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- Antigen structure
- References [144]
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- Product number
- 22665-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22665-1-AP, RRID:AB_2631204
- Product name
- FSHR antibody
- Antibody type
- Polyclonal
- Description
- FSHR antibody (Cat. #22665-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibiting TRIM21 Neddylation Rejuvenates Oocyte Quality in PCOS by Regulating Ubiquitination of CPT1A.
Effect of arginine on proliferation of porcine ovarian granulosa cells and steroid hormone synthesis.
Identification of TSHB gene expression profile in Duolang sheep and its functional role in granulosa cells.
IL-22/IL-22R signaling attenuates mitochondrial damage in PCOS by modulating granulosa cell lipid metabolism through ETS1.
Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway.
13-cis-retinoic acid modulates porcine ovarian granulosa cell differentiation via retinoic acid signaling-FoxA1 axis: Implications for ovarian follicular development and luteinization.
Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.
Circadian rhythm disruption impairs ovarian follicular development via NAD(+) metabolic reprogramming.
Florfenicol impairs steroid hormone secretion in bovine ovarian granulosa cells: Involvement of the cAMP/PKA/StAR signaling pathway and oxidative stress.
Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency.
From hormones to neurodegeneration: how FSH drives Alzheimer's disease.
Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents.
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
A Novel Culture System for Inhibiting In Vitro Differentiation of Ovine Granulosa Cells.
Gonadotropin inhibitory hormone (GnIH) induces glucose metabolism disorders and ovarian dysfunction in ovarian white follicles of hens.
RNA binding protein SERBP1 is indispensable for oocyte development and maturation in mice.
Role of cellular prion protein in mouse granulosa cells and its effects on ovarian function in knockout mice.
Propofol-mediated inhibition of ovarian function by mitophagy over-activation via TGF-β1/SMAD2/3 signaling pathway.
Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation.
Enhanced maturation of mouse immature oocytes using a novel three-dimensional culture system.
Exosomes derived from mesenchymal stem cells repair ovarian function by suppressing NLRP3-mediated pyroptosis in cyclophosphamide-induced premature ovarian failure.
FSH-Induced Nuclear Exclusion of FOXO1 Mediated by PI3K/Akt Signaling Pathway in Granulosa Cells Is Associated with Follicle Selection and Growth of the Hen Ovary.
Optimizing in vitro maturation outcomes of oocytes following gonadotropin priming in premenarcheal girls undergoing ovarian tissue cryopreservation.
Menstrual Blood-Derived Endometrial Stem Cells Ameliorate Ovarian Senescence by Relieving Oxidative Stress-Induced Inflammation.
HuMSCs-derived exosomal YBX1 participates in oxidative damage repair in granulosa cells by stabilizing COX5B mRNA in an m5C-dependent manner.
Adolescent cetylpyridinium chloride exposure impairs homologous recombination repair and induces granulosa cell apoptosis and follicular atresia via FOXM1/CREBBP complex suppression.
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
High-Calorie Diet Exacerbates the Crosstalk Between Gestational Diabetes and Youth-Onset Diabetes in Female Offspring Through Disrupted Estrogen Signaling.
Expression Dynamics and Estrogen Response of Estrogen Receptors in Duolang Sheep During Puberty.
MACS and acellular autologous non-ovarian tissue scaffolds: a promising strategy for safe and efficient follicle transplantation in hematologic cancer.
Loss of FUT8 impairs embryonic development by reducing cAMP production in granulosa cells.
Core fucosylation regulates the ovarian response via FSH receptor during follicular development.
Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.
Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.
Molecular characterization of MSX2 gene and its role in regulating steroidogenesis in yak (Bos grunniens) cumulus granulosa cells.
PTX3 impairs granulosa cell function by promoting the secretion of inflammatory cytokines in M1 macrophages via the JAK pathway.
Mesenchymal stem cells improve ovarian function by suppressing fibrosis through CTGF/FAK signalling in systemic lupus erythematosus.
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
Cholic acid inhibits ovarian steroid hormone synthesis and follicular development through farnesoid X receptor signaling in mice.
FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway.
3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization.
SO(2) derivatives impair ovarian function by inhibiting Serpine1/NF-κB pathway-mediated ovarian granulosa cell survival.
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.
FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation.
Moxibustion ameliorates ovarian function in premature ovarian insufficiency rats by activating cAMP/PKA/CREB to promote steroidogenesis in ovarian granulosa cells.
GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline.
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.
Peroxiredoxin 4 deficiency induces accelerated ovarian aging through destroyed proteostasis in granulosa cells.
Identification of apelin/APJ signaling dysregulation in a human iPSC-derived granulosa cell model of Turner syndrome.
Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis.
Cholecystokinin-mediated effect of insulin pathway on the steroidogenic activity of follicular granulosa cells in Camelus bactrianus: In vitro study.
P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1.
Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances.
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
M(6)A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis.
Transforming growth factor-β1 mediates the SMAD4/BMF pathway to regulate ovarian granulosa cell apoptosis in small tail Han sheep.
Resveratrol-βcd inhibited premature ovarian insufficiency progression by regulating granulosa cell autophagy.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
High FSH levels impair VEGF secretion of human, frozen-thawed ovarian cortical tissue in vitro.
Heme Oxygenase-1 Regulates Zearalenone-Induced Oxidative Stress and Apoptosis in Sheep Follicular Granulosa Cells.
Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis.
Regulation of Follicular Development in Chickens: WIF1 Modulates Granulosa Cell Proliferation and Progesterone Synthesis via Wnt/β-Catenin Signaling Pathway.
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
Effect of the LIF gene on the cell cycle and apoptosis of ovarian granulosa cells in white Muscovy ducks.
Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice.
Single-cell transcriptomic analysis reveals regulative mechanisms of follicular selection and atresia in chicken granulosa cells.
IGF2/IGFBP4 reduces apoptosis and increases free cholesterol of chicken granulosa cells in vitro.
Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve.
Caulerpin alleviates cyclophosphamide-induced ovarian toxicity by modulating macrophage-associated granulosa cell senescence during breast cancer chemotherapy.
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.
Follicular fluid-derived exosomal HMOX1 promotes granulosa cell ferroptosis involved in follicular atresia in geese (Anser cygnoides).
Galaxamide alleviates cisplatin-induced premature ovarian insufficiency via the PI3K signaling pathway in HeLa tumor-bearing mice.
Lin28B overexpression decreases let-7b and let-7g levels and increases proliferation and estrogen secretion in Dolang sheep ovarian granulosa cells.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes.
Tumor-Derived Oxidative Stress Triggers Ovarian Follicle Loss in Breast Cancer.
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.
Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin.
Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.
Altered m6A modification is involved YAP-mediated apoptosis response in 4-vinylcyclohexene diepoxide induced ovotoxicity.
Pubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1α-JNK signaling pathway in rat.
Effects of Oxidative Stress on the Autophagy and Apoptosis of Granulosa Cells in Broody Geese.
Role and mechanism of the p-JAK2/p-STAT3 signaling pathway in follicular development in PCOS rats.
Large extracellular vesicles in bovine follicular fluid inhibit the apoptosis of granulosa cell and stimulate the production of steroid hormones.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.
Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.
HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway.
Purinergic receptor P2X7 activates NOX2/JNK signaling to participate in granulosa cell inflammation and apoptosis in polycystic ovary syndrome.
Protective effect of L‑carnitine against oxidative stress injury in human ovarian granulosa cells.
The Dynamic Transcription Profiles of Proliferating Bovine Ovarian Granulosa When Exposed to Increased Levels of β-Hydroxybutyric Acid.
Acute hypoxia induced dysregulation of clock-controlled ovary functions.
The salmonella effector Hcp modulates infection response, and affects salmonella adhesion and egg contamination incidences in ducks.
Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling.
Multi-biofunctional graphene oxide-enhanced poly-L-lactic acid composite nanofiber scaffolds for ovarian function recovery of transplanted-tissue.
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
MiR-34c-5p promotes granulosa cells apoptosis by targeting Bcl2 in broody goose (Anser cygnoides).
Construction of a competing endogenous RNA network to identify drug targets against polycystic ovary syndrome.
Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells.
Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments.
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
The Role of Inactivated NF-κB in Premature Ovarian Failure.
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.
Expression of GnIH and its effects on follicle development and steroidogenesis in quail ovaries under different photoperiods.
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.
Smad4 mediates Bmf involvement in sheep granulosa cell apoptosis.
Cadmium disrupts mouse embryonic stem cell differentiation into ovarian granulosa cells through epigenetic mechanisms.
FSH modulated cartilage ECM metabolism by targeting the PKA/CREB/SOX9 pathway.
TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids.
Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic-pituitary-adrenal/ovary axis and activating BDNF- TrkB-CREB signaling pathway.
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.
The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS.
Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway.
FSH directly regulates chondrocyte dedifferentiation and cartilage development.
CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells.
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.
After cyclophosphamide exposure, granulosa cells recover their anti-müllerian hormone-producing ability but not their numbers.
Role of FSH and FSH receptor on HUVECs migration.
Synergistic effect of Huyang Yangkun Formula and embryonic stem cells on 4-vinylcyclohexene diepoxide induced premature ovarian insufficiency in mice.
Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
Effects of Osthole on Progesterone Secretion in Chicken Preovulatory Follicles Granulosa Cells.
Chlorogenic acid rescues zearalenone induced injury to mouse ovarian granulosa cells.
Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway.
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.
Cell-free mitochondrial DNA increases granulosa cell apoptosis and reduces aged oocyte blastocyst development in the mouse.
Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells.
Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells.
Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency.
Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.
miR-323-3p regulates the steroidogenesis and cell apoptosis in polycystic ovary syndrome (PCOS) by targeting IGF-1.
Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol.
Silencing of LncRNA steroid receptor RNA activator attenuates polycystic ovary syndrome in mice.
Role of nuclear factor-κB pathway in the transition of mouse secondary follicles to antral follicles.
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.
Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice.
Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells.
A novel homozygous mutation in the FSHR gene is causative for primary ovarian insufficiency.
Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure.
Na X, Liu J, Tan Y, Meng L, Guo C, Zuo N, Dai W, Cong R, Zhang B, Shi W, Hu J, Liang J, Wei S, Zhao Z, Chen J, Qiao X, Li D
Research (Washington, D.C.) 2026;9:1223
Research (Washington, D.C.) 2026;9:1223
Effect of arginine on proliferation of porcine ovarian granulosa cells and steroid hormone synthesis.
Zhang T, Lu X, Wang X, Liu Z, Shao X, Han R, Che D
Frontiers in veterinary science 2026;13:1766335
Frontiers in veterinary science 2026;13:1766335
Identification of TSHB gene expression profile in Duolang sheep and its functional role in granulosa cells.
Sun H, Zhu L, Shahbaz G, Gu R, He C, Chen S, Wang C, Xing F, Yan X
BMC genomics 2026 May 1;27(1)
BMC genomics 2026 May 1;27(1)
IL-22/IL-22R signaling attenuates mitochondrial damage in PCOS by modulating granulosa cell lipid metabolism through ETS1.
Luo M, Chen Y, Chen H, Wen Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Mar 17;75(1)
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Mar 17;75(1)
Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway.
Zhang Q, Ren J, Ye J, Chen F, Xiang F, Shi B, Zhou Z, Zhou J, Wang F, Qu F
Chinese medicine 2026 Jan 23;21(1):50
Chinese medicine 2026 Jan 23;21(1):50
13-cis-retinoic acid modulates porcine ovarian granulosa cell differentiation via retinoic acid signaling-FoxA1 axis: Implications for ovarian follicular development and luteinization.
Zhang HL, Wang HB, Mi YX, Wu XM, Bao L, Zhao M, Ma L, Wang SL
Theriogenology 2026 Jan 15;250:117682
Theriogenology 2026 Jan 15;250:117682
Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.
Fang Q, Luo L, Jin R, Wang Y, Wang J, Jin Q, Meng Y, Shi B, Qiao Z, Li F, Chen M, Chen S, Xu B, Bao J, Han H, Wu L
Science advances 2026 Feb 27;12(9):eady4767
Science advances 2026 Feb 27;12(9):eady4767
Circadian rhythm disruption impairs ovarian follicular development via NAD(+) metabolic reprogramming.
Ying YY, Chen X, Yao SY, Chen RX, Ying Y, Qiu H, Xu QQ, Li ZY, Ye CQ, Qian YL, Liang HQ, Sun X, Zhang D
EBioMedicine 2026 Apr;126:106200
EBioMedicine 2026 Apr;126:106200
Florfenicol impairs steroid hormone secretion in bovine ovarian granulosa cells: Involvement of the cAMP/PKA/StAR signaling pathway and oxidative stress.
Zhao J, Zhou X, You B, Cheng B, Hu J, Lu Y, Xu D, Zhang X, Yan C, Gao Q, Liu H, Jin Q
Theriogenology 2026 Apr 23;261:117956
Theriogenology 2026 Apr 23;261:117956
Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature Ovarian Insufficiency.
Chen J, Huo X, Qian M, Xue Q, He Y, Xu P, Wang Y, Tang X, Luo Q, Bao H, Xiong Y
International journal of nanomedicine 2025;20:10195-10212
International journal of nanomedicine 2025;20:10195-10212
From hormones to neurodegeneration: how FSH drives Alzheimer's disease.
Xue Y, Zuo S, Wang F, Qi X
Frontiers in aging neuroscience 2025;17:1578439
Frontiers in aging neuroscience 2025;17:1578439
Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents.
Lu X, Han Y, Song J, Wan Q, Liu P, Chen L, Wang Y, Xue P, Dai X
Frontiers in endocrinology 2025;16:1616965
Frontiers in endocrinology 2025;16:1616965
HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF-κB/SOD2 Signaling Pathway.
Li H, Cai S, Mu H, Chang T, Wang X, Tang T, Dong T, Zhang Y, Zhang L, Li H, Zhou L, Xiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e03828
A Novel Culture System for Inhibiting In Vitro Differentiation of Ovine Granulosa Cells.
Zhao Y, Liu H, Mu Z, Li H, Qi W
Biomolecules 2025 Sep 4;15(9)
Biomolecules 2025 Sep 4;15(9)
Gonadotropin inhibitory hormone (GnIH) induces glucose metabolism disorders and ovarian dysfunction in ovarian white follicles of hens.
Shen B, Han D, Xin Y, Zhang J, Xu C, Song X, Zhang X, Liu C, Li J, Wei Y, Wang X, Hu C, Li X
Theriogenology 2025 Sep 15;244:117497
Theriogenology 2025 Sep 15;244:117497
RNA binding protein SERBP1 is indispensable for oocyte development and maturation in mice.
Wang L, OuYang S, Li B, Kong N
Molecular and cellular endocrinology 2025 Sep 1;:112644
Molecular and cellular endocrinology 2025 Sep 1;:112644
Role of cellular prion protein in mouse granulosa cells and its effects on ovarian function in knockout mice.
Cao Q, Wang H, Hu J, Wang Y, Dai T, Liu F, Yang X, Yang Q, Tu C
Molecular medicine reports 2025 Oct;32(4)
Molecular medicine reports 2025 Oct;32(4)
Propofol-mediated inhibition of ovarian function by mitophagy over-activation via TGF-β1/SMAD2/3 signaling pathway.
Miao L, Chen M, Zhou Y, Pan S, Li X, Wang Y, Zhang J, Zhu X
Cellular signalling 2025 Oct;134:111916
Cellular signalling 2025 Oct;134:111916
Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation.
Zhang H, Li Z, Zhu Y, Lyu W, Wei W, Wang H, Tian S, Yue W, Zhong J, Sun QY, Guan Y
Nature communications 2025 Oct 8;16(1):8955
Nature communications 2025 Oct 8;16(1):8955
Enhanced maturation of mouse immature oocytes using a novel three-dimensional culture system.
Zhao X, Zhang X, Wu S, Zhang S, Chang HM, Leung PCK, Tan J
Theriogenology 2025 Oct 1;245:117518
Theriogenology 2025 Oct 1;245:117518
Exosomes derived from mesenchymal stem cells repair ovarian function by suppressing NLRP3-mediated pyroptosis in cyclophosphamide-induced premature ovarian failure.
Cui X, Li H, Huang X, Xue T, Wang S, Zhu X, Jing X
Journal of ovarian research 2025 Oct 1;18(1):216
Journal of ovarian research 2025 Oct 1;18(1):216
FSH-Induced Nuclear Exclusion of FOXO1 Mediated by PI3K/Akt Signaling Pathway in Granulosa Cells Is Associated with Follicle Selection and Growth of the Hen Ovary.
Yan C, Ou Y, Sun X, Sun Y, Zhao J, Qin N, Xu R
Cells 2025 Nov 26;14(23)
Cells 2025 Nov 26;14(23)
Optimizing in vitro maturation outcomes of oocytes following gonadotropin priming in premenarcheal girls undergoing ovarian tissue cryopreservation.
Zhao W, Guo Y, Zhou C, Sun P, Li T, Zeng H, Li J, Fang C, Liang X
Fertility and sterility 2025 Nov 15;124(5 Pt 2):1082-1092
Fertility and sterility 2025 Nov 15;124(5 Pt 2):1082-1092
Menstrual Blood-Derived Endometrial Stem Cells Ameliorate Ovarian Senescence by Relieving Oxidative Stress-Induced Inflammation.
Song H, Zhang R, Liu Y, Wu J, Fan W, Wu J, Liu Y, Lin J
Reproductive sciences (Thousand Oaks, Calif.) 2025 May;32(5):1566-1579
Reproductive sciences (Thousand Oaks, Calif.) 2025 May;32(5):1566-1579
HuMSCs-derived exosomal YBX1 participates in oxidative damage repair in granulosa cells by stabilizing COX5B mRNA in an m5C-dependent manner.
Zhu X, Lu M, Li WX, Lin L, Liu Y, Zhou J, Shang J, Shi X, Lu J, Xing J, Zhang M, Zhao S, Zhao D
International journal of biological macromolecules 2025 May;310(Pt 4):143288
International journal of biological macromolecules 2025 May;310(Pt 4):143288
Adolescent cetylpyridinium chloride exposure impairs homologous recombination repair and induces granulosa cell apoptosis and follicular atresia via FOXM1/CREBBP complex suppression.
Ma L, Yin X, Zhang Y, Ma Y, Geng Y, Mu X, Gao R, Chen X, He J
Ecotoxicology and environmental safety 2025 May;296:118193
Ecotoxicology and environmental safety 2025 May;296:118193
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
Xu H, Cai Y, Yang H, Zhang C, Liu W, Zhao B, Wang F, Zhang Y
Communications biology 2025 May 29;8(1):824
Communications biology 2025 May 29;8(1):824
High-Calorie Diet Exacerbates the Crosstalk Between Gestational Diabetes and Youth-Onset Diabetes in Female Offspring Through Disrupted Estrogen Signaling.
Jia X, Cao X, Wang Y, Yang S, Ji L
Nutrients 2025 Jun 26;17(13)
Nutrients 2025 Jun 26;17(13)
Expression Dynamics and Estrogen Response of Estrogen Receptors in Duolang Sheep During Puberty.
Zhu L, Shahbaz GM, Sun H, Zhang J, Li W, Gu R, Xing F
Genes 2025 Jun 24;16(7)
Genes 2025 Jun 24;16(7)
MACS and acellular autologous non-ovarian tissue scaffolds: a promising strategy for safe and efficient follicle transplantation in hematologic cancer.
Yin L, Zhao Y, Zhang P, Qi T, Han P, Cai L, Pan J, Yang Y, Shi J, Feng S, Zou Y, He K, Xie G, He W, Zhou X, Qian J
Journal of ovarian research 2025 Jun 10;18(1):126
Journal of ovarian research 2025 Jun 10;18(1):126
Loss of FUT8 impairs embryonic development by reducing cAMP production in granulosa cells.
Wang T, Zhang Z, Qu C, Shi Y, Chen S, Li W, Li M
Journal of assisted reproduction and genetics 2025 Jul;42(7):2437-2448
Journal of assisted reproduction and genetics 2025 Jul;42(7):2437-2448
Core fucosylation regulates the ovarian response via FSH receptor during follicular development.
Wang T, Zhang Z, Qu C, Song W, Li M, Shao X, Fukuda T, Gu J, Taniguchi N, Li W
Journal of advanced research 2025 Jan;67:105-120
Journal of advanced research 2025 Jan;67:105-120
Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.
Li Y, Li F, Shu J, Meng C, Zhang J, Zhang J, Qian Y, Wang H, Ding Q, Cao S
Animal reproduction science 2025 Jan;272:107649
Animal reproduction science 2025 Jan;272:107649
Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.
Shi L, Ying H, Dai Y, Rong Y, Chen J, Zhou F, Wang S, Xu S, Tong X, Zhang S
Human reproduction (Oxford, England) 2025 Jan 1;40(1):119-137
Human reproduction (Oxford, England) 2025 Jan 1;40(1):119-137
Molecular characterization of MSX2 gene and its role in regulating steroidogenesis in yak (Bos grunniens) cumulus granulosa cells.
Ma J, Yang G, Qin X, Mo L, Xiong X, Xiong Y, He H, Lan D, Fu W, Li J, Yin S
Theriogenology 2025 Jan 1;231:101-110
Theriogenology 2025 Jan 1;231:101-110
PTX3 impairs granulosa cell function by promoting the secretion of inflammatory cytokines in M1 macrophages via the JAK pathway.
Chen Y, Luo X, Li Y, Liu L, Liu Z, Tan Y, Chen Y
Steroids 2025 Feb;214:109541
Steroids 2025 Feb;214:109541
Mesenchymal stem cells improve ovarian function by suppressing fibrosis through CTGF/FAK signalling in systemic lupus erythematosus.
Zhang H, Yang H, Wu Y, Shi Y, Xu M, Zhang Y, Chen H, Sun L
Lupus science & medicine 2025 Aug 5;12(2)
Lupus science & medicine 2025 Aug 5;12(2)
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
Chen L, Zeng L, Pan S, Zu L, Pan H, Fan L
Cytotechnology 2025 Apr;77(2):76
Cytotechnology 2025 Apr;77(2):76
Cholic acid inhibits ovarian steroid hormone synthesis and follicular development through farnesoid X receptor signaling in mice.
Zhu W, Cheng X, Zhang H, Li J, Li L, Wei H, Zhang S
International journal of biological macromolecules 2025 Apr;301:140458
International journal of biological macromolecules 2025 Apr;301:140458
FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway.
Chen Y, Xu N, Zhang WW, Wang Y, Su T, Zhou YM, Xu J
FEBS open bio 2025 Apr;15(4):622-633
FEBS open bio 2025 Apr;15(4):622-633
3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization.
Robinson MA, Kung SH, Youssef KY, Scheck KM, Bell RH, Sar F, Haegert AM, Asmae MM, Cheng C, Yeack SV, Mathur BT, Jiang F, Collins CC, Hach F, Willerth SM, Flannigan RK
Advanced healthcare materials 2025 Apr;14(10):e2402606
Advanced healthcare materials 2025 Apr;14(10):e2402606
SO(2) derivatives impair ovarian function by inhibiting Serpine1/NF-κB pathway-mediated ovarian granulosa cell survival.
Wu S, Zhang X, Lu Y, Ma Y, Qi X, Wang X, Tan J
Journal of hazardous materials 2025 Apr 5;487:137116
Journal of hazardous materials 2025 Apr 5;487:137116
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85
Journal of ovarian research 2025 Apr 26;18(1):85
Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.
Huang L, Sun S, Jiang G, Xie G, Yang Y, Chen S, Luo J, Lv C, Li X, Liao J, Wang Z, Zhang Z, Xiong J
Frontiers in molecular neuroscience 2024;17:1459858
Frontiers in molecular neuroscience 2024;17:1459858
FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation.
Xu X, Zhuang X, Yu H, Li P, Li X, Lin H, Teoh JP, Chen Y, Yang Y, Cheng Y, Chen W, Fu X
Theranostics 2024;14(5):2151-2166
Theranostics 2024;14(5):2151-2166
Moxibustion ameliorates ovarian function in premature ovarian insufficiency rats by activating cAMP/PKA/CREB to promote steroidogenesis in ovarian granulosa cells.
Zhao R, Ran L, Yao H, He Y, Lu X, Zhu W, Zhang Y, Zhang T, Shi S, Luo Z, Zhang C
The Journal of steroid biochemistry and molecular biology 2024 Sep;242:106547
The Journal of steroid biochemistry and molecular biology 2024 Sep;242:106547
GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline.
Mou L, Sun D, Qu J, Tan X, Wang S, Zeng Q, Liu C
Journal of hazardous materials 2024 Sep 5;476:135101
Journal of hazardous materials 2024 Sep 5;476:135101
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.
Jamal MA, Cheng Y, Jiao D, Cheng W, Zou D, Wang X, Wei T, Guo J, Xu K, Zhao H, Pu S, Yang C, Qing Y, Jia B, Li H, Zhao R, Zhao HY, Wei HJ
Biological research 2024 Sep 4;57(1):60
Biological research 2024 Sep 4;57(1):60
Peroxiredoxin 4 deficiency induces accelerated ovarian aging through destroyed proteostasis in granulosa cells.
Zou X, Liang X, Dai W, Zhu T, Wang C, Zhou Y, Qian Y, Yan Z, Gao C, Gao L, Cui Y, Liu J, Meng Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167334
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167334
Identification of apelin/APJ signaling dysregulation in a human iPSC-derived granulosa cell model of Turner syndrome.
Chen WJ, Chao YY, Huang WK, Chang WF, Tzeng CR, Chuang CH, Lai PL, Schuyler SC, Li LY, Lu J
Cell death discovery 2024 Nov 14;10(1):468
Cell death discovery 2024 Nov 14;10(1):468
Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis.
Ji R, Wang S, Chen X, Yang Z, Zhang Z, Bao S, Xiao Z, Zhang Y, Yin T, Yang J
Free radical biology & medicine 2024 Nov 1;224:707-722
Free radical biology & medicine 2024 Nov 1;224:707-722
Cholecystokinin-mediated effect of insulin pathway on the steroidogenic activity of follicular granulosa cells in Camelus bactrianus: In vitro study.
Guo L, Zhang Y
Reproduction in domestic animals = Zuchthygiene 2024 May;59(5):e14586
Reproduction in domestic animals = Zuchthygiene 2024 May;59(5):e14586
P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1.
Zhao T, He M, Zhu Z, Zhang T, Zheng W, Qin S, Gao M, Wang W, Chen Z, Han J, Liu L, Zhou B, Wang H, Zhang H, Xia G, Wang J, Wang F, Wang C
Cellular and molecular life sciences : CMLS 2024 May 20;81(1):221
Cellular and molecular life sciences : CMLS 2024 May 20;81(1):221
Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances.
Squatrito M, Vervier J, Bindels J, Bernet L, Blacher S, Nisolle M, Munaut C
Reproduction (Cambridge, England) 2024 May 1;167(5)
Reproduction (Cambridge, England) 2024 May 1;167(5)
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
Li D, Zhou L, Liu Z, Zhang Z, Mao W, Shi W, Zhu M, Wang F, Wan Y
Theriogenology 2024 Mar 1;216:20-29
Theriogenology 2024 Mar 1;216:20-29
M(6)A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis.
Zhu X, Li W, Lu M, Shang J, Zhou J, Lin L, Liu Y, Xing J, Zhang M, Zhao S, Lu J, Shi X
Journal of nanobiotechnology 2024 Jun 25;22(1):367
Journal of nanobiotechnology 2024 Jun 25;22(1):367
Transforming growth factor-β1 mediates the SMAD4/BMF pathway to regulate ovarian granulosa cell apoptosis in small tail Han sheep.
Li M, Liang W, Luo Y, Wang J, Liu X, Li S, Hao Z
Theriogenology 2024 Jan 15;214:360-369
Theriogenology 2024 Jan 15;214:360-369
Resveratrol-βcd inhibited premature ovarian insufficiency progression by regulating granulosa cell autophagy.
Hu B, Zheng X, Zhang W
Journal of ovarian research 2024 Jan 15;17(1):18
Journal of ovarian research 2024 Jan 15;17(1):18
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
High FSH levels impair VEGF secretion of human, frozen-thawed ovarian cortical tissue in vitro.
Einenkel R, Schallmoser A, Sänger N
Scientific reports 2024 Feb 8;14(1):3287
Scientific reports 2024 Feb 8;14(1):3287
Heme Oxygenase-1 Regulates Zearalenone-Induced Oxidative Stress and Apoptosis in Sheep Follicular Granulosa Cells.
Li Y, Gao Y, Yao D, Li Z, Wang J, Zhang X, Zhao X, Zhang Y
International journal of molecular sciences 2024 Feb 23;25(5)
International journal of molecular sciences 2024 Feb 23;25(5)
Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
Li S, Zeng L, Miao F, Li N, Liao W, Zhou X, Chen Y, Quan H, He Y, Zhang H, Li J, Yuan X
International journal of molecular sciences 2024 Feb 20;25(5)
International journal of molecular sciences 2024 Feb 20;25(5)
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis.
Yang Z, Pan J, Zhou C, Yu C, Zhou Z, Ding G, Liu X, Sheng J, Jin L, Huang H
iScience 2024 Feb 16;27(2):108522
iScience 2024 Feb 16;27(2):108522
Regulation of Follicular Development in Chickens: WIF1 Modulates Granulosa Cell Proliferation and Progesterone Synthesis via Wnt/β-Catenin Signaling Pathway.
Nie R, Zhang W, Tian H, Li J, Ling Y, Zhang B, Zhang H, Wu C
International journal of molecular sciences 2024 Feb 1;25(3)
International journal of molecular sciences 2024 Feb 1;25(3)
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
Ju W, Zhao S, Wu H, Yu Y, Li Y, Liu D, Lian F, Xiang S
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
Effect of the LIF gene on the cell cycle and apoptosis of ovarian granulosa cells in white Muscovy ducks.
Tao QH, Sun NN, Wang MS, Zhao WX, Liu W, Zhang X, Li A
Theriogenology 2024 Dec;230:91-100
Theriogenology 2024 Dec;230:91-100
Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice.
Zhu L, Zhou X, Ma L, Hu Y
Hormones (Athens, Greece) 2024 Dec;23(4):821-829
Hormones (Athens, Greece) 2024 Dec;23(4):821-829
Single-cell transcriptomic analysis reveals regulative mechanisms of follicular selection and atresia in chicken granulosa cells.
Zhang W, Chen X, Nie R, Guo A, Ling Y, Zhang B, Zhang H
Food research international (Ottawa, Ont.) 2024 Dec;198:115368
Food research international (Ottawa, Ont.) 2024 Dec;198:115368
IGF2/IGFBP4 reduces apoptosis and increases free cholesterol of chicken granulosa cells in vitro.
Zhang W, Chen X, Guo A, Zhao Z, Zhang B, Li F, Zhang H
Poultry science 2024 Dec;103(12):104416
Poultry science 2024 Dec;103(12):104416
Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve.
Zhou Z, Li Y, Ding J, Sun S, Cheng W, Yu J, Cai Z, Ni Z, Yu C
Scientific reports 2024 Dec 28;14(1):30681
Scientific reports 2024 Dec 28;14(1):30681
Caulerpin alleviates cyclophosphamide-induced ovarian toxicity by modulating macrophage-associated granulosa cell senescence during breast cancer chemotherapy.
Ren X, Yao B, Zhou X, Nie P, Xu S, Wang M, Li P
International immunopharmacology 2024 Dec 25;143(Pt 3):113513
International immunopharmacology 2024 Dec 25;143(Pt 3):113513
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.
Li W, Lu M, Shang J, Zhou J, Lin L, Liu Y, Zhao D, Zhu X
Stem cell research & therapy 2024 Dec 18;15(1):484
Stem cell research & therapy 2024 Dec 18;15(1):484
Follicular fluid-derived exosomal HMOX1 promotes granulosa cell ferroptosis involved in follicular atresia in geese (Anser cygnoides).
Zhang Y, Jiang Y, Dong X, Luo S, Jiao G, Weng K, Bao Q, Zhang Y, Vongsangnak W, Chen G, Xu Q
Poultry science 2024 Aug;103(8):103912
Poultry science 2024 Aug;103(8):103912
Galaxamide alleviates cisplatin-induced premature ovarian insufficiency via the PI3K signaling pathway in HeLa tumor-bearing mice.
Tao H, Chen Z, Yao B, Ren X, Shuai H, Xu S, Zha Q, Li P
BMC cancer 2024 Aug 28;24(1):1060
BMC cancer 2024 Aug 28;24(1):1060
Lin28B overexpression decreases let-7b and let-7g levels and increases proliferation and estrogen secretion in Dolang sheep ovarian granulosa cells.
Sui Z, Zhang Y, Zhang Z, Wang C, Li X, Xing F
Archives animal breeding 2023;66(3):217-224
Archives animal breeding 2023;66(3):217-224
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
Dai W, Yang H, Xu B, He T, Liu L, Ma X, Ma J, Yang G, Si R, Pei X, Du X, Fu X
Journal of ovarian research 2023 Sep 30;16(1):198
Journal of ovarian research 2023 Sep 30;16(1):198
N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway.
Jing YX, Li HX, Yue F, Li YM, Yu X, He JJ, Zhang XH
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Oct 26;39(1):2276167
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Oct 26;39(1):2276167
Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes.
Ge T, Wen Y, Li B, Huang X, Jiang S, Zhang E
Journal of animal science and biotechnology 2023 Nov 14;14(1):144
Journal of animal science and biotechnology 2023 Nov 14;14(1):144
Tumor-Derived Oxidative Stress Triggers Ovarian Follicle Loss in Breast Cancer.
Wu Y, Huang J, Chen H, Tao H, He Y, Yang G, Zha Q, Lash GE, Li P
The American journal of pathology 2023 May;193(5):608-623
The American journal of pathology 2023 May;193(5):608-623
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.
Zhao X, Zhang S, Gao S, Chang HM, Leung PCK, Tan J
ACS applied materials & interfaces 2023 Mar 29;15(12):15084-15095
ACS applied materials & interfaces 2023 Mar 29;15(12):15084-15095
Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin.
Du R, Cheng X, Ji J, Lu Y, Xie Y, Wang W, Xu Y, Zhang Y
Scientific reports 2023 Mar 17;13(1):4463
Scientific reports 2023 Mar 17;13(1):4463
Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.
Zhao Y, Wang Y, Ling Z, Xue Y, Luan D, Kang J, Zhang Y, Quan F
Theriogenology 2023 Mar 15;199:121-130
Theriogenology 2023 Mar 15;199:121-130
Altered m6A modification is involved YAP-mediated apoptosis response in 4-vinylcyclohexene diepoxide induced ovotoxicity.
Li Y, Li M, Liu J, Nie G, Yang H
Ecotoxicology and environmental safety 2023 Jun 30;262:115192
Ecotoxicology and environmental safety 2023 Jun 30;262:115192
Pubertal lead exposure affects ovary development, folliculogenesis and steroidogenesis by activation of IRE1α-JNK signaling pathway in rat.
Shan D, Wen X, Guan X, Fang H, Liu Y, Qin M, Wang H, Xu J, Lv J, Zhao J, Chen H
Ecotoxicology and environmental safety 2023 Jun 1;257:114919
Ecotoxicology and environmental safety 2023 Jun 1;257:114919
Effects of Oxidative Stress on the Autophagy and Apoptosis of Granulosa Cells in Broody Geese.
Hou L, Gu T, Weng K, Zhang Y, Zhang Y, Chen G, Xu Q
International journal of molecular sciences 2023 Jan 21;24(3)
International journal of molecular sciences 2023 Jan 21;24(3)
Role and mechanism of the p-JAK2/p-STAT3 signaling pathway in follicular development in PCOS rats.
Wang H, Feng X, Wang T, Pan J, Zheng Z, Su Y, Weng H, Zhang L, Chen L, Zhou L, Zheng L
General and comparative endocrinology 2023 Jan 1;330:114138
General and comparative endocrinology 2023 Jan 1;330:114138
Large extracellular vesicles in bovine follicular fluid inhibit the apoptosis of granulosa cell and stimulate the production of steroid hormones.
Ying W, Yunqi Z, Zimeng L, Kangning X, Deji L, Chen Q, Yong Z, Fusheng Q
Theriogenology 2023 Jan 1;195:149-158
Theriogenology 2023 Jan 1;195:149-158
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.
Bao Y, Li X, El-Samahy MA, Yang H, Wang Z, Yang F, Yao X, Wang F
Theriogenology 2023 Feb;197:198-208
Theriogenology 2023 Feb;197:198-208
Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.
Wu Y, Yang R, Lan J, Wu Y, Huang J, Fan Q, You Y, Lin H, Jiao X, Chen H, Cao C, Zhang Q
Free radical biology & medicine 2023 Feb 20;196:37-52
Free radical biology & medicine 2023 Feb 20;196:37-52
HD-sEVs in bovine follicular fluid regulate granulosa cell apoptosis and estradiol secretion through the autophagy pathway.
Wang Y, Zhao Y, Ling Z, Luan D, Kang J, Dong X, Quan F
Theriogenology 2023 Dec;212:91-103
Theriogenology 2023 Dec;212:91-103
Purinergic receptor P2X7 activates NOX2/JNK signaling to participate in granulosa cell inflammation and apoptosis in polycystic ovary syndrome.
Shen C, Jiang Y, Lin J, He Y, Liu Y, Fang D
Journal of bioenergetics and biomembranes 2023 Aug;55(4):313-322
Journal of bioenergetics and biomembranes 2023 Aug;55(4):313-322
Protective effect of L‑carnitine against oxidative stress injury in human ovarian granulosa cells.
Li X, Wu X, Ma T, Zhang Y, Sun P, Qi D, Ma H
Experimental and therapeutic medicine 2023 Apr;25(4):161
Experimental and therapeutic medicine 2023 Apr;25(4):161
The Dynamic Transcription Profiles of Proliferating Bovine Ovarian Granulosa When Exposed to Increased Levels of β-Hydroxybutyric Acid.
Gong J, Zhao S, Heng N, Wang Y, Hu Z, Wang H, Zhu H
Frontiers in veterinary science 2022;9:915956
Frontiers in veterinary science 2022;9:915956
Acute hypoxia induced dysregulation of clock-controlled ovary functions.
Ding M, Lu Y, Huang X, Xing C, Hou S, Wang D, Zhang Y, Wang W, Zhang C, Zhang M, Meng F, Liu K, Liu G, Zhao J, Song L
Frontiers in physiology 2022;13:1024038
Frontiers in physiology 2022;13:1024038
The salmonella effector Hcp modulates infection response, and affects salmonella adhesion and egg contamination incidences in ducks.
Song L, Wu J, Weng K, Yao F, Vongsangnak W, Zhu G, Chen G, Zhang Y, Xu Q
Frontiers in cellular and infection microbiology 2022;12:948237
Frontiers in cellular and infection microbiology 2022;12:948237
Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling.
Wei X, Zheng L, Tian Y, Wang H, Su Y, Feng G, Wang C, Lu Z
Journal of molecular cell biology 2022 Sep 27;14(7)
Journal of molecular cell biology 2022 Sep 27;14(7)
Multi-biofunctional graphene oxide-enhanced poly-L-lactic acid composite nanofiber scaffolds for ovarian function recovery of transplanted-tissue.
Yan L, Wang L, Wu J, Wu Y, Zhu X, Mei Q, Song Y, Liu Y, Zhang L, Ai J, Li K, Qing G, Zhang Y, Xiao X, Zhao Y, Xiang W
NPJ Regenerative medicine 2022 Sep 16;7(1):52
NPJ Regenerative medicine 2022 Sep 16;7(1):52
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Liu J, Shi D, Ma Q, Zhao P
Journal of ethnopharmacology 2022 Sep 15;295:115398
Journal of ethnopharmacology 2022 Sep 15;295:115398
MiR-34c-5p promotes granulosa cells apoptosis by targeting Bcl2 in broody goose (Anser cygnoides).
Hou L, Ji W, Gu T, Weng K, Liu D, Zhang Y, Zhang Y, Xu Q, Chen G
Animal biotechnology 2022 Nov;33(6):1280-1288
Animal biotechnology 2022 Nov;33(6):1280-1288
Construction of a competing endogenous RNA network to identify drug targets against polycystic ovary syndrome.
Wu T, Gao YY, Tang XN, Li Y, Dai J, Zhou S, Wu M, Zhang JJ, Wang SX
Human reproduction (Oxford, England) 2022 Nov 24;37(12):2856-2866
Human reproduction (Oxford, England) 2022 Nov 24;37(12):2856-2866
Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells.
Tang X, Dong H, Fang Z, Li J, Yang Q, Yao T, Pan Z
Reproductive biology and endocrinology : RB&E 2022 May 24;20(1):84
Reproductive biology and endocrinology : RB&E 2022 May 24;20(1):84
Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments.
Yang M, Feng J, Lan X, Tang Y, Zhang Y, Zhang H, Wang S
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):243-254
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):243-254
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Miao Y, Wan W, Zhu K, Pan M, Zhao X, Ma B, Wei Q
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
The Role of Inactivated NF-κB in Premature Ovarian Failure.
Luo X, Xu J, Zhao R, Qin J, Wang X, Yan Y, Wang LJ, Wang G, Yang X
The American journal of pathology 2022 Mar;192(3):468-483
The American journal of pathology 2022 Mar;192(3):468-483
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure.
Zheng S, Ma M, Chen Y, Li M
Basic & clinical pharmacology & toxicology 2022 Feb;130(2):240-253
Basic & clinical pharmacology & toxicology 2022 Feb;130(2):240-253
Expression of GnIH and its effects on follicle development and steroidogenesis in quail ovaries under different photoperiods.
Zhou X, Jiang D, Zhang Z, Shen X, Pan J, Xu D, Tian Y, Huang Y
Poultry science 2022 Dec;101(12):102227
Poultry science 2022 Dec;101(12):102227
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.
Shao T, Ke H, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y, Zhao S
Autophagy 2022 Aug;18(8):1864-1878
Autophagy 2022 Aug;18(8):1864-1878
Smad4 mediates Bmf involvement in sheep granulosa cell apoptosis.
Li M, Liang W, Zhu C, Qin S
Gene 2022 Apr 5;817:146231
Gene 2022 Apr 5;817:146231
Cadmium disrupts mouse embryonic stem cell differentiation into ovarian granulosa cells through epigenetic mechanisms.
Liu J, Li L, Zhu J, Luo L, Li Y, Zhang C, Zhang W
Ecotoxicology and environmental safety 2022 Apr 15;235:113431
Ecotoxicology and environmental safety 2022 Apr 15;235:113431
FSH modulated cartilage ECM metabolism by targeting the PKA/CREB/SOX9 pathway.
Zhang M, Wang Y, Huan Z, Liu Y, Zhang W, Kong D, Kong L, Xu J
Journal of bone and mineral metabolism 2021 Sep;39(5):769-779
Journal of bone and mineral metabolism 2021 Sep;39(5):769-779
TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids.
Wang N, Si C, Xia L, Wu X, Zhao S, Xu H, Ding Z, Niu Z
Reproductive biology and endocrinology : RB&E 2021 Sep 9;19(1):139
Reproductive biology and endocrinology : RB&E 2021 Sep 9;19(1):139
Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic-pituitary-adrenal/ovary axis and activating BDNF- TrkB-CREB signaling pathway.
Li J, He P, Zhang J, Li N
Phytotherapy research : PTR 2021 Oct;35(10):5795-5807
Phytotherapy research : PTR 2021 Oct;35(10):5795-5807
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
Xi H, Ren F, Li Y, Du Y, Wang L, Hu J
Biology of reproduction 2021 Nov 15;105(5):1344-1354
Biology of reproduction 2021 Nov 15;105(5):1344-1354
LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.
Li D, Wang X, Li G, Dang Y, Zhao S, Qin Y
Cell death discovery 2021 May 16;7(1):107
Cell death discovery 2021 May 16;7(1):107
The function of BAP18 on modulation of androgen receptor action in luteinized granulosa cells from normal weight women with and without PCOS.
Tang T, Jiao J, Li D, Sun G, Lin L, Wang C, Wang S, Zou R, Liu W, Zhao Y, Wang X
Molecular and cellular endocrinology 2021 May 1;527:111228
Molecular and cellular endocrinology 2021 May 1;527:111228
Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway.
Liu H, Jiang C, La B, Cao M, Ning S, Zhou J, Yan Z, Li C, Cui Y, Ma X, Wang M, Chen L, Yu Y, Chen F, Zhang Y, Wu H, Liu J, Qin L
Stem cell research & therapy 2021 Jun 2;12(1):317
Stem cell research & therapy 2021 Jun 2;12(1):317
FSH directly regulates chondrocyte dedifferentiation and cartilage development.
Wang Y, Zhang M, Huan Z, Shao S, Zhang X, Kong D, Xu J
The Journal of endocrinology 2021 Feb;248(2):193-206
The Journal of endocrinology 2021 Feb;248(2):193-206
CXCL12 and its receptors regulate granulosa cell apoptosis in PCOS rats and human KGN tumor cells.
Jin L, Ren L, Lu J, Wen X, Zhuang S, Geng T, Zhang Y
Reproduction (Cambridge, England) 2021 Feb;161(2):145-157
Reproduction (Cambridge, England) 2021 Feb;161(2):145-157
Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.
Wang Y, Li N, Zeng Z, Tang L, Zhao S, Zhou F, Zhou L, Xia W, Zhu C, Rao M
Molecular human reproduction 2021 Feb 5;27(2)
Molecular human reproduction 2021 Feb 5;27(2)
After cyclophosphamide exposure, granulosa cells recover their anti-müllerian hormone-producing ability but not their numbers.
Kim J, You S
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2021 Aug;99(8):807-813
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2021 Aug;99(8):807-813
Role of FSH and FSH receptor on HUVECs migration.
Tan D, Zhao Y, Ma D, Tong F
Gene therapy 2021 Apr;28(3-4):155-161
Gene therapy 2021 Apr;28(3-4):155-161
Synergistic effect of Huyang Yangkun Formula and embryonic stem cells on 4-vinylcyclohexene diepoxide induced premature ovarian insufficiency in mice.
Li M, Xie L, Li Y, Liu J, Nie G, Yang H
Chinese medicine 2020;15:83
Chinese medicine 2020;15:83
Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
Hayashi S, Nakamura T, Motooka Y, Ito F, Jiang L, Akatsuka S, Iwase A, Kajiyama H, Kikkawa F, Toyokuni S
Redox biology 2020 Oct;37:101726
Redox biology 2020 Oct;37:101726
Effects of Osthole on Progesterone Secretion in Chicken Preovulatory Follicles Granulosa Cells.
Sun N, Zhang Y, Hou Y, Yi Y, Guo J, Zheng X, Sun P, Sun Y, Khan A, Li H
Animals : an open access journal from MDPI 2020 Nov 4;10(11)
Animals : an open access journal from MDPI 2020 Nov 4;10(11)
Chlorogenic acid rescues zearalenone induced injury to mouse ovarian granulosa cells.
Yi Y, Wan S, Hou Y, Cheng J, Guo J, Wang S, Khan A, Sun N, Li H
Ecotoxicology and environmental safety 2020 May;194:110401
Ecotoxicology and environmental safety 2020 May;194:110401
Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway.
Liu M, Qiu Y, Xue Z, Wu R, Li J, Niu X, Yuan J, Wang Y, Wu Q
Stem cell research & therapy 2020 Jan 3;11(1):3
Stem cell research & therapy 2020 Jan 3;11(1):3
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.
Yin N, Wu C, Qiu J, Zhang Y, Bo L, Xu Y, Shi M, Zhu S, Yang G, Mao C
Stem cell research & therapy 2020 Feb 4;11(1):49
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Journal of assisted reproduction and genetics 2019 Jun;36(6):1185-1194
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Scientific reports 2015 Sep 11;5:13983
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FSHR antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FSHR. This antibody recognizes human, mouse antigen. The FSHR antibody has been validated for the following applications: ELISA, WB analysis.
