Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 348410 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#348410, RRID:AB_2067121
- Product name
- APC anti-human CD317 (BST2, Tetherin)
- Antibody type
- Monoclonal
- Antigen
- CD317
- Description
- CD317, also known as BST2, Tetherin, and HM1.24, is a type II transmembrane GPI-protein with a molecular weight of about 29-33 kD. It is an interferon-induced protein expressed on dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells, and some non-hematopoietic cells. BST2 inhibits cytokine production through interaction with ILT7 (CD85g). It is also involved in the regulation of B cell growth. More importantly, BST2 has been found to restrict the release of a number of viruses from infected cells, including all tested retroviruses (such as HIV-1) and some arenaviruses and filoviruses. In HIV-1 studies, it has been reported that BST2 retains the nascent virons on the surface of infected cells by incorporation of the protein into HIV-1 particles. HIV-1 Vpu is able to induce BST2 degradation.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice.
Sato K, Misawa N, Fukuhara M, Iwami S, An DS, Ito M, Koyanagi Y
Journal of virology 2012 May;86(9):5000-13
Journal of virology 2012 May;86(9):5000-13
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood monocytes stained with RS38E APC
- Conjugate
- Red dye