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- Antigen structure
- References [15]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12869-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12869-1-AP, RRID:AB_10915469
- Product name
- UGCG antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UGCG antibody (Cat. #12869-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B.
The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
Integrating Machine Learning and Bulk and Single-Cell RNA Sequencing to Decipher Diverse Cell Death Patterns for Predicting the Prognosis of Neoadjuvant Chemotherapy in Breast Cancer.
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.
Inhibition of glycosphingolipid synthesis with eliglustat in combination with immune checkpoint inhibitors in advanced cancers: preclinical evidence and phase I clinical trial.
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway.
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids.
Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation.
Identification of long-term survival-associated gene in breast cancer.
A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C (XPC) Enhances Glycolysis-Mediated Drug Resistance in DLD-1 Colon Cancer Cells.
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Long JC, Liu CX, Wang MY, Liu CH, Zhang F, Liu ZQ, An L, Wang CY
Acta pharmacologica Sinica 2026 Feb;47(2):370-382
Acta pharmacologica Sinica 2026 Feb;47(2):370-382
The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
Ansari MN, Jha SK, Khan A, Rajput K, Pandey N, Jain D, Tripathi R, Medatwal N, Sharma P, Datta S, Kar A, Pani T, Ali SA, Cholke K, Rana K, Snijesh VP, Mukherjee G, Deo SVS, Basak S, Mishra A, Prabhu JS, Mukhopadhyay A, Bajaj A, Dasgupta U
PLoS biology 2025 Sep;23(9):e3003362
PLoS biology 2025 Sep;23(9):e3003362
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
Fan W, Yao C, Ma Y, Wang H, Liu P, Zhang Z, Chu B, Yang G, Wang M
International journal of biological macromolecules 2025 Jan;285:138303
International journal of biological macromolecules 2025 Jan;285:138303
Integrating Machine Learning and Bulk and Single-Cell RNA Sequencing to Decipher Diverse Cell Death Patterns for Predicting the Prognosis of Neoadjuvant Chemotherapy in Breast Cancer.
Xiang L, Yang J, Rao J, Ma A, Liu C, Zhang Y, Huang A, Xie T, Xue H, Chen Z, Yuan J, Yan H
International journal of molecular sciences 2025 Apr 13;26(8)
International journal of molecular sciences 2025 Apr 13;26(8)
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.
La Monica S, Vacondio F, Eltayeb K, Lodola A, Volta F, Viglioli M, Ferlenghi F, Galvani F, Galetti M, Bonelli M, Fumarola C, Cavazzoni A, Flammini L, Verzè M, Minari R, Petronini PG, Tiseo M, Mor M, Alfieri R
Scientific reports 2024 Mar 18;14(1):6491
Scientific reports 2024 Mar 18;14(1):6491
Inhibition of glycosphingolipid synthesis with eliglustat in combination with immune checkpoint inhibitors in advanced cancers: preclinical evidence and phase I clinical trial.
Dong L, Cao Z, Chen M, Liu Y, Ma X, Lu Y, Zhang Y, Feng K, Zhang Y, Meng Z, Yang Q, Wang Y, Wu Z, Han W
Nature communications 2024 Aug 14;15(1):6970
Nature communications 2024 Aug 14;15(1):6970
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804
Nature communications 2023 Sep 19;14(1):5804
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway.
Cui S, Zhang X, Li Y, Hu S, Wu B, Fang Z, Gao J, Li M, Wu H, Tao B, Xia H, Xu L
Cellular & molecular biology letters 2023 Sep 1;28(1):71
Cellular & molecular biology letters 2023 Sep 1;28(1):71
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Li ZB, Jiang L, Ni JD, Xu YH, Liu F, Liu WM, Wang SG, Liu ZQ, Wang CY
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids.
Liu J, van der Hoeven R, Kattan WE, Chang JT, Montufar-Solis D, Chen W, Wong M, Zhou Y, Lebrilla CB, Hancock JF
Nature communications 2023 Jan 28;14(1):465
Nature communications 2023 Jan 28;14(1):465
Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation.
Li Z, Chiang YP, He M, Worgall TS, Zhou H, Jiang XC
iScience 2021 Dec 17;24(12):103449
iScience 2021 Dec 17;24(12):103449
Identification of long-term survival-associated gene in breast cancer.
Ning S, Li H, Qiao K, Wang Q, Shen M, Kang Y, Yin Y, Liu J, Liu L, Hou S, Wang J, Xu S, Pang D
Aging 2020 Oct 20;12(20):20332-20349
Aging 2020 Oct 20;12(20):20332-20349
A Novel Drug Resistance Mechanism: Genetic Loss of Xeroderma Pigmentosum Complementation Group C (XPC) Enhances Glycolysis-Mediated Drug Resistance in DLD-1 Colon Cancer Cells.
Han Y, Qu YQ, Mok SWF, Chen J, Xia CL, He HQ, Li Z, Zhang W, Qiu CL, Liu L, Law BYK, Wong VKW
Frontiers in pharmacology 2019;10:912
Frontiers in pharmacology 2019;10:912
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A
Cancer research 2017 Oct 1;77(19):5272-5286
Cancer research 2017 Oct 1;77(19):5272-5286
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Henriques A, Croixmarie V, Priestman DA, Rosenbohm A, Dirrig-Grosch S, D'Ambra E, Huebecker M, Hussain G, Boursier-Neyret C, Echaniz-Laguna A, Ludolph AC, Platt FM, Walther B, Spedding M, Loeffler JP, Gonzalez De Aguilar JL
Human molecular genetics 2015 Dec 20;24(25):7390-405
Human molecular genetics 2015 Dec 20;24(25):7390-405
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 12869-1-AP(UGCG antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UGCG antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UGCG. This antibody recognizes human, mouse, rat antigen. The UGCG antibody has been validated for the following applications: ELISA, WB, IHC analysis.
