Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- BS7943 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- FBXO11 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human FBXO11.
- Description
- F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I°ÙB-Ï« and ÉÇ-catenin, for proteasomal degradation. FBXO11 (F-box only protein 11), also known as VIT1 (vitiligoassociated protein 1), is a 927 amino acid nuclear protein that contains one UBR-type zinc finger, one F-box domain and 19 PbH1 repeats. Involved in protein ubiquitination, FBXO11 functions as a substrate recognition component of the SCF complex and is thought to bind to and inhibit the transcriptional activity of p53. Reduced expression of FBXO11 is associated with vitiligo, a disease characterized by progressive skin depigmentation. Multiple isoforms of FBXO11 exist due to alternative splicing events.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
No comments: Submit comment
Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- WesternBlot (WB) analysis of FBXO11 polyclonal antibody