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- Antibody Data
- Antigen structure
- References [324]
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- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 11451-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11451-1-AP, RRID:AB_2298729
- Product name
- NQO1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NQO1 antibody (Cat. #11451-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
A novel UVA-associated circUBE2I mediates ferroptosis in HaCaT cells.
Oxidised rice bran oil induced oxidative stress and apoptosis in IPEC-J2 cells via the Nrf2 signalling pathway.
Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Essential oil from Citrus depressa peel exhibits antimicrobial, antioxidant and cancer chemopreventive effects.
Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens.
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine.
Glycyrrhizin regulates antioxidation through Nrf2 signaling pathway in rat temporomandibular joint osteoarthritis.
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells.
Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway.
GAS41 modulates ferroptosis by anchoring NRF2 on chromatin.
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment.
The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo.
Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.
KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage.
Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways.
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis.
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Emodin ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through the remodeling of gut microbiota composition.
Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway.
Human umbilical cord mesenchymal stem cells protect MC3T3-E1 osteoblasts from dexamethasone-induced apoptosis via induction of the Nrf2-ARE signaling pathway.
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.
Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Inhaled aerosolized algal polysaccharides: A novel and reliable strategy for treating pneumonia through inflammation and oxidative stress inhibition.
Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Dental Pulp Stem Cells Ameliorate Elastase-Induced Pulmonary Emphysema by Regulating Inflammation and Oxidative Stress.
Risk factors for fatty pancreas and effects of fatty infiltration on pancreatic cancer.
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway.
Caffeoylquinic acids isolated from Lonicera japonica Thunb. as TAK1 inhibitors protects against LPS plus IFN-γ-stimulated inflammation by interacting with KEAP1-regulated NRF2 activation.
Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice.
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Aflatoxin B1 triggers apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway.
Taxifolin protects against doxorubicin-induced cardiotoxicity and ferroptosis by adjusting microRNA-200a-mediated Nrf2 signaling pathway.
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
Quercetin Attenuates the Combined Effects of Zearalenone and Lipopolysaccharide on IPEC-J2 Cell Injury through Activating the Nrf2 Signaling Pathway.
Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.
Autoregulatory control of mitochondrial glutathione homeostasis.
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.
A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression.
T Cell Nrf2/Keap1 Gene Editing Using CRISPR/Cas9 and Experimental Kidney Ischemia-Reperfusion Injury.
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.
ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer.
The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity.
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats.
Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy.
Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in hepatocytes.
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss.
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
Schisandrin B Improves the Hypothermic Preservation of Celsior Solution in Human Umbilical Cord Mesenchymal Stem Cells.
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury.
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism.
Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1.
Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer by targeting the NRF2/GPX4 signal axis to induce ferroptosis of drug-resistant human epithelial ovarian cancer cells.
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Protective effects of dietary dimethyl itaconate supplementation on oxidative stress, inflammation, and apoptosis in broilers under chronic heat stress.
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Amelioratory effects of astragaloside IV on hepatocarcinogenesis via Nrf2-mediated pSmad3C/3L transformation.
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway.
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury.
Protection of Human Lens Epithelial Cells from Oxidative Stress Damage and Cell Apoptosis by KGF-2 through the Akt/Nrf2/HO-1 Pathway.
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis.
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Caryophyllene Oxide Induces Ferritinophagy by Regulating the NCOA4/FTH1/LC3 Pathway in Hepatocellular Carcinoma.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota.
Berberine prevents lethal EV71 neurological infection in newborn mice.
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Type 2 Diabetes Mellitus Makes Corneal Endothelial Cells Vulnerable to Ultraviolet A-Induced Oxidative Damage Via Decreased DJ-1/Nrf2/NQO1 Pathway.
Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with high-energy and low-protein diets.
6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling.
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells.
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway.
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2.
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Early-life galacto-oligosaccharides supplementation alleviates the small intestinal oxidative stress and dysfunction of lipopolysaccharide-challenged suckling piglets.
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants.
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway.
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder.
Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat.
Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy.
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Ellagic Acid Alleviates Oxidative Stress by Mediating Nrf2 Signaling Pathways and Protects against Paraquat-Induced Intestinal Injury in Piglets.
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway.
Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway.
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
N-acetylcysteine promotes cyclic mechanical stress-induced osteogenic differentiation of periodontal ligament stem cells by down-regulating Nrf2 expression.
Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Relationship between Neuroprotective Effects and Structure of Procyanidins.
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis.
SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes.
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice.
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Resveratrol protects intestinal integrity, alleviates intestinal inflammation and oxidative stress by modulating AhR/Nrf2 pathways in weaned piglets challenged with diquat.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation.
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch.
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation.
Exosomes are involved in total body irradiation-induced intestinal injury in mice.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Tolerable upper intake level of iron damages the liver of weaned piglets.
Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway.
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis.
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.
Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation.
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl(4)-induced liver injury in vivo.
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351.
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets.
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Artemisinin attenuates early renal damage on diabetic nephropathy rats through suppressing TGF-β1 regulator and activating the Nrf2 signaling pathway.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke.
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Neuroprotective Effect of Dioscin on the Aging Brain.
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Lactobacillus helveticus KLDS1.8701 alleviates d-galactose-induced aging by regulating Nrf-2 and gut microbiota in mice.
Knockdown of Nrf2 inhibits angiogenesis by downregulating VEGF expression through PI3K/Akt signaling pathway in cerebral microvascular endothelial cells under hypoxic conditions.
Activation of the Nuclear Erythroid 2-Related Factor 2 Antioxidant Responsive Element (Nrf2-ARE) Signaling Pathway Alleviates Acute Graft-Versus-Host Disease by Reducing Oxidative Stress and Inhibiting Infiltration of Inflammatory Cells in an Allogeneic Stem Cell Transplantation Mouse Model.
Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice.
Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway.
Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes.
Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway.
The electrophilic character of quinones is essential for the suppression of Bach1.
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway.
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics.
Myricetin alleviates cuprizone-induced behavioral dysfunction and demyelination in mice by Nrf2 pathway.
Keap1 hypomorphism protects against ischemic and obstructive kidney disease.
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats.
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling.
Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
The decrease of NAD(P)H:quinone oxidoreductase 1 activity and increase of ROS production by NADPH oxidases are early biomarkers in doxorubicin cardiotoxicity.
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.
Clustering of plasma membrane-bound cytochrome b5 reductase within 'lipid raft' microdomains of the neuronal plasma membrane.
Wang H, Mao W, Zhang Y, Feng W, Bai B, Ji B, Chen J, Cheng B, Yan F
Free radical biology & medicine 2024 Sep;222:331-343
Free radical biology & medicine 2024 Sep;222:331-343
A novel UVA-associated circUBE2I mediates ferroptosis in HaCaT cells.
Yi P, Huang Y, Zhao X, Qin Z, Zhu D, Liu L, Zheng Y, Feng J, Long M
Photochemistry and photobiology 2024 Sep-Oct;100(5):1365-1377
Photochemistry and photobiology 2024 Sep-Oct;100(5):1365-1377
Oxidised rice bran oil induced oxidative stress and apoptosis in IPEC-J2 cells via the Nrf2 signalling pathway.
Wang R, Wang C, Chen P, Qi H, Zhang J
Journal of animal physiology and animal nutrition 2024 Nov;108(6):1844-1855
Journal of animal physiology and animal nutrition 2024 Nov;108(6):1844-1855
Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
Huang W, Wu D, Cai C, Yao H, Tian Z, Yang Y, Pang M, Rong L, Liu B
Redox biology 2024 May;71:103104
Redox biology 2024 May;71:103104
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Chen X, Wang B, Zhou Y, Wu X, Du A, Al Mamun A, Xu Y, Wang S, Jiang C, Xie L, Zhou K, Hu S, Xiao J
Advanced healthcare materials 2024 May;13(12):e2303462
Advanced healthcare materials 2024 May;13(12):e2303462
Essential oil from Citrus depressa peel exhibits antimicrobial, antioxidant and cancer chemopreventive effects.
Weng YX, Wang HC, Chu YL, Wu YZ, Liao JA, Su ZY
Journal of the science of food and agriculture 2024 May;104(7):3982-3991
Journal of the science of food and agriculture 2024 May;104(7):3982-3991
Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens.
Fan Y, Zhou W, Li G, Liu X, Zhong P, Liu K, Liu Y, Wang D
Poultry science 2024 May;103(5):103541
Poultry science 2024 May;103(5):103541
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
Liu X, Liu R, Wang Y
Biochemical and biophysical research communications 2024 May 28;710:149880
Biochemical and biophysical research communications 2024 May 28;710:149880
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.
Wang Y, Fu X, Zeng L, Hu Y, Gao R, Xian S, Liao S, Huang J, Yang Y, Liu J, Jin H, Klaunig J, Lu Y, Zhou S
Communications biology 2024 May 23;7(1):621
Communications biology 2024 May 23;7(1):621
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Lu P, Li S, Zhang C, Jiang X, Xiang J, Xu H, Dong J, Wang K, Shi Y
European journal of histochemistry : EJH 2024 May 22;68(2)
European journal of histochemistry : EJH 2024 May 22;68(2)
Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine.
Guan T, Li N, Xu X, Xiong D, Wang B, Xiao L, Yang W, Chu G, Yusuf A, Zhang J, Yue W
Archives of biochemistry and biophysics 2024 Mar;753:109928
Archives of biochemistry and biophysics 2024 Mar;753:109928
Glycyrrhizin regulates antioxidation through Nrf2 signaling pathway in rat temporomandibular joint osteoarthritis.
Hu Z, Zhao J, Liu X, Li Y, Jiang H, Fang W, Long X
Journal of oral rehabilitation 2024 Mar;51(3):611-622
Journal of oral rehabilitation 2024 Mar;51(3):611-622
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Miao L, Wang ST, Wei QH, Ma RF, Zhang H
Phytochemistry 2024 Mar;219:113984
Phytochemistry 2024 Mar;219:113984
Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells.
Li J, Zhu J, Gray O, Sobreira DR, Wu D, Huang RT, Miao B, Sakabe NJ, Krause MD, Kaikkonen MU, Romanoski CE, Nobrega MA, Fang Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway.
Liu H, Lu Q
International journal of molecular sciences 2024 Mar 27;25(7)
International journal of molecular sciences 2024 Mar 27;25(7)
GAS41 modulates ferroptosis by anchoring NRF2 on chromatin.
Wang Z, Yang X, Chen D, Liu Y, Li Z, Duan S, Zhang Z, Jiang X, Stockwell BR, Gu W
Nature communications 2024 Mar 21;15(1):2531
Nature communications 2024 Mar 21;15(1):2531
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment.
Yi T, Liu Z, Jia H, Liu Q, Peng J
Iranian journal of immunology : IJI 2024 Mar 12;21(1):37-52
Iranian journal of immunology : IJI 2024 Mar 12;21(1):37-52
The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo.
Yuan W, Ji G, Shi X, Sun Z, Liu C, Yu Y, Li W, Wang X, Hu H
Ecotoxicology and environmental safety 2024 Jun 15;278:116465
Ecotoxicology and environmental safety 2024 Jun 15;278:116465
Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.
Wen Y, Deng S, Wang B, Zhang F, Luo T, Kuang H, Kuang X, Yuan Y, Huang J, Zhang D
Ecotoxicology and environmental safety 2024 Jun 15;278:116439
Ecotoxicology and environmental safety 2024 Jun 15;278:116439
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Yang J, Zhang Z, Du X, Wang Y, Meng R, Ge K, Wu C, Liang X, Zhang H, Guo H
Environmental research 2024 Jul 1;252(Pt 4):119113
Environmental research 2024 Jul 1;252(Pt 4):119113
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Chen L, Qi E, Liu X, Cui L, Fan X, Wei T, Hu Y
Toxicology and applied pharmacology 2024 Jan;482:116766
Toxicology and applied pharmacology 2024 Jan;482:116766
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.
Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, Liang C, Yang Y, Fu X, Zhang Y, Liu J, Shi S, Cong J, Han Z, Xu Y, Du L, Yin C, Zhang Y, Sun J, Gu W, Chai R, Zhu S, Chu B
Nature cell biology 2024 Jan;26(1):124-137
Nature cell biology 2024 Jan;26(1):124-137
KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage.
Ergashev A, Shi F, Liu Z, Pan Z, Xie H, Kong L, Wu L, Sun H, Jin Y, Kong H, Geng D, Ibrohimov A, Obeng E, Wang Y, Ma F, Chen G, Zhang T
Free radical biology & medicine 2024 Jan;210:130-145
Free radical biology & medicine 2024 Jan;210:130-145
Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways.
Chen J, Zhou Z, Wu N, Li J, Xi N, Xu M, Wu F, Fu Q, Yan G, Liu Y, Xu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116003
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116003
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z
International immunopharmacology 2024 Jan 5;126:111183
International immunopharmacology 2024 Jan 5;126:111183
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Xiao Y, Duan C, Gong P, Zhao Q, Wang XH, Geng F, Zeng J, Luo T, Xu Y, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis.
Yuan S, Wang Y, Yang J, Tang Y, Wu W, Meng X, Jian Y, Lei Y, Liu Y, Tang C, Zhao Z, Zhao F, Liu W
Aging 2024 Jan 29;16(2):1374-1389
Aging 2024 Jan 29;16(2):1374-1389
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Wu W, Li G, Dong S, Huihan Chu C, Ma S, Zhang Z, Yuan S, Wu J, Guo Z, Shen Y, Wang J, Tang C
International immunopharmacology 2024 Jan 25;127:111423
International immunopharmacology 2024 Jan 25;127:111423
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Zhao Z, Du JF, Wang QL, Qiu FN, Li P, Jiang Y, Li HJ
Chemical research in toxicology 2024 Jan 15;37(1):57-71
Chemical research in toxicology 2024 Jan 15;37(1):57-71
Emodin ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through the remodeling of gut microbiota composition.
Hu S, Zhou J, Hao J, Zhong Z, Wu H, Zhang P, Yang J, Guo H, Chi J
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C161-C176
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C161-C176
Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
Wang J, Jin B, Chen Y, Chen Y, Zuo W, Huang L, Lin J, Jiang Y, Xie L, Lian X, Wang Y
Drug development research 2024 Feb;85(1):e22150
Drug development research 2024 Feb;85(1):e22150
Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway.
Wu M, Liu X, Yu Q, Shi J, Guo W, Zhang S
European journal of pharmacology 2024 Feb 5;964:176224
European journal of pharmacology 2024 Feb 5;964:176224
Human umbilical cord mesenchymal stem cells protect MC3T3-E1 osteoblasts from dexamethasone-induced apoptosis via induction of the Nrf2-ARE signaling pathway.
Qiu C, Li Z, Peng P
Regenerative therapy 2024 Dec;27:1-11
Regenerative therapy 2024 Dec;27:1-11
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.
Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T
Journal of gastroenterology 2024 Aug;59(8):682-698
Journal of gastroenterology 2024 Aug;59(8):682-698
Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.
Liang W, Yang H, Pan L, Wei S, Li Z, Zhang P, Li R, Wu Y, Liu M, Liu X
Applied biochemistry and biotechnology 2024 Aug;196(8):4807-4822
Applied biochemistry and biotechnology 2024 Aug;196(8):4807-4822
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Dong Y, Kang H, Peng R, Liu Z, Liao F, Hu SA, Ding W, Wang P, Yang P, Zhu M, Wang S, Wu M, Ye D, Gan X, Li F, Song K
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Inhaled aerosolized algal polysaccharides: A novel and reliable strategy for treating pneumonia through inflammation and oxidative stress inhibition.
Zhang X, Lv D, Li B, Ding Y
International immunopharmacology 2024 Aug 20;137:112532
International immunopharmacology 2024 Aug 20;137:112532
Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis.
Liu S, Qin T, Zou F, Dong H, Yu L, Wang H, Zhang L
Inflammopharmacology 2024 Apr;32(2):1133-1146
Inflammopharmacology 2024 Apr;32(2):1133-1146
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
Mechanisms of ageing and development 2024 Apr;218:111914
Mechanisms of ageing and development 2024 Apr;218:111914
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
Huang Q, Liu J, Peng C, Han X, Tan Z
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Zeng Q, Wen BB, Liu X, Luo YY, Hu ZG, Huang L, Zhang XH, Huang XT, Zhou TT, Sang XX, Luo YY, Xiong DY, Luo ZQ, Liu W, Tang SY
Chinese medicine 2024 Apr 8;19(1):60
Chinese medicine 2024 Apr 8;19(1):60
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
Li Q, Li Z, Liu C, Xu M, Li T, Wang Y, Feng J, Yin X, Du X, Lu C
The American journal of Chinese medicine 2023;51(4):929-951
The American journal of Chinese medicine 2023;51(4):929-951
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Chen F, Zhan J, Liu M, Mamun AA, Huang S, Tao Y, Zhao J, Zhang Y, Xu Y, He Z, Du S, Lu W, Li X, Chen Z, Xiao J
International journal of biological sciences 2023;19(13):4340-4359
International journal of biological sciences 2023;19(13):4340-4359
Dental Pulp Stem Cells Ameliorate Elastase-Induced Pulmonary Emphysema by Regulating Inflammation and Oxidative Stress.
Gao X, Liu Z, Wang Z
Journal of inflammation research 2023;16:1497-1508
Journal of inflammation research 2023;16:1497-1508
Risk factors for fatty pancreas and effects of fatty infiltration on pancreatic cancer.
Otsuka N, Shimizu K, Taniai M, Tokushige K
Frontiers in physiology 2023;14:1243983
Frontiers in physiology 2023;14:1243983
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway.
Lou L, Wang M, He J, Yang S, Meng F, Wang S, Jin X, Cai J, Cai C
Frontiers in pharmacology 2023;14:1067402
Frontiers in pharmacology 2023;14:1067402
Caffeoylquinic acids isolated from Lonicera japonica Thunb. as TAK1 inhibitors protects against LPS plus IFN-γ-stimulated inflammation by interacting with KEAP1-regulated NRF2 activation.
Ge L, Jiang Y, Li Y, Xie Q, Miao Y, Wu Z, Zeng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115038
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115038
Deletion of IL-1β exacerbates acrylamide-induced neurotoxicity in mice.
Fergany A, Zong C, Ekuban FA, Suzuki A, Kimura Y, Ichihara S, Iwakura Y, Ichihara G
Toxicological sciences : an official journal of the Society of Toxicology 2023 Sep 28;195(2):246-256
Toxicological sciences : an official journal of the Society of Toxicology 2023 Sep 28;195(2):246-256
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.
Tao M, Yan W, Chen C, Tang M, Zhao X, Feng Q, Fei X, Fu Y
Life sciences 2023 Sep 1;328:121847
Life sciences 2023 Sep 1;328:121847
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Liang C, Zhang HY, Wang YQ, Yang LA, Du YS, Luo Y, Zhang TC, Xu Y
Current medical science 2023 Oct;43(5):1023-1032
Current medical science 2023 Oct;43(5):1023-1032
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
Tian J, Zhang S, Li L, Lin X, Li Y, Zhao K, Zheng F, Chen Y, Yang Y, Wu T, Pang J
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
bioRxiv : the preprint server for biology 2023 Oct 11;
bioRxiv : the preprint server for biology 2023 Oct 11;
Aflatoxin B1 triggers apoptosis in rabbit hepatocytes via mediating oxidative stress and switching on the mitochondrial apoptosis pathway.
Zhang L, Shi S, Liu Y, Cui Y, Zhu Y, Bao Y, Chen B, Shi W
Ecotoxicology and environmental safety 2023 Oct 1;264:115478
Ecotoxicology and environmental safety 2023 Oct 1;264:115478
Taxifolin protects against doxorubicin-induced cardiotoxicity and ferroptosis by adjusting microRNA-200a-mediated Nrf2 signaling pathway.
Lin Z, Wang J
Heliyon 2023 Nov;9(11):e22011
Heliyon 2023 Nov;9(11):e22011
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Wang X, Wu H, An J, Zhang G, Chen Y, Fu L, Tao L, Liang G, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Guo H, Chen J, Yu H, Dong L, Yu R, Li Q, Song J, Chen H, Zhang H, Pu J, Wang W
International immunopharmacology 2023 Nov;124(Pt A):110864
International immunopharmacology 2023 Nov;124(Pt A):110864
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
She Y, Shao L, Jiao K, Sun R, Lang T, Long H, Tang Y, Zhang W, Ding C, Deng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Quercetin Attenuates the Combined Effects of Zearalenone and Lipopolysaccharide on IPEC-J2 Cell Injury through Activating the Nrf2 Signaling Pathway.
Wang C, Fu Y, Wang R, Wang Q, Yu H, Zhang J
Toxins 2023 Nov 30;15(12)
Toxins 2023 Nov 30;15(12)
Cinnamaldehyde Alleviates Bone Loss by Targeting Oxidative Stress and Mitochondrial Damage via the Nrf2/HO-1 Pathway in BMSCs and Ovariectomized Mice.
Lin BH, Ma RX, Wu JT, Du SQ, Lv YY, Yu HN, Zhang W, Mao SM, Liu GY, Bu YT, Chen ZH, Jin C, Wu ZY, Yang L
Journal of agricultural and food chemistry 2023 Nov 2;
Journal of agricultural and food chemistry 2023 Nov 2;
Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.
Sun Q, Liu D, Cui W, Cheng H, Huang L, Zhang R, Gu J, Liu S, Zhuang X, Lu Y, Chu B, Li J
Communications biology 2023 Nov 1;6(1):1108
Communications biology 2023 Nov 1;6(1):1108
A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression.
Culbertson B, Garcia K, Markett D, Asgharian H, Chen L, Fish L, Navickas A, Yu J, Woo B, Nanda AS, Choi B, Zhou S, Rabinowitz J, Goodarzi H
Nature cancer 2023 May;4(5):682-698
Nature cancer 2023 May;4(5):682-698
T Cell Nrf2/Keap1 Gene Editing Using CRISPR/Cas9 and Experimental Kidney Ischemia-Reperfusion Injury.
Kurzhagen JT, Noel S, Lee K, Sadasivam M, Gharaie S, Ankireddy A, Lee SA, Newman-Rivera A, Gong J, Arend LJ, Hamad ARA, Reddy SP, Rabb H
Antioxidants & redox signaling 2023 May;38(13-15):959-973
Antioxidants & redox signaling 2023 May;38(13-15):959-973
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.
Shao D, Shen W, Miao Y, Gao Z, Pan M, Wei Q, Yan Z, Zhao X, Ma B
Journal of animal science and biotechnology 2023 May 3;14(1):61
Journal of animal science and biotechnology 2023 May 3;14(1):61
ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer.
Ji J, Ma S, Zhu Y, Zhao J, Tong Y, You Q, Jiang Z
Journal of medicinal chemistry 2023 May 11;66(9):6070-6081
Journal of medicinal chemistry 2023 May 11;66(9):6070-6081
The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity.
Zhang Z, Cheng J, Yang L, Li X, Hua R, Xu D, Jiang Z, Li Q
Free radical biology & medicine 2023 May 1;200:26-35
Free radical biology & medicine 2023 May 1;200:26-35
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Liu X, Liu Y, Chen L, Zhang Z, Cui L, Wei T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats.
Gao X, Chen F, Xu X, Liu J, Dong F, Liu Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Mar;32(3):106971
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Mar;32(3):106971
Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy.
Zhang T, Zhang D, Zhang Z, Tian J, An J, Zhang W, Ben Y
Hormones (Athens, Greece) 2023 Mar;22(1):95-105
Hormones (Athens, Greece) 2023 Mar;22(1):95-105
Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in hepatocytes.
Yao Y, Wang H, Yang Y, Jiang Z, Ma H
Molecular immunology 2023 Mar;155:110-123
Molecular immunology 2023 Mar;155:110-123
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss.
Guo J, Ren R, Guo Z, Sun K, He J, Shao J, Wang X
International immunopharmacology 2023 Mar;116:109820
International immunopharmacology 2023 Mar;116:109820
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
Lai X, Zhang Y, Wu J, Shen M, Yin S, Yan J
Neurotoxicity research 2023 Jun;41(3):242-255
Neurotoxicity research 2023 Jun;41(3):242-255
Schisandrin B Improves the Hypothermic Preservation of Celsior Solution in Human Umbilical Cord Mesenchymal Stem Cells.
Zhang Y, Wang P, Jin MX, Zhou YQ, Ye L, Zhu XJ, Li HF, Zhou M, Li Y, Li S, Liang KY, Wang Y, Gao Y, Pan MX, Zhou SQ, Peng Q
Tissue engineering and regenerative medicine 2023 Jun;20(3):447-459
Tissue engineering and regenerative medicine 2023 Jun;20(3):447-459
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Li C, Hao J, Qiu H, Xin H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Liang C, Yi K, Zhou X, Li X, Zhong C, Cao H, Xie C, Zhu J
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Li X, Yu X, He S, Li J
International immunopharmacology 2023 Jul;120:110404
International immunopharmacology 2023 Jul;120:110404
Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury.
Fan K, Chen K, Zan X, Zhi Y, Zhang X, Zhang X, Qiu J, Liu G, Li L, Tang L, Hu K, Wan J, Gong X, Yang Y, Zhang L
Cell death & disease 2023 Jul 31;14(7):486
Cell death & disease 2023 Jul 31;14(7):486
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Chen F, Zhan J, Al Mamun A, Tao Y, Huang S, Zhao J, Zhang Y, Xu Y, Du S, Lu W, Li X, Chen Z, Xiao J
Food & function 2023 Jul 31;14(15):7176-7194
Food & function 2023 Jul 31;14(15):7176-7194
Protective effect of total flavonoids of Engelhardia roxburghiana Wall. leaves against radiation-induced intestinal injury in mice and its mechanism.
Wu S, Tian C, Tu Z, Guo J, Xu F, Qin W, Chang H, Wang Z, Hu T, Sun X, Ning H, Li Y, Gou W, Hou W
Journal of ethnopharmacology 2023 Jul 15;311:116428
Journal of ethnopharmacology 2023 Jul 15;311:116428
Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1.
Qi M, Zhong H, Cheng Z, Chen S, Xiao H, Shang J, Chen L, Sun J
Journal of medicinal chemistry 2023 Jul 13;66(13):9184-9200
Journal of medicinal chemistry 2023 Jul 13;66(13):9184-9200
Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer by targeting the NRF2/GPX4 signal axis to induce ferroptosis of drug-resistant human epithelial ovarian cancer cells.
Ma B, Zhong Y, Chen R, Zhan X, Huang G, Xiong Y, Tan B
Biochemical and biophysical research communications 2023 Jul 12;665:178-186
Biochemical and biophysical research communications 2023 Jul 12;665:178-186
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Shao D, Gao Z, Zhao Y, Fan M, Zhao X, Wei Q, Pan M, Ma B
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
Protective effects of dietary dimethyl itaconate supplementation on oxidative stress, inflammation, and apoptosis in broilers under chronic heat stress.
Wang H, Yang Y, Huang B, Cui Z, Li L
Journal of animal science 2023 Jan 3;101
Journal of animal science 2023 Jan 3;101
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
Wang F, Zhan Y, Li M, Wang L, Zheng A, Liu C, Wang H, Wang T
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors.
Liang X, Wei Y, Hou X, Guo Q, Liang H, Zeng K, Tu P, Zhang Q
Phytochemistry 2023 Feb;206:113530
Phytochemistry 2023 Feb;206:113530
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.
Huang B, Hu G, Zong X, Yang S, He D, Gao X, Liu D
International immunopharmacology 2023 Feb;115:109698
International immunopharmacology 2023 Feb;115:109698
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Zhu D, Kong M, Chen C, Luo J, Kong L
International immunopharmacology 2023 Feb;115:109689
International immunopharmacology 2023 Feb;115:109689
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Li M, Peng Y, Chen W, Gao Y, Yang M, Li J, He J
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Zhang M, Zhang J, Zhu QM, Zhao WY, Lv X, Yi J, Huo XK, Wang MJ, Sun CP
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Huang J, Zhu Y, Li S, Jiang H, Chen N, Xiao H, Liu J, Liang D, Zheng Q, Tang J, Meng X
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Wang H, Yang G, Zhang X, Zhang H, Liu Y, Wang C, Miao L, Li Y, Huang Y, Teng H, Wang S, Cheng H, Zeng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
Sun Y, Xu L, Zheng D, Wang J, Liu G, Mo Z, Liu C, Zhang W, Yu J, Xing C, He L, Zhuang C
Redox biology 2023 Aug;64:102793
Redox biology 2023 Aug;64:102793
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Wan D, Zhu Z, Zhou J, Deng Z, Lei P, Liu Q, Sun X, Huang B
Toxicology research 2023 Aug;12(4):635-647
Toxicology research 2023 Aug;12(4):635-647
Amelioratory effects of astragaloside IV on hepatocarcinogenesis via Nrf2-mediated pSmad3C/3L transformation.
Fang Gong Y, Hou S, Xu JC, Chen Y, Zhu LL, Xu YY, Chen YQ, Li MM, Li LL, Yang JJ, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154903
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154903
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, Duan H, Shi Y
Cellular signalling 2023 Aug;108:110712
Cellular signalling 2023 Aug;108:110712
Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.
Kimura Y, Ekuban FA, Zong C, Sugie S, Zhang X, Itoh K, Yamamoto M, Ichihara S, Ohsako S, Ichihara G
Toxicological sciences : an official journal of the Society of Toxicology 2023 Aug 29;195(1):28-41
Toxicological sciences : an official journal of the Society of Toxicology 2023 Aug 29;195(1):28-41
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma.
Jiang Z, Gao L, Liu C, Wang J, Han Y, Pan J
Journal of clinical and translational hepatology 2023 Aug 28;11(4):863-876
Journal of clinical and translational hepatology 2023 Aug 28;11(4):863-876
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway.
Hu Y, Yan Z, He Y, Li Y, Li M, Li Y, Zhang D, Zhao Y, Ommati MM, Wang J, Huo M, Wang J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113647
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113647
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.
Tang Y, Han Y, Zhao J, Lv Y, Fan C, Zheng L, Zhang Z, Liu Z, Li C, Lin Y
Nano-micro letters 2023 Apr 30;15(1):112
Nano-micro letters 2023 Apr 30;15(1):112
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Li H, Wu M, Guo C, Zhai R, Chen J
The American journal of Chinese medicine 2022;50(8):2125-2151
The American journal of Chinese medicine 2022;50(8):2125-2151
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury.
Li X, Chen J, Yuan S, Zhuang X, Qiao T
Oxidative medicine and cellular longevity 2022;2022:8973509
Oxidative medicine and cellular longevity 2022;2022:8973509
Protection of Human Lens Epithelial Cells from Oxidative Stress Damage and Cell Apoptosis by KGF-2 through the Akt/Nrf2/HO-1 Pathway.
Liu S, Jin Z, Xia R, Zheng Z, Zha Y, Wang Q, Wan X, Yang H, Cai J
Oxidative medicine and cellular longevity 2022;2022:6933812
Oxidative medicine and cellular longevity 2022;2022:6933812
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Chen P, Yang J, Wu N, Han B, Kastelic JP, Gao J
Oxidative medicine and cellular longevity 2022;2022:2549772
Oxidative medicine and cellular longevity 2022;2022:2549772
4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis.
Zhang P, Wang Y, Yang W, Yin Y, Li C, Ma X, Shi L, Li R, Tao K
International journal of biological sciences 2022;18(16):6189-6209
International journal of biological sciences 2022;18(16):6189-6209
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Wang J, Wang K, Ding L, Zhao P, Zhang C, Wang H, Yang Z, Liu Z
Frontiers in pharmacology 2022;13:969892
Frontiers in pharmacology 2022;13:969892
Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.
Jiang Z, Qi G, Lu W, Wang H, Li D, Chen W, Ding L, Yang X, Yuan H, Zeng Q
Frontiers in pharmacology 2022;13:952950
Frontiers in pharmacology 2022;13:952950
Caryophyllene Oxide Induces Ferritinophagy by Regulating the NCOA4/FTH1/LC3 Pathway in Hepatocellular Carcinoma.
Xiu Z, Zhu Y, Han J, Li Y, Yang X, Yang G, Song G, Li S, Li Y, Cheng C, Li Y, Fang J, Li X, Jin N
Frontiers in pharmacology 2022;13:930958
Frontiers in pharmacology 2022;13:930958
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota.
Wu K, Liu X, Meng X, Cao L, Li H, Bi Y, Wang M, Wang M, Jiang Y
Frontiers in microbiology 2022;13:1084257
Frontiers in microbiology 2022;13:1084257
Berberine prevents lethal EV71 neurological infection in newborn mice.
Cui G, Wang H, Yang C, Zhou X, Wang J, Wang T, Ma T
Frontiers in pharmacology 2022;13:1027566
Frontiers in pharmacology 2022;13:1027566
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Jing S, Wan J, Wang T, He Z, Ding Q, Sheng G, Wang S, Zhao H, Zhu Z, Wu H, Li W
Frontiers in bioengineering and biotechnology 2022;10:1071776
Frontiers in bioengineering and biotechnology 2022;10:1071776
A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.
Wang X, Liu Y, Xue C, Hu Y, Zhao Y, Cai K, Li M, Luo Z
Nature communications 2022 Sep 28;13(1):5685
Nature communications 2022 Sep 28;13(1):5685
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.
Bondi CD, Rush BM, Hartman HL, Wang J, Al-Bataineh MM, Hughey RP, Tan RJ
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 14;11(9)
Antihepatofibrotic effect of Guizhifuling pill on carbon tetrachloride-induced liver fibrosis in mice.
Baogui XU, Jiawen Z, Xiaoxiao T, Falei Y, Zhongliang L, Zuisu Y, Xianjun D
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):715-722
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Hao H, Xie F, Xu F, Wang Q, Wu Y, Zhang D
International immunopharmacology 2022 Oct;111:109170
International immunopharmacology 2022 Oct;111:109170
Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease.
Zhao H, Xian G, Zeng J, Zhong G, An D, Peng Y, Hu D, Lin Y, Li J, Su S, Ning Y, Xu D, Zeng Q
Antioxidants (Basel, Switzerland) 2022 Oct 24;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 24;11(11)
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Wang T, Liu J, Huang X, Zhang C, Shangguan M, Chen J, Wu S, Chen M, Yang Z, Zhao S
Oncology reports 2022 Nov;48(5)
Oncology reports 2022 Nov;48(5)
Type 2 Diabetes Mellitus Makes Corneal Endothelial Cells Vulnerable to Ultraviolet A-Induced Oxidative Damage Via Decreased DJ-1/Nrf2/NQO1 Pathway.
Zhang X, Qiu J, Huang F, Shan K, Zhang C
Investigative ophthalmology & visual science 2022 Nov 1;63(12):25
Investigative ophthalmology & visual science 2022 Nov 1;63(12):25
Dehydroepiandrosterone activates the GPER-mediated AMPK signaling pathway to alleviate the oxidative stress and inflammatory response in laying hens fed with high-energy and low-protein diets.
Yao Y, Wang H, Yang Y, Jiang Z, Ma H
Life sciences 2022 Nov 1;308:120926
Life sciences 2022 Nov 1;308:120926
6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling.
Chen WF, Shih YH, Liu HC, Cheng CI, Chang CI, Chen CY, Lin IP, Lin MY, Lee CH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154025
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154025
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Li J, Li Y, Lin S, Zhao W, Chen Y, Jin H
Journal of food science 2022 May;87(5):2185-2196
Journal of food science 2022 May;87(5):2185-2196
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells.
Zhang X, Liu X, Wan F, You W, Tan X, Sheng Q, Li C, Hu Z, Liu G, Zhao H
Meat science 2022 Mar;185:108724
Meat science 2022 Mar;185:108724
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Zhang W, Dun Y, You B, Qiu L, Ripley-Gonzalez JW, Cheng J, Fu S, Li C, Liu S
BMJ open diabetes research & care 2022 Mar;10(2)
BMJ open diabetes research & care 2022 Mar;10(2)
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.
Fiore A, Zeitler L, Russier M, Groß A, Hiller MK, Parker JL, Stier L, Köcher T, Newstead S, Murray PJ
Molecular cell 2022 Mar 3;82(5):920-932.e7
Molecular cell 2022 Mar 3;82(5):920-932.e7
Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway.
Shan Y, Yang G, Lu Q, Hu X, Qi D, Zhou Y, Xiao Y, Cao L, Tian F, Pan Q
Aging 2022 Mar 10;14(5):2367-2382
Aging 2022 Mar 10;14(5):2367-2382
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Xu F, Zhang J, Zhou X, Hao H
Experimental cell research 2022 Mar 1;412(1):113025
Experimental cell research 2022 Mar 1;412(1):113025
Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2.
Qiao J, Zhao Y, Liu Y, Zhang S, Zhao W, Liu S, Liu M
Molecular medicine reports 2022 Jun;25(6)
Molecular medicine reports 2022 Jun;25(6)
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
Shi L, Wang X, Duan Y, Li K, Ren Y
Theriogenology 2022 Jun;185:43-49
Theriogenology 2022 Jun;185:43-49
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H
Stem cell research & therapy 2022 Jun 7;13(1):241
Stem cell research & therapy 2022 Jun 7;13(1):241
Early-life galacto-oligosaccharides supplementation alleviates the small intestinal oxidative stress and dysfunction of lipopolysaccharide-challenged suckling piglets.
Tian S, Wang J, Gao R, Wang J, Zhu W
Journal of animal science and biotechnology 2022 Jun 3;13(1):70
Journal of animal science and biotechnology 2022 Jun 3;13(1):70
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Han N, Wang Z, Luo H, Chi Y, Zhang T, Wang B, Li Y
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Mesenchymal stem cells improve redox homeostasis and mitochondrial respiration in fibroblast cell lines with pathogenic MT-ND3 and MT-ND6 variants.
Navaratnarajah T, Bellmann M, Seibt A, Anand R, Degistirici Ö, Meisel R, Mayatepek E, Reichert A, Baertling F, Distelmaier F
Stem cell research & therapy 2022 Jun 17;13(1):256
Stem cell research & therapy 2022 Jun 17;13(1):256
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Zhou X, Wang S, Zhou R, Zhang T, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhou X, Song N
Toxicology 2022 Jun 15;475:153227
Toxicology 2022 Jun 15;475:153227
Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.
Wang L, Liu Q, Chen Y, Zheng X, Wang C, Qi Y, Dong Y, Xiao Y, Chen C, Chen T, Huang Q, Zhai Z, Long C, Yang H, Li J, Wang L, Zhang G, Liao P, Liu YX, Huang P, Huang J, Wang Q, Chu H, Yin J, Yin Y
Microbiome 2022 Jun 1;10(1):83
Microbiome 2022 Jun 1;10(1):83
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
Zhang QY, Han SC, Huang RP, Jiang MY, Yan CY, Li XY, Zhan YJ, Li XM, Li YF, Kurihara H, Tan RR, Li WX, He RR
Food & function 2022 Jul 4;13(13):6962-6974
Food & function 2022 Jul 4;13(13):6962-6974
Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway.
Sun Y, Xu H, Tan B, Yi Q, Liu H, Chen T, Xiang H, Wang R, Xie Q, Tian J, Zhu J
Stem cell research & therapy 2022 Jul 18;13(1):326
Stem cell research & therapy 2022 Jul 18;13(1):326
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Yu G, Ji S, Yun Y, Cheng K, Zhang H, Jia P, Wang T, Zhang L
Journal of animal science 2022 Jul 1;100(7)
Journal of animal science 2022 Jul 1;100(7)
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder.
Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T
Neurology(R) neuroimmunology & neuroinflammation 2022 Jan;9(1)
Neurology(R) neuroimmunology & neuroinflammation 2022 Jan;9(1)
Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat.
Zhou Y, Peng L, Li Y, Zhao Y
Brain research bulletin 2022 Jan;178:37-48
Brain research bulletin 2022 Jan;178:37-48
Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy.
Zheng LY, Zou X, Wang YL, Zou M, Ma F, Wang N, Li JW, Wang MS, Hung HY, Wang Q
European journal of pharmacology 2022 Jan 5;914:174686
European journal of pharmacology 2022 Jan 5;914:174686
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Qiu D, Song S, Wang Y, Bian Y, Wu M, Wu H, Shi Y, Duan H
Journal of translational medicine 2022 Jan 28;20(1):44
Journal of translational medicine 2022 Jan 28;20(1):44
Ellagic Acid Alleviates Oxidative Stress by Mediating Nrf2 Signaling Pathways and Protects against Paraquat-Induced Intestinal Injury in Piglets.
Xiao Y, Huang R, Wang N, Deng Y, Tan B, Yin Y, Qi M, Wang J
Antioxidants (Basel, Switzerland) 2022 Jan 27;11(2)
Antioxidants (Basel, Switzerland) 2022 Jan 27;11(2)
Discovery of Potent and Selective 2-(Benzylthio)pyrimidine-based DCN1-UBC12 Inhibitors for Anticardiac Fibrotic Effects.
He ZX, An Q, Wei B, Zhou WJ, Wei BF, Gong YP, Zhang X, Gao G, Dong GJ, Huo JL, Zhang XH, Yang FF, Liu HM, Ma LY, Zhao W
Journal of medicinal chemistry 2022 Jan 13;65(1):163-190
Journal of medicinal chemistry 2022 Jan 13;65(1):163-190
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Huang L, Han Y, Zhou Q, Sun Z, Yan J
Translational neuroscience 2022 Jan 1;13(1):301-308
Translational neuroscience 2022 Jan 1;13(1):301-308
Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway.
Qi Y, Fu S, Pei D, Fang Q, Xin W, Yuan X, Cao Y, Shu Q, Mi X, Luo F
Free radical research 2022 Feb;56(2):209-221
Free radical research 2022 Feb;56(2):209-221
Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss.
Kang H, Guo Q, Dong Y, Peng R, Song K, Wang J, Liu H, Zhu M, Zhao H, Guan H, Li F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22167
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22167
Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway.
Wang Y, Liu B, Wu P, Chu Y, Gui S, Zheng Y, Chen X
Antioxidants (Basel, Switzerland) 2022 Feb 10;11(2)
Antioxidants (Basel, Switzerland) 2022 Feb 10;11(2)
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Zhang J, Zhang M, Zhang WH, Zhu QM, Huo XK, Sun CP, Ma XC, Xiao HT
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Zhang J, Zhang M, Zhang WH, Zhu QM, Ning J, Huo XK, Xiao HT, Sun CP
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Ye H, Ma Z, Liu L, Zhang T, Han Q, Xiang Z, Xia Y, Ke Y, Guan X, Shi Q, Ataullakhanov FI, Panteleev M
ChemMedChem 2022 Dec 16;17(24):e202200317
ChemMedChem 2022 Dec 16;17(24):e202200317
MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway.
Li T, Chen Q, Dai J, Huang Z, Luo Y, Mou T, Pu J, Yang H, Wei X, Wu Z
Molecular biology reports 2022 Aug;49(8):7575-7585
Molecular biology reports 2022 Aug;49(8):7575-7585
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
Peng X, Su S, Zeng J, Xie K, Yang X, Xian G, Xiao Z, Zhu P, Zheng S, Xu D, Zeng Q
Free radical biology & medicine 2022 Aug 1;188:404-418
Free radical biology & medicine 2022 Aug 1;188:404-418
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
Zhou W, Dong G, Gao G, He Z, Xu J, Aziz S, Ma L, Zhao W
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
N-acetylcysteine promotes cyclic mechanical stress-induced osteogenic differentiation of periodontal ligament stem cells by down-regulating Nrf2 expression.
Xi X, Li ZX, Zhao Y, Liu H, Chen S, Liu DX
Journal of dental sciences 2022 Apr;17(2):750-762
Journal of dental sciences 2022 Apr;17(2):750-762
Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator.
Guo T, Fang X, Liu Y, Ruan Y, Hu Y, Wang X, Hu Y, Wang G, Xu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Apr;162:112898
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Apr;162:112898
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Relationship between Neuroprotective Effects and Structure of Procyanidins.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis.
Ma H, Xie C, Chen Z, He G, Dai Z, Cai H, Zhang H, Lu H, Wu H, Hu X, Zhou K, Zheng G, Xu H, Xu C
Cell death discovery 2022 Apr 19;8(1):209
Cell death discovery 2022 Apr 19;8(1):209
SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production.
Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F, Sun X
Frontiers in cell and developmental biology 2021;9:639851
Frontiers in cell and developmental biology 2021;9:639851
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Yang F, He X, Chen T, Liu J, Luo Z, Sun S, Qin D, Huang W, Tang Y, Liu C, Luo F
Oxidative medicine and cellular longevity 2021;2021:9426314
Oxidative medicine and cellular longevity 2021;2021:9426314
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Lv D, Luo M, Cheng Z, Wang R, Yang X, Guo Y, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Oxidative medicine and cellular longevity 2021;2021:5577019
Oxidative medicine and cellular longevity 2021;2021:5577019
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Lin Y, Xie Y, Hao Z, Bi H, Liu Y, Yang X, Xia Y
Journal of immunology research 2021;2021:5151168
Journal of immunology research 2021;2021:5151168
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y, Tian H
Oxidative medicine and cellular longevity 2021;2021:4714649
Oxidative medicine and cellular longevity 2021;2021:4714649
Tert-Butylhydroquinone Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in Rat Chondrocytes.
Yang B, Huang H, He Q, Lu W, Zheng L, Cui L
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1905995
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1905995
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Pang Z, Jiang Z, Zhu R, Song C, Tang H, Cao L, Guo C
Drug design, development and therapy 2021;15:3735-3747
Drug design, development and therapy 2021;15:3735-3747
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H
Journal of inflammation research 2021;14:745-760
Journal of inflammation research 2021;14:745-760
The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice.
Xu Q, Li S, Tang W, Yan J, Wei X, Zhou M, Diao H
Frontiers in physiology 2021;12:751501
Frontiers in physiology 2021;12:751501
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K
Frontiers in pharmacology 2021;12:651444
Frontiers in pharmacology 2021;12:651444
PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization.
Rana MN, Lu J, Xue E, Ruan J, Liu Y, Zhang L, Dhar R, Li Y, Hu Z, Zhou J, Ma W, Tang H
Frontiers in pharmacology 2021;12:643215
Frontiers in pharmacology 2021;12:643215
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Zhang M, Hou G, Hu P, Feng D, Wang J, Zhu W
The British journal of nutrition 2021 Sep 28;126(6):801-812
The British journal of nutrition 2021 Sep 28;126(6):801-812
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Resveratrol protects intestinal integrity, alleviates intestinal inflammation and oxidative stress by modulating AhR/Nrf2 pathways in weaned piglets challenged with diquat.
Xun W, Fu Q, Shi L, Cao T, Jiang H, Ma Z
International immunopharmacology 2021 Oct;99:107989
International immunopharmacology 2021 Oct;99:107989
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis.
Meng X, Zhang L, Han B, Zhang Z
Environmental toxicology 2021 Nov;36(11):2266-2277
Environmental toxicology 2021 Nov;36(11):2266-2277
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Xu JJ, Cui J, Lin Q, Chen XY, Zhang J, Gao EH, Wei B, Zhao W
International journal of cardiology 2021 Nov 1;342:82-93
International journal of cardiology 2021 Nov 1;342:82-93
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation.
Zhu J, Li X, Liang C, Zhou X, Ge M, Chen Y, Jin J, Yin J, Xu H, Xie C, Zhong C
Cell death discovery 2021 May 12;7(1):102
Cell death discovery 2021 May 12;7(1):102
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
Feng XH, Xu HY, Wang JY, Duan S, Wang YC, Ma CM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Wang W, Zhai D, Bai Y, Xue K, Deng L, Ma L, Du T, Ye Z, Qu D, Xiang A, Chen G, Zhao Y, Wang L, Lu Z
Cell death discovery 2021 Mar 23;7(1):58
Cell death discovery 2021 Mar 23;7(1):58
CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression.
Tan S, Zhang M, Shi X, Ding K, Zhao Q, Guo Q, Wang H, Wu Z, Kang Y, Zhu T, Sun J, Zhao X
Journal of experimental & clinical cancer research : CR 2021 Mar 1;40(1):85
Journal of experimental & clinical cancer research : CR 2021 Mar 1;40(1):85
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Liu Z, He Q, Liu Y, Zhang Y, Cui M, Peng H, Wang Y, Chen S, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2021 Jun 30;458:152838
Toxicology 2021 Jun 30;458:152838
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch.
Xi X, Zhao Y, Liu H, Li Z, Chen S, Liu D
Experimental cell research 2021 Jun 15;403(2):112598
Experimental cell research 2021 Jun 15;403(2):112598
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
Chen Y, Zhang H, Chen Y, Jia P, Ji S, Zhang Y, Wang T
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
Bisavenathramide Analogues as Nrf2 Inductors and Neuroprotectors in In Vitro Models of Oxidative Stress and Hyperphosphorylation.
Cores Á, Abril S, Michalska P, Duarte P, Olives AI, Martín MA, Villacampa M, León R, Menéndez JC
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Exosomes are involved in total body irradiation-induced intestinal injury in mice.
Li H, Jiang M, Zhao SY, Zhang SQ, Lu L, He X, Feng GX, Wu X, Fan SJ
Acta pharmacologica Sinica 2021 Jul;42(7):1111-1123
Acta pharmacologica Sinica 2021 Jul;42(7):1111-1123
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Huang Z, Guo L, Huang L, Shi Y, Liang J, Zhao L
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Tolerable upper intake level of iron damages the liver of weaned piglets.
Ding H, Zhao Y, Yu X, Chen L, Han J, Feng J
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Journal of animal physiology and animal nutrition 2021 Jul;105(4):668-677
Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway.
Shu M, Lei W, Su S, Wen Y, Luo F, Zhao L, Chen L, Lu C, Zhou Z, Li Z
Life sciences 2021 Jul 15;277:119502
Life sciences 2021 Jul 15;277:119502
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
Li S, Wang X, Xiao Y, Wang Y, Wan Y, Li X, Li Q, Tang X, Cai D, Ran B, Wu C
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis.
Huang CR, Chang TW, Lee CT, Shen CJ, Chang WC, Chen BK
Oncogenesis 2021 Jan 14;10(1):11
Oncogenesis 2021 Jan 14;10(1):11
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Wang Z, Cai B, Cao C, Lv H, Dai Y, Zheng M, Zhao G, Peng Y, Gou W, Wang J, Liu D, Hu Y
Free radical biology & medicine 2021 Feb 20;164:249-257
Free radical biology & medicine 2021 Feb 20;164:249-257
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Lu Q, Gu W, Luo C, Wang L, Hua W, Sun Y, Tang L
Journal of ethnopharmacology 2021 Feb 10;266:113454
Journal of ethnopharmacology 2021 Feb 10;266:113454
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Xu Y, Sang W, Zhong Y, Xue S, Yang M, Wang C, Lu H, Huan R, Mao X, Zhu L, He C, Ma J
Cell proliferation 2021 Dec;54(12):e13142
Cell proliferation 2021 Dec;54(12):e13142
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.
Deng J, Huang M, Wu H
Bioengineered 2021 Dec;12(1):7975-7984
Bioengineered 2021 Dec;12(1):7975-7984
Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation.
Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z
eLife 2021 Dec 23;10
eLife 2021 Dec 23;10
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Feng X, Jiang T, Yang C, Pang S, Ding Z, Hu H, Wang H, Dong L, Yang N
Cell death & disease 2021 Dec 17;13(1):6
Cell death & disease 2021 Dec 17;13(1):6
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Hou X, Liu H, Ping Y, Zhang F, Zhi L, Jiang X, Zhang F, Song C, Zhang Z, Song J
Brain research bulletin 2021 Aug;173:74-81
Brain research bulletin 2021 Aug;173:74-81
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
Liu C, Hua H, Zhu H, Cheng Y, Guo Y, Yao W, Qian H
International journal of biological macromolecules 2021 Aug 31;185:804-812
International journal of biological macromolecules 2021 Aug 31;185:804-812
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl(4)-induced liver injury in vivo.
Xin C, Liu S, Qu H, Wang Z
International journal of biological macromolecules 2021 Aug 31;185:338-349
International journal of biological macromolecules 2021 Aug 31;185:338-349
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Yuan J, Che S, Ruan Z, Song L, Tang R, Zhang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351.
Park JY, Sohn HY, Koh YH, Jo C
Scientific reports 2021 Apr 19;11(1):8430
Scientific reports 2021 Apr 19;11(1):8430
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Yuan J, Che S, Zhang L, Ruan Z
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.
Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, Koh K, Hayashi Y, Kanamori Y, Kasahara M, Kohashi K, Kato M, Yoshioka T, Matsumoto K, Oka A, Taguchi T, Sanada M, Tanaka Y, Miyano S, Hata K, Ogawa S, Takita J
NPJ precision oncology 2020;4:20
NPJ precision oncology 2020;4:20
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Tian TT, Li QR, Gan SQ, Chang CR, Shen XC
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo.
Wang H, Jiang Z, Pang Z, Zhou T, Gu Y
Drug design, development and therapy 2020;14:4801-4813
Drug design, development and therapy 2020;14:4801-4813
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110
Frontiers in pharmacology 2020;11:621110
Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets.
Zhang H, Chen Y, Chen Y, Ji S, Jia P, Li Y, Wang T
Journal of animal science and biotechnology 2020;11:52
Journal of animal science and biotechnology 2020;11:52
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Wang J, Fang Z, Song C, Kang H, Guo Q, Dong Y, Zhang Y, Peng R, Guan H, Li F
Frontiers in pharmacology 2020;11:1175
Frontiers in pharmacology 2020;11:1175
Artemisinin attenuates early renal damage on diabetic nephropathy rats through suppressing TGF-β1 regulator and activating the Nrf2 signaling pathway.
Zhang H, Qi S, Song Y, Ling C
Life sciences 2020 Sep 1;256:117966
Life sciences 2020 Sep 1;256:117966
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Long Q
Biomaterials 2020 Oct;257:120264
Biomaterials 2020 Oct;257:120264
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice.
Tamatam CM, Reddy NM, Potteti HR, Ankireddy A, Noone PM, Yamamoto M, Kensler TW, Reddy SP
Scientific reports 2020 Nov 4;10(1):19034
Scientific reports 2020 Nov 4;10(1):19034
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo GM, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S, Yue Z
Autophagy 2020 May;16(5):917-931
Autophagy 2020 May;16(5):917-931
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke.
Hou X, Xu H, Chen W, Zhang N, Zhao Z, Fang X, Zhang X, Chen H, Xu Y
Annals of translational medicine 2020 Mar;8(6):375
Annals of translational medicine 2020 Mar;8(6):375
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Cell proliferation 2020 Mar;53(3):e12779
Cell proliferation 2020 Mar;53(3):e12779
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, Zhou C, Abudunaibi M, Tasiken B, Li J, Cheng H, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Zhang L, Zhang J, Yan E, He J, Zhong X, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Wang S, Cheng H, Wang L, Zhao R, Guan D
International journal of molecular sciences 2020 Mar 16;21(6)
International journal of molecular sciences 2020 Mar 16;21(6)
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z
Nature communications 2020 Mar 13;11(1):1386
Nature communications 2020 Mar 13;11(1):1386
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.
Lazzara PR, David BP, Ankireddy A, Richardson BG, Dye K, Ratia KM, Reddy SP, Moore TW
Journal of medicinal chemistry 2020 Jun 25;63(12):6547-6560
Journal of medicinal chemistry 2020 Jun 25;63(12):6547-6560
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Lu Y, Sun Y, Liu Z, Lu Y, Zhu X, Lan B, Mi Z, Dang L, Li N, Zhan W, Tan L, Pi J, Xiong H, Zhang L, Chen Y
Science translational medicine 2020 Jul 29;12(554)
Science translational medicine 2020 Jul 29;12(554)
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, Chen Y, Wei Y, He X, Zhao J, Han H, Sun M, Xiao K
Cell death & disease 2020 Jan 2;11(1):6
Cell death & disease 2020 Jan 2;11(1):6
Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia.
Hang H, Wang LK, Ren SY, Song AJ, Wu GF
Current medical science 2020 Feb;40(1):55-62
Current medical science 2020 Feb;40(1):55-62
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Life sciences 2020 Feb 15;243:117244
Life sciences 2020 Feb 15;243:117244
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
Zhang P, Yin Y, Wang T, Li W, Li C, Zeng X, Yang W, Zhang R, Tang Y, Shi L, Li R, Tao K
Free radical biology & medicine 2020 Feb 1;147:23-36
Free radical biology & medicine 2020 Feb 1;147:23-36
Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.
Song S, Nguyen V, Schrank T, Mulvaney K, Walter V, Wei D, Orvis T, Desai N, Zhang J, Hayes DN, Zheng Y, Major MB, Weissman BE
Molecular cancer research : MCR 2020 Dec;18(12):1777-1788
Molecular cancer research : MCR 2020 Dec;18(12):1777-1788
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, Leng X
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Huang K, Zhao X
Experimental cell research 2020 Aug 15;393(2):112100
Experimental cell research 2020 Aug 15;393(2):112100
Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis.
Yang G, Yin H, Lin F, Gao S, Zhan K, Tong H, Tang X, Pan Q, Gou X
Pathology, research and practice 2020 Apr;216(4):152851
Pathology, research and practice 2020 Apr;216(4):152851
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Li AL, Shen T, Wang T, Zhou MX, Wang B, Song JT, Zhang PL, Wang XL, Ren DM, Lou HX, Wang XN
Free radical biology & medicine 2019 Sep;141:21-33
Free radical biology & medicine 2019 Sep;141:21-33
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, Chen F, Tang L
Journal of ethnopharmacology 2019 Oct 28;243:112089
Journal of ethnopharmacology 2019 Oct 28;243:112089
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA
Nature 2019 Nov;575(7784):688-692
Nature 2019 Nov;575(7784):688-692
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Sparaneo A, Fabrizio FP, la Torre A, Graziano P, Di Maio M, Fontana A, Bisceglia M, Rossi A, Pizzolitto S, De Maglio G, Tancredi A, Grimaldi F, Balsamo T, Centra F, Manzorra MC, Trombetta D, Pantalone A, Bonfitto A, Maiello E, Fazio VM, Muscarella LA
International journal of molecular sciences 2019 May 23;20(10)
International journal of molecular sciences 2019 May 23;20(10)
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Ren L, Zhan P, Wang Q, Wang C, Liu Y, Yu Z, Zhang S
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, Ke P, Zhuang J, Huang X
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, Qiao H, Li L, Yang J, Yu S, Zhao L, Wang S, Liu HM, Suo Z, Zhao W
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Li WY, Zhou HZ, Chen Y, Cai XF, Tang H, Ren JH, Wai Wong VK, Kwan Law BY, Chen Y, Cheng ST, Yu HB, Cai HY, Chen WX, Tang N, Zhang WL, Tao NN, Yang QX, Ren F, He L, Jiang H, Huang AL, Chen J
Cancer letters 2019 Jun 1;451:156-167
Cancer letters 2019 Jun 1;451:156-167
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Huang J, Lu Y, Zhang B, Yang S, Zhang Q, Cui H, Lu X, Zhao Y, Yang X, Li R
Toxicology 2019 Jan 15;412:29-36
Toxicology 2019 Jan 15;412:29-36
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Li Y, Chen Y, Qiu C, Ma X, Lei K, Cai G, Liang X, Liu J
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Journal of cellular biochemistry 2019 Feb;120(2):1560-1576
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Wang Y, Jiang F, Cheng H, Tan X, Liu Y, Wei C, Song E
International journal of molecular sciences 2019 Dec 5;20(24)
International journal of molecular sciences 2019 Dec 5;20(24)
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
Betharia S, Rondόn-Ortiz AN, Brown DA
Neurochemical research 2019 Aug;44(8):1878-1892
Neurochemical research 2019 Aug;44(8):1878-1892
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Anti-Inflammatory and Antioxidant Effects of Kelong-Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats.
Zhang L, Fan XR, Xie H, He QH, Nie YS, Zhang M, Yan M
Evidence-based complementary and alternative medicine : eCAM 2018;2018:5290514
Evidence-based complementary and alternative medicine : eCAM 2018;2018:5290514
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Wang K, Lv Q, Miao YM, Qiao SM, Dai Y, Wei ZF
Biochemical pharmacology 2018 Sep;155:494-509
Biochemical pharmacology 2018 Sep;155:494-509
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, Liu TC, Zhang Q
Medicine and science in sports and exercise 2018 May;50(5):945-956
Medicine and science in sports and exercise 2018 May;50(5):945-956
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.
Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R
Toxicology and applied pharmacology 2018 May 1;346:28-36
Toxicology and applied pharmacology 2018 May 1;346:28-36
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Tang X, Liu B, Wang X, Yu Q, Fang R
International journal of molecular sciences 2018 Mar 14;19(3)
International journal of molecular sciences 2018 Mar 14;19(3)
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J
Redox biology 2018 Jun;16:189-198
Redox biology 2018 Jun;16:189-198
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C, Li Y, Zhang Q
Neurochemistry international 2018 Jun;116:1-12
Neurochemistry international 2018 Jun;116:1-12
Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Pu D, Zhao Y, Chen J, Sun Y, Lv A, Zhu S, Luo C, Zhao K, Xiao Q
Neuroscience 2018 Jun 15;381:35-45
Neuroscience 2018 Jun 15;381:35-45
Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.
Endo H, Owada S, Inagaki Y, Shida Y, Tatemichi M
Scientific reports 2018 Jul 4;8(1):10122
Scientific reports 2018 Jul 4;8(1):10122
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
Shi A, Shi H, Wang Y, Liu X, Cheng Y, Li H, Zhao H, Wang S, Dong L
International immunopharmacology 2018 Jan;54:125-130
International immunopharmacology 2018 Jan;54:125-130
Lactobacillus helveticus KLDS1.8701 alleviates d-galactose-induced aging by regulating Nrf-2 and gut microbiota in mice.
Li B, Evivie SE, Lu J, Jiao Y, Wang C, Li Z, Liu F, Huo G
Food & function 2018 Dec 13;9(12):6586-6598
Food & function 2018 Dec 13;9(12):6586-6598
Knockdown of Nrf2 inhibits angiogenesis by downregulating VEGF expression through PI3K/Akt signaling pathway in cerebral microvascular endothelial cells under hypoxic conditions.
Huang Y, Mao Y, Li H, Shen G, Nan G
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Aug;96(4):475-482
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Aug;96(4):475-482
Activation of the Nuclear Erythroid 2-Related Factor 2 Antioxidant Responsive Element (Nrf2-ARE) Signaling Pathway Alleviates Acute Graft-Versus-Host Disease by Reducing Oxidative Stress and Inhibiting Infiltration of Inflammatory Cells in an Allogeneic Stem Cell Transplantation Mouse Model.
Yi T, Li X, Wang E, Zhang Y, Fu Y, Li J, Jiang T
Medical science monitor : international medical journal of experimental and clinical research 2018 Aug 27;24:5973-5979
Medical science monitor : international medical journal of experimental and clinical research 2018 Aug 27;24:5973-5979
Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice.
Wu H, Zhang G, Huang L, Pang H, Zhang N, Chen Y, Wang G
Oxidative medicine and cellular longevity 2017;2017:3631565
Oxidative medicine and cellular longevity 2017;2017:3631565
Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
Niu L, Shao M, Liu Y, Hu J, Li R, Xie H, Zhou L, Shi L, Zhang R, Niu Y
Chemico-biological interactions 2017 Sep 25;275:133-144
Chemico-biological interactions 2017 Sep 25;275:133-144
Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway.
Wang W, Chen R, Wang J
Biochemical and biophysical research communications 2017 Nov 4;493(1):794-799
Biochemical and biophysical research communications 2017 Nov 4;493(1):794-799
Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes.
Yuan X, Huang H, Huang Y, Wang J, Yan J, Ding L, Zhang C, Zhang L
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(9):930-938
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(9):930-938
Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway.
Sang Y, Zhang F, Wang H, Yao J, Chen R, Zhou Z, Yang K, Xie Y, Wan T, Ding H
Food & function 2017 Jun 21;8(6):2331-2340
Food & function 2017 Jun 21;8(6):2331-2340
The electrophilic character of quinones is essential for the suppression of Bach1.
Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y
Toxicology 2017 Jul 15;387:17-26
Toxicology 2017 Jul 15;387:17-26
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Shen S, Li J, You H, Wu Z, Wu Y, Zhao Y, Zhu Y, Guo Q, Li X, Li R, Ma P, Yang X, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Hu YR, Ma H, Zou ZY, He K, Xiao YB, Wang Y, Feng M, Ye XL, Li XG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jan;85:313-322
Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway.
Zhang Y, Liu B, Chen X, Zhang N, Li G, Zhang LH, Tan LY
Rejuvenation research 2017 Dec;20(6):462-472
Rejuvenation research 2017 Dec;20(6):462-472
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics.
Wang PW, Hung YC, Li WT, Yeh CT, Pan TL
Oncotarget 2016 Sep 13;7(37):60270-60289
Oncotarget 2016 Sep 13;7(37):60270-60289
Myricetin alleviates cuprizone-induced behavioral dysfunction and demyelination in mice by Nrf2 pathway.
Zhang Q, Li Z, Wu S, Li X, Sang Y, Li J, Niu Y, Ding H
Food & function 2016 Oct 12;7(10):4332-4342
Food & function 2016 Oct 12;7(10):4332-4342
Keap1 hypomorphism protects against ischemic and obstructive kidney disease.
Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y
Scientific reports 2016 Nov 2;6:36185
Scientific reports 2016 Nov 2;6:36185
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Zheng ZG, Xu H, Suo SS, Xu XL, Ni MW, Gu LH, Chen W, Wang LY, Zhao Y, Tian B, Hua YJ
Scientific reports 2016 May 19;6:26093
Scientific reports 2016 May 19;6:26093
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats.
Li H, He H, Wang Z, Cai J, Sun B, Wu Q, Zhang Y, Zhou G, Yang L
Gene 2016 Jul 10;585(2):256-64
Gene 2016 Jul 10;585(2):256-64
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, Wang Y, Xia X, Song E, Song Y
Toxicology 2016 Jul 1;363-364:48-57
Toxicology 2016 Jul 1;363-364:48-57
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
Zhu Y, Li J, Wu Z, Lu Y, You H, Li R, Li B, Yang X, Duan L
Toxicology research 2016 Jan 1;5(1):268-277
Toxicology research 2016 Jan 1;5(1):268-277
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Zhou ZY, Ren LW, Zhan P, Yang HY, Chai DD, Yu ZW
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling.
Ni S, Wang D, Qiu X, Pang L, Song Z, Guo K
International journal of clinical and experimental pathology 2015;8(7):7752-61
International journal of clinical and experimental pathology 2015;8(7):7752-61
Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo.
Shi Z, Niu Y, Wang Q, Shi L, Guo H, Liu Y, Zhu Y, Liu S, Liu C, Chen X, Zhang R
Journal of hazardous materials 2015 Nov 15;298:310-9
Journal of hazardous materials 2015 Nov 15;298:310-9
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Su C, Zhang P, Song X, Shi Q, Fu J, Xia X, Bai H, Hu L, Xu D, Song E, Song Y
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
Sugiyama K, Ebinuma H, Nakamoto N, Sakasegawa N, Murakami Y, Chu PS, Usui S, Ishibashi Y, Wakayama Y, Taniki N, Murata H, Saito Y, Fukasawa M, Saito K, Yamagishi Y, Wakita T, Takaku H, Hibi T, Saito H, Kanai T
PloS one 2014;9(4):e94460
PloS one 2014;9(4):e94460
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S
International journal of clinical and experimental pathology 2014;7(6):2780-9
International journal of clinical and experimental pathology 2014;7(6):2780-9
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
The decrease of NAD(P)H:quinone oxidoreductase 1 activity and increase of ROS production by NADPH oxidases are early biomarkers in doxorubicin cardiotoxicity.
Lagoa R, Gañán C, López-Sánchez C, García-Martínez V, Gutierrez-Merino C
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2014 Mar;19(2):142-53
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2014 Mar;19(2):142-53
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
Endo H, Niioka M, Kobayashi N, Tanaka M, Watanabe T
PloS one 2013;8(5):e63388
PloS one 2013;8(5):e63388
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D
Cell reports 2013 May 30;3(5):1663-77
Cell reports 2013 May 30;3(5):1663-77
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Kwon J, Han E, Bui CB, Shin W, Lee J, Lee S, Choi YB, Lee AH, Lee KH, Park C, Obin MS, Park SK, Seo YJ, Oh GT, Lee HW, Shin J
EMBO reports 2012 Feb 1;13(2):150-6
EMBO reports 2012 Feb 1;13(2):150-6
Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.
Bui CB, Shin J
Biochemical and biophysical research communications 2011 Aug 26;412(2):347-52
Biochemical and biophysical research communications 2011 Aug 26;412(2):347-52
Clustering of plasma membrane-bound cytochrome b5 reductase within 'lipid raft' microdomains of the neuronal plasma membrane.
Samhan-Arias AK, Garcia-Bereguiain MA, Martin-Romero FJ, Gutierrez-Merino C
Molecular and cellular neurosciences 2009 Jan;40(1):14-26
Molecular and cellular neurosciences 2009 Jan;40(1):14-26
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 11451-1-AP(NQO1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using NQO1 antibody 11451-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NQO1 (IP:11451-1-AP, 3ug; Detection:11451-1-AP 1:1000) with K-562 cells lysate 2000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 11451-1-AP(NQO1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
