11994-1-AP

antibody from Proteintech Group

Targeting: GRIA2 GluA2, GLUR2, GLURB

Provider product page for 11994-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [36]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 11994-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11994-1-AP, RRID:AB_2113725
Product name: Glutamate receptor 2 antibody
Antibody type: Polyclonal
Description: Glutamate receptor 2 antibody (Cat. #11994-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GRIA2 protein structure - 11994-1-AP shown in red.

Submitted references The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1.

Wang M, Gu Y, Li Q, Feng B, Lv X, Zhang H, Kong Q, Dong Z, Tian X, Zhang Y
Genes & diseases 2024 May;11(3):100997

The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease.

Liu K, Aierken A, Liu M, Parhat N, Kong W, Yin X, Liu G, Yu D, Hong J, Ni J, Quan Z, Liu X, Ji S, Mao J, Peng W, Chen C, Yan Y, Qing H
iScience 2024 Mar 15;27(3):109281

Impaired Response to Mismatch Novelty in the Li(2+)-Pilocarpine Rat Model of TLE: Correlation with Hippocampal Monoaminergic Inputs.

Nascimento C, Guerreiro-Pinto V, Pawlak S, Caulino-Rocha A, Amat-Garcia L, Cunha-Reis D
Biomedicines 2024 Mar 12;12(3)

Cognitive impairment in Alzheimer's disease FAD(4T) mouse model: Synaptic loss facilitated by activated microglia via C1qA.

Zhang C, Qi H, Jia D, Zhao J, Xu C, Liu J, Cui Y, Zhang J, Wang M, Chen M, Tang B
Life sciences 2024 Mar 1;340:122457

Trim46 knockout impaired neuronal architecture and caused hypoactive behavior in rats.

Guan F, Gao S, Sheng H, Ma Y, Chen W, Qi X, Zhang X, Gao X, Pang S, Zhang L, Zhang L
Developmental dynamics : an official publication of the American Association of Anatomists 2024 Jul;253(7):659-676

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.

Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy T, Wood MA, Luptak A
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Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for synaptic lipid raft disruption in early metaplasticity?

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Frontiers in cellular neuroscience 2023;17:1117697

Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice.

Wang Z, Niu M, Zheng N, Meng J, Jiang Y, Yang D, Yao P, Yao T, Luo H, Xu H, Ge Y, Zhang YW, Zhang X
Journal of cellular and molecular medicine 2023 May;27(9):1214-1226

Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.

Pang S, Luo Z, Dong W, Gao S, Chen W, Liu N, Zhang X, Gao X, Li J, Gao K, Shi X, Guan F, Zhang L, Zhang L
Life science alliance 2023 Mar;6(3)

Magnify is a universal molecular anchoring strategy for expansion microscopy.

Klimas A, Gallagher BR, Wijesekara P, Fekir S, DiBernardo EF, Cheng Z, Stolz DB, Cambi F, Watkins SC, Brody SL, Horani A, Barth AL, Moore CI, Ren X, Zhao Y
Nature biotechnology 2023 Jun;41(6):858-869

Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.

Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy TW, Wood MA, Lupták A
bioRxiv : the preprint server for biology 2023 Jun 9;

Opposing reduced VPAC(1) and enhanced VPAC(2) VIP receptors in the hippocampus of the Li(2+)-pilocarpine rat model of temporal lobe epilepsy.

Serpa A, Bento M, Caulino-Rocha A, Pawlak S, Cunha-Reis D
Neurochemistry international 2022 Sep;158:105383

RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission.

Ma P, Wan LP, Li Y, He CH, Song NN, Zhao S, Wang H, Ding YQ, Mao B, Sheng N
Science advances 2022 Sep 30;8(39):eabq4736

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.

Meng J, Han L, Zheng N, Wang T, Xu H, Jiang Y, Wang Z, Liu Z, Zheng Q, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Jun 22;42(25):4958-4979

A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.

Qin Y, Du Y, Chen L, Liu Y, Xu W, Liu Y, Li Y, Leng J, Wang Y, Zhang XY, Feng J, Zhang F, Jin L, Qiu Z, Gong X, Wang H
Molecular psychiatry 2022 Jul;27(7):2985-2998

Hippocampal AMPA receptors mediate the impairment of spatial learning and memory in prenatally stressed offspring rats.

Yao D, Mu Y, Lu Y, Li L, Shao S, Zhou J, Li J, Chen S, Zhang D, Zhang Y, Zhu Z, Li H
Journal of psychiatric research 2022 Jul;151:17-24

Long-term variable photoperiod exposure impairs the mPFC and induces anxiety and depression-like behavior in male wistar rats.

Hou Y, Wang Y, Song S, Zuo Y, Zhang H, Bai C, Zhao H, Zhang T
Experimental neurology 2022 Jan;347:113908

Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders.

Wang L, Wang X, Deng L, Zhang H, He B, Cao W, Cui Y
International immunopharmacology 2022 Dec;113(Pt B):109436

Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice.

Zhang M, Zhou Y, Jiang Y, Lu Z, Xiao X, Ning J, Sun H, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW
Frontiers in cell and developmental biology 2021;9:669798

Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.

Wang Y, Yuan J, Yu X, Liu X, Tan C, Chen Y, Xu T
Cell death & disease 2021 Oct 12;12(10):936

The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.

Liu J, Liu L, Han YS, Yi J, Guo C, Zhao HQ, Ling J, Wang YH
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353

Mammalian target of rapamycin signaling pathway is involved in synaptic plasticity of the spinal dorsal horn and neuropathic pain in rats by regulating autophagy.

Hu J, Chen X, Cheng J, Kong F, Xia H, Wu J
Neuroreport 2021 Aug 4;32(11):925-935

RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy.

Niu M, Zheng N, Wang Z, Gao Y, Luo X, Chen Z, Fu X, Wang Y, Wang T, Liu M, Yao T, Yao P, Meng J, Zhou Y, Ge Y, Wang Z, Ma Q, Xu H, Zhang YW
Frontiers in cell and developmental biology 2020;8:598622

Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging.

Zhang J, Xiao B, Li CX, Wang Y
Neural regeneration research 2020 Jul;15(7):1308-1315

Decrease of GSK-3β Activity in the Anterior Cingulate Cortex of Shank3b (-/-) Mice Contributes to Synaptic and Social Deficiency.

Wang M, Liu X, Hou Y, Zhang H, Kang J, Wang F, Zhao Y, Chen J, Liu X, Wang Y, Wu S
Frontiers in cellular neuroscience 2019;13:447

As a Histone Deacetylase Inhibitor, γ-Aminobutyric Acid Upregulates GluR2 Expression: An In Vitro and In Vivo Study.

Xing A, Li X, Jiang C, Chen Y, Wu S, Zhang J, An L
Molecular nutrition & food research 2019 Sep;63(17):e1900001

TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation.

Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, Li Y, Ma Y, Chen C, Yang Y, Yang M, Yang Y, Liu F, Zhou R, He M, Xiao F, Wang X
The Journal of clinical investigation 2019 Sep 3;129(9):3864-3876

Behavioral and electrophysiological changes in female mice overexpressing ORAI1 in neurons.

Maciąg F, Majewski Ł, Boguszewski PM, Gupta RK, Wasilewska I, Wojtaś B, Kuznicki J
Biochimica et biophysica acta. Molecular cell research 2019 Jul;1866(7):1137-1150

CAMK2-Dependent Signaling in Neurons Is Essential for Survival.

Kool MJ, Proietti Onori M, Borgesius NZ, van de Bree JE, Elgersma-Hooisma M, Nio E, Bezstarosti K, Buitendijk GHS, Aghadavoud Jolfaei M, Demmers JAA, Elgersma Y, van Woerden GM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 10;39(28):5424-5439

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons.

Capauto D, Colantoni A, Lu L, Santini T, Peruzzi G, Biscarini S, Morlando M, Shneider NA, Caffarelli E, Laneve P, Bozzoni I
Molecular neurobiology 2018 Oct;55(10):7635-7651

ZDHHC8 critically regulates seizure susceptibility in epilepsy.

Yang Q, Zheng F, Hu Y, Yang Y, Li Y, Chen G, Wang W, He M, Zhou R, Ma Y, Xu D, Tian X, Gao X, Wang Q, Wang X
Cell death & disease 2018 Jul 23;9(8):795

Ca(2+) -permeable AMPA receptors associated with epileptogenesis of hypothalamic hamartoma.

Kitaura H, Sonoda M, Teramoto S, Shirozu H, Shimizu H, Kimura T, Masuda H, Ito Y, Takahashi H, Kwak S, Kameyama S, Kakita A
Epilepsia 2017 Apr;58(4):e59-e63

Down-regulation of Pin1 in Temporal Lobe Epilepsy Patients and Mouse Model.

Tang L, Zhang Y, Chen G, Xiong Y, Wang X, Zhu B
Neurochemical research 2017 Apr;42(4):1211-1218

AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons.

Gruszczynska-Biegala J, Sladowska M, Kuznicki J
Frontiers in cellular neuroscience 2016;10:251

Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells.

Casimiro TM, Nawy S, Carroll RC
Molecular and cellular neurosciences 2013 Sep;56:384-92

mGluR and NMDAR activation internalize distinct populations of AMPARs.

Casimiro TM, Sossa KG, Uzunova G, Beattie JB, Marsden KC, Carroll RC
Molecular and cellular neurosciences 2011 Oct;48(2):161-70

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 11994-1-AP(GRIA2 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas using 11994-1-AP(GRIA2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Glutamate receptor 2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Glutamate receptor 2. This antibody recognizes human,mouse,rat antigen. The Glutamate receptor 2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 11994-1-AP.pdf

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