
Leverson JD, Zhang H, Chen J, Tahir SK, Phillips DC, Xue J, Nimmer P, Jin S, Smith M, Xiao Y, Kovar P, Tanaka A, Bruncko M, Sheppard GS, Wang L, Gierke S, Kategaya L, Anderson DJ, Wong C, Eastham-Anderson J, Ludlam MJ, Sampath D, Fairbrother WJ, Wertz I, Rosenberg SH, Tse C, Elmore SW, Souers AJ
Cell death & disease 2015 Jan 15;6(1):e1590
Cell death & disease 2015 Jan 15;6(1):e1590
Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8.
Bouchard A, Ratthé C, Girard D
Journal of leukocyte biology 2004 May;75(5):893-900
Journal of leukocyte biology 2004 May;75(5):893-900
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of Mcl-1 in Raji cells using a Mcl-1 monoclonal antibody (Product # AHO0102).
