15546-1-AP

antibody from Proteintech Group

Targeting: VAMP8 EDB

Provider product page for 15546-1-AP

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ELISA

Antibody data

Antibody Data
Antigen structure
References [31]
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Validations
Western blot [1]

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Product number: 15546-1-AP - Provider product page
Provider: Proteintech Group
Product name: VAMP8 antibody
Antibody type: Polyclonal
Description: VAMP8 antibody (Cat. #15546-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

VAMP8 protein structure - 15546-1-AP shown in red.

Submitted references Z-Guggulsterone Inhibits Triple-Negative Breast Cancer Progression by Blocking Autophagosome-Lysosome Fusion via OGT-Mediated SNAP29 O-GlcNAcylation.

Qian D, Mu Y, Liu H, Yang Z, Hu J, Zeng X, Liu K, He C, Liu X, Zhu L, Zhang J, Meng X
Phytotherapy research : PTR 2026 May;40(5):2364-2379

tRNA m(2)G methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation.

Yuan W, Li S, Xi Y, Tian R, Liu Y, Chen X, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Qin W, Yan C, Chen XZ, Zhou C, Tang J
Molecular cancer 2026 Jan 13;25(1)

Staphylococcus aureus escapes endosomes and autophagosomes via α-hemolysin.

Xu H, Qi C, Qu C, Lou J, Wang X, Zhang H, Liu J, Liu Y
International immunopharmacology 2026 Feb 1;170:116072

Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway.

Zhao L, Wu Y, Zhang X, Li Y, Li Y, Fu Z
Journal of ovarian research 2025 Sep 29;18(1):207

METTL3-dependent m(6)A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation.

Yang N, Lai Y, Yu G, Zhang X, Shi J, Xiang L, Zhang J, Wu Y, Jiang X, Zhang X, Yang L, Gao W, Ding J, Wang X, Xiao J, Zhou K
Autophagy 2025 Oct;21(10):2168-2191

IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.

Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.

Liang X, Zeng Y, Zhang P, Zhu B, Feng J, Deng T, Fu Z, Liu C, Chen C, Zhang Y
Journal of translational medicine 2025 Jun 5;23(1):631

Platycodin D2 Mediates Incomplete Autophagy and Ferroptosis in Breast Cancer Cells by Regulating Mitochondrial ROS.

Li Y, Lin H, Sun Y, Zhao R, Liu Y, Han J, Zhu Y, Jin N, Li X, Zhu G, Li Y
Phytotherapy research : PTR 2025 Feb;39(2):581-592

STAT1-VAMP8 axis drives nasopharyngeal carcinoma progression via autophagy enhancement.

Liu L, Yu W, Liu H, He Y, Zhu L, Yang C, Su X, Cao P, Gong H, Liu J, He J, Li H, Zhang J
Biochemical pharmacology 2025 Dec;242(Pt 3):117299

Syntaxin-2 balances phagocytic uptake and phagolysosomal clearance in macrophages.

Samanta S, Nandi A, Datta R, Dolai S
Journal of cell science 2025 Aug 1;138(15)

USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis.

Kang S, Liu S, Dong X, Li H, Qian Y, Dai A, He W, Li X, Chen Q, Wang H, Ding PH
Autophagy 2025 Apr;21(4):771-788

RAB23 facilitates clathrin-coated nascent vesicle formation at the plasma membrane and modulates cell signaling.

Hasan MR, Takatalo M, Nieminen P, Rice R, Mustonen T, Rice DP
Cellular and molecular life sciences : CMLS 2025 Apr 22;82(1):171

PRL2 negatively regulates FcεRI mediated activation of mast cells.

Guo X, Lei Y, Xu Y, Du X, Lin L, Luo Y, Xi Y, Guo Y, Niu X, Wang Z, Chen G
Cell death & disease 2025 Apr 21;16(1):322

Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.

Ren X, Wang J, Wei H, Li X, Tian Y, Wang Z, Yin Y, Guo Z, Qin Z, Wu M, Zeng X
International journal of biological sciences 2024;20(5):1905-1926

Upregulation of Amy1 in the salivary glands of mice exposed to a lunar gravity environment using the multiple artificial gravity research system.

Ouchi T, Kono K, Satou R, Kurashima R, Yamaguchi K, Kimura M, Shibukawa Y
Frontiers in physiology 2024;15:1417719

MK8722 initiates early-stage autophagy while inhibiting late-stage autophagy via FASN-dependent reprogramming of lipid metabolism.

Wang L, Zhu H, Shi Z, Chen B, Huang H, Lin G, Li J, Yu H, Xu S, Chen G, Ou R, Dai C
Theranostics 2024;14(1):75-95

Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.

Li Y, Xiao P, Sun Y, Li Y, Zhao H, Sun J, Wang X, Han X, Jin N, Li X, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215

Migfilin promotes autophagic flux through direct interaction with SNAP29 and Vamp8.

Cai R, Bai P, Quan M, Ding Y, Wei W, Liu C, Yang A, Xiong Z, Li G, Li B, Deng Y, Tian R, Zhao YG, Wu C, Sun Y
The Journal of cell biology 2024 Nov 4;223(11)

Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury.

Wu C, Pan Y, Wang L, Liu M, Tu P, Chen S, Shi L, Yan D, Ma Y, Guo Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14439

BMAL1 upregulates STX17 levels to promote autophagosome-lysosome fusion in hippocampal neurons to ameliorate Alzheimer's disease.

Zhou X, Du K, Mao T, Wang N, Zhang L, Tian Y, Liu T, Wang L, Wang X
iScience 2024 Dec 20;27(12):111413

Identification of the SNARE complex that mediates the fusion of multivesicular bodies with the plasma membrane in exosome secretion.

Liu C, Liu D, Wang S, Gan L, Yang X, Ma C
Journal of extracellular vesicles 2023 Sep;12(9):e12356

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857

Impaired autophagy flux by lncRNA NEAT1 is critical for inflammation factors production in human periodontal ligament stem cells with nicotine treatment.

Zhang T, Yang K, Chen Y, Jiang Y, Zhou Z, Liu J, Du Y, Wang L, Han X, Wu X, Wang X
Journal of periodontal research 2023 Feb;58(1):70-82

VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma.

Yang S, Zhou P, Zhang L, Xie X, Zhang Y, Bo K, Xue J, Zhang W, Liao F, Xu P, Hu Y, Yan R, Liu D, Chang J, Zhou K
Cancer biology & therapy 2023 Dec 31;24(1):2230641

Weakened interaction of ATG14 and the SNARE complex blocks autophagosome-lysosome fusion contributes to fluoride-induced developmental neurotoxicity.

Zhang Y, Han X, Tang Y, Zhang J, Hu Z, Xu W, Yao P, Niu Q
Ecotoxicology and environmental safety 2022 Jan 15;230:113108

Improving Lipophagy by Restoring Rab7 Cycle: Protective Effects of Quercetin on Ethanol-Induced Liver Steatosis.

Lin H, Guo X, Liu J, Liu P, Mei G, Li H, Li D, Chen H, Chen L, Zhao Y, Jiang C, Yu Y, Liu W, Yao P
Nutrients 2022 Feb 4;14(3)

Mystery of methamphetamine-induced autophagosome accumulation in hippocampal neurons: loss of syntaxin 17 in defects of dynein-dynactin driving and autophagosome-late endosome/lysosome fusion.

Xu H, Zhu Y, Chen X, Yang T, Wang X, Song X, Xie X, Hu M, Jiang L, Cheng J, Gao R, Wang J
Archives of toxicology 2021 Oct;95(10):3263-3284

Autophagy impairment as a key feature for acetaminophen-induced ototoxicity.

Zhao T, Zheng T, Yu H, Hu BH, Hu B, Ma P, Yang Y, Yang N, Hu J, Cao T, Chen G, Yan B, Peshoff M, Hatzoglou M, Geng R, Li B, Zheng QY
Cell death & disease 2021 Jan 4;12(1):3

Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.

Liu A, Wang W, Lu Z, Liu Z, Zhou W, Zhong Z, Ye Q
Biochemical and biophysical research communications 2021 Apr 23;550:15-21

DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.

Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, Cai Y
Cell death & disease 2021 Apr 20;12(5):416

Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells.

Li Z, Liu S, Fu T, Peng Y, Zhang J
Stem cell research & therapy 2019 Nov 27;10(1):351

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The VAMP8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VAMP8. This antibody recognizes human,mouse,rat antigen. The VAMP8 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 15546-1-AP.pdf

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