ABIN350058

antibody from antibodies-online

Targeting: VAMP8 EDB

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN350058

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN350058, RRID:AB_10786244

Product name

anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (Extracellular Domain) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit alpha (SCNN1A, SCNEA, Alpha-ENaC) conjugated to an immunogenic carrier protein was used as the immunogen.

Reactivity

Human, Mouse, Rat

Host

Goat

Epitope

Extracellular Domain

Vial size

100 μL

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.

Handling

Avoid freeze and thaw cycles.

References

Submitted references

Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.

McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM
American journal of physiology. Renal physiology 2002 Sep;283(3):F431-6

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Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes.

Saxena A, Hanukoglu I, Saxena D, Thompson RJ, Gardiner RM, Hanukoglu A
The Journal of clinical endocrinology and metabolism 2002 Jul;87(7):3344-50

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Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.

Snyder PM, Olson DR, Thomas BC
The Journal of biological chemistry 2002 Jan 4;277(1):5-8

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The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

Harvey KF, Dinudom A, Cook DI, Kumar S
The Journal of biological chemistry 2001 Mar 16;276(11):8597-601

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Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?

Arai K, Zachman K, Shibasaki T, Chrousos GP
The Journal of clinical endocrinology and metabolism 1999 Jul;84(7):2434-7

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Hormonal regulation and genomic organization of the human amiloride-sensitive epithelial sodium channel alpha subunit gene.

Chow YH, Wang Y, Plumb J, O'Brodovich H, Hu J
Pediatric research 1999 Aug;46(2):208-14

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Structural organisation of the gene encoding the alpha-subunit of the human amiloride-sensitive epithelial sodium channel.

Ludwig M, Bolkenius U, Wickert L, Marynen P, Bidlingmaier F
Human genetics 1998 May;102(5):576-81

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Cloning and functional studies of splice variants of the alpha-subunit of the amiloride-sensitive Na+ channel.

Tucker JK, Tamba K, Lee YJ, Shen LL, Warnock DG, Oh Y
The American journal of physiology 1998 Apr;274(4 Pt 1):C1081-9

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Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel.

McDonald FJ, Snyder PM, McCray PB Jr, Welsh MJ
The American journal of physiology 1994 Jun;266(6 Pt 1):L728-34

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The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning.

Voilley N, Lingueglia E, Champigny G, Mattéi MG, Waldmann R, Lazdunski M, Barbry P
Proceedings of the National Academy of Sciences of the United States of America 1994 Jan 4;91(1):247-51