14937-1-AP

antibody from Proteintech Group

Targeting: SLC22A12 OAT4L, RST, URAT1

Provider product page for 14937-1-AP

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ELISA

Antibody data

Antibody Data
Antigen structure
References [72]
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Product number: 14937-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14937-1-AP, RRID:AB_2191270
Product name: URAT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated URAT1 antibody (Cat. #14937-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, pig, rat and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC22A12 protein structure - 14937-1-AP shown in red.

Submitted references The impact of chrysanthemi indici flos-enriched flavonoid part on the model of hyperuricemia based on inhibiting synthesis and promoting excretion of uric acid.

Jiao L, Wang R, Dong Y, Su J, Yu J, Yan M, Chen S, Lv G
Journal of ethnopharmacology 2024 Oct 28;333:118488

Piperine Improves Hyperuricemic Nephropathy by Inhibiting URAT1/GLUT9 and the AKT-mTOR Pathway.

Li L, Zhao K, Luo J, Tian J, Zheng F, Lin X, Xie Z, Jiang H, Li Y, Zhao Z, Wu T, Pang J
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6565-6574

Catalpol ameliorates fructose-induced renal inflammation by inhibiting TLR4/MyD88 signaling and uric acid reabsorption.

Chen Y, Liu Q, Meng X, Zhao L, Zheng X, Feng W
European journal of pharmacology 2024 Mar 15;967:176356

Xanthoceras sorbifolium leaves alleviate hyperuricemic nephropathy by inhibiting the PI3K/AKT signaling pathway to regulate uric acid transport.

Liu Y, Han Y, Liu Y, Huang C, Feng W, Cui H, Li M
Journal of ethnopharmacology 2024 Jun 12;327:117946

Eupatilin inhibits xanthine oxidase in vitro and attenuates hyperuricemia and renal injury in vivo.

Xu G, Wu L, Yang H, Liu T, Tong Y, Wan J, Han B, Zhou L, Hu X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jan;183:114307

Integrating multi-level interactive network and in vivo/vitro studies to explore the protective mechanism of Ampelopsis grossedentata in hyperuricemia.

Zhou QX, Zhou Q, Zhang P, Xie YQ, Yang ZY, Tan WH, Khan A, Duan WG, Zhou ZH, Liu L
Fitoterapia 2024 Jan;172:105718

Chinese Sumac (Rhus chinensis Mill.) Fruits Prevent Hyperuricemia and Uric Acid Nephropathy in Mice Fed a High-Purine Yeast Diet.

Ma N, Cai S, Sun Y, Chu C
Nutrients 2024 Jan 5;16(2)

Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.

Du J, Wang N, Yu D, He P, Gao Y, Tu Y, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155305

Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats.

Xu R, Deng P, Ma Y, Li K, Ren F, Li N
Metabolites 2024 Feb 10;14(2)

Piper longum L. ameliorates gout through the MAPK/PI3K-AKT pathway.

Wu C, Zhang Z, Bai L, Lei S, Zou M, Bao Z, Ren Z, Liu K, Gong HH, Ma W, Chen L
Journal of ethnopharmacology 2024 Aug 10;330:118254

Punicalagin attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions.

Han QQ, Ren QD, Guo X, Farag MA, Zhang YH, Zhang MQ, Chen YY, Sun ST, Sun JY, Li NY, Liu C
Journal of advanced research 2024 Apr 10;

Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter α/β to reduce bile acids reabsorption.

Zhao X, Yang T, Zhou J, Chen Y, Shen Q, Zhang J, Qiu Q
Current research in pharmacology and drug discovery 2023;5:100159

Eurycoma longifolia alkaloid components ameliorate hyperuricemic nephropathy via regulating serum uric acid level and relieving inflammatory reaction.

Wang D, Liu L, Li K, Cao H, Liu M, Chen Q, Wu Y, Zhang Y, Wang T
Journal of natural medicines 2023 Sep;77(4):867-879

Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.

Zhang Y, Li Y, Li C, Zhao Y, Xu L, Ma S, Lin F, Xie Y, An J, Wang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154957

URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.

Tanaka Y, Nagoshi T, Takahashi H, Oi Y, Yasutake R, Yoshii A, Kimura H, Kashiwagi Y, Tanaka TD, Shimoda M, Yoshimura M
iScience 2023 Sep 15;26(9):107730

Whey protein peptides PEW and LLW synergistically ameliorate hyperuricemia and modulate gut microbiota in potassium oxonate and hypoxanthine-induced hyperuricemic rats.

Qi X, Guan K, Liu C, Chen H, Ma Y, Wang R
Journal of dairy science 2023 Nov;106(11):7367-7381

Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.

Guo XL, Gao YY, Yang YX, Zhu QF, Guan HY, He X, Zhang CL, Wang Y, Xu GB, Zou SH, Wei MC, Zhang J, Zhang JJ, Liao SG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154868

Oxyberberrubine, a novel liver microsomes-mediated secondary metabolite of berberine, alleviates hyperuricemic nephropathy in mice.

Zhong L, Lin Y, Gong S, Wu X, Liu Y, Chen J, Li Y, Yan F, Su Z, Xie Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154521

Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis.

Ai G, Huang R, Xie J, Zhong L, Wu X, Qin Z, Su Z, Chen J, Yang X, Dou Y
Journal of ethnopharmacology 2023 Jan 30;301:115775

Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway.

Wang JC, Tsai SH, Tsai HY, Lin SJ, Huang PH
BMC cardiovascular disorders 2023 Jan 30;23(1):55

Identification and Anti-Hyperuricemic Activity of Xanthine Oxidase Inhibitory Peptides from Pacific White Shrimp and Swimming Crab Based on Molecular Docking Screening.

Mao Z, Jiang H, Mao X
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1620-1627

Naringenin Ameliorates Hyperuricemia by Regulating Renal Uric Acid Excretion via the PI3K/AKT Signaling Pathway and Renal Inflammation through the NF-κB Signaling Pathway.

Yang B, Xin M, Liang S, Huang Y, Li J, Wang C, Liu C, Song X, Sun J, Sun W
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1434-1446

Multi-omics analysis reveals therapeutic effects of Bacillus subtilis-fermented Astragalus membranaceus in hyperuricemia via modulation of gut microbiota.

Wang R, Lin F, Ye C, Aihemaitijiang S, Halimulati M, Huang X, Jiang Z, Li L, Zhang Z
Food chemistry 2023 Jan 15;399:133993

Ferulic acid supplementation alleviates hyperuricemia in high-fructose/fat diet-fed rats via promoting uric acid excretion and mediating the gut microbiota.

Zhang N, Zhou J, Zhao L, Zhao Z, Wang S, Zhang L, Zhou F
Food & function 2023 Feb 6;14(3):1710-1725

Anti-Hyperuricemic Effect of Anserine Based on the Gut-Kidney Axis: Integrated Analysis of Metagenomics and Metabolomics.

Halimulati M, Wang R, Aihemaitijiang S, Huang X, Ye C, Zhang Z, Li L, Zhu W, Zhang Z, He L
Nutrients 2023 Feb 15;15(4)

The antihyperuricemia activity of Astragali Radix through regulating the expression of uric acid transporters via PI3K/Akt signalling pathway.

Zhang MQ, Sun KX, Guo X, Chen YY, Feng CY, Chen JS, Barreira JCM, Prieto MA, Sun JY, Zhang JD, Li NY, Liu C
Journal of ethnopharmacology 2023 Dec 5;317:116770

Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.

Hua L, Zhang S, Yang J, Zhou X, Shi S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114970

Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.

Zhang Y, Wang S, Dai X, Liu T, Liu Y, Shi H, Yin J, Xu T, Zhang Y, Zhao D, Sukhorukov V, Orekhov AN, Gao S, Wang L, Zhang D
Journal of ethnopharmacology 2023 Aug 10;312:116530

Diacylated anthocyanins from purple sweet potato (Ipomoeabatatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet.

Shen L, Yang Y, Zhang J, Feng L, Zhou Q
Journal of Zhejiang University. Science. B 2023 Apr 15;24(7):587-601

Berberine Attenuates Hyperuricemia by Regulating Urate Transporters and Gut Microbiota.

Shan B, Wu M, Chen T, Tang W, Li P, Chen J
The American journal of Chinese medicine 2022;50(8):2199-2221

Effects of polysaccharides-riched Prunus mume fruit juice concentrate on uric acid excretion and gut microbiota in mice with adenine-induced chronic kidney disease.

Huang Y, Wu CX, Guo L, Zhang XX, Xia DZ
Current research in food science 2022;5:2135-2145

Hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester in hyperuricemic mice through inhibiting XOD and down-regulating URAT1.

Yong T, Liang D, Xiao C, Huang L, Chen S, Xie Y, Gao X, Wu Q, Hu H, Li X, Liu Y, Cai M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113303

Live and pasteurized Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric acid metabolism, inflammation, and gut microbiota.

Zhang L, Liu J, Jin T, Qin N, Ren X, Xia X
Food & function 2022 Nov 28;13(23):12412-12425

Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway.

Liu T, Gao H, Zhang Y, Wang S, Lu M, Dai X, Liu Y, Shi H, Xu T, Yin J, Gao S, Wang L, Zhang D
Pharmaceuticals (Basel, Switzerland) 2022 Nov 21;15(11)

Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway.

Li MH, Guan J, Chen Z, Mo JX, Wu KR, Hu XG, Lan T, Guo J
Journal of ethnopharmacology 2022 Nov 15;298:115644

Effects of black tea and black brick tea with fungal growth on lowering uric acid levels in hyperuricemic mice.

Yuan D, Lin L, Peng Y, Zhou Y, Li L, Xiao W, Gong Z
Journal of food biochemistry 2022 Jul;46(7):e14140

URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice.

Tanaka Y, Nagoshi T, Takahashi H, Oi Y, Yoshii A, Kimura H, Ito K, Kashiwagi Y, Tanaka TD, Yoshimura M
Molecular metabolism 2022 Jan;55:101411

The Active Components of Sunflower (Helianthus annuus L.) Calathide and the Effects on Urate Nephropathy Based on COX-2/PGE2 Signaling Pathway and the Urate Transporter URAT1, ABCG2, and GLUT9.

Dai H, Lv S, Qiao Z, Wang K, Zhou X, Bao C, Zhang S, Fu X, Li W
Frontiers in nutrition 2021;8:769555

Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model.

Li Q, Huang Z, Liu D, Zheng J, Xie J, Chen J, Zeng H, Su Z, Li Y
Drug design, development and therapy 2021;15:3241-3254

Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.

Xu L, Lin G, Yu Q, Li Q, Mai L, Cheng J, Xie J, Liu Y, Su Z, Li Y
Frontiers in pharmacology 2021;12:645879

Low Expression Levels of SLC22A12 Indicates a Poor Prognosis and Progresses Clear Cell Renal Cell Carcinoma.

Xu J, Liu Y, Liu J, Shou Y, Xiong Z, Xiong H, Xu T, Wang Q, Liu D, Liang H, Yang H, Yang X, Zhang X
Frontiers in oncology 2021;11:659208

Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats.

Qi X, Chen H, Guan K, Wang R, Ma Y
Journal of the science of food and agriculture 2021 Sep;101(12):4916-4924

Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice.

Zhang CL, Zhang JJ, Zhu QF, Guan HY, Yang YX, He X, Fu Y, Chen TX, Dong L, Yang XS, Tang KF, Xu GB, Liao SG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153765

Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.

Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600

Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice.

Zhu JX, Yang HY, Hu WQ, Cheng J, Liu Y, Yi LT, Cheng HY
Inflammopharmacology 2021 Aug;29(4):1187-1200

Resveratrol affects the expression of uric acid transporter by improving inflammation.

Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)

Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway.

Chang YH, Chiang YF, Chen HY, Huang YJ, Wang KL, Hong YH, Ali M, Shieh TM, Hsia SM
Antioxidants (Basel, Switzerland) 2021 Apr 6;10(4)

Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats.

Kang L, Miao JX, Cao LH, Miao YY, Miao MS, Liu HJ, Xiang LL, Song YG
Journal of ethnopharmacology 2020 Oct 28;261:113054

Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.

Wang Y, Kong W, Wang L, Zhang T, Huang B, Meng J, Yang B, Xie Z, Zhou H
International journal of molecular sciences 2020 Oct 18;21(20)

The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity.

Wang G, Zuo T, Li R
Drug development research 2020 Nov;81(7):859-866

Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals.

Niu Y, Yang P, Li H, Li Q, Lin H, Gao L, Li L
Biological & pharmaceutical bulletin 2020 Nov 1;43(11):1653-1659

RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.

Liu N, Wang Y, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Li Y, Sun H, Yang M, Sun J, Yang X
Journal of agricultural and food chemistry 2020 Jul 8;68(27):7143-7151

Anti-hyperuricemic potential of stevia (Stevia rebaudiana Bertoni) residue extract in hyperuricemic mice.

Mehmood A, Zhao L, Ishaq M, Xin W, Zhao L, Wang C, Hossen I, Zhang H, Lian Y, Xu M
Food & function 2020 Jul 22;11(7):6387-6406

Discovery of a novel rice-derived peptide with significant anti-gout potency.

Liu N, Meng B, Zeng L, Yin S, Hu Y, Li S, Fu Y, Zhang X, Xie C, Shu L, Yang M, Wang Y, Yang X
Food & function 2020 Dec 1;11(12):10542-10553

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice.

Xu WH, Wang HT, Sun Y, Xue ZC, Liang ML, Su WK
The Journal of pharmacy and pharmacology 2020 Apr;72(4):551-560

Effects of Alismatis Rhizoma and Rhizoma Smilacis Glabrae Decoction on Hyperuricemia in Rats.

Cheng S, Sun H, Li X, Yan J, Peng Z, You Y, Zhang L, Chen J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:4541609

Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice.

Bao R, Liu M, Wang D, Wen S, Yu H, Zhong Y, Li Z, Zhang Y, Wang T
Frontiers in pharmacology 2019;10:1464

MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.

Zhou Z, Dong Y, Zhou H, Liu J, Zhao W
Biochemical and biophysical research communications 2019 Sep 24;517(3):413-420

Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.

Tan J, Wan L, Chen X, Li X, Hao X, Li X, Li J, Ding H
Molecular nutrition & food research 2019 Jun;63(12):e1801402

Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition.

Lin H, Tu C, Niu Y, Li F, Yuan L, Li N, Xu A, Gao L, Li L
European journal of pharmacology 2019 Jun 15;853:371-380

Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate.

Chau YT, Chen HY, Lin PH, Hsia SM
Marine drugs 2019 Jun 10;17(6)

Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes.

Zhang B, Duan M, Long B, Zhang B, Wang D, Zhang Y, Chen J, Huang X, Jiao Y, Zhu L, Zeng X
Molecular medicine reports 2019 Aug;20(2):1645-1654

Cordycepin, a Characteristic Bioactive Constituent in Cordyceps militaris, Ameliorates Hyperuricemia through URAT1 in Hyperuricemic Mice.

Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Jiao C, Zuo D
Frontiers in microbiology 2018;9:58

Hypouricemic Effects of Extracts From Agrocybe aegerita on Hyperuricemia Mice and Virtual Prediction of Bioactives by Molecular Docking.

Yong T, Chen S, Xie Y, Shuai O, Li X, Chen D, Su J, Jiao C, Liang Y
Frontiers in pharmacology 2018;9:498

Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.

Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Hu H, Zuo D, Liang D
The American journal of Chinese medicine 2018;46(3):585-599

Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9.

Zhou Y, Zhang X, Li C, Yuan X, Han L, Li Z, Tan X, Song J, Wang G, Jia X, Feng L, Qiao X, Liu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:434-442

Urate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson's disease.

Bao LH, Zhang YN, Zhang JN, Gu L, Yang HM, Huang YY, Xia N, Zhang H
Journal of neuroinflammation 2018 May 2;15(1):131

Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9.

Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Jiao C, Zuo D
Frontiers in pharmacology 2017;8:996

Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.

Zhang HJ, Li LN, Zhou J, Yang QQ, Liu PG, Xu P, Liang WQ, Cheng L, Zhang YQ, Pu JB, Hu YJ
Journal of ethnopharmacology 2017 May 5;203:304-311

Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model.

Jiang Y, Lin Y, Hu YJ, Song XJ, Pan HH, Zhang HJ
BMC complementary and alternative medicine 2017 Jun 17;17(1):320

Taurine decreased uric acid levels in hyperuricemic rats and alleviated kidney injury.

Feng Y, Sun F, Gao Y, Yang J, Wu G, Lin S, Hu J
Biochemical and biophysical research communications 2017 Jul 29;489(3):312-318

Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy.

Wu X, Zhang J, Liu T, Yan M, Liu H, Xie H, Zhang S, Sun B, Ke B, Zhou H
Journal of physiology and biochemistry 2015 Jun;71(2):217-26

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The URAT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human URAT1. This antibody recognizes human,mouse,rat antigen. The URAT1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14937-1-AP.pdf

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