RA0244

antibody from Oursmab

Targeting: FCGRT alpha-chain, FCRN

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0244

Provider

Oursmab

Product name

Batoclimab (Biosimilar Reference Antibody) (FCGRT)

Antibody type

Monoclonal

Description

Batoclimab is a fully human monoclonal antibody designed as a high-affinity antagonist of the neonatal Fc receptor (FcRn). It functions by competitively binding to FcRn at the acidic pH of the endosome, thereby blocking the recycling of IgG antibodies (including pathogenic autoantibodies) and accelerating their lysosomal degradation. This leads to a rapid and sustained reduction in circulating levels of all IgG subtypes. It is in clinical development for the treatment of various IgG-driven autoimmune diseases, including myasthenia gravis, thyroid eye disease, chronic inflammatory demyelinating polyneuropathy (CIDP), and warm autoimmune hemolytic anemia (wAIHA).

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.