66363-1-Ig

antibody from Proteintech Group

Targeting: CHRNA5

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66363-1-Ig

Provider

Proteintech Group

Product name

CHRNA5 antibody

Antibody type

Monoclonal

Description

CHRNA5 antibody (Cat. #66363-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, pig and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3G8C11

Vial size

20ul, 150ul

References

Submitted references

The α5-nAChR/GINS4 axis contributed to nicotine-promoted lung adenocarcinoma progression.

Wang Z, Cai J, Yang M, Yang S, Wang J, Jia Y, Sun H, Ma X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jan;207:115828

---

Hypertension Induces Cognitive Impairment and Alterations of Acetylcholine Receptor mRNA Expression in the Hippocampus and Cortex of Mice.

Liu J, Hou J, Wu J, Chen W
Neuromolecular medicine 2025 Sep 15;27(1):64

---

Nicotinic acetylcholine receptors regulate growth hormone in pituitary somatotrophs of tigers.

Liu L, Yang S, Chai L, Zhang S, Liu D, Xu H, Zhao Y, Chen S, Jiang G, Li B
Communications biology 2025 Mar 31;8(1):526

---

Repurposing neuroleptics: clozapine as a novel, adjuvant therapy for melanoma brain metastases.

Wikerholmen T, Taule EM, Rigg E, Berle BF, Sættem M, Sarnow K, Saed HS, Sundstrøm T, Thorsen F
Clinical & experimental metastasis 2025 Jan 25;42(2):12

---

Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway.

Feng C, Mao W, Yuan C, Dong P, Liu Y
Cell death & disease 2024 Oct 29;15(10):785

---

Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma.

Kang G, Song H, Bo L, Liu Q, Li Q, Li J, Pan P, Wang J, Jia Y, Sun H, Ma X
Cancer immunology, immunotherapy : CII 2024 Nov 2;74(1):11

---

α5-nAChR/ADAM10 signaling mediates nicotine-related cutaneous melanoma progression via STAT3 activation.

Li X, Meng X, Fan H, Wang Y, Jia Y, Jiao J, Ma X
Archives of dermatological research 2024 May 25;316(6):269

---

PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma.

Li Q, Li J, Wang J, Wang J, Lu T, Jia Y, Sun H, Ma X
Molecular carcinogenesis 2024 Feb;63(2):253-265

---

α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape.

Kang G, Jiao Y, Pan P, Fan H, Li Q, Li X, Li J, Wang Y, Jia Y, Wang J, Sun H, Ma X
Carcinogenesis 2023 Dec 15;44(10-11):773-784

---

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Jiao Y, Kang G, Pan P, Fan H, Li Q, Li X, Li J, Wang Y, Jia Y, Zhang L, Sun H, Ma X
Cellular and molecular life sciences : CMLS 2023 Apr 7;80(5):119

---

CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models.

Wang J, Li X, Zhang P, Yang T, Liu N, Qin L, Ma G, Li X, Fan H, Huang S, Dang N
The Journal of investigative dermatology 2022 Nov;142(11):2978-2987.e6

---

α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer.

Zhang Q, Jia Y, Pan P, Zhang X, Jia Y, Zhu P, Chen X, Jiao Y, Kang G, Zhang L, Ma X
Carcinogenesis 2022 May 19;43(4):393-404

---

The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration.

Jia Y, Zhang Q, Liu Z, Pan P, Jia Y, Zhu P, Jiao Y, Kang G, Ma X
Toxicology 2022 Mar 15;469:153120

---

The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion.

Zhu P, Kang G, Jiao Y, Gui C, Fan H, Li X, Jia Y, Zhang L, Ma X
Human cell 2022 Jul;35(4):1207-1218

---

Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling.

Zhu P, Jin Z, Kang G, Jia Y, Liu D, Zhang Q, Guo F, Jia Y, Jiao Y, Li J, Sun H, Ma X
Cell communication and signaling : CCS 2022 Aug 15;20(1):121