VEGFB

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

Description

Vascular endothelial growth factor B

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

11 (64234584 - 64239264)

Ensembl ID

ENSG00000173511  (ver. 103.38)

Orthologs

Mouse Vegfb: ENSMUSG00000024962

UniProt

P49765

neXtProt

NX_P49765

Human splice variants
Mouse splice variants

Protein structure