BDKRB1

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq, Aug 2020]

Description

Bradykinin receptor B1

Tissue specificity

Tissue enhanced (gallbladder, urinary bladder)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

14 (96256210 - 96268967)

Ensembl ID

ENSG00000100739  (ver. 103.38)

Orthologs

Mouse Bdkrb1: ENSMUSG00000041347

UniProt

P46663

neXtProt

NX_P46663

Human splice variants
Mouse splice variants

Protein structure