66489-1-Ig

antibody from Proteintech Group

Targeting: S100A4 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98

Provider product page for 66489-1-Ig

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Antibody data

Antibody Data
Antigen structure
References [31]
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Product number: 66489-1-Ig - Provider product page
Provider: Proteintech Group
Product name: S100A4 antibody
Antibody type: Monoclonal
Description: KD/KO validated S100A4 antibody (Cat. #66489-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2G11B4
Vial size: 20ul, 150ul

S100A4 protein structure - 66489-1-Ig shown in red.

Submitted references S100A4 expression in the enteric nerve system of young and aged rats.

Xiaoyi F, Yiman H, Tianhao X, Kesheng H, Zhenghua X, Hongbin Y
Molecular biology reports 2026 Apr 21;53(1)

Esomeprazole inhibits proliferation of scleroderma fibroblasts via cell cycle regulation.

Khan MA, Koniyan S, Ahir M, Jegga AG, Mayes MD, Gius D, Leung J, Bonnen MD, Montesi SB, Ghebre YT
Frontiers in pharmacology 2025;16:1703115

Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence.

Fang L, Lyu L, Zhong H, Lin J, Ren P, Wang Y, Yin Y, Zhang M, Qu Y
European journal of pharmacology 2025 Oct 15;1005:178043

NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.

Duan WL, Wang XJ, Gu LH, Guo A, Ding YY, Lin P, Zhang BG
Cell death discovery 2025 Nov 10;11(1):520

Tumor exosomal circPTBP3 drives gastric cancer peritoneal metastasis via mesothelial-mesenchymal transition.

Dong C, Zhou Y, Shen X, Hu S, Duan K, Chen T, Li W, Sun X, Li P, Wang P, Han Y, Li D, Zhi Q, Zhou J
Cell death & disease 2025 Jun 11;16(1):444

Fibroblast to macrophage-like cell transition in renal inflammatory injury through the MR/CSF1 pathway induced by aldosterone.

Lv R, Liu Z, Guo H, Zhang B, Wang X, Peng Y, Chang Y, Yang F, Xiong Y, Hao J, Gao X, Wang X, Xu Q, Shimosawa T, Qiang P
Life sciences 2025 Jul 1;372:123627

Luteolin Mitigates Photoaging Caused by UVA-Induced Fibroblast Senescence by Modulating Oxidative Stress Pathways.

Yan Y, Huang H, Su T, Huang W, Wu X, Chen X, Ye S, Zhong J, Li C, Li Y
International journal of molecular sciences 2025 Feb 20;26(5)

PU.1/Spi1 exacerbates ischemia-reperfusion induced acute kidney injury via upregulating Gata2 and promoting fibroblast activation.

Zong C, Xu GL, Ning M, Li JY, Wang X, Guo HJ, Zhang LH, Zhou L, Xu C, Yang ZH, Lu LM, Niu JY
Acta pharmacologica Sinica 2025 Aug;46(8):2251-2266

Proliferator-Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy.

Li X, Liu A, Zhou Y, Qi H, Wang J, Chen M, Sun T, Wu J, Huang Y, Wang L
Investigative ophthalmology & visual science 2025 Apr 1;66(4):36

Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression.

Bai M, Xu S, Jiang M, Guo Y, Hu D, He J, Wang T, Zhang Y, Guo Y, Zhang Y, Huang S, Jia Z, Zhang A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2309754

Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer.

Wang H, Chen J, Chen X, Liu Y, Wang J, Meng Q, Wang H, He Y, Song Y, Li J, Ju Z, Xiao P, Qian J, Song Z
Cancer research 2024 Oct 15;84(20):3371-3387

LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.

Wu HH, Du JM, Liu P, Meng FL, Li YY, Li WJ, Wang SX, Du NL, Zheng Y, Zhang L, Wang HY, Liu YR, Song CH, Ni X, Li Y, Su GH
International immunopharmacology 2024 Jul 30;136:112338

S100A4 reprofiles lipid metabolism in mast cells via RAGE and PPAR-γ signaling pathway.

Shihui M, Shirong Y, Jing L, Jingjing H, Tongqian W, Tian T, Chenyu W, Fang Y
International immunopharmacology 2024 Feb 15;128:111555

Immunocompetent mouse models revealed that S100A4(+) monocytes/macrophages facilitate long-term Zika virus infection in the testes.

Yang W, Zhang C, Liu LB, Bian ZZ, Chang JT, Fan DY, Gao N, Wang PG, An J
Emerging microbes & infections 2024 Dec;13(1):2300466

TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.

Wu M, Jin Q, Xu X, Fan J, Chen W, Miao M, Gu R, Zhang S, Guo Y, Huang S, Zhang Y, Zhang A, Jia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301753

Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies.

Julian CG, Houck JA, Fallahi S, Lazo-Vega L, Matarazzo CJ, Diamond B, Miranda-Garrido V, Krause BJ, Moore LG, Shortt JA, Toledo-Jaldin L, Lorca RA
Physiological genomics 2023 Sep 1;55(9):357-367

MicroRNA 9 Is a Regulator of Endothelial to Mesenchymal Transition in Diabetic Retinopathy.

Wang E, Feng B, Chakrabarti S
Investigative ophthalmology & visual science 2023 Jun 1;64(7):13

LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.

Wu M, Li T, Li G, Niu B, Wu T, Yan L, Wang S, He S, Huang C, Tong W, Li N, Jiang J
European journal of pharmacology 2023 Jul 5;950:175732

C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse.

Yang LX, Zhang CT, Yang MY, Zhang XH, Liu HC, Luo CH, Jiang Y, Wang ZM, Yang ZY, Shi ZP, Yang YC, Wei RQ, Zhou L, Mi J, Zhou AW, Yao ZR, Xia L, Yan JS, Lu Y
Blood 2023 Feb 16;141(7):766-786

Neuropilin 1 promotes unilateral ureteral obstruction-induced renal fibrosis via RACK1 in renal tubular epithelial cells.

Hou L, Du Y
American journal of physiology. Renal physiology 2023 Dec 1;325(6):F870-F884

Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis.

Du Y, Shang Y, Qian Y, Guo Y, Chen S, Lin X, Cao W, Tang X, Zhou A, Huang S, Zhang A, Jia Z, Zhang Y
Cell death & disease 2023 Aug 29;14(8):571

ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation.

Cheng J, Xue F, Cheng C, Sui W, Zhang M, Qiao L, Ma J, Ji X, Chen W, Yu X, Xi B, Xu F, Su G, Zhao Y, Hao P, Zhang Y, Zhang C
Frontiers in pharmacology 2022;13:997916

Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.

Li Z, Geng J, Xie B, He J, Wang J, Peng L, Hu Y, Dai H, Wang C
Frontiers in pharmacology 2022;13:834604

Upregulation of Wilms' Tumor 1 in epicardial cells increases cardiac fibrosis in dystrophic mice.

Guo Z, Geng M, Huang Y, Han G, Jing R, Lin C, Zhang X, Zhang M, Fan G, Wang F, Yin H
Cell death and differentiation 2022 Oct;29(10):1928-1940

FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis.

Wang Y, Sun Q, Ye Y, Sun X, Xie S, Zhan Y, Song J, Fan X, Zhang B, Yang M, Lv L, Hosaka K, Yang Y, Nie G
JCI insight 2022 May 23;7(10)

A functional role of S100A4/non-muscle myosin IIA axis for pro-tumorigenic vascular functions in glioblastoma.

Inukai M, Yokoi A, Ishizuka Y, Hashimura M, Matsumoto T, Oguri Y, Nakagawa M, Ishibashi Y, Ito T, Kumabe T, Saegusa M
Cell communication and signaling : CCS 2022 Apr 7;20(1):46

Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.

Kuang X, McAndrew MJ, Mustachio LM, Chen YC, Atanassov BS, Lin K, Lu Y, Shen J, Salinger A, Macatee T, Dent SYR, Koutelou E
Cancers 2021 Aug 25;13(17)

Polydatin inhibits ZEB1-invoked epithelial-mesenchymal transition in fructose-induced liver fibrosis.

Zhao X, Yang Y, Yu H, Wu W, Sun Y, Pan Y, Kong L
Journal of cellular and molecular medicine 2020 Nov;24(22):13208-13222

S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma.

Hiruta A, Oguri Y, Yokoi A, Matsumoto T, Oda Y, Tomohiro M, Hashimura M, Jiang Z, Tochimoto M, Nakagawa M, Saegusa M
The American journal of pathology 2020 Nov;190(11):2304-2316

S100A4+ macrophages facilitate zika virus invasion and persistence in the seminiferous tubules via interferon-gamma mediation.

Yang W, Wu YH, Liu SQ, Sheng ZY, Zhen ZD, Gao RQ, Cui XY, Fan DY, Qin ZH, Zheng AH, Wang PG, An J
PLoS pathogens 2020 Dec;16(12):e1009019

TGF-β-mediated upregulation of brachyury contributes to constitutively up-regulated type I collagen expression in skin fibroblasts: possible role in systemic sclerosis.

Teng L, Yao G, Gao R, Wang Y, Lin W, Jin Y, Wang Y, Chen H, Wang Z, Chen J
European journal of dermatology : EJD 2019 Aug 1;29(4):359-365

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