orb386061

antibody from Biorbyt
Targeting: FSHR FSHRO, LGR1, ODG1
Provider product page for orb386061
Immunohistochemistry

Antibody data

Product number
orb386061 - Provider product page
Provider
Biorbyt
Product name
FSH Receptor Antibody
Antibody type
Monoclonal
Description
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
FSHR/1400
Vial size
20 ug
Storage
Store the FSHR antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
FSHR protein structure - orb386061 shown in red.