RA0246

antibody from Oursmab

Targeting: FCGRT alpha-chain, FCRN

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0246

Provider

Oursmab

Product name

Orilanolimab (Biosimilar Reference Antibody) (FCGRT)

Antibody type

Monoclonal

Description

Orilanolimab (also known as SYNT001 or ALXN1830) is a humanized IgG4-kappa monoclonal antibody that functions as a neonatal Fc receptor (FcRn) antagonist. By binding with high affinity to FcRn, it competitively blocks the interaction between FcRn and the Fc region of immunoglobulin G (IgG). This inhibition disrupts the normal recycling of IgG, leading to accelerated degradation of endogenous IgG (including pathogenic autoantibodies and alloantibodies) and a reduction in circulating IgG levels.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Orilanolimab (Biosimilar Reference Antibody) (FCGRT)-RA0246-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Orilanolimab (Biosimilar Reference Antibody) (FCGRT)-RA0246 in a linear range of 0.18¨C15 ng/mL.