Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS7875 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- COMP polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human COMP.
- Description
- Thrombospondin 5 (also designated THBS5, cartilage oligomeric matrix protein or COMP) is the fifth member of the Thrombospondin family of extracellular matrix proteins. The Thrombospondin family share overall homology, with significant homology in their carboxy-terminal globular domains. They all contain type 2 (epidermal growth factor-like) and type 3 (calmodulin-like) repeats in their central domains. The human COMP/THBS5 gene maps to chromosome 19p13.1. Thrombospondin 5 is expressed in all types of cartilage, tendon and vascular smooth muscle. Its localization in cartilage is developmentally regulated to the chondrocyte territorial and interterritorial matrix. Thrombospondin 5 also binds to Collagen Type I, II and IX in a zinc-dependent manner. Mutations in the COMP/THBS5 gene are associated with the human genetic disorders pseudoachondroplasia (PSACH) and some types of multiple epiphyseal dysplasia (MED). PSACH and MED are autosomal dominant chondrodysplasias, which cause mild to severe short-limb dwarfism and early-onset osteoarthritis.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of COMP polyclonal antibody