BS8382

antibody from Bioworld Technology, Inc

Targeting: RGS3 C2PA, FLJ20370, PDZ-RGS3

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS8382

Provider

Bioworld Technology, Inc

Product name

RGS3 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human RGS3.

Description

Heterotrimeric G proteins function to relay information from cell surface receptors to various intracellular effectors. G proteins comprise a, b and g subunits, and following activation, the a subunit binds GTP and dissociates from the bg complex. A large group of proteins have been identified as GTPase-activating proteins (GAPs), including the RGS (regulator of G protein signaling) family, which serve to deactivate specific Ga isoforms by increasing the rate at which they convert GTP to GDP. RGS3 is a protein of the RGS family that preferentially binds to the activated form of Ga11. Through this association, RGS3 inhibits Ga11-induced signaling, leading to a decrease in the accumulation of intracellular calcium and the inhibition of MAP kinase phosphorylation. RGS3 is highly expressed in adult kidney and myocardium, and it is primarily localized to the cytoplasm. Upon activation of Ga11, RGS3 translocates from the cytosol to the plasma membrane, thereby bringing RGS3 within close proximity to the targeted G protein.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.