RA0698

antibody from Oursmab

Targeting: SORT1 Gp95, NT3

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0698

Provider

Oursmab

Product name

Latozinemab (Biosimilar Reference Antibody) (SORT1)

Antibody type

Monoclonal

Description

Latozinemab (also known as AL-001) is an investigational, human monoclonal antibody designed to target progranulin (PGRN), a key regulatory glycoprotein. It functions as a progranulin elevator by binding to and inhibiting the sortilin-1 (SORT1) receptor, which is responsible for the cellular uptake and lysosomal degradation of progranulin. By blocking this clearance pathway, Latozinemab aims to increase levels of functional progranulin in the brain and peripheral tissues. It is currently in clinical development for the treatment of frontotemporal dementia with progranulin gene mutations (FTD-GRN), a condition characterized by haploinsufficiency and abnormally low progranulin levels.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.