ABIN967637

antibody from antibodies-online

Targeting: MCL1 BCL2L3, Mcl-1

Western blot (Data presented on provider website)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

ABIN967637

Provider

antibodies-online

Product name

anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (C-Term) antibody

Antibody type

Monoclonal

Antigen

Purified recombinant human Mcl-1 lacking the hydrophobic domain

Description

Purified from tissue culture supernatant or ascites by affinity chromatography.

Reactivity

Human

Host

Mouse

Epitope

C-Term

Isotype

IgG

Antibody clone number

LPR-02

Vial size

0.1 mg

Concentration

0.5 mg/ml

Storage

4°C

References

Submitted references

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.

Wang JM, Chao JR, Chen W, Kuo ML, Yen JJ, Yang-Yen HF
Molecular and cellular biology 1999 Sep;19(9):6195-206

---

BCL-2 family members and the mitochondria in apoptosis.

Gross A, McDonnell JM, Korsmeyer SJ
Genes & development 1999 Aug 1;13(15):1899-911

---

The Bcl-2 protein family: arbiters of cell survival.

Adams JM, Cory S
Science (New York, N.Y.) 1998 Aug 28;281(5381):1322-6

---

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2.

Yang T, Kozopas KM, Craig RW
The Journal of cell biology 1995 Mar;128(6):1173-84

---

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

Oltvai ZN, Milliman CL, Korsmeyer SJ
Cell 1993 Aug 27;74(4):609-19

---

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW
Proceedings of the National Academy of Sciences of the United States of America 1993 Apr 15;90(8):3516-20