15539-1-AP

antibody from Proteintech Group

Targeting: KRT7 CK7, K2C7, K7, SCL

Provider product page for 15539-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [39]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 15539-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15539-1-AP, RRID:AB_2249769
Product name: Cytokeratin 7 antibody
Antibody type: Polyclonal
Description: Cytokeratin 7 antibody (Cat. #15539-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

KRT7 protein structure - 15539-1-AP shown in red.

Submitted references Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta-on-a-Chip Model.

Liu H, Wang Y, Cai Y, Guo R, Liu S, Chen T, Sun T, Huo R, Liu T, Lv Q, Wang X
Advanced healthcare materials 2026 May;15(18):e04027

Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway.

You H, Li LG, Xiao CY, Wang X, Kong C, Leng F, Bai XF, Han N, Li TF, Wang MF
Molecular pharmaceutics 2026 May 4;23(5):3131-3145

Total astragalus saponins enhance the anti-liver fibrosis efficacy of Numb-overexpressed hUC-MSCs through stabilizing the Numb-p53 axis.

Zhang SH, Yang MY, Xu YN, Xing FF, Zhan JY, Wang DX, Chen JM, Chen GF, Liu P, Liu W, Mu YP
Journal of ethnopharmacology 2026 Mar 1;358:120980

Reduced Wiskott-Aldrich syndrome protein expression in preeclampsia placenta impairs trophoblast syncytialization by modulating syncytin-2 via FAK/β-catenin pathway.

Zhang S, Wang J, Ge Y, Cao P, Bai Z, Shen H, Wang D, Qiao C
Frontiers in cell and developmental biology 2025;13:1678878

Comparison of clinical manifestations and immunoreactivities of Meckel's diverticulum with and without gastric heteroplasia.

Zhang TT, Zhou XG, Cai P, Zhang RY, Zhu ZW
Frontiers in pediatrics 2025;13:1617214

Reduced level of BMI1 inhibits trophoblast proliferation and migration via the epigenetic enhancement of CSTA and TGFB2 in spontaneous abortion.

Li H, Wang G, Meng Q, Zhu R, Liu M, Zhang X, Wang J, Li H
Placenta 2025 Sep;169:82-93

Blue light pollution induces dry eye by damaging conjunctival stem cells through cAMP-PKA-Pax6 signaling pathway.

Zhang L, Zhang M, Zhong M, Zhang P, Yang H, Qian Y, Wang Z, Li Q
Ecotoxicology and environmental safety 2025 Sep 15;303:118984

Numb-exon3 and full length Numb equivalently alleviate cholestatic liver fibrosis by inhibiting ductular reaction.

Xu YN, Zong MY, Xu W, Zhang SH, Wang DY, Zheng XR, Xing FF, Zhan JY, Chen JM, Chen GF, Liu P, Liu W, Mu YP
Scientific reports 2025 Nov 14;15(1):39983

Pasteurized Akkermansia muciniphila ameliorates preeclampsia via inhibiting mitochondrial dysfunction-mediated placental apoptosis in vivo and in vitro.

Wang H, Wang Y, Zhong Y, Yu B, Liu D, Jia C, Wu J, Zeng G, Wang Q, Liu F, Sheng C, Huang L
Free radical biology & medicine 2025 Jul;234:233-247

Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.

Cheng J, Zhang S, Gui Q, Pu Z, Chen Z, Wei Q, Qi H, Zhang J
Nature communications 2025 Jul 25;16(1):6850

Toll-like receptor 4 inhibition by pyridostigmine is associated with a reduction in hypertension and inflammation in rat models of preeclampsia.

Ali MA, Zeng M, Alkuhali AA, Zeng Z, Yuan M, Wang X, Liu X, Issotina Zibrila A, Liu J, Wang Z
Journal of hypertension 2025 Feb 1;43(2):336-350

Exploratory study on the role of Clonorchis sinensis infection in promoting cholangiocarcinoma progression.

Li S, Jiang Y, Kawanokuchi J, Deng X, Wu Y, Chen Y, Zeng L, Deng G, Li D, Zhan T, Liu D, Ma N, Tang Z
Parasites & vectors 2025 Dec 9;19(1):29

The cancer-testis lncRNA LINC01940 promotes gastric cancer malignant progression and chemoresistance by enhancing ribosome biogenesis via TAF15-mediated NOL11 SUMOylation.

Zang W, Fan D, Lu Z, Gao X, Xing D, Zhang G, Liu L, Yi J, Chen J, Hu Y, Xue W
Cellular & molecular biology letters 2025 Dec 16;31(1):14

OTUB2/NR4A1 restrains the development of preeclampsia by suppressing macrophage M1 polarization.

Wang Y, Wang Y, Tong F, Gao Q, Li B, Zhao Y
Communications biology 2025 Aug 29;8(1):1304

PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1.

Liu L, Liu L, Yue C, Du S, Liu J, Yu Z
Molecular medicine (Cambridge, Mass.) 2025 Apr 27;31(1):155

GelMA loaded with exosomes from human minor salivary gland organoids enhances wound healing by inducing macrophage polarization.

Qian J, Lu E, Xiang H, Ding P, Wang Z, Lin Z, Pan B, Zhang C, Zhao Z
Journal of nanobiotechnology 2024 Sep 6;22(1):550

A Novel Method to Repair Thin Endometrium and Restore Fertility Based on Menstruation-Derived Stem Cell.

Chen K, Wang H, Zhao X, Wang J, Jin Q, Tong X, Zheng S
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jun;31(6):1662-1673

PANoptosis subtypes predict prognosis and immune efficacy in gastric cancer.

Liu Z, Sun L, Peng X, Zhu J, Wu C, Zhu W, Huang C, Zhu Z
Apoptosis : an international journal on programmed cell death 2024 Jun;29(5-6):799-815

Combining TIGIT blockade with IL-15 stimulation is a promising immunotherapy strategy for lung adenocarcinoma.

Luo B, Sun Y, Zhan Q, Luo Y, Chen Y, Fu T, Yang T, Ren L, Xie Z, Situ X, Liu B, Tang K, Ke Z
Clinical and translational medicine 2024 Jan;14(1):e1553

Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men.

Wu PY, Van Scoyk M, McHale SS, Chou CF, Riddick G, Farouq K, Hu B, Kraskauskiene V, Koblinski J, Lyons C, Rijal A, Vudatha V, Zhang D, Trevino JG, Shah RD, Nana-Sinkam P, Huang Y, Ma SF, Noth I, Hughes-Halbert C, Seewaldt VL, Chen CY, Winn RA
iScience 2024 Feb 16;27(2):108858

α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation.

Wang H, Cui X, Wang L, Fan N, Yu M, Qin H, Liu S, Yan Q
Cell death & disease 2023 Oct 6;14(10):651

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis.

Wu Q, Liang Z, Jiang J, Feng X, Liu J, Zhang Z, Wang H, Wang N, Gou Y, Li Z, Cao Y
Cell death & disease 2023 Oct 11;14(10):668

Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture.

Zhai J, Xu Y, Wan H, Yan R, Guo J, Skory R, Yan L, Wu X, Sun F, Chen G, Zhao W, Yu K, Li W, Guo F, Plachta N, Wang H
Cell 2023 May 11;186(10):2078-2091.e18

BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction.

Xu YN, Xu W, Zhang X, Wang DY, Zheng XR, Liu W, Chen JM, Chen GF, Liu CH, Liu P, Mu YP
Stem cell research & therapy 2023 Mar 20;14(1):45

Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.

Pang H, Lei D, Huang J, Guo Y, Fan C
Molecular and cellular probes 2023 Feb;67:101896

Role of poFUT1 and O-fucosylation in placental angiogenesis†.

Liang C, Li Y, Qin H, Ramzan MN, Wang H, Liu S, Yan Q
Biology of reproduction 2023 Apr 11;108(4):553-563

Establishment and characterization of an immortalized epithelial cell line from human gallbladder.

Wang Z, Wang S, Jia Z, Zhao Y, Yang M, Yan W, Chen T, Xiang D, Shao R, Liu Y
Frontiers in oncology 2022;12:994087

[Overexpression of Numb gene can inhibit the progression of biliary liver fibrosis in adult liver].

Xu YN, Xu W, Chen JM, Liu W, Chen GF, Zhang H, Liu P, Mu YP
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2022 Nov 20;30(11):1175-1181

CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.

Tan J, Xu T, Gou Y, Wang H, Liang Z, Cao Y, Wang H, Yu Y, Jiao N, Zhang Z
Stem cell research & therapy 2022 Jul 15;13(1):294

CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion.

Zhang S, Ding J, Wang J, Yin T, Zhang Y, Yang J
Frontiers in immunology 2021;12:717483

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations.

Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF
Cancer cell 2021 Jun 14;39(6):866-882.e11

A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus.

Blaine-Sauer S, Shin MK, Matkowskyj KA, Ward-Shaw E, Lambert PF
mBio 2021 Aug 31;12(4):e0161121

Establishment of human trophoblast stem cells from human induced pluripotent stem cell-derived cystic cells under micromesh culture.

Li Z, Kurosawa O, Iwata H
Stem cell research & therapy 2019 Aug 7;10(1):245

Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7.

Zheng J, Wang H, Zhou W
Reproductive biology and endocrinology : RB&E 2018 Mar 2;16(1):17

Pravastatin alleviates lipopolysaccharide-induced placental TLR4 over-activation and promotes uterine arteriole remodeling without impairing rat fetal development.

Yang MY, Diao ZY, Wang ZY, Yan GJ, Zhao GF, Zheng MM, Dai AY, Dai YM, Hu YL
Journal of biomedical research 2018 Jul 23;32(4):288-297

Huang Qi Decoction Prevents BDL-Induced Liver Fibrosis Through Inhibition of Notch Signaling Activation.

Zhang X, Xu Y, Chen JM, Liu C, Du GL, Zhang H, Chen GF, Jiang SL, Liu CH, Mu YP, Liu P
The American journal of Chinese medicine 2017;45(1):85-104

Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity.

Yamaleyeva LM, Pulgar VM, Lindsey SH, Yamane L, Varagic J, McGee C, daSilva M, Lopes Bonfa P, Gurley SB, Brosnihan KB
American journal of physiology. Endocrinology and metabolism 2015 Jul 1;309(1):E84-94

Astragaloside prevents BDL-induced liver fibrosis through inhibition of notch signaling activation.

Yongping M, Zhang X, Xuewei L, Fan W, Chen J, Zhang H, Chen G, Liu C, Liu P
Journal of ethnopharmacology 2015 Jul 1;169:200-9

LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface.

Liu S, Wang J, Qin HM, Yan XM, Yang XS, Liu C, Yan Q
Cell death & disease 2014 Aug 28;5(8):e1396

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 15539-1-AP(KRT7 antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using KRT7 antibody 15539-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line