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Protein structure
PTPRN
Protein tyrosine phosphatase receptor type NIA-2, ICA512
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Top validated antibodies |
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| Proteintech Group |  10584-1-AP |
4 references | Polyclonal |
WB
EL
IP
IHC
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| Invitrogen Antibodies | 10584-1-AP |
Polyclonal |
WB
IP
IHC
OA
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| Novus Biologicals | 25870002 |
2 references | Polyclonal |
WB
EL
IHC
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| NovoPro Bioscience Inc. | 107271 |
Monoclonal |
WB
EL
ICC
IHC
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| FineTest Biotech | FNab04092 |
Polyclonal |
WB
EL
IP
IHC
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