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- References [26]
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- Product number
- 15070-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15070-1-AP, RRID:AB_2236759
- Product name
- PCBP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PCBP2 antibody (Cat. #15070-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references eEF2K-Mediated Stabilization of PCBP2 Promotes Oncogenic mRNA Programs in Triple-Negative Breast Cancer.
SNHG7 interacts with PCBP2 to promote CDKN2A expression and modulate cuproptosis in colorectal cancer.
PCBP2 inhibits antiviral innate immune responses via the MAVS-mediated signaling pathway in severe fever with thrombocytopenia syndrome.
PCBP2 mediates MTUS1 degradation through 3'-UTR binding to restrict pyroptosis and augment malignant progression in esophageal squamous cell carcinoma.
PCBP2 promotes immune evasion via cGAS-STING pathway in biochemical recurrence of prostate cancer.
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer.
PCBP2 Promotes NRG4 mRNA Stability to Diminish Angiotensin II-Induced Hypertrophy, NLRP3 Inflammasome Activation, and Oxidative Stress of AC16 Cardiomyocytes.
Eukaryotic translation elongation factor 1 alpha 1 facilitates coxsackievirus B replication through interacting with PABP, viral protein 3 CD and viral RNA.
The binding of PCBP2 to IGF2 mRNA restores mitochondrial function in granulosa cells to ameliorate ovarian function in premature ovarian insufficiency mice.
Structural analysis of the lncRNA SChLAP1 reveals protein binding interfaces and a conformationally heterogenous retroviral insertion.
O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export.
Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins.
Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac.
UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
Human brain small extracellular vesicles contain selectively packaged, full-length mRNA.
Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
Human hematopoietic stem cell vulnerability to ferroptosis.
N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71.
PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C(pro).
Cellular poly(C) binding protein 2 interacts with porcine epidemic diarrhea virus papain-like protease 1 and supports viral replication.
Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2.
Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury.
Cheng Y, Jiang T, Zhu W, He L, Chen Z, Li H, Zhao R, Jiang S, Cheng Y
International journal of biological sciences 2026;22(7):3714-3730
International journal of biological sciences 2026;22(7):3714-3730
SNHG7 interacts with PCBP2 to promote CDKN2A expression and modulate cuproptosis in colorectal cancer.
Chen Q, Song Q, Zhang H, Lin Z, Shi Y, Chai Y, Fang X, Li N, Zheng Y, Yang Y, Wu X, Wang S, He C, Li M
Translational oncology 2026 May;67:102724
Translational oncology 2026 May;67:102724
PCBP2 inhibits antiviral innate immune responses via the MAVS-mediated signaling pathway in severe fever with thrombocytopenia syndrome.
Yu X, Dai Y, Ji X, Pu Q, Zhang R, Shi M, Hu N, Jin K, Zhu J, Li J
Virus research 2026 Mar;365:199699
Virus research 2026 Mar;365:199699
PCBP2 mediates MTUS1 degradation through 3'-UTR binding to restrict pyroptosis and augment malignant progression in esophageal squamous cell carcinoma.
Jiang C, Lu Q, Wang A, Chen H, Yao L
Esophagus : official journal of the Japan Esophageal Society 2026 Mar 19;
Esophagus : official journal of the Japan Esophageal Society 2026 Mar 19;
PCBP2 promotes immune evasion via cGAS-STING pathway in biochemical recurrence of prostate cancer.
Zhou Z, Li T, Zhang Y, Zhou X, Song X, Ji S, Huang Y, Zhang Y, Ruan Y
APL bioengineering 2025 Mar;9(1):016112
APL bioengineering 2025 Mar;9(1):016112
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer.
Yu D, Hu H, Zhang Q, Wang C, Xu M, Xu H, Geng X, Cai M, Zhang H, Guo M, Lu D, Xu H, Li L, Zhang X, Shen R, Lin S, Wang Q, Zhang W, Liu S
Signal transduction and targeted therapy 2025 Jul 7;10(1):211
Signal transduction and targeted therapy 2025 Jul 7;10(1):211
PCBP2 Promotes NRG4 mRNA Stability to Diminish Angiotensin II-Induced Hypertrophy, NLRP3 Inflammasome Activation, and Oxidative Stress of AC16 Cardiomyocytes.
Zhang Y, Liu Y, Wang Y
Cell biochemistry and biophysics 2025 Dec;83(4):4989-5001
Cell biochemistry and biophysics 2025 Dec;83(4):4989-5001
Eukaryotic translation elongation factor 1 alpha 1 facilitates coxsackievirus B replication through interacting with PABP, viral protein 3 CD and viral RNA.
Zhao S, Dong Y, Wang Y, Yang H, Luan T, He Y, Lin L, Chen Y, Fei Y, Wang G, Wang Y, Zhong Z, Qi N, Zhao W
Virulence 2025 Dec;16(1):2563925
Virulence 2025 Dec;16(1):2563925
The binding of PCBP2 to IGF2 mRNA restores mitochondrial function in granulosa cells to ameliorate ovarian function in premature ovarian insufficiency mice.
Chen Y, Pan X, Tang J, Liu Z, Luo M, Wen Y
Cellular signalling 2025 Dec;136:112103
Cellular signalling 2025 Dec;136:112103
Structural analysis of the lncRNA SChLAP1 reveals protein binding interfaces and a conformationally heterogenous retroviral insertion.
Falese JP, McFadden EJ, D'Inzeo CA, Hargrove AE
RNA (New York, N.Y.) 2025 Aug 18;31(9):1260-1286
RNA (New York, N.Y.) 2025 Aug 18;31(9):1260-1286
O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export.
Liu S, Lv Q, Mao X, Dong H, Xu W, Du X, Jia W, Feng K, Zhang J, Zhang Y
International journal of biological sciences 2024;20(9):3675-3690
International journal of biological sciences 2024;20(9):3675-3690
Gigaxonin, mutated in Giant Axonal Neuropathy, interacts with TDP-43 and other RNA binding proteins.
Phillips CL, Faridounnia M, Battaglia RA, Evangelista BA, Cohen TJ, Opal P, Bouldin TW, Armao D, Snider NT
bioRxiv : the preprint server for biology 2024 Sep 5;
bioRxiv : the preprint server for biology 2024 Sep 5;
Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac.
Qu T, Cha L, Liu H, Tian L, Hu X, Zou H, Feng Y, Sun C, Cao J, Guo W, Qiu F, Zhou B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70028
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70028
UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
Li Y, Liu L
Biochimica et biophysica acta. Molecular cell research 2024 Aug;1871(6):119755
Biochimica et biophysica acta. Molecular cell research 2024 Aug;1871(6):119755
Primate-Specific DAZ Regulates Translation of Cell Proliferation-Related mRNAs and is Essential for Maintenance of Spermatogonia.
Ou N, Wang Y, Xu S, Luo J, Zhang C, Zhang Y, Shi X, Xiong M, Zhao L, Ji Z, Zhang Y, Zhao J, Bai H, Tian R, Li P, Zhi E, Huang Y, Chen W, Wang R, Jin Y, Wang D, Li Z, Chen H, Yao C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400692
Human brain small extracellular vesicles contain selectively packaged, full-length mRNA.
Ransom LS, Liu CS, Dunsmore E, Palmer CR, Nicodemus J, Ziomek D, Williams N, Chun J
Cell reports 2024 Apr 23;43(4):114061
Cell reports 2024 Apr 23;43(4):114061
Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
Huang L, Ma B, Zhang C, Shi J, Shen R, Zhang E, Lian C, Wang C, Liu J
BMC cancer 2023 Oct 9;23(1):957
BMC cancer 2023 Oct 9;23(1):957
Human hematopoietic stem cell vulnerability to ferroptosis.
Zhao J, Jia Y, Mahmut D, Deik AA, Jeanfavre S, Clish CB, Sankaran VG
Cell 2023 Feb 16;186(4):732-747.e16
Cell 2023 Feb 16;186(4):732-747.e16
N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71.
Hao H, Liu W, Miao Y, Ma L, Yu B, Liu L, Yang C, Zhang K, Chen Z, Yang J, Zheng Z, Zhang B, Deng F, Gong P, Yuan J, Hu Z, Guan W
Nucleic acids research 2022 Sep 9;50(16):9339-9354
Nucleic acids research 2022 Sep 9;50(16):9339-9354
PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.
Gu H, Yang J, Zhang J, Song Y, Zhang Y, Xu P, Zhu Y, Wang L, Zhang P, Li L, Chen D, Sun Q
Nature communications 2022 Mar 23;13(1):1564
Nature communications 2022 Mar 23;13(1):1564
METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and promotes tumourigenesis.
Wei X, Huo Y, Pi J, Gao Y, Rao S, He M, Wei Q, Song P, Chen Y, Lu D, Song W, Liang J, Xu L, Wang H, Hong G, Guo Y, Si Y, Xu J, Wang X, Ma Y, Yu S, Zou D, Jin J, Wang F, Yu J
Nature cell biology 2022 Aug;24(8):1278-1290
Nature cell biology 2022 Aug;24(8):1278-1290
PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E.
Wang X, Guo Q, Wang H, Yuan X, Wang B, Lobie PE, Zhu T, Tan S, Wu Z
Molecular cancer research : MCR 2021 Jan;19(1):86-98
Molecular cancer research : MCR 2021 Jan;19(1):86-98
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C(pro).
Xiao H, Li J, Yang X, Li Z, Wang Y, Rui Y, Liu B, Zhang W
Virologica Sinica 2021 Dec;36(6):1363-1374
Virologica Sinica 2021 Dec;36(6):1363-1374
Cellular poly(C) binding protein 2 interacts with porcine epidemic diarrhea virus papain-like protease 1 and supports viral replication.
Zhang P, Yu L, Dong J, Liu Y, Zhang L, Liang P, Wang L, Chen B, Huang L, Song C
Veterinary microbiology 2020 Aug;247:108793
Veterinary microbiology 2020 Aug;247:108793
Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2.
Chen C, Lei J, Zheng Q, Tan S, Ding K, Yu C
FEBS open bio 2018 May;8(5):764-773
FEBS open bio 2018 May;8(5):764-773
Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury.
Chen Z, Zhang W, Ni L, Wang G, Cao Y, Wu W, Sun C, Yuan D, Ni H, Wang Y, Yang H
Cellular and molecular neurobiology 2016 Jul;36(5):725-35
Cellular and molecular neurobiology 2016 Jul;36(5):725-35
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15070-1-AP(PCBP2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PCBP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PCBP2. This antibody recognizes human,mouse,rat antigen. The PCBP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
