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- Antigen structure
- References [18]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 66026-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66026-1-Ig, RRID:AB_11041711
- Product name
- MCL1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated MCL1 antibody (Cat. #66026-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1E3C2
- Vial size
- 20ul, 150ul
Submitted references Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma.
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.
Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction.
Targeting EZH2 Promotes Chemosensitivity of BCL-2 Inhibitor through Suppressing PI3K and c-KIT Signaling in Acute Myeloid Leukemia.
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
miR-25 and miR-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis.
The emerging oral pathogen, Filifactor alocis, extends the functional lifespan of human neutrophils.
Adipose-derived stem cells (ADSCs) inhibit the expression of anti-apoptosis proteins through up-regulation of ATF4 on breast cancer cells.
Intermittent Fasting Aggravates Lupus Nephritis through Increasing Survival and Autophagy of Antibody Secreting Cells in MRL/lpr Mice.
Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.
Downregulation of MicroRNA-125a in Placenta Accreta Spectrum Disorders Contributes Antiapoptosis of Implantation Site Intermediate Trophoblasts by Targeting MCL1.
Hsa-miRNA-125b may induce apoptosis of HTR8/SVneo cells by targeting MCL1.
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
Downregulation of miR-29a/b/c in placenta accreta inhibits apoptosis of implantation site intermediate trophoblast cells by targeting MCL1.
Reduced ubiquitin-specific protease 9X expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cells.
Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer.
Reduced high-mobility group box 1 expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cell line HCCLM3.
Li L, Yang W, Pan Y, Ye R, Wang Y, Li S, Jiang H, Zhang Q, Wang X, Yan J
Leukemia & lymphoma 2024 Jul;65(7):895-910
Leukemia & lymphoma 2024 Jul;65(7):895-910
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Zhou L, Cai E, Liu H, Cheng H, Ye X, Zhu H, Chang X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.
Liu S, Tao Y, Wu S, Lin J, Fu S, Lu J, Zhang J, Fu B, Zhang E, Xu J, Wang J, Li L, Zhang L, Wang Z
Chinese medicine 2024 Jan 9;19(1):7
Chinese medicine 2024 Jan 9;19(1):7
Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction.
Adhikary U, Paulo JA, Godes M, Roychoudhury S, Prew MS, Ben-Nun Y, Yu EW, Budhraja A, Opferman JT, Chowdhury D, Gygi SP, Walensky LD
Cell reports 2023 Oct 31;42(10):113176
Cell reports 2023 Oct 31;42(10):113176
Targeting EZH2 Promotes Chemosensitivity of BCL-2 Inhibitor through Suppressing PI3K and c-KIT Signaling in Acute Myeloid Leukemia.
Yang C, Gu Y, Ge Z, Song C
International journal of molecular sciences 2022 Sep 27;23(19)
International journal of molecular sciences 2022 Sep 27;23(19)
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Wang X, Li X, Xia Y, Wang D, Li X, Liu L, Zheng Q, Li D, Jiang Q
Journal of natural products 2022 May 27;85(5):1351-1362
Journal of natural products 2022 May 27;85(5):1351-1362
miR-25 and miR-92b regulate insulin biosynthesis and pancreatic β-cell apoptosis.
Shen Z, Yu Y, Yang Y, Xiao X, Sun T, Chang X, Tang W, Zhu Y, Han X
Endocrine 2022 Jun;76(3):526-535
Endocrine 2022 Jun;76(3):526-535
The emerging oral pathogen, Filifactor alocis, extends the functional lifespan of human neutrophils.
Miralda I, Vashishta A, Rogers MN, Lamont RJ, Uriarte SM
Molecular microbiology 2022 Jun;117(6):1340-1351
Molecular microbiology 2022 Jun;117(6):1340-1351
Adipose-derived stem cells (ADSCs) inhibit the expression of anti-apoptosis proteins through up-regulation of ATF4 on breast cancer cells.
Ren J, Kong W, Lu F, Li Y
Annals of translational medicine 2021 Aug;9(16):1300
Annals of translational medicine 2021 Aug;9(16):1300
Intermittent Fasting Aggravates Lupus Nephritis through Increasing Survival and Autophagy of Antibody Secreting Cells in MRL/lpr Mice.
Hong SM, Lee J, Jang SG, Song Y, Kim M, Lee J, Cho ML, Kwok SK, Park SH
International journal of molecular sciences 2020 Nov 11;21(22)
International journal of molecular sciences 2020 Nov 11;21(22)
Decreased DHRS2 expression is associated with HDACi resistance and poor prognosis in ovarian cancer.
Han Y, Wang Z, Sun S, Zhang Z, Liu J, Jin X, Wu P, Ji T, Ding W, Wang B, Gao Q
Epigenetics 2020 Jan-Feb;15(1-2):122-133
Epigenetics 2020 Jan-Feb;15(1-2):122-133
Downregulation of MicroRNA-125a in Placenta Accreta Spectrum Disorders Contributes Antiapoptosis of Implantation Site Intermediate Trophoblasts by Targeting MCL1.
Gu Y, Meng J, Zuo C, Wang S, Li H, Zhao S, Huang T, Wang X, Yan J
Reproductive sciences (Thousand Oaks, Calif.) 2019 Dec;26(12):1582-1589
Reproductive sciences (Thousand Oaks, Calif.) 2019 Dec;26(12):1582-1589
Hsa-miRNA-125b may induce apoptosis of HTR8/SVneo cells by targeting MCL1.
Gu Y, Zhao S, Wan J, Meng J, Zuo C, Wang S, Zhou Y, Li H, Wang X
Reproductive biology 2019 Dec;19(4):368-373
Reproductive biology 2019 Dec;19(4):368-373
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
He J, Shi J, Zhang K, Xue J, Li J, Yang J, Chen J, Wei J, Ren H, Liu X
Molecular medicine reports 2017 Apr;15(4):1693-1701
Molecular medicine reports 2017 Apr;15(4):1693-1701
Downregulation of miR-29a/b/c in placenta accreta inhibits apoptosis of implantation site intermediate trophoblast cells by targeting MCL1.
Gu Y, Bian Y, Xu X, Wang X, Zuo C, Meng J, Li H, Zhao S, Ning Y, Cao Y, Huang T, Yan J, Chen ZJ
Placenta 2016 Dec;48:13-19
Placenta 2016 Dec;48:13-19
Reduced ubiquitin-specific protease 9X expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cells.
Hu H, Tang C, Jiang Q, Luo W, Liu J, Wei X, Liu R, Wu Z
Oncology letters 2015 Jul;10(1):268-272
Oncology letters 2015 Jul;10(1):268-272
Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer.
Sun Y, Liu Z, Zou X, Lan Y, Sun X, Wang X, Zhao S, Jiang C, Liu H
Journal of bioenergetics and biomembranes 2015 Aug;47(4):319-29
Journal of bioenergetics and biomembranes 2015 Aug;47(4):319-29
Reduced high-mobility group box 1 expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cell line HCCLM3.
Jiang W, Wang Z, Li X, Li J, Huang Y, Fan X, Duan Y
Digestive diseases and sciences 2012 Jan;57(1):92-8
Digestive diseases and sciences 2012 Jan;57(1):92-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 66026-1-Ig(MCL1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using MCL1 antibody 66026-1-lg at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 66026-1-Ig(MCL1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 66026-1-Ig(MCL1 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
