12369-1-AP

antibody from Proteintech Group

Targeting: SORT1 Gp95, NT3

Provider product page for 12369-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

Submit

Product number: 12369-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12369-1-AP, RRID:AB_2302242
Product name: Sortilin antibody
Antibody type: Polyclonal
Description: KD/KO validated Sortilin antibody (Cat. #12369-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SORT1 protein structure - 12369-1-AP shown in red.

Submitted references Sortilin is Associated with PGRN-Mediated Endoplasmic Reticulum Stress and Activation of Microglia in a Rat Model of Degenerative Cervical Myelopathy.

Lei L, Wang X, Zhang J, Zhao J
Neuromolecular medicine 2026 Apr 25;28(1)

RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.

Huo Y, Zhao D, Zhu X, Zheng N, Yang D, Meng J, Chen Y, Zhang YW
Theranostics 2025;15(4):1338-1352

Dysfunctional Decidual CD4(+)T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation.

Cui L, Meng X, Luo Y, Qian J, Sun F, Qiu M, Wang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(38):e00971

EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis.

Ma F, Longo M, Meroni M, Bhattacharya D, Paolini E, Mughal S, Hussain S, Anand SK, Gupta N, Zhu Y, Navarro-Corcuera A, Li K, Prakash S, Cogliati B, Wang S, Huang X, Wang X, Yurdagul A Jr, Rom O, Wang L, Fried SK, Dongiovanni P, Friedman SL, Cai B
Cell metabolism 2025 May 6;37(5):1152-1170.e7

Astragalin-functionalized ultrasmall nanoparticles modulate the complement pathway to inhibit microglial synaptic phagocytosis for reducing anesthetic neurotoxicity.

Wang G, Han Y, Peng K, Jiang Z, Wang T, Zheng Q, Li W, Xu H, Ji F, Li Z
Materials today. Bio 2025 Jun;32:101714

Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway.

Wu Q, Zhou Y, Ou C, Gao Z, Wu X, Zhao Y, Wang Y, Wu Z, Yu H
Brain and behavior 2025 Feb;15(2):e70328

Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients.

Tongu Y, Kasahara T, Akiyama Y, Suzuki T, Ho HJ, Matsumoto Y, Kujirai R, Kikuchi K, Nata K, Kanzaki M, Suzuki K, Watanabe S, Kawabe C, Miyata Y, Itai S, Toyohara T, Suzuki C, Tanaka T, Wada J, Tomioka Y, Abe T
Scientific reports 2025 Feb 17;15(1):5762

Sortilin-1, Targeted by miR-146a, Regulates the Behavior of Non-Small Cell Lung Cancer.

Lin X, Yan Z, Hai L, Niu Y, Wen JX, Zhu HZ, Yan C, Cha SN, Yan L, Zheng WQ, Zhang M, Hu ZD
Thoracic cancer 2025 Aug;16(15):e70129

P75(NTR) activation limits CD21(lo) B cell subsets expansion in response to autoimmune-inducing challenges.

Luo C, Zha AH, Luo RY, Hu ZL, Shen WY, Dai RP
iScience 2025 Aug 15;28(8):113055

Impaired chaperone-mediated autophagy leads to abnormal SORT1 (sortilin 1) turnover and CES1-dependent triglyceride hydrolysis.

Choi YJ, Nam YA, Hyun JY, Yu J, Mun Y, Yun SH, Lee W, Park CJ, Han BW, Lee BH
Autophagy 2025 Apr;21(4):827-839

Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice.

Yang M, Ge J, Liu YL, Wang HY, Wang ZH, Li DP, He R, Xie YY, Deng HY, Peng XM, Wang WS, Liu JD, Zhu ZZ, Yu XF, Maretich P, Kajimura S, Pan RP, Chen Y
Nature communications 2024 Sep 5;15(1):7746

Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats.

Wu Z, Yang Y, Wang M
Journal of orthopaedic surgery and research 2024 Mar 20;19(1):192

Identification and experimental verification of immune-related hub genes in intervertebral disc degeneration.

Huang Z, Cai X, Shen X, Chen Z, Zhang Q, Liu Y, Lu B, Xu B, Li Y
Heliyon 2024 Jul 30;10(14):e34530

Single-cell RNA-Seq reveals the heterogeneity of fibroblasts within the tympanojugular paraganglioma microenvironment.

Wang S, Zhang B, Lou Z, Hu Y, Wang J, Wang J, Chen Z, Yin S
Heliyon 2024 Aug 15;10(15):e35478

Inductive effect of SORT1 on odontoblastic differentiation of human dental pulp-derived stem cells.

Omagari D, Toriumi T, Tsuda H, Hayatsu M, Watanabe K, Mizutami Y, Honda M, Mikami Y
Differentiation; research in biological diversity 2023 Sep-Oct;133:88-97

Time-resolved single-cell transcriptomics reveals the landscape and dynamics of hepatic cells in sepsis-induced acute liver dysfunction.

Chen G, Ren C, Xiao Y, Wang Y, Yao R, Wang Q, You G, Lu M, Yan S, Zhang X, Zhang J, Yao Y, Zhou H
JHEP reports : innovation in hepatology 2023 Jun;5(6):100718

ProBDNF Upregulation in Murine Hind Limb Ischemia Reperfusion Injury: A Driver of Inflammation.

Aby K, Antony R, Li Y
Biology 2023 Jun 24;12(7)

Sortilin acts as an endocytic receptor for α-synuclein fibril.

Ishiyama S, Hasegawa T, Sugeno N, Kobayashi J, Yoshida S, Miki Y, Wakabayashi K, Fukuda M, Kawata Y, Nakamura T, Sato K, Ezura M, Kikuchi A, Takeda A, Aoki M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jul;37(7):e23017

Obata H, Naito K, Kikui A, Nakamura S, Suzuki K, Kawakita S, Suzuki T, Goto K, Nagura N, Sugiyama Y, Nagaoka I, Ishijima M
Experimental and therapeutic medicine 2022 Nov;24(5):682

Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion.

Black HL, Livingstone R, Mastick CC, Al Tobi M, Taylor H, Geiser A, Stirrat L, Kioumourtzoglou D, Petrie JR, Boyle JG, Bryant NJ, Gould GW
Journal of cell science 2022 Dec 1;135(1)

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis.

Camus SM, Camus MD, Figueras-Novoa C, Boncompain G, Sadacca LA, Esk C, Bigot A, Gould GW, Kioumourtzoglou D, Perez F, Bryant NJ, Mukherjee S, Brodsky FM
The Journal of cell biology 2020 Jan 6;219(1)

Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.

Xiao Y, Yan W, Lu Y, Zhou K, Cai W
EBioMedicine 2018 Sep;35:133-141

Prions amplify through degradation of the VPS10P sorting receptor sortilin.

Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das NR, Nykjaer A, Sakaguchi S
PLoS pathogens 2017 Jun;13(6):e1006470

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.

Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB
Proceedings of the National Academy of Sciences of the United States of America 2017 Dec 19;114(51):E11029-E11036

Mapping of the N-linked glycoproteome of human spermatozoa.

Wang G, Wu Y, Zhou T, Guo Y, Zheng B, Wang J, Bi Y, Liu F, Zhou Z, Guo X, Sha J
Journal of proteome research 2013 Dec 6;12(12):5750-9

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 12369-1-AP(SORT1 antibody) at dilution of 1:1200
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Sortilin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Sortilin. This antibody recognizes human,mouse,rat antigen. The Sortilin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12369-1-AP.pdf

: Show more