Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 348402 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#348402, RRID:AB_10588013
- Product name
- Purified anti-human CD317 (BST2, Tetherin)
- Antibody type
- Monoclonal
- Antigen
- CD317
- Description
- CD317, also known as BST2, Tetherin, and HM1.24, is a type II transmembrane GPI-protein with a molecular weight of about 29-33 kD. It is an interferon-induced protein expressed on dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells, and some non-hematopoietic cells. BST2 inhibits cytokine production through interaction with ILT7 (CD85g). It is also involved in the regulation of B cell growth. More importantly, BST2 has been found to restrict the release of a number of viruses from infected cells, including all tested retroviruses (such as HIV-1) and some arenaviruses and filoviruses. In HIV-1 studies, it has been reported that BST2 retains the nascent virons on the surface of infected cells by incorporation of the protein into HIV-1 particles. HIV-1 Vpu is able to induce BST2 degradation.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Antibody-mediated enhancement of HIV-1 and HIV-2 production from BST-2/tetherin-positive cells.
Miyagi E, Andrew A, Kao S, Yoshida T, Strebel K
Journal of virology 2011 Nov;85(22):11981-94
Journal of virology 2011 Nov;85(22):11981-94
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood monocytes stained with RS38E APC
- Conjugate
- Unconjugated